방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

순비기나무 (Vitex rotundifolia L. f.) 삽수 종류 및 생장조정제 처리에 따른 발근율

Jeong Yeob Kim,Yoon Ki Hong,Song Hee Ahn,Jung Seob Moon,Eun Seok Park,Hee June Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05

Background : This study was conducted to developed the propagation method by cutting for mass cultivation of Vitex roundifolia. We were pitched the cutting two times and treated plant growth regulators to enhance the rooting percentage. Vitex roundifolia is live in beach sandy soil south of Hwanghae-Do and Gangwon-Do. Vitex roundifolia have been used to bath foam. It is good for aromatic plant. It has 0.8% essential oil content in leaf and flower. Major components of essential oil were alpha-Pinene, Sabinene, beta-Pinen, 1,8-cineole, d-Limone. Despite the superior usability, it had not yet been made by the artificial cultivation Methods and Results : We were pitched the cutting of a first-year branch on June 5, which was greenwood cutting and July 17, which was semi-hardwood cutting at Kwangseung-ri beach, Gochanggun, Jeonbuk. The length of cutting was 10cm. It had 3~4 nodes, we stuck a cutting remain 2 nodes above ground on ordinary raise seedling soil. Rooting percentage was measured at 60 days after stuck a cutting. Rooting percentage was higher greenwoody cutting(95%) than semi-hardwood cutting(57.6%). In green wood cutting, there was no significance with plant growth, but chemical injury was occurred in IBA 5,000ppm. In semi-hardwood cutting, there was significance with plant growth regulators. The rooting percentages of all the treat were higher than control(no treatment). Rooting percentage was the highest in NAA 5,000ppm treated. Conclusion : Greenwood cutting method was more proper to propagation for Vitex roundifolia than semi-hardwood cutting. The optimum time to cutting for Vitex roundifolia propagation was the early in June. If miss a time to propagation Rooting percent was elevated by plant growth regulator.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

高脂肪性食餌로 因한 高脂血症 白鼠에 首烏延壽丹이 미치는 影響

金庸柱,최달영,김준기,박원환 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

This study was done in order to investigate the effect of Suoyensudan on hyperlipidemia. Results: 1. The level of serum total cholesterol was decreased with the significance in the sample groups as compared with the control groups. 2. The level of serum HDL-cholesterol was increased with significance in sample groups as compared with the control groups. 3. The level of serum phospholipid was increased with significance in Sample 1 group as compared with Control 1 group, but Sample 2 group did not show significance as compared with Control 2 group. 4. The level of serum β-lipoprotein was decreased with the significance in Control 1 group, but control 2 group did not show significance. 5. Rate of total cholesterol vs. HDL-cholesterol and total cholesterol vs phospholipid were increased in the sample groups as compared with the control groups. Conclusion; It is considered that Suoyensudan respectively had recovering effect on the Hyperlipidemia induced by cholesterol in male rats. So it can be use to prvent and treat hyperlipidemia and related deseases.

벼 農事의 肥料施用이 水質에 미치는 影響

김기준 건국대학교 생명과학연구원 1995 생명과학지 Vol.2 No.-

A lot of agrochemicals are applied in paddy field to increase grain yield of rice per unit area especially in the small scale farming system and it would be generated or associated with environmental problems. This experiment was carried out to evaluate the effect of fertilizer application on the quality of water in paddy field. Concentration of nitrogen, phosphorus and potassium in the surface water was increased in 2 to 3 days after fertilizer application and then decreased. Nutrients concentration in the surface water was lower in whole-layer application of fertilizer than those of surface application. But very small amount of nutrients was lost to percolating water and there was no difference between the fertilizer application methods. Nitrogen, phosphorus and potassium contents in the rice plant were higher in the whole-layer application than in the surface application of fertilizer. Removal of nitrogen, phosphorus and potassium by rice plant at 60 days after transplanting was 6, 2 and 7㎏ per 10a, respectively. This result suggested that most of applied nitrogen and potassium could be uptake by rice cropping but not for phosphorus.

下利의 傷寒論的 觀点과 四象醫學的 觀點의 比較·考察

金庸柱,金俊錡,崔達永 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

病證分析에 있어 病證을 細密히 觀察하면 體質에 따르는 특수한 病證이 있고 一般病證이라도 體質에 따르는 內的成因이 다름을 알 수 있는데, 이에 본 硏究에서는 證治醫學의 代表的인 書籍인 『傷寒論』과 體質醫學의 代表的인 書籍인 『東醫壽世保元』에서는 少陰人裏病證과 少陽人表病證에서 주로 言及되었다. 李濟馬는 三陰病證은 모두 少陰人病證이라 하였는데 下利症은 그 病機 에 있어 주로 少陰人病證과 聯關性이 많았으나, 少陰病熱化證의 경우에 있어서는 少陰人 病機로 理解하기에는 어려움이 있었으며 오히려 少陽人 病機로 推定할 수 있었다. The results of the pathogenesis analysis of a diarrhea of the differential diagnosis suggested in Sanghnnlun and Dongyishoushibaoyuan are as followings. 1. The various factors such as cold, asthenia and sthenia are the pathogenesis of a diarrhea. Among of them, the asthenia-cold is the main pathogenesis, and theis shows that the above pathogenesis could belong under the constitutional pathogensis of Shaoyinren. 2. Dong-Mu proved that all the symptoms of Sanyinbing were the symptom of Shaovinern. The case of Shanyinbing involved by the heat-evil, however, indicates that it is not the pathogenesis of Shaoyangren. 3. To understand the various differential diagnosis of the pathogenesis in Sanghanlun, the study on the theoretical relation with the constitutional pathogenesis in Dongyishibaoyuan will be necessary.

傷寒論 第28條에 대한 文獻的 考察

金俊錡 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.1

傷寒論 第 28條는 病機의 分析과 主治처방의 構成에 대해서 歷代 傷寒論 注釋家와 現代 中醫學者間에 많은 논란이 있는 條文이다. 本 論文은 28條에 대하여 表邪의 有無와 主治處方의 錯簡說 등에 대한 歷代 注釋을 檢討하였다. 論者는 이러한 論難을 咳嗽하기 위한 方法으로 有關 處方에 대한 方後注文과 傷寒論의 條文 配列 順序의 意味에 根據하여 本條가 水飮內停證에 속하며 계지거계가복령백출탕이 本證의 主治處方임을 論證하였다. Many arguments on the interpretation of the 28th articles of Shanghanlun(傷寒論) which deals with the analysis of pathogenesis and the constitution of the chief prescription, have been made between the previous interpretators and moderm chinese medical scholars. In this paper I have examined the previous comments on the 28th article by focusing on the existence of Biaoxie(表邪) and the misunderstanding of the chief prescription Based upon the meanings of the annotated explanation about the related prescription and the article arrangement of Shanghanlun(傷寒論), my analysis shows that the 28th article belongs to the symptoms of Shuiyinneitingzheng(水飮內停證) and therefore Guizhiquguijiafulingbaizhutang(계지거계가복령백출탕) should be chief prescription for the symptoms.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

순막조건화에서의 적핵과 소뇌 중간핵의 기능

김현택,최준식,김기석 한국심리학회 1996 한국심리학회지 생물 및 생리 Vol.3 No.1

토끼 순막조건화에 관여하는 뇌간과 소뇌의 구조물들의 기능을 검토하고자 뇌간의 대표적 운동핵인 적핵과 소뇌의 심부핵 중 하나인 중간핵을 연구대상으로 선정하였다. 실험 1에서는 조건자극으로 400msec동안의 정현파 청각자극을 제시하고 무조건자극으로는 뇌간의 운동핵이며 순막반응의 출력핵이라고 알려진 적핵에 자극용 전극을 삽입하여 전기자극을 가함과 동시에 각막 공기분사를 복합적으로 제시하면서 전형적인 지연조건화를 시켰다. 그리고 소거시에는 조건자극과 함께 적핵전기자극만을 제시하였다. 이와함께 조건반응의 신경적 가소성 형성의 후보구조물로 알려진 중간핵에 기록용 전극을 삽입하여 조건화동안의 중간핵 뉴런들의 다단위 활동을 기록하였다. 실험 결과 적핵자극은 조건화의 습득과 소거에 유의미한 영향을 미치지 못하였다. 따라서 적핵은 순막조건화에서는 단순운동 출력핵임을 확인하였다. 그와 함께 소뇌 중간핵에서의 다단위활동의 기록은 이 핵이 조건반응이 형성되는 가소성구조물 또는 그 출력을 받는 구조물임을 입증해 주었다. 실험 2에서는 조건자극 및 무조건자극복합은 실험 1과 동일하게 하였다. 단지 소뇌 중간핵에 자극전극을 삽입하여 전기자극을 가하면서 조건화를 시킨 점만 다를 뿐이다. 결과를 보면 중간핵을 자극하면 순막조건화의 습득에서 유의미한 지체를 보였고 소거에서 유의미한 촉진을 보였다. 이는 중간핵이 조건반응의 형성 및 해제에 중요한 역할을 하는 구조물임을 시사하는 것이다. The red nucleus and the cerebellar interpositus nucleus were successively investigated in terms of multiple plastic structures mediating the classical conditioning of the rabbit's nictitating membrane response (NMR). In experiment 1, monopolar tungsten stimulating electrodes and low-impedance monopolar tungsten recording microelectrodes were chronically implanted into the red nucleus and the interpositus nucleus respectively. All animals were trained with delay conditioning paradigm. In order to investigate any involvment of the red nucleus in the conditioning of NMR, animals of the experimental group were trained with the tone conditioned stimulus (CS) (400msec, 1㎑, 85㏈, sine wave) and unconditioned stimulus (US) consisted of the electrical stimulation of the red nucleus (100msec, 400㎐, pulse width 0.1msec, 60~150㎂) and simultaneous corneal airpuff(100msec, 100g/㎠) in the five aquisition sessions. In two successive extinction sessions, the animals were trained with the tone CS and the electrical stimulation US of the red nucleus alone. Animals of the control group were trained with the tone CS and the corneal airpuff US in the same aquisition sessions and with the tone CS alone in the same extinction sessions. Results showed that the electrical stimulation US of the red nucleus neither facillitates the learning rate in the aquistion stage nor maintains the conditioned response(CR) in the extinction stage. It may be concluded that the red nucleus is a mere output structure and is not an essential one in the neural network mediating the conditioning of NMR. Multiple unit activity(MUA) recorded from the cerebellar interpositus nucleus was processed to 16msec-bin histogram and the NMR was averaged in each session. The averaged NMR was highly correlated with the histogram and the histogram of MUA preceded the averaged NMR. This supports the previous reports that the cerebellar interpositus nucleus may be the neural substrate of the conditioning of NMR. In experiment 2, stimulating electrodes and recording microelectrodes were chronically implanted into the cerebellar interpositus nucleus and the red nucleus respectively. All training methods were identical with the experiment 1, except for exchanging the stimulating target structure for the recording one. Results showed that the electrical stimulation US of the cerebellar interpositus nucleus severely retarded the aqusition of the CR. It is concluded that the cerebellar interpositus nucleus may be a structure of plasticity included in an essential neural network mediating the conditioning of NMR. Possible interpretations of the result, concerning the side effect of the electrical stimulation and the function of the inferior olive-cerebellar cortex-interpositus nucleus-inferior olive recurrent loop, are discussed.