서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

등줄쥐 연수의 Tyrosine Hydroxylase, Dopamine-β-Hydroxylase 및 Phenylethanolamine-N-Methyltransferase 면역반응신경세포

정영길,이남섭,민성기 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

야생 등줄쥐 (Apodemus agrarius coreae) 간뇌의 Dopamine성 신경세포

정영길,이남섭,민성기,김무강 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

전동휠체어용 Variable Reluctance Motor의 개발에 관한 연구

李奉燮,李英美 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.2

In this paper, the variable reluctance motor(VRM) has a simple rotor construction with no winding. It also has simple concentrated windings on the stator. Thus, it is expected to be a lower cost machine to manufacture than the squirrel cage induction motor. The main object of this paper is to predict the locked rotor torque waveforms for the VRM. The locked rotor torque for VRM has been calculated using two-dimensional FEM(Flux2d) and the results are shown in the paper.

마그네슘 판재의 초정밀 디버링에 관한 연구

이정인,김태완,박영환,곽재섭 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Drilling process is usually used in various manufacturing processes. The burrs took place when drilling process is conducted. Therefore the burr problem occurred from drilling process is very significant. Sometimes, burrs cause unexpected problems such as no good quality product that has a good surface roughness. Therefore, it is important to know characteristics of burr formation and to remove the burr from the drilled material at machining process. This study aims that how to produce the better drilled products by controlling of process factors.

자속횡방향형 클로폴 리니어 스테핑 모터의 개발

이봉섭,진광윤,오홍석,김영흥 三陟大學校 2002 論文集 Vol.35 No.-

In this paper, the new transverse flux machine type claw pole linear stepping motor(TFM_CPLSM) is proposed. And the magnetic equivalent circuit of TFM_ CPLSM is derived by the structure of the TFM_CPLSM. The design parameter, the magnetic flux density and the static thrust force of TFM_CPLSM are Performed with three-dimensional finite element method.

모형식품의 해동방법에 따른 물성변화

이재학,박영덕,강현아,장규섭 충남대학교 농업과학연구소 1994 농업과학연구 Vol.21 No.2

Optimal thawing conditions of frozen model foods containing protein and starch were investigated at various thawing conditions such as room temperature, hot air, and microwave heating. Hardness of the frozen model foods was getting higher as the water content increased. Thawing rates at room temperature, hot-air heating at 50℃, and microwave heating were 0.02Kg/min, 0.08Kg/min. 0.01 Kg/min. respectively. Final thawing time was as follows; control 60min, 5% sucrose: 50min, 10% sucrose: 30 min, 5% NaCl: 30 min. Total drip loss was as follows; room temperature thawing: 22.5%, 200W microwave thawing 1.3%, and 50℃ hot air thawing nearly negligible.

사회공포증 환자의 성격요인과 방어기제에 대한 연구

이시형,백상빈,노경선,오강섭,신영철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 사회공포 환자의 성격요인과 방어기제의 특징을 알아보고, 비가해형 및 가해형에 따라 유의미한 차이가 있는지 알아보고자 본 연구를 시행하였다. 방 법: 강북삼성병원 외래치료 환자중 DSM-Ⅳ에 근거하여 사회공포로 진단된 환자 28명을 대상으로 성격요인검사(Sixteen Personality Factor Questionnaire 한국판) 및 이화방어기제검사를 시행하였고 통계처리는 각 검사에 대한 빈도분석과 비가해형과 가해형에 대한 Independent-Sample t-test를 시행하였다. 결 과: 사회공포 환자에서 성격요인(평균점수) 중 shyness/boldness 요인이 정상보다 낮은 소견을 보였으며 방어기제에서는 유우머 항목이 정상보다 낮은 소견을 보였다. 성격요인과 방어기제 모두에서 비가해형과 가해형간에 유의미한 차이는 보이지 않았다. 결 론: 성격요인의 결과상 사회공포 환자들은 감정 표현을 억제하며 비사교적이다. 또한 자기주장을 못하여 타인에게 순종적, 동조적이며 정서적 불안정감이 심하다. 이러한 성격요인들은 모두 자율신경계의 약화, 불안의 증가, 공포증의 유발가능성의 증가등으로 사회공포와 관련되어 있다. 또한 방어기제의 결과상 사회공포 환자들은 유우머가 부족하고 지나치게 긴장, 경직되어 있어 사회공포 증세를 유발하기 쉬운 것으로 판단되었다. 사회공포의 두 유형인 비가해형과 가해형간에는 성격요인, 방어기제 모두에서 유의미한 차이가 없는 것으로 나타났다. Objectives: The purpose of this study was to evaluate the characteristics of personality factor and defense mechanism and to compare the difference between non-offensive and offensive types of social phobia patients. Methods: Study subjects consisted of 28 social phobia patients diagnosed with the criteria of DSM-Ⅳ. Data were collected through Sixteen Personality Factor Questionnaire and Ehwa Diagnostic Test of Defense Mechanism. We employed was the independent sample t-test for the analysis. Result: Among the personality factor, the shyness/boldness factor scored lower than normal in social phobia patients. Humor defense scored lower than normal among defense mechanisms. There was no significant correlation between non-offensive and offensive types of social phobia in personality factors and defense mechanisms. Conclusions: Social phobia patients were shier and less frequently use humor defense than the ordinary people. There was no significant correlation between non-offensive and offensive types of social phobia patients in personality factors and defense mechanisms.

농축공정이 Kindorase의 생산수율에 미치는 영향

고영환,이은현,장규섭 충남대학교 농업과학연구소 1996 농업과학연구 Vol.23 No.2

In order to improve the production yield of kindorase as complex antiphlogistic agent, molecular weight of concentration membrane, membrane configration, temperature, pressure and pH of concentration solution, fouling, etc. were investigated, and the results obtained are as follows ; 1. High production yield was shown using 10k Dalton molecular weight cut-off concentration membrane and spiral membrane made of polysulfone. 2. And it was reasonable conditions for maintaining the concentration solution at 3Bar in pressure. 3. The optimum pH of solution for improving production yield of kindorase were the range of 7.5 to 8.5, and for obtaining better production yield, clean in place(C.I.P) of membrane was treated with 0.1N NaOH at 40 to 50℃ for 30minutes.