열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

최씨 훅을 이용한 복강경 버찌씨 수술

김영혜 ( Young Hye Kim ),박준선 ( Jun Seon Park ),최상준 ( Sang Joon Choi ),송창훈 ( Chang Hoon Song ),한세준 ( Sei Jun Han ),정혁 ( Hyuk Jung ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6

Objective: Burch operation has been effective method for the treatment of stress incontinence. Burch operation is a well-accepted procedure for treating stress urinary incontinence secondary to urethral hypermobility without intrinsic sphincter deficiency and is the reference standard with which other procedures are compared. This study is to evaluate the effectiveness of the Choi`s hook in laparoscopic Burch operation. Methods: This study included 47 patients who had undergone laparoscopic Burch operation from October 2000 through March 2005. Of these 47 patients, 27 patients underwent traditional laparoscopic Burch operation (Group 1) and 20 patients underwent laparoscopic Burch operation with Choi`s Hook on anchoring the endopelvic fascia to the Cooper`s ligament (Group 2). Results: The mean age of patients of Group 1 was 55.6±9.37 years of age and that of Group 2 was 56.0±5.93 years of age. There is no difference in the mean age of patients (P>0.05). The mean operating time was 90.5±15.32 minutes for Group 1 and 38.5±10.14 minute for Group 2. The mean operating time was shorter in Group 2 than Group 1 (P<0.05). There was no difference in recurrence rate and complication rate between Group 1 and Group 2 (P>0.05). Conclusion: We performed laparoscopic Burch operation with the Choi`s Hook on anchoring the endopelvic fascia to the Cooper`s ligament. When we compared traditional laparoscopic Burch operation with laparoscopic Burch operation with Choi`s Hook, we could shorten the operation time using the Choi`s Hook.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

석탄 슬러리 기포탑에서 초음파에 의한 슬러리 입자의 축방향 분산 촉진

최상원,나종복,서호준 麗水水産大學産業技術硏究所 1992 産業基術硏究所 論文集 Vol.1 No.-

In a semi-batch coal slurry bubble column(0.10m-IDx1.53 m-height),the effects of gas velocity(0.02-0.10 m/s),apparent slurry viscosity(1.2x10?-3.82x10?Pa·s),concentration of slurry particles(10.04-51.25kg-solid/m³-slurry)and ultrasound on the axial concentration distribution of slurry particles have been determined. Sedimentation-dispersion model and modified sedimentation-dispersion model have been applied to analyze axal concentration distribution of slurry particles. The axial distribution of slurry particles became uniform with increases in gas velocity, apparent slurry viscosity and slurry concentration,and by introduction of ultrasound. The axial dispersion coefficient of slurry particles increased with increasing gas velocity,but it decresed with increasing apparent viscosity of slurry. The magnitude of the axial dispersion coefficient increased to about 2-5 times by using ultrasound in comparison with that without ultrasound. The axial distriution of slurry particles from the experiments agreed well with that obtained from the modified sedimentation-dispersion model, in which the particle size distribution of slurry particles was considerd.

골다공증에 의한 압박 골절의 치료에 있어서 경피적 추세 성형술의 의의

최재영,윤승환,조준,문창택,장상근 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Percutaneous vertebroplasty has recently been introduced as a therapeutic alternative for the treatment of pain associated with osteoporotic compression fractures and performed popularly at a few centers by neurosurgeons. This technique allows marked pain relief through stabilization of microfractures and strengthening of weakened vertebral body. Authors retrospectively analyzed the clinical outcome of 100 patients with osteoporotic compression fractures for investigating the therapeutic effectiveness of percutaneous vertebroplasty. They were treated with vertebroplasty from April to August 1999. Plain X-ray of all patients showed osteoporotic compression fractures at more than one level.

위내시경에 의한 칫솔제거

최성곤,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

최근 내시경술의 발전으로 진단적인 측면 뿐 아니라 그 치료적인 면에서도 많이 이용되고 있는 실정이다. 저자들은 오심을 해결하기 위해 칫솔로 설근부를 자극하여 구토를 유발하던 중 우발적으로 연하되어 식도·위 접합부 및 위내에 있다가 내시경으로 제거된 칫솔 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. With the improvement of the technique and instrument, the gastroduodenal endoscope has been used not only in diagnostic purpose but in therapeutic approach. In this case, we removed a swallowed toothbrush in esophagus and stomach with gastroduodenal endoscope and snare without complication.

Pt(111)와 Fe(111) 고체표면에서 CO₂화학흡착에 관한 분자궤도론적 연구

최상준 인제대학교기초과학연구소 1998 자연과학 Vol.2 No.-

Pt(111)와 Fe(111)표면위의 CO₂ 흡착성질을 비교하였다. 고체표면위의 CO₂ 흡착자리는 di-o(₁), π, μ, π/μ, 1-fold, 2-fold, 3-fold등 7개 흡착상태로 계산하였다. Pt(111) 표면에 흡착된 CO₂의 결합에너지는 1.35 eV, 0.06 eV, 0.05 eV, 0.04 eV, 1.70 eV, 1.93 eV 그리고 0.88 eV이다. Fe(111)표면에 흡착된 CO₂의 결합에너지는 2.65 eV, 1.31 eV, 2.04 eV, 1.90 eV, 2.32 eV, 2.05 eV 그리고 2.17 eV 이다. di-o(₁) 흡착자리에서는 Pt(111)와 Fe(111)모두 화학흡착을 하고 CO₂분자가 찌그러진 구조를 가진다. 1-fold, 2-fold 및 3-fold의 경우는 CO₂분자중 산소의 한끝이 고체표면과 결합하는 수직형태의 화학흡착이 Pt(111)와 Fe(111) 고체표면에서 일어남을 알았다. π, μ 및 π/μ흡착자리에서는 Pt(111)의 경우 물리흡착으로 거의 선형의 구조에 가깝고 Fe(111)의 경우는 화학흡착으로 찌그러진 구조를 가짐을 알 수있다. Fe(111)표면의 경우가 Pt(111)보다 더 강한 CO₂분자 흡착이 일어남을 알았고 CO₂분자가 찌그러짐은 2πu-orbital이 금속의 d-orbital과 섞임이 일어나기 때문이다. Comparing the adsorption properties on a Pt(111) with a Fe(111) surface, we calculated seven types of binding state; di-o(₁), π, μ, π/μ, 1-fold, 2-fold and 3-fold. On a Pt(111) surface, calculated binding energies are 1.35 eV, 0.06 eV, 0.05 eV, 0.04 eV, 1.70 eV and 0.88 eV, respectively. On Fe(111) surface, calculated binding energies are 2.65 eV, 1.31 eV, 2.04 eV, 1.90 eV, 2.32 eV, 2.05 eV and 2.17 eV, respectively. Chemisorbed molecular CO₂ for di-o(₁) on the Pt(111) and Fe(111) is bent, and for 1-fold, 2-fold and 3-fold is normal with O one end down to surface plane. The adsorbed molecular CO₂ for π, μ and π/μ-site on the Pt(111) surface is physisorbed molecule and close to linear structure. The binding sites for adsorbing CO₂ on the Fe(111) surface are stronger chemisorption than Pt(111), and chemsorbed CO₂ bend because of metal d mixing with 2πu-orbital.

수종의 접착제를 사용한 아말감 수복시의 미세 변연 누출에 관한 연구

최상철,박준일,권혁춘 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.1

한번의 간질발작 후 혈청 Neuron-Specific Enolase 농도 변화

최승호,박영춘,이장준,임정근,김지언,이상도 啓明大學校 醫科大學 1999 계명의대학술지 Vol.18 No.4

An increase in neuron-specific enolase (NSE) levels in serum and CSF has been shown to be an useful marker of brain damage after stroke, global ischemia, and coma. We report the changes of serum NSE levels after seizure attacks in epileptic patients compared with the levels in normal controls and epileptic patients without seizure attack at least 7 days (epileptic controls). Twenty-four seizures were included in this study. Blood was drawn within 1 hour, at 12 hour, 24 hour, and 48 hour after seizure attack. Serum NSE levels were measured with radioimmunoassay. The mean NSE levels for normal controls and epileptic controls were 6.94 ng/ml and 7.46 ng/ml, respectively. There were significant increase in level of serum NSE measured within 1 hour after seizure attack in epileptics compared with the level in normal controls (15.10ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (15.10ng/ml versus 7.46ng/ml, p<0.05). Serum NSE measured at 12 hours after seizure also increased compared with normal controls (12.32ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (12.43ng/ml versus 7.46ng/ml, p<0.05). Between normal controls and epileptic controls, there were no significant difference in serum NSE levels. We conclude that serum NSE level was elevated in epileptic patients who had seizure attack within 12 hours. Serum NSE levels can be useful marker for seizure within 12 hours after onser. The elevated serum NSE level after single seizure attack may suggest that the brain was injured in single seizure.