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하악골 절단술 후 강성고정과 반강성고정이 골치유과정에 미치는 영향에 관한 병리조직학적 연구
윤규호,이희철 인제대학교 1999 仁濟醫學 Vol.20 No.1S
이 연구의 목적은 성견의 하악골을 인위적으로 골절단술을 시행하여 강성 및 반강성고정을 한 후 골치유과정을 육안적, 병리조직학적으로 비교 관찰하는데 있다. 체중 10∼12kg 정도의 성견 3두를 자웅 구별없이 선택하여 Ketamine-Hcl로 전신 마취하에 제4 소구치와 제1 대구치 사이의 하악골 양측 골체부를 인위적으로 단순 골절시켰으며, 이때 구강내로 골절편이 개방되지 않도록 그리고 하치조신경 및 혈관에 손상을 주지 않도록 주의하였다. 우측 골절단부에는 비압접성 소형금속판과 나사를 이용하여 고정하였고 좌측 부위는 직경 0.46mm의 강선을 이용하여 결찰하였다. 수술 4주, 6주 및 8주 경과 후 실험동물을 희생시켜 하악골을 절제하고 연조직을 제거하였으며, 골절부위의 치유 과정을 육안적 및 병리조직학적으로 광학현미경상에서 관찰하였다. 이 연구를 통해서 강성고정군 4주 소견에서 이미 판상골에 의한 신속한 골유합 양상을 보임으로써 반강성고정군에 비해 양호한 골치유과정을 보여준다는 것을 확인할 수 있었다. The purpose of this study was to investigate the histopathologic difference of the repair process between rigid and semi-rigid fixation applied after mandibular osteotomy in dogs. Three Korean dogs weighting about 10∼12kg were selected in order to carry out this sxperiment. Under the general anesthesia with Ketamine-Hcl, in order to make a fracture with minimal bony defect between fragments and without copuound fracture into the oral cavity and damage of the inferior bur, disc and osteotome. In the right side of osteotomy site was fixed with noncompressive miniplate and screws and in the left side, fixation was performed with stainless steel wire in 0.46mm diameter. Experimental dogs were sacrificed at 4. 6 and 8 weeks after surgery and soft tissues were dissected from the mandible. The fracture sites were observed grossly and examined under the light microscope to observe the bony repair process histopathologically. It has been confirmed through this study that the bony union process of rigid fixation group was filled with lamellated bone more rapidly at 4th week and therefore showed better healing process than semirigid fixation group.
Hydrogenation of Undesired Biomass-derived Chemical to Valuable Solvent by Green Chemistry
윤규호,황성연,제갈종건,차현길 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Levulinic acid (LA) is an undesired biomass-derived chemical, which can be a precursor for the synthesis of γ-valerolactone (GVL). GVL is a key intermediate used as bio-derived valuable chemical produced by hydrogenation of LA. Carbon-supported metal is widely used in industry as catalysts. Herein, LA was hydrogenated to GVL by a flow reactor, generating hydrogen source in situ by the electrolysis of water.
7, 12-dimethylbenz[a]anthracene(DMBA)로 유발된 햄스터 협낭암에서 chlorophylln의 암예방효과에 관한 실험적 연구
윤규호(Kyu Ho Yoon) 대한구강악안면외과학회 2000 대한구강악안면외과학회지 Vol.26 No.2
Carcinogenesis is a multi-stage process that generally consists of at least three steps; initiation, promotion, and progression. If one of these carcinogenic steps were suppressed or delayed, the cancer could be prevented. Cancer chemoprevention is defined to be inhibition or reversal of the carcinogenic process by the specific chemical agents and is a novel approach to cancer management alternative to conventional chemotherapy. Chlorophylln(CHL), a water-soluble derivative of chlorophyll, containing sodium and copper, has been known to be strong antimutagen in several test systems, but its mechanism of antimutagenic action is unknown. In the present experiment, the possibility of CHL as chemopreventive drugs on 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal pouch carcinogenesis was investigated by mutagenicity test, carcinogenicity test, and frequency or spectrum of H-ras mutations in the both of DMBA-induced and chlorophylln-pretreated-DMBA induced tumor by polymerase chain reaction and non-isotopic restriction fragment length polymorphism. The treatment of CHL reduced the yields and multiplicity of the 0.5% DMBA-induced tumor, 86% to 62.5% and 3.7±0.6 to 1.4±0.3, respectively. The occurrence of histidine revertant by 20μmole DMBA was inhibited 25.6 to 81.7% by 1 to 5μM CHL in a dose-dependent manner. The mutation rates of H-ras gene in DMBA-induced and CHL-pretreated-DMBA induced tumor were 96%, 94% of which the most mutations were in codon 12/13. These results suggest that CHL inhibits the carcinogenic action of DMBA by the formation of complex between CHL and DMBA or the inhibition of the activation of DMBA in vivo. But CHL did not affect the mutation rates or its spectrum in already formed tumor.
하악골 골절 환자에 있어 수술후 합병증으로 발생한 골수염의 치험례
윤규호,전인성,신용길,박준호,허남오,방석준 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4
The term osteomyelitis literally means inflammation of bone marrow. It is described as an inflammatory condition of bone primarily engaging the medullary Following circulatory collapse and ischemia, the involved portions of the bone become necrotic. Cellulitis and osteomyelitis are the most frequent complications of fractures of the mandible and maxilla, because there is an abscessed tooth in the line of fracture. Since most fractures are compound fractures, infection may develop because of contact with oral secretions or outside air. The treatment of chronic osteomyelitis is still under debate. Some authors rely on antibiotics alone, while others advocate combination with surgery. But when infection occurs, establish proper drainage and administer antibiotics. Author treated a case of infected mandibular fracture with mandibular osteotomy, sequestrectomy, iliac bone graft and hyperbaric oxygen therapy, who had suffered suppurative osteomyelitis and mandibular nonunion following the open reduction of the mandibular fracture.
한지훈(Ji-Hoon Han)윤규호(Kyu-Ho Yoon),정정권(Jeong-Kwon Cheong),배정호(Jung-Ho Bae),이설옥( Hsueh-Yu Li),오영일(Young-Il Oh),신재명(Jae-Myung Shin),백지선(Jee-Seon Baik),박관수( Kwan-Soo Park) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.6
Synovial sarcoma (SS) is a malignant soft tissue tumor comprising 5-10% of all soft tissue sarcomas. This tumor normally occurs in the paraarticular regions of the extremities but is rare in head and neck sites. SS is sometimes difficult to diagnose because it can mimic benign lesions both clinically and radiologically. This paper presents a rare case of a SS of the buccal space of a 25-year old man. The histology examination and immunohistochemistry of the mass led to a diagnosis of synovial sarcoma. The patient was treated primarily with a surgical resection, followed by radiotherapy and chemotherapy. The follow up examination 17-months after surgery showed no signs of tumor relapse or metastasis.
양측성으로 하악골에 순차적으로 발생한 방사선골괴사증: 증례보고
김해린,윤규호,박관수,정정권,배정호,권준,박군찬,신재명,백지선,Kim, Hae-Lin,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Bae, Jung-Ho,Kwon, Jun,Park, Gun-Chan,Shin, Jae-Myung,Baik, Jee-Seon 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.3
Radiation therapy for malignancy of head and neck leads to secondary effects, such as mucositis, xerostomia, dental caries and osteoradionecrosis. Osteoradionecrosis is a delayed complication which causes chronic pain, infection and constant deformity after necrosis. It occurs spontaneously or after primary oncologic surgery, dental extraction or by trauma of prosthesis. To reduce the incidence of osteoradionecrosis, appropriate antibiotic usage, atraumic procedure, tension-free primary suture and hyperbaric oxygen therapy are essential. This case is about a 74 years old woman who was treated for osteoradionecrosis after extraction of right lower molar at year 2006. She had received radiation therapy for angiosarcoma on tongue at year 2004. At year 2008 the patient came to our hospital for extraction of the opposite premolar but despite careful treatment, osteoradionecrosis occurred again. She was successfully treated by surgical procedure so we report this case.
상계백병원 응급실에 내원한 구강악안면외과 응급환자에 대한 임상적 연구
백지선,윤규호,박관수,정정권,신재명,최민혜,권준,Baik, Jee-Seon,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Shin, Jae-Myung,Choi, Min-Hye,Kwon, Jun 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.6
This is a retrospective clinical study on 2,955 patients who had visited the Emergency Room of Sang-gye Paik Hospital and then been treated in the Department of Oral and Maxillofacial Surgery during recent 4 years from Aug. 2002 to Dec. 2006. The obtained results were as follows. The total number of patients was 2,955 and the ratio of male to female was 1.72:1. The age distribution peak was the 1st decade (30.8%), followed by the 3rd decade (14.3%) and the 4th decade (14.0%). Trauma (62.3%) was the most frequent cause in dental emergency patients, pulpitis (13.0%) and infection patients were next in order of frequency. In trauma patients group, facial bone injury, tooth injury, soft tissue injury were included and soft tissue injury group was most prevalent, followed by tooth injury group and facial bone group. In total patient, the ratio of admission was 3.5%. We obtained the results of the distribution of primary emergency care in the traumatic injury, causal distribution of the jaw fracture, distribution of related medical department in multiple associated injuries, distribution of emergency care in infection, causal distribution and control methods of oral bleeding, distribution of TMJ disorder. The trauma patient group was major in the dental patients who had visited the emergency room, but other various groups were included. So we should analyze the pattern and the variation of the dental emergent patient to provide the proper treatment.
매복과잉치 및 영구치 동시 발거 후 임플란트의 즉시 식립 증례
권준,윤규호,박관수,정정권,신재명,최민혜,나혜정,Kwon, Jun,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Shin, Jae-Myung,Choi, Min-Hye,Na, Hye-Jung 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.4
Supernumerary teeth are extra teeth or tooth-like structures which may have either erupted or unerupted in addition to the 20 deciduous teeth and the 32 permanent teeth. Clinicians sometimes confront unerupted supernumerary teeth where implants would be placed. Many clinicians consider immediate placement of implant into an extracted socket as an effective technique compared to the conventional method of waiting several months for bone healing, because of the advantages such as reduction of treatment period, preservation of alveolar bone and soft tissue, etc. We could hardly find the case of immediate placement of implant after extraction of impacted supernumerary teeth and permanent teeth together. Therefore we report the case of immediate implantation following extraction of impacted supernumerary teeth and poor periodontal conditioned permanent teeth.