8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

大學生의 學校 및 社會에 대한 情報追求行爲 : 부산 대학생을 중심으로

姜大基,黃甲鎭 釜山大學校 學生生活硏究所 1982 硏究報 Vol.18 No.1

The study attempted to investigate the relationship between information-seeking behavior about the university life and society in general and background variables including family structure, class size and departmental employment rate. In this study, alienation and self-esteem were treated as intervening variables. For the analysis, 523 questionnaires were collected from undergraduate students at the Busan National University. A path analysis showed that respondent's self-esteem played a significant role in affecting student's information-seeking behavior and alienation. Among the background variables, class size was the only significant variable related to self-esteem. However, alienation which was assumed to be the major variable influencing information-seeking behavior among students did not show a significant effect on information-seeking behavior. It was assumed that one of the reasons for the very low relationship between these two variables was the structural constraints created by the university system such as extreme competition and anxiety for the among lower grade students.

Berkshire豚의 産仔數와 育成率의 反復力

姜大珍,林鍾佑,朴忠生 慶尙大學校 1976 論文集 Vol.15 No.-

國立種?場 酉州支場에서 1969年부터 1972年까지 保有 縷?에 供用한 62頭의 Berkshire의 總 225부에 대한 資料를 기초로하여 産仔數와 育成率에 대한 反復力을 推定하였다. 産仔數는 年度 季節 및 産次의 差異에 대하여 複定하였고,育成率은 年度, 戒節, 産次, 産仔數 및 仔?의 性別 差異 대하여 統計的으로 補正하였다. 産仔數의 反復力은 0.293±0.073, 그리고 育成率의 反復力은 0.089±0.066으로 推定되었다. Repreatabilities of letter size at birth adn percent pigs raised to weaning of Berkshire swine were estimated based on the data from 225 litters produced at the Sacheon Branch of the National livestock Breeding Station from 1969 to 1972. The litter size at bith was adjusted for differences in year-season of farrowing and number of farrowing of sows and the percent pigs faised to weaning was adjusted for differences in year-season of farrowing, number of farrowing, letter size at birth and sex of pigs. Repeatabilities estimated were 0.293+0.073 for litter size at birth and 0.089+0.066 for percent pigs raised to weaning at 56 days of age.

삼각형 모양에 의한 회절현상에 관한 연구

강성수,성덕용,육도진,홍성대,이원진 대구산업정보대학 2003 논문집 Vol.17 No.-

A review of diffraction phenomena for double slit and regularly triangular aperture has been done. First, as a width b and a space d of double slit vary, a diffraction pattern has been calculated by theory. Second, an intensity of diffraction light and separation between fringes for slit has been measured. And, we can expect that the calculated diffraction pattern for a regularly triangular aperture has three symmetric axes.

위선암에서 E-cadherin의 표출양상에 관한 연구

강동하,김대중,김창진,김의한,양승하 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Gastric adenocarcinoma is the most common malignant tumor in Korea. Many oncogens have been found in malignant tumor cells. E-cadherin located in cell membrane is important for progression and metastasis of tumor. To evaluate the expression of E-cadherin according to histopathologic features and the relation between E-cadherin and prognosis on gastric adenocarcinoma, we have performed immune staining, using mouse HECD-1 for 97 cases. The results were as follows; 1) Gastric adenocacinoma showed the loss or marked reduction of the expression of E-cadherin in 30.9% of 97 cases, and early carcinoma 34.2% and advanced 28.8%. 2) According to differentiation of gastric adenocarcinoma, cases showing the loss or marked reduction of the expression of E-cadherin was well differentiated form 16.1%, moderately 35.7%, poorly 31.9% and mucinous carcinoma 100%. 3) According to the degree of invasion in early carcinoma, cases showing the loss or marked reduction of the expression of E-cadherin was carcinoma within mucosa 41.2% and carcinoma invaded to submucosa 28.6%, but there is no significant difference according to types. 4) According to absence or presence of lymph node metastasis in advanced carcinoma, cases showing the loss or marked reduction of the expression of E-cadherin was 17.6% in non-metastatic cases and 33.3% in metastatic cases, but there is no significant difference according to degree of invasion. Above results indicated that the loss or marked reduction of the expression of E-cadherin in gastric adenocarcinoma may be related to prognosis of the patients.

Kim,Seong-soo : Possiblity of Low Salting Process in Gae-Woo Jeot(Salted and Fermented Gastrophoda) and Changes in Fatty Acid Composition during Fermntation 低鹽化 可能性 檢討 및 熱成중 脂肪酸 組成의 變化

姜永周,河璡桓,金永東,宋大鎭,金洙賢,金成洙 제주대학교 1990 논문집 Vol.30 No.-

To establish the way of processing of Gae-Woo jeot which used abalone intestine that has not been systematically used compare to its characteristic taste and fame as main ingredient and to develop as a local tourist good, the change of constituents the quality of salted fish products suring Gae-Woo jeot fermentation were examined. The results are as follows. 1. In the organoleptic test, Gae-Woo jeot which fermented through 65 days were dominant and the group of 105 salkt concentration were better than that of 20%. It was the best of 10% salted products to add small abalone. Both law salted(10%) and high salted (20%) Gae-Woo jeot were similar in general constityents, nutrients and texture. 2. Compositions of highly unsaturated acid were farely high to 45.6% and 46.1% in small abalone added froup and top sheel added group respectively. during 3 months fermentation low decreasing rate of 3~4% was shown. EPA(eicosapentaenoic acid) was approximately 7~8% and DHA(docosahexaenoic acid) was extremely low to be less than 0.3%. 3. In the changes General composition and pH, pH was within range of 4~5.5, 9~12% in protein, 3~5% in total sugar, 0.5~1% in lipid and approximately 1% in ash. 4. Gae-Woo jeot can be made with 10% low salting method, and 10% group gets all the better for taste, small abalone adding is recommended. 5. When low salt fermented fish of 10% is processed, it is highly recommended to put sorbitol, ethyl alcohol, lactic acid or other humectant for better taste and longer storage and good quality food additives must be developed for tourist and presently applied mil ordering transportation must be sought.

중복종으로 발생한 담낭의 신경 내분비 암종

백대현,민성기,김진만,서광선,강대영 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.24 No.3

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

食品工場廢水의 活性汚泥處理中 오존에 依한 酸化分解效果

康京壽,崔永贊,宋大鎭,河璡桓 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

잔류염소를 함유한 發水를 活性汚泥에 의한 處理效率을 增加시키기 위하여 전압 100Volt, 유속 10ℓ-air/min, 0.8g-O₃/hr의 오존으로 처리했을때 COD의 除去效果및 투과율의 變化를 實驗한 結果를 要約하면 다음과 같다. 1. 잔류염소를 함유한 시료를 0.8g-O₃/hr의 오존으로 處理하였을때 pH의 變化 및 反應時間에 의한 COD의 除去率은 中性溶液(pH=7.2)에서 오존處理時間 50分 후 35%의 除去效果를 나타내어 酸性溶液(pH=3.2)의 20%, 알칼리性溶液(pH=12.0)의 10%의 除去效果보다 좋았다. 2. 잔류염소를 함유한 試料를 오존으로 50分間 處理하여 F/M比 0.1㎏·BOD/㎏·MLSS로 한 후 3. 6. 9 및 15時間 活性汚泥로 反應시켰을 때 反應時間 6時間 후 85.8%의 COD의 除去效果가 있어 티오황산나트륨(Na₂S₂O₃)으로 處理한 試料의 除去率 60.5%보다 좋았으며, 反應時間의 단축효과도 있었다. 3. Polyphenol色素 等 暗褐色을 띄는 試料를 酸性, 中性, 알칼리性 溶液으로 하여 오존으로 50分間 處理하였을 때 투과율이 30~40%에서 70% 以上 상승하였으며 알칼리성溶液에서가 투과율이 더 좋았다. For the increase of treatment efficiency when waste water which included residual chlorine was biologically treated with activated sludge, elimination efficiency of COD and change of transmittance by activated sludge method were examined after the treatment of residual chlorine with ozone of 100 volt and 10ℓ-air/min., 0.8g-O₃/hr. in velocity. The results were as follows. 1) When the sample which included residual chlorine was treated with ozone of 0.8g-O₃/hr., COD removal rate by the change of pH and ozonization time was more efficient than acidity solution of pH 3.2(20%) and alkaline solution of pH 12.0(10%). Since the COD removal rate become 35% after 50 minutes of ozonization time at neutral solution of pH 7.2. 2) After the residual chlorine included sample was treated with ozone for 50 minutes to make the F/M rate of 0.1㎏·BOD/㎏·MLSS, the sample was reacted with activated sludge for 3, 6, 9 and 15 hours. The 6 hours reaction gave 85.8% COD elimination which showed higher efficiency than 60.5% by Na₂S₂O₂ treatment togather with shorting efficiency of reaction time. 3) When such sample as polyphenol which gives dark brown color was treated with ozone for 50 minutes after being made into acidic, neutral and alkaline solution, the transmittance increased from 30-40% to 70% and gave better result in alkaline solution.