A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield

Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5

A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

만성 근골격계 환자에서 Prolotherapy시 고농도 포도당용액에 첨가한 Sarapin^(®)의 효과

강규식,이호철,안기량 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background: Musculoskeletal injury is a major cause of chronic pain due to a weakness of the tendons and ligaments. Currently, prolotherapy is used for treating chronic pain by strengthening the tendons and ligaments. This study was designed to evaluate the effects of prolotherapy using Sarapin^(®) in patients with chronic musculoskeletal diseases. Methods: Forty, chronic musculoskeletal disease patients were randomly divided into two groups. Group 1 (N=20) had been treated with a 15% dextrose solution, 0.2% lidocaine. Group 2 (N=20) had been treated with a 15% dextrose solution, 0.2% lidocaine and 25% Sarapin^(®). The VAS (visual analogue scales) were measured before the injection and two months after the injection. Incidence of side effect and complication were checked too. Results: Both groups showed that a post-prolotherapy VAS was significantly reduced compared to the pre-prolotherapy VAS in 80%, 85% but there was no significant difference. Side effect and complication were not significant difference between both groups such as dizziness during injection, new pain development, and a hematoma except pain after the injection. Conclusions: These results show that prolotherapy using Sarapin^(®) is another good method for treating chronic musculoskeletal diseases.

Streptococcus에 대한 chlorhexidine dihydrochloride와 불화나트륨의 효과

강인성,양규호,최남기,김선미,오종석 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

Chlorhexidine dihydrochloride와 불화나트륨은 구강 내 세균을 억제하고 치태의 형성을 억제하기 위하여 많이 사용되고 있는 물질이다. 그러나 구강에는 여러 종류의 세균들이 상주하며 이들 물질에 대한 감수성도 다르다. 본 연구에서는 chlorhexidine dihydrochloride와 불화나트륨에 의해 Streptococcus mutans의 인공치태 형성이 억제되었을 때 Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Streptococcus salivarius의 증식에 미치는 이들 물질의 영향을 관찰하여 다음과 같은 결과를 얻었다. Streptococcus mutans를 8시간 배양하면 와이어에 형성된 인공치태 무게는 106.1±18.1㎎이었으나, 1.0μM chlorhexidine dihydrochloride를 첨가하면 5.1±1.5㎎으로 감소되었다(p<0.05). 이 때 배양액의 흡광도도 감소되었다. Streptococcus sobrinus의 배양액 흡광도는 감소되었으나 Streptococcus oralis에서는 감소되지 않았고 Streptococcus salivarius에서는 배양 8시간에 감소되었다가 배양 24시간에 대조군과 차이가 없었다. 배지에 3.0 mM 불화나트륨을 첨가하여 Streptococcus mutans를 8시간 배양하면 와이어에 인공치태 무게는 26.7±8.3㎎으로 감소되었다(p<0.05). 이 때 배양액의 흡광도도 감소되었다. Streptococcus sobrinus와 Streptococcus oralis에서의 배양액의 흡광도도 감소되었으나 Streptococcus salivarius에서는 거의 감소되지 않았다. 이상의 결과는 Streptococcus mutans의 인공치태 형성을 억제하는 chlorhexidine dihydrochloride와 불화나트륨 농도에서 Streptococcus의 여러 종의 감수성이 각각 다르다는 것을 시사하였다. Chlorhexidine dihydrochloride and sodium fluoride have been used as agents inhibiting the replication of oral bacteria and the formation of dental plaque. There are various kinds of bacteria with different sensitivity against these agents. In this study, chlorhexidine dihydrochloride and sodium fluoride were studied about their effects on the replication of Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis and Streptococcus salivarius at their concentrations inhibiting the formation of artificial plaque by Streptococcus mutans. When Streptococcus mutans was cultured for 8 hours in the media added with l.0μM chlorhexidine dihydrochloride, the weight of formed artificial plaque was decreased to 5.1 ±1.5mg compared with 106.1±18.1mg of the control(p〈0.05). At the same time, the optical density of cultured media was decreased. The optical density of cultured media was slightly decreased in Streptococcus sobrinus. but was not decreased in Streptococcus oralis. The optical density of Streptococcus salivarius was decreased at 8 hours-incubation, was not decreased at 24 hours-incubation. When Streptococcus mutans was cultured for 8 hours in the media added with 3.0 mM sodium fluoride. the weight of formed artificial plaque was decreased to 26.7i8.3 mg(p〈0.05). At the same time. the optical density of cultured media was decreased. The optical density of cultured media was decreased in Streptococcus sobrinus and Streptococcus oralis, but was slightly decreased in Streptococcus salivarius. These results suggest that at the concentration of chlorhexidine dihydrochloride and sodium fluoridehe inhibiting the formation of artificial plaque by Streptococcus mutans, different species of genus Streptococcus show the different sensitivity against these agents.

Cyclophosphamide가 Mouse 肝臟의 燐酸鹽 分解酵素 活性에 미치는 影響

강성준,이군자,정호삼,이규식 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

Cyclophosphamide which is known as a widely used anticancer drug is very effective against a lymphosarcoma, leukemia and nonneoplasmic diseases such as rhematoid arthritis and lupus erythematosus. Cyclophosphamide acts on a DNA as a alkylating agent inhibiting the cell division and growth. And it is also known that metabolites of cyclophosphamide damages the liver cell. The authors have, therefore, undertaken to pursue the effect of cyclophosphamide on the phosphatase activity in the liver. Albino mice, DDY strain, weighing 20gm were used as experimental animals. The experimental animals were administered daily with 200gm of cyclophosphamide per kilogram of body weight were divided into 7-day treatment group and 10-day treatment group. The specimens obtained from the liver were fixed with 10% formalin and sliced at 16 μm thickness in a frozen cryostat. The activity of alkaline phosphatase was observed by the Gomori's method and activity of the adenosine triphosphatase was observed by the Wachstein-Meisel's method for histochemical study. The results were as follows. 1. Alkaline phosphatase activity of the hepatic lobule was moderately positive at the periportal and intermediate zone of the 7-day cyclophosphamide treatment group and trace activity of alkaline phosphatase was observed at the periportal and intermediate zone of the 10-day cyclophosphamide treatment group. 2. Adenosine triphosphatase activity of the hepatic lobule was moderately positive at the periportal, central and intermediate zone of the 7-day cyclophosphamide treatment group and weakly positive at the central and periportal zone of the 10-day cyclophosphamide treatment group.

III급 부정교합 어린이의 수완부 골성숙과 하악 3대구치 발육에 대한 연구

강근영,양규호,최남기,김선미 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

본 연구는 I급 부정교합과 III급 부정교합 어린이의 수완부 골성숙 단계와 하악 제3대구치 발육을 비교 · 평가하고자 하였다. 이를 위해 전남대학교병원 소아치과에 내원한 환자들로 8세부터 15세 사이의 Angle I급 부정교합을 지난 남자 149명,여자 155명 그리고 Angle III급 부정교합을 지닌 남자 153명,여자 155명,총 612명을 대상으로 하였으며 골성숙 단계 평가를 위해 수완부 사진을 이용한 Fishman의 방법을 사용하였고 하악 제3대구치의 발육 단계를 평가하기 위해 Orthopantomogram을 이용한 Gat 등의 New Six-Developmental-Stage 방법으로 판독하여 다음과 같은 결과를 얻었다. 1. 골성숙 단계는 I급 부정교합과 III급 부정교합군 모두 전반적으로 여자가 남자보다 빠르나(p<O.05) 하악 제3대구치의 석회화 단계는 성별 차이가 없었다. 2. 남녀별 골성숙 단계와 하악 제3대구치의 석회화 단계는 I급과 III급 부정교합군 간에서 유의한 차이가 없었다. 3. I급 부정교합과 III급 부정교합군의 수완부 골성숙 단계와 하악 제3대구치 석회화 단계 사이의 상관관계는 두 군 모두 높은 상관성을 보였다(p<O.O1). 4. I급 부정교합과 III급 부정교합군의 하악 제3대구치 석회화 단계와 연령사이의 상관관계는 두 군 모두 높은 상관성을 보였다(p<O.O1). 이상의 결과로 수완부 골성숙도와 하악 제3대구치 발육은 I급 부정교합과 III급 부정교합군 간에 차이가 없었다. The purpose of this study was to investigate the relationship of the skeletal maturity of hand-wrist and the development of mandibular third molar in subjects with class I and class III malocclusion. The subjects used in this study were 304 children(149 boys, 155 girls) with class I malocclusions and 308 children(153 boys, 155 girls) with class III malocclusions, ranged from 8 to 15 years of age. Hand-wrist radiographs and panoramic radiographs were used to evaluate the stage of skeletal maturity and teeth development. Fishman s method for the skeletal maturity stages of the hand-wrist and new six-developmental-stage method for the calcification stages of mandibular third molars were analyzed. The results were as follows: 1. In subjects with class I and class III malocclusion, skeletal maturity of the hand-wrist occured earlier in females than in ma1es(p<0.05), while the calcification stages of mandibular third molars were no significant gender differences. 2. There were no significant differences between the groups, when comparing the skeletal maturity stages of the hand-wrist and the calcification stages of mandibular third molars between subjects with the class I and the class III malocclusion. 3. The correlation coefficients between the calcification stages of mandibular third molars and the skeletal maturity stages of the hand-wrist in subjects with class I and class III malocclusion showed a high interrelationship(p<0.01). 4. The correlation coefficients between the calcification stages of mandibular third molars and chronological age in subjects with class I and class III malocclusion showed a high interrelationship (p<0.01). As a result, there were no significant differences between class I and class III malocclusion group for skeletal maturity of the hand-wrist and third molar development.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

디메칠포름아미드에 의한 간기능 장해에 관한 연구

강성규,장재연,이경용,정호근 大韓産業醫學會 1991 대한직업환경의학회지 Vol.3 No.1

To investigate the liver dysfunction among workers exposed to dimethylformamide, 24 workers were examined on the liver transaminases and the urine metabolite. The results were as follows: 1. Nine of 24 workers examined had abnormal values in serum aspartate aminotransferase(AST), 5 in serum alanine aminotransferase (ALT), 1 in Υ-glutamyl transferase(Υ-GT). The possibilties of hepatitis due to other causes were excluded by the viral serologic tests and other results. 2. The urinary excretion values of N-methylformamide(NMF), metabolite of dimethylformamide(DMF) were over biological exposure index(BEI) in 4 of 24 workers. 3. The air concentration of dimethylformamide was over threshold limit values(TLV-TWA) in 1 of 5 workers sampled by personal air sampler. 4. The correlation coefficients between age, working part and the values of liver transaminases were not statistically significant.

Furfuryl Chloride와 치환 피리딘류의 반응에 관한 속도론적 연구

강호숙,황규탁 대구대학교 부설 과학교육연구소 1993 과학교육 Vol.6 No.-

The rates and the activation parameters for the reaction of furfuryl chloride with substitude pyridines have been measured in protic solvent(methanol) and aprotic solvents(DMF) at 40℃, 50℃, and 60℃. The rates of reaction were increased with the electron donating power of substitutents and have larger values in aprotic solvent than in protic solvent. The isokinetic relationships were seen between activation energy and activation entropy except for 4-amino pyridine in methanol and DMF. The excellent linear relationships given by the equation (3), (4) were observed between logk and pka of pyridines. The Hammett plot showed a good linearity about substituted pyridine except for 4-amino. The ρ values of Hammett plot were given to be -0.506 in MeOH and -L009 in DMF at 60℃. This deviation of 4-amino group was considered to be attributed to the localization of π election on pyridine ring induced by the nitrogen atom and to be attributed to the resonance and solvent effects. From all of the results for substitutent effects, solvent effects and application of Hammett plot, the reaction was found as a typical S_(N)2 mechnism.