정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

翁方綱이 추사금석학 형성에 미친 영향

이승연(Lee, Seung Yeon) 한국서예학회 2016 서예학연구 Vol.29 No.-

한국금석학의 역사에서 가장 주목해야할 일은 19세기에 있었던 한·중 금석탁본의 교류와 연구이다. 이 시기는 청조를 방문했던 많은 문인들과 역관들에 의해 금석학자들의 적극적인 학문적 교류가 확대되었고, 이를 계기로 금석문을 연구대상으로 삼 고자 하는 학풍이 생겨나기 시작한 시점으로, 그 중심에 覃溪 翁方綱(1733~1818)과 秋史 金正喜(1786~1856)가 있었다. 특히 이 두 학자간의 직접적인 만남과 교류는 韓中의 금석탁본을 서로 교환하고 분석하면서 자연스럽게 추사금석학을 탄생하 게 하는 결과를 낳았다. 조선의 18세기 후반과 경화지역은 청대의 학문과 예술에 대해 관심이 증폭된 시기로, 추사는 1809년 10월 24세에 司馬試에 합격하여 生員이 되면서 아버지 김노경이 冬至副使로 연경에 갈때 子弟軍官의 자격으로 함께 중국에 가게 되어 40일간 머무르며 계획적이고 체계적인 공부를 하게 되었다. 이 짧은 기간동안 옹방강을 비롯한 曹江(?~?) ․ 徐松(1781-1848) · 阮元(1764~1849) ․ 朱鶴年(1760-1834) ․ 李鼎元(1749-?) ․ 李林松(?-?) 등과 만나면서 시서화는 물론 청조고증학을 받아 들이는 창구를 만들어 놓았고, 귀국후에도 이들과의 지속적인 교류를 유지하면서 새로운 학문에 대한 열망으로 추사금석학을 체계화시켰다. 특히 옹방강은 당시 최고의 학자로 조선의 젊은 청년과의 만남이 쉽지 않았으나 추사의 스승인 朴齊家(1750~1805)의 소개편지로 귀한 만남의 시간을 가질 수 있었으며, 이러한 인연으로 옹방강의 서재인 石墨書樓에서 중국의 귀중한 탁본진본과 서화진적을 볼 수 있었던 행운의 기회를 얻을 수 있었다. 이러한 경험은 추사로 하여금 금석학과 고증학에 전념하는 큰 계기가 되었으며, 귀국 후에도 종종 서신을 나누면서 금석문을 분석하는 방법과 고증하는 과정, 제발, 쌍구의 체제를 지도 받았다. 당시 조선은 금석학 분야의 심도 있는 연구보다는 금석문을 서법연마의 자료로 활용하거나, 탁본을 통해 완상의 대상으로 삼았던 게 전부였으나 추사가 금석학의 체계를 세운 이후부터 금석문을 학문의 대상으로 삼아 체계적인 연구를 하면서 고 증과 분석을 하는 작업이 활발히 진행되어 여러 학자들에 의해 많은 성과가 있었다. 따라서 탁본첩의 제작이나 금석문 목록집의 편찬에서 더 나아가 금석문의 내용에 관해 釋文을 하고, 그 역사적인 유래와 의미, 서체를 연구하기 시작하면서 독립된 학문으로서의 체계를 갖추게 된 것이다. 따라서 목록집의 경우에도 단순히 비석의 위치나 명칭을 기록하는데서 더 나아가 건립 시기를 추정하고 간략한 해제를 첨가하는 데까지 나아가게 되었으며, 題跋文, 서예작품, 쌍구작품 등의 형태로도 분석결과를 남기게 되어 한국서예사 발전에도 큰 영향을 미쳤다. The most noticable thing in history of Korean epigraphy is study and exchange of Korean and Chinese epigraphy in 19th century. In this time, social intercourse with epigrapher was enlarged by many literator and interpreter who visited the Ching dynasty and academic tradition trying to study epigraphy started to appear with this as a momentum. And there were Dam-gye Eong-bang-gang (覃溪翁方綱, 1733~1818) and Chu-sa Kim-Jeong-hee (秋史金正喜, 1786~1856) in the center of that. The interchange between these two scholars led to the birth of Chu-sa s epigraphy by intercourse between Korean and Chinese epigraphic rubbing and calligraphic effect. Kyung-hwa region of the late 18th century had a lots of interest in study and art of Ching dynasty. Chu-sa passed Sa-ma-si in October 24, 1809 and became saeng-won. He went to China for 40 days as child officer and studied systematically when his father, Kim No Kyung went to Yanjing as Dong-ji-bu-sa. In this short period, Chu-sa met Eong-bang-gang ․ Jo-gang (曹江, ?~?) ․ Seo-song(徐松, 1781-1848) · Wan-won (阮元, 1764~1849) ․ Ju-hak-yeon (朱鶴年, 1760-1834) ․ Lee-jeong-won (李鼎元, 1749-?) ․ Lee-im-song (李林松, ?-?) and made a window for accepting the study of ancient documents of Ching dynasty as well as poem, writing and painting. After coming back, he maintained continuous intercourse with them and systematized the epigraphy of Chu-sa with an enthusiasm to the new study. Especially, it was not easy to meet young man in Joseon as Eong-bang-gang was the greatest scholar in Ching dynasty but he met Chu-sa thanks to the introduction letter of Park-je-ga (朴齊家, 1750~1805) who was a teacher of Chu-sa. Also, he could luckily have a chance to see Chinese precious original copy of rubbing and real relics. It was a great opportunity for Chu-sa to concentrate on epigraphy and the study of the ancient, so they often sent letters to each other to learn the method of analyzing epigraph and studying historical evidence and system of Jebal and Ssang-gu. At that time, scholars of Joseon could only just use epigraph as a material of polishing writing style rather than intensive study on epigraph and regard an epigraph as appreciating object by rubbing. But, after Chu-sa systemize an epigraph, studying and analyzing epigraph systematically paid off by many scholars. So, they systemized epigraph as independent study as doing Jebal about epigraph and studying its historical origin, meaning and font making a headway from making rubbing book and lists of epigraph. Therefore, in case of lists of epigraph, they not only just write location or name of stone but estimate the contruction period and adding brief explanation so it had a great effect on developing Korean calligraphy history leaving the work of Jebal, calligraphic work and Ssang-gu work.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

성인에서 Haemophilus influenzae 감염증의 임상양상과 미생물학적 특성

이종섭,황병연,정희진,김우주,박승철,이도현,이창규,신종희,황규잠,이영희 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.2

목적 : H. influenzae는 성인에서 흔히 호흡기 감염을 일으키는 균주로, 최근 ampicillin 내성 β-lactamase 생성 균주들이 지속적인 증가를 보이고 있어, 이에 국내 성인에서 H. influenzae에 의한 감염의 임상양상과 분리된 균주들의 미생물학적 특성을 조사하고자 하였다. 방법 : 1998년 3월부터 1999년 9월까지 고려대 구로병원에 내원한 환자중에서 H. influenzae가 분리된 68명을 대상으로 임상양상을 조사하고 항균제 감수성 검사를 시행하였다. 분리된 33주에 대해서 혈청형, 생물형, 세포외막 단백분석을 시행하였고, β-lactamase 생성여부에 따른 감염 환자군간 임상상 및 예후의 차이를 비교하였다. 결과 : 환자의 평균연령은 68세였고, 지역사회 획득감염이 전체의 85%를 차지하였다. 폐렴과 기관지염과 같은 하기도 감염이 전체환자의 75%를 차지하였고 분리 검체 역시 객담이 84%로 가장 많았다. 환자의 71%가 기저질환을 가지고 있었으며, 그 중에 만성 폐쇄성 폐질환, 심혈관 질환, 악성종양, 당뇨병이 대부분이었다. 혈청형으로는 nontypeable 형이 68%로 가장 많았고 b형은 한 예도 없었다. β-lactamase 생성율은 63.2%였고, β-lactamase 양성균주의 항균제 내성율이 음성균주에 비하여 높았으나 β-lactamase 생성 여부에 관계없이 cefotaxime, azithromycin, ciprofloxacin에 대하여 100%의 감수성을 나타내었고 cefaclor, cefuroxime에 대해서는 10% 이하의 낮은 내성율을 보여 이들 항균제들이 치료에 효과적일 것으로 사료된다. 세포외막 단백분석에서는 C형과 D형이 전체의 64%로 가장 많았으며, 혈청형과의 유의한 연관성은 보이지 않았다. 결론 : 성인에서 H. influenzae는 주로 만성 기저질환자에서 급성 호흡기감염 또는 만성 폐쇄성 폐질환의 급성 악화를 유발한다. 기존의 보고에 비해 β-lactamase 양성율이 증가하였고, 이에 따른 항균제 내성율도 증가하여 항균제의 선택에 유의하여야 할 것으로 생각된다. 세포외막 단백분석상 특정한 유형의 균주에 의해 감염이 집중적으로 발생하고 있어 향후 역학 조사의 도구로 이용할 수 있겠다. Purpose : H. influenzae is one of the common causative microorganisms of respiratory tract infections in adults. Recently. β-lactamase producing, ampicillin-resistant H. infiuenzae has become worldwide problem as well as in Korea. We studied to investigate the clinical features and microbiologic characteristics of H. infiuenzae infections in adults. Materials & Methods : From March 1998 to September 1999, 68 patients were enrolled in this study. Clinical features of H. infiuenzae infections were investigated, 68 isolates were subjected to the β-lactamase test, and 33 isolates were used for serotyping. biotyping, antibiotic susceptibility and outer membrane protein (OMP) analysis. Results : Mean age of study patients was 68 years-old and the acquisition rate in community was 85%. Pneumonia and bronchitis were the most common type of infection such as 80%, sputum was the most common clinical specimen for H. mQuenzae isolation. 70% of patients had chronic underlying diseases. Non-typeable strains were 68% and β-lactamase producing rate was 63%. There was no difference in the clinical features and prognosis of H. influenzae infection between the β-lactamase positivie and -negative groups. The susceptibility of cefotaxime, azithromycin, and ciprofloxacin was 100% and that of cefaclor, cefuroxime was under 10% in spite of β-lactamase positivity. In OMP analysis, C and D types were dominant (64%). Conclusion : H. influenzae caused acute respiratory infections in adults with chronic underlying disorders. This study shows higher β-lactamase producing rate and antibiotic-resistance rate than that were reported previously. OMP analysis shows that two major types of strains cause clinical infections intensively.

모래상자놀이를 통한 부적응 행동유아의 자아존중감 및 친사회적 행동 변화양상에 관한 연구

이연승(Lee Yeon Seung),유명순(Yoo Myeong Soon) 한국어린이미디어학회 2007 어린이미디어연구 Vol.6 No.2

본 연구는 모래상자놀이를 통한 부적응 행동유아의 자아존중감과 친사회적 행동의 변화양상에 관한 연구로서, 모래상자놀이가 유아들의 전인적인 성장발달을 위한 기초자료로 활용될 수 있는지 확인하는데 그 목적이 있다. 이러한 연구목적을 달성하기 위하여, 부적응한 행동유아가 모래상자놀이를 통하여 어떻게 자신을 표현하고 집중할 수 있는 기회가 늘어나고, 또한 자아존중감 향상에 도움을 받으며, 친사회적 행동 관계에 어떤 영향을 주는지에 대한 비교 분석을 하였다. 연구과정은 25주에 걸쳐 사전검사, 모래상자놀이실시, 사후검사 순으로 진행되었다. 본 연구의 결과는 다음과 같다; 모래상자놀이를 통한 부적응 행동유아의 자아존중감 변화양상은 하위요인인 지적 능력에서 유아의 자아존중감이 향상되었고, 유아개인별 자아존중감 변화추이에서 향상되는 변화를 보였다. 또한, 부적응 행동유아의 친사회적 행동 변화양상은 나누기, 도와주기, 협동하기 등 친사회적 행동이 향상되었고, 유아개인별 친사회적 행동 변화추이에서 향상되는 변화를 보여주었다. The purpose of this study is to investigate the self-esteem and pro-sociality of the maladjusted children and this study is synthetic with using quantitative research. This study is made to present the possibility of the play with sand box to be the basic material for building children’s personality. For this purpose, the practical case has been analyzed to understand the effect on children’s sociality and self-esteem, as well as the way of expression of themselves and the opportunity of concentration on themselves. The target of the researcher is the 5~6 year old children in N child-care center which is attached to welfare facility in J area in Busan. The children are distracted, disturb others and have difficulty of social management, revealing the problem with a external maladjustment and their low self-esteem. Their home backgrounds are also normal except for one child whose parents are divorced. The research has been made in a daily life without any variable factor. The period of this research is 25 weeks, from August 16, 2006 to February 16, 2007 and pre examination, processing program, post examination are operated in order. As qualitative study, Young sook Kim’s modification on the Pictorial Scale of Perceived Competence and Social Acceptance for Young Children by Harter and Pike were used. In addition, Won young Lee’s revision and its questionnaire paper and assist material on the "Skill Situation Measues" by Mcginnis and Goldstein were used as measuring tool of pro-sociable behavior. For qualitative analysis tools used for this study are as follows. The results of this study were as follows: First, there was an improvement of self-esteem in cognitive ability of the children which is one of the sub factors and difference in each children who played with sand box. Second, there was an improvement of pro-sociality in sharing, help, and collaboration and it was shown in each children who played with sand box. And there was a change in children's pro-Behavior.

연구논문 : 제주지역 미세먼지의 장기변동 및 농도변화에 관한 국지기상 분석

박연희 ( Yeon Hee Park ),송상근 ( Sang Keun Song ),이수정 ( Soo Jeong Lee ),김석우 ( Suk Woo Kim ),한승범 ( Seung Bum Han ) 한국환경과학회 2016 한국환경과학회지 Vol.25 No.1

Long-term variations of PM_{10} and the characteristics of local meteorology related to its concentration changes were analyzed at 4 air quality sites (Ido-dong, Yeon-dong, Donghong-dong, and Gosan) in Jeju during two different periods, such as PI (2001-2006) and PII (2007-2013), over a 13-year period. Overall, the long-term trend of PM_{10} was very slightly downward during the whole study period, while the high PM_{10} concentrations in PII were observed more frequently than those in PI. The concentration variations of PM_{10} during the study period was clarified in correlation between PM_{10} and meteorological variables, e.g. the low (high) PM_{10} concentration with large (small) precipitation or high (low) radiation and in part high PM_{10} concentrations (especially, Donghong-dong and Gosan) with strong wind speed and the westerly/northwesterly winds. This was likely to be caused by the transport effect (from the polluted regions of China) rather than the contribution of local emission sources. The PM_{10} concentrations in “Asian dust” and “Haze” weather types were higher, whereas those in “Precipitation”, “Fog”, and “Thunder and Lighting” weather types were lower. The contribution of long-range transport to the observed PM_{10} levels in the urban center (Ido-dong, Yeon-dong, and Donghong-dong), if estimated by comparison to the data of the background site (Gosan), was found to explain about 80% (on average) of its input.

판상형 충전제의 함량과 배향에 따른 PP복합체의 열팽창계수 영향 연구

이기윤(Kee Yoon Lee),이용현(Yong Hyun Lee),정선경(Sun Kyoung Jeoung),황효연(Hyo Yeon Hwang),이승구(Seung Goo Lee) 한국고분자학회 2012 폴리머 Vol.36 No.3

두 가지의 종횡비(ρα=a1/a3 and ρβ=a1/a2)에 의해 특징지어진 3차원 타원체(a1 > a2 > a3)를 사용하여 polypropylene 복합체의 판상형 충전제 함량과 방향이 열팽창률에 미치는 영향에 대해 실험적인 연구를 수행하였다. 측정된 실험적인 값은 Lee와 그의 연구자들이 제안한 이론적인 모델에 의한 계산 값과 비교분석되었다. 판상형충전제로는 운모와 탈크가 사용되었다. 실험 결과로 운모의 경우 종횡비는 ρα= 13.5, ρβ= 1.8이 사용되 어, 20 wt% 함량일때 α11/αm는 약 0.56으로 감소하였으나, α33/αm는 오히려 1.018로 증가함을 보였다. 탈크의 경우의 종횡비는 ρα=3.7, ρβ= 1.4이었고 α11/αm는 0.63으로 감소하였다. 결국 운모와 탈크 모두 그 함량증가에 따라 종단방향과 횡단방향에서 열팽창률은 감소하였으나 수직방향에서는 초기 낮은 충전제 함량에서는 오히려 증가하는 경향을 보였다. Experimental study was performed regarding the effects of disc-like filler orientation and contents on the coefficient of thermal expansion (CTE) of polypropylene composites using the three dimensional ellipsoids (a1 > a2 > a3) analyzed by two aspect ratios(ρα=a1/a3 and ρβ=a1/a2). Measured data were compared with the theoretical approaches proposed by Lee et al. Mica and talc were useed as disk-like fillers in the composites. As experimental results, α11/αm decreased down to ca. 0.56 with mica content of 20 wt% and the aspect ratios, ρα=13.5, ρβ=1.8. However, α33/αm increased to more than 1. In the case of talc, α11/αm decreased to ca. 0.63 with 20 wt% and ρα=3.7, ρβ=1.4. Finally, the longitudinal CTEs (α11) of polypropylene composites decreased as filler contents increased, but normal CTE (α33) increased in the low filler contents like the theory.

하루 콩단백질 25g 섭취를 위한 메뉴작성 및 영양성분 분석

한재숙,김정애,서봉순,이연정,서향순,조연숙,한경필,이신정,오옥희,우경자,조은자,구성자,김수진,李承彦,南出隆久 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.2

The purpose of this study was to develop menus for daily intake of 25g soybean protein and to analyse nutrients of these foods. Analytical values were compared to the theoretical one using the food composition table and recommended dietary allowances for Koreans (7th revision). The results are as follows. 1. Soybean curd residue stew, Soybean curd, Kimchi saute, and hard boiled soybean and lotus root were selected for the menu for January, of which the content of soy bean protein(SBP) was 33.1g, soybean stew, soybean curd and soybean sprout saute, and Italian deep fried soybean curd were for February, of which the content of SBP was 35.0g. The content of SBP in soybean paste soup with soybean curd, fried soybean curd and fried soybean curd roll, the menu for March, was 24.9g. That of April were soybean curd gratin with soymilk, soybean curd and ham with garlic dressing and the content of SBP was 26.3g. That of May were soybean porridge, soybean flour cake with honey (Dasik), soybean sprout soup and the content of SBP was 26.7g. That of June were soymilk, pan-fried soybean curd, steamed soybean curd with chicken and the content of SBP was 28.4g. That of July were noodle with soymilk, mapatofu, soybean curd salad and the content of SBP was 24.7g. That of August were soybean sprout with mustard dressing, Tossed green pepper with raw soybean flour, Tofu and Kimchi stew, soybean curd steak and the content of SBP was 26.2g. That of September were Chinese cabbage soup with raw soybean flour, sweet and sour tofu and the content of SBP was 23.2g. That of Oct. were Fermented soybean stew, soybean pan cake and the content of SBP was 24.3g. That of November were not-pressed soybean curd casserole, pan-fried mashed soybean curd with egg, stir frying deep-fried soybean curd with vegetables and the content of SBP was 22.4g. That of December were soybean curd and mushroom casserole, fried soybean curd and vegetables, hard boiled soybean curd and the content of SBP was 28.9g. 2. The ratio of the analytical value over theoretical value (A/B%) of one serving in kcal, carbohydrate, protein, fat, ash and dietary fiber were 57.7~107.7%, 42.9~131.9%, 79.2~118.3%, 54.5~100%, 40.7~80.8% and 42.1~113.2%, respectively. 3. The ratio of A/B% of one serving in Ca, K, Na, P and Fe were 44.1~93.6%, 59.0~153.1%, 53.1~117.7% 64.6%~138.8 and 33.8~77.3%, respectively. That in Fe was the lowest among minerals. 4. The ratio of analytical value over Korean R.D.A(A/C%) in Ca was relatively higher (22.0~85.9%) than that in kcal(18~63%). 5. The ratio of A/C% in Fe was 25.1~64.3% and lower than that in Ca and protein in general.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.

Ziprasidone의 자연적 임상경험에 대한 후향적 조사 연구 : 3개 대학병원의 경험

이승재,강도형,홍경수,주연호,김남식,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Objectives : This naturalistic retrospective study investigated the effectiveness of ziprasidone measured by mean improve-ments of the Cltnical Global Impression (CGI-I). Secondary objectives included prescribing patterns, tolerability and safety. Methods : From May to July 2006, 98 psychiatric patients who have been taking ziprasidone for at least 2 weeks were selected. Their current clinical statuses were assessed by the interview and laboratory tests including electrocardiogram (ECG). Data on DSM-IV diagnoses, dosing, concomitant psychotropic medications, clinical changes, adverse effects, and laboratory findings were collected retrospectively. Results : Ziprasidone was mostly prescribed for a switch from another antipsychotics for the treatment of schizophrenia. Two main reasons for a switch were unsatisfactory efficacy and poor tolerance, especially weight gain, of the preceding anti-psychotic medication, Participants as a whole showed mean 2.7±1.0 of the CGI-Improvement. Significant weight reduction after switching to ziprasidone occurred, which was related to the clinical improvement. No significant increase of the QTc interval except one case was observed. Conclusion : The present study confirmed previous tolerability and safety data of ziprasidone as well as the results of its effectiveness.