정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

암세포 단백합성기구에 미치는 Nocodazole의 영향

김선희,김주영,성언기,이융창 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.3

구개부에 발생한 다형성선종의 치험례

이창진,김태열,김효언,김희광,전인성,윤규호 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Pleomorphic adenoma is the most common of all salivary gland tumors, constituting over 50 per cent of all cases of tumors, and approximately 90 per cent of all benign salivary gland tumors. Since the term mixed tumor' was introduced by Broca for its dual origin of epithelial and mesenchymal elements, the term plemorphic adenoma suggested by Willis characterizes closely the unusual histologic pattern of the lesion. The parotid gland is the most common site but it may occur in any of the salivary glands. It is somewhat more frequent in women and in the fourth to sixth decades, but they are also relatively common in young adult and have been known to occur in children. Treatment of choice is surgical excision. Adequate surgery with safe margin reduce its recurrence rate. We represent a case of pleomorphic adenoma with literature review in 65-year old male occured in the palate. The lesion was successfully treated by surgical excision.

디지털 마이크로웨이브 수신기에서의 선형 증폭기와 ADC 접속 해석 및 고해상도 스펙트럼 추정

이민혁,최희주,박지언,변건식 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1

An analysis of the relationship between a linear amplifier chain and an analog-to-digital converter(ADC) in a digital microwave wideband receiver, with respect to sensitivity and dynamic range issues, is presented. The effects of gain, third-order intermodulation products and ADC characteristics on the performance of teh receiver are illustrated and design criteria for the linear amplifier chain are developed. Simulated results are also presented and compared with theoretical values. If there are two signals with frequencies very close, an FFT operation may generate one peak containing both signals. Therefore, high resolution spectrum estimation may need ot separate the two signals.

민가 유형의 문화적 해석 : 제주도의 부엌 구조와 생활과의 대응을 바탕으로 Based on Fittness of Kitchen Structure with Life Style in the Cheju Island:

이희봉,송병언 中央大學校 建設環境硏究所 1999 環境科學硏究 Vol.10 No.-

The purpose of this study is to interpret a house as material into culture. Main method is a participant observation, a kind qualitative study, with an ethnographic interview. Two significantly different types of folk housing are discovered in two areas, East and West of the Cheju Island. In the East, kitchen itself form a separated building, Jeogji-gori, whereas in the West, kitchen is within a main building, An-gori. The reason of separated kitchen building is inferred by the different family system, life style, and natural environment, such as soil and wind. In order to explain folk house type, a culture area concept is suggested. Behind a surfacial physical 'type' of architecture, the 'cultural type' is suggested as a new typology.

원예치료가 정신 및 지체 장애인의 재활에 미치는 영향

손기철,고언희,엄수진,이상훈,송종은 建國大學校附設農業資源開發硏究所 2002 農資源開發論集 Vol.24 No.-

This study was to investigate the effect of horticulture therapy on the healing and rehabilitation of the mentally retarded (MR) and physical disorder (PD) persons. Horticultural therapy program was carried at S rehabilitation center located in Kyounggi-DO from Jun 29, 1999 to Oct 12, 1999. The participants in this program were 36 clients of MR and PD. They attended 14 times once a week for 1 hour at a time for horticultural therapy. Evaluation of horticultural activities and ADL (Activities of daily living) has been assessed two times, that is, before and after horticultural therapy program (HTP) whereas horticultural therapy group activity treatment procedure and horticulture task skill inventory have been assessed 3 times, that is, before HTP and after each 7 weeks. MR in the evaluation of horticultural activities showed statistically significant in participation, interest and assistance, verbal interaction during activity, self-concept and identity, need-drive adaptation, interpersonal and social relations, cognition and problem solving, exercise perceptivity, life-tasks skill and vocational adjustment. In activities group of MR also showed significant improvement in terms of physical perceptual abilities, cognitive ability, writing ability, social interaction (P<0.001). Additionally, their horticulture task skill were improved significantly in skill and efficiency factor (P<0.008) and their ADL were changed positively but not significant. On the other hand, PD in evaluation of horticultural activities showed significantly positive changes in self-concept and identity, interpersonal and social relations, life-tasks skill and vocational adjustment. However, physical perceptual abilities factor was proven to be effective in horticultural therapy group activities treatment procedure (P<0.002). Only grooming was significantly improved in ADL evaluation of PD (P<0.03). Putting these results together, it was found that horticultural therapy programs would be very useful for rehabilitation and healing method in both MR and PD.

크레아틴 로딩이 지구운동 및 스프린트 파워발휘에 미치는 효과

오이표,김희수,이신언 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

A study was conducted on the effect f creatine loading on persistent exercise and outcome in sprint which was performed immediately after such exercise and subjects of this study were 12 cycle load athletes. Persistent exercise for the purpose of experiment was carried out for 2 hours and 30 minutes. Then it was continued until the condition of tiredness and exhaustion was reaching with showing density of lactate in blood of 4mmol/ℓand then immediately thereafter for 10 seconds 5 sets maximum sprint were carried out. The subject athletes carried out C Performance which featured absorption of placebo liquid during the exercise involving creatine loading prior to experiment exercise, CC Performance featuring absorption of creatine liquid during the exercise involving creatine loading and P Performance featuring absorption of placebo liquid during the exercise without creatine loading-thus totally 3 Performances were carried out. Comparing with P Performance C Performance showed significant improvement in all the 5 sets in terms of peak power and average power for maximum sprint. On the other hand in CC Performance it was same as P Performance. Creatine loading and creatine absorption liquid did not have any effect on duration of persisting exercise until reaching to fatigue and exhaustion. From the result of this study it could be observed that creatine loading improved maximum sprint ability within a short period of time after persistent exercise leading to fatigue and exhaustion However such effect declined when creatine liquid was absorbed during the exercise.

대안정치성의 접합경쟁, 안철수 현상, 이정희 효과

조희연(Cho, Hee-Yeon),이창언(Chang-eon Lee) 비판사회학회 2013 경제와 사회 Vol.- No.97

필자는 2012년 대선결과를 출발점으로 하여 그것의 정치사회학적 의미와 박근혜 정부의 출현이 갖는 구조적 의미를 분석하고자 했다. 이를 위해 대선에서의 담론경쟁, 안철수 현상, 이정희 효과의 출현을 중심적인 분석대상으로 설정하였다. 먼저 2012년 대선은 이명박 정부의 사회경제적 실패로 조성된 ‘진보적의제 공간’에서의 경쟁이었다. 여기서 박근혜 후보는 반(反)복지세력으로서의 이미지를 벗어던지고 문재인 진영의 ‘전면적 복지’담론에 대항하는 ‘현실적 복지’담론으로 대중들의 저항적 정치성을 전유할 수 있었다. 다음으로 안철수 현상을 제도정치와 대중의 괴리에서 발생하는 대안정치성이 특정 인물에게 투사 되는 현상인데, 이것과 대선의 관계를 논하였다. 다음으로 ‘이정희 효과’를 ‘주류정당 간의 경쟁에서 급진진보세력이 세력이 갖는 정치적 효과’로 규정했는데, 2002년에는 이것이 ‘부정적인 위협효과’를 발휘하는 식으로 나타났다. 이는 급진진보정치세력의 ‘주변화’이자 ‘개혁적 국민정치와 계급정치의 분리’라고 하는 새로운 콘텍스트가 출현했기 때문이었다. 마지막으로 이명박 정부로부터의 대중의 이반에 의해서 강제된 ‘박근혜 진영의 온정적 보수로의 전환’을 제3수동혁명의 경향성을 갖는 것으로 규정했다. This article discusses the political and social implication of the presidential election in 2012 and structural meaning of emergence of Park Geun-Hye, based on its result. For this, I brought the discourse competition, Ahn Cheol-Soo phenomenon, and Lee Jung-Hee effect to the front. First, this election has been held in a kind of ‘political space’ bounded by progressive issues like welfare, economic reform, etc. In this space, the conservative candidate could appropriate the progressive and oppositive political demands with a discourse strategy of making a new image as a ‘realist welfare’ -oriented candidate against the ‘all-out radical welfare’ -oriented one. Second, I evaluated the presidential election by such a new concept as ‘the Ahn Cheol-Soo phenonenon’ was defined as projection of alternative political demands onto a certain outside-party figure, which comes from gap between the existing parties and the people. Third, Idiscussed the ‘Lee Jung-Hee effect’, which means the political effect of the radical candidate onto competition among mainstream candidates. This was expressed as ‘a negative threat effect’ rather than ‘a positive one’ demonstrated by Kwon Yeon-Gil candidate in the 1997 and 2002 election. This means a ‘marginalization of radical political force’, which came from a new context of ‘separation of reformative national politics and class politics.’ Before, the radical class political forces have been identified as a force to drive the reform of the national politics, despite radical. Finally, I defined transition of Park Geun-Hye camp to so-called ‘compassionate conservatism as having a potential of the third passive revolution’ preceded by the May 16 military coup and its developmental drive and June 29th Declaration coerced by the April 29 Student Revolution and June Democratic Struggle.

Structural Characteristics of Immunostimulating Polysaccharides from Lenitinus edodes

Hee Hwan Lee,Jong Seok Lee,Jae Yeol Cho,Young Eon Kim,Eock Kee Hong 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.5

Study on Immunostimulating Activity of Macrophage Treated with Purified Polysaccharides from Liquid Culture and Fruiting Body of Lentinus edodes

Hee Hwan Lee,Jong Seok Lee,Jae Youl Cho,Young Eon Kim,Eock Kee Hong 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.6