서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

WTO 시대의 한국수출기업의 반덤핑 대응방안

윤주한,서진원 조선대학교 경영경제연구소 2001 經營經濟硏究 = Management and economics research Vol.24 No.1

황정(黃精) 추출물의 화학구조결정에 관한 연구 (Ⅰ)

윤중호,박주희,김정주,권기락,안철진,주우홍,강진호,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1

본 연구에서는 황정 속에 포함되어 있는 생리활성 물질을 hexane, CHCl₃과 n-butanol층에서 각각의 성분들을 추출하였고, hexane층에서 분리된 화합물 I과 H 중에서, 화합물 I의 봐학구조를 ¹H-nmr, ??, DEPT135, COSY, HMQC, HMBC 스펙트럼 및 MS 스펙트럼 등의 분광학적인 방법에 의해 결정하였다. 화합물 I의 구조는 9,12-(9E, 12E)-octadecadienoic acid 임을 확인하였다. In this Paper, biologically active compounds were extracted using organic solvents as hexane. CHC1₃, n-butanol to give each component. Chemical structure of compound I was characterized using ¹H-nmr, ??, DEPT135, COSY, HMQC, HMBC spectrum and MS-spectrum, in separated compound I and Ⅱ from hexane layer. Finally, chemical structure of compound I was determined as 9,12-(9E,12E)-octadecadienoic acid.

Praziquantel이 肺吸蟲의 幼若成蟲에 미치는 영향에 관한 電子顯微鏡的 硏究

尹疇植,金洙鎭,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

This study was undertaken to observe the morphological changes of young adult worms(45th day after infection) of Paragonimus westermani obtained from experimentally infected dogs after treatment with praziquantel. For this study 8 dogs were artificially infected with metacercariae isolated from crayfish, Cambaroides similes. After 45th and 90th day of infection, three dogs were each given praziquantel 3×25 mg/kg×1day respectively, and autopsied at 24 hours after the last medication. With the young adult worms from the cysts in the lungs of treated dogs, the fine structural changes were observed by means of scanning and transmission electron-microscope. The findings were compared with those of adult worms in treated and untreated control host. The results are as follows: 1. The majority of the young adult worms obtained from the treated dogs showed a large balloon-shape structure on the tegumental surface between oral and ventral suckers. This structural change has never been reported in the adult worms obtained from the treated hosts. 2. The scanning electron-microscopy revealed formations of bleb-like structures on sensory papillae near the oral and ventral suckers. 3. The transmission electron-microscopy showed that the axons of the nerve endings in the sensory papillae around two suckers were degenerated and formed large vesicles which upon rupturing on the tegumental surface have formed bleb-like structures. 4. The numerous mitochondriae in the tegumental syncytium of the worms in treated hosts appeared to be degenerated and formed small vacuoles, and a different size of vacuoles interspersed in the distal part of the tegumental syncytium. These vacuoles were fused to each other and led to the disruption of the apical region of tegumental syncytium along the basement layer, which was finally detached from the circular muscles of the worm. 5. Many host cells (granulocytes) invaded and destroyed the degenerated tegument by the occurrence of blebs or the exposed muscular layer of the worm after exfoliation of the tegument.

수산화세륨(Ⅲ)으로부터 질산암모늄세륨(Ⅳ)의 제조

윤호성,김철주,이진영,김성돈,김준수,유승준 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.3

본 연구에서는 수산화세륨으로부터 질산세륨 용액 제조 후 질산암모늄 첨가에 의한 질산암모늄세륨 제조시, 출발용액의 산도와 농도 그리고 질산암모늄 첨가량, 반응온도 및 반응시간이 질산암모늄세륨 합성에 미치는 영향을 고찰하였으며, XRD, SEM 그리고 TGA 분석을 통하여 결정의 형태 및 구조에 대한 고찰을 수행하였다. 4가의 수산화세륨을 질산에 용해한 질산세륨(Ⅳ)수용액으로부터 질산암모늄 첨가에 의한 질산암모늄세륨 제조시 회수율을 고려한 최적 합성조건은 출발물질의 세륨 농도 70-100g/l, 출발용액의 산도 7 mol/l, 질산암모늄 첨가량 2.5당량, 감압·가열온도 65℃ 및 반응시간 15-30min.이었으며, 제조된 질산암모늄세륨의 결정 화학식은 (NH_4)_2[Ce(NO_3)_6) · ×H_2O(x=6-8)인 것을 알 수 있었다. Synthetic process of ammonium cerium nitrate from cerium hydroxide was presented and influences of concentration and acidity of starting solution, addition quantity of ammonium nitrate, reaction temperature, reaction time on the yield of ammonium cerium nitrate are discussed. The shape and composition of crystal were determined by SEM, thermogravimetry differential thermal, x-ray diffraction and chemical analysis. The optimum synthesizing conditions of ammonium cerium nitrate were discribed as follows; rare earth concentration of starting solution 70-100 g/l. acidity of starting solution 7 mol/l, addition quantity of ammonium nitrate 2-3 equivalent, the condition of rotary evaporation 65℃ and reaction time 15-30 min. It was also known that the chemical formulae of ammonium cerium nitrate was (NH_4)_2[Ce(NO_3)_6] ·×H_2O(x=6-8) from TGA.

임신 전반기 여성의 철분영양상태 개선을 위한 영양교육 방안 연구

주숙경,장희경,윤진숙 계명대학교 생활과학연구소 2001 科學論集 Vol.27 No.-

The purpose of this study was to investigate the nutritional status of iron, food habit, general characteristics for pregnant women and to suggest the direction of nutritional education for pregnant women. Among 171 pregnant women who provided baseline data, 21 women voluntarily participated Fe supplementation and nutrition education program. Nutritional education was provided six times at two-week intervals in the form of telephone interview. The effectiveness of nutritional education was evaluated by measurement of Fe status before and after nutrition education. It appealed that most of subjects took less amount of energy, calcium and iron than Korean RDA. The results indicated that nutrition education was ineffective to improve Fe status for pregnant women. The main barrier of nutritional education process was overconcern about weight gain and body shape, inadequate Fe intake for food source. In addition, the indirect education by telephone interview appeared unsuitable. Therefore, our results indicated the further study to develop nutritional education materials for Pregnant women to overcome the limitation of telephone interview.

만성 정신분열병 환자에서 지연성 운동장애와 음성증상 및 인지기능 장애와의 연관성

심주철,반철식,성기수,이정구,정도운,정청,윤진상,김영훈 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 정신과 전문병원에 입원해 있는 만성정신분열병 환자들을 대상으로 첫째 지연성 운동장애의 유병율과 위험인자들을 조사하고, 둘째 지연성 운동장애와 정신분열병의 음성증상 및 인지기능 장애와의 상관성을 조사하고자 한다. 방법: 연구대상자는 마산동서병원에 입원 중인 환자 중 DSM-IV의 정신분열별 진단기준에 부합하며, 최근 3개월 이상 동일 용량의 항정신병약물 복용한 271명(남자 174명, 여자 97명)의 환자들이었다. 지연성 운동장애에 대한 평가는 Abnormal Involuntary Movement Scale(AIMS)을 이용하였고, DSM-IV와 Sc-hooler와 Kane(1982)의 진단기준 양자에 부합하는 환자들만을 지연성 운동장애군으로 분류하였다, 정신 분열병 정신병리에 대한 평가는 Brief Psychiatric Rating Scale(BPRS)와 Schedule for the Deficit Syndrome(SDS)을 이용하였고, 인지기능에 대한 평가는 Mini-Mental Status Examination(MMSE)을 이용하였다. 결과: 지연성 운동장애의 유병율은 50.9%이었고, 50세 이상, 남자에서 높았다. 그러나 입원기간과 항정신병 약물의 일일 사용량에 따른 차이는 없었다. 지연성 운동장애의 호발부위는 혀, 상지, 입술과 입 주위의 순이었다. BPRS 총점 및 소항목 척도점수와 SDS 척도점수는 지연성 운동장애의 유무에 따른 차이가 없었다. MMSE 총점 및 소항목 점수도 지연성 운동장애의 유무에 따른 차이가 없었다. 결론: 평균입원기간이 9년 이상인 만성정신분열병 환자들에게서의 지연성 운동장애의 유병율은 50.5%이었고, 연령이 가장 의미있는 위험인자임을 확인했다. 만성정신분열병 환자들이 주 대상인 본 연구에서는 지연성 운동장애와 정신분열병의 음성증상 및 인지기능 장애와의 상관성은 입증하지 못했다. Objectives: The purpose of present study was to determine the prevalence rate of tardive dyskinesia and to search for its risk factors in chronically institutionalized schizophrenic subjects. We also examined the relationship between tardive dyskinesia and both negative symptoms and cognitive impairments in the same subjects. Methods: Subjects were 271 in-patients(174 males, 97 females) at Masan Dongsuh Hospital. They met DSM-IV criteria for schizophrenia and had been taking fixed doses of antipsychotics for at least 3 months. Tardive dyskinesia was assessed by Abnormal Involuntary Movement Scale(AIMS). Cases of tardive dyskinesia were ascertained by the criteria of Schooler and Kane (1982) and DSM-IV. The rating of psychopathology was acquired using Brief Psychiatric Rating Scale(BPRS) and Schedule for the Deficit Syndrome(SDS) and the assessment of cognitive function using Mini-Mental State Examination(MMSE). Results: The prevalence of tardive dyskinesia is 50.9% and the frequency of tardive dyskinesia was high est in male above the age of fifty. But there was no statistically significant relationship between the frequency of tardive dyskinesia and both the length of hospitalization and the daily dose of antipsychotics. The frequency order of abnormal movement in the patients with tardive dyskinesia was as follows : tongue, upper extremities, lips and perioral area. We couldn't find any significant difference in the total and subscale scores of BPRS between the groups with and without tardive dyskinesia. There were no differences in MMSE scores between the groups with and without tardive dyskinesia. Conclusion: This study gave us that the prevalence of tardive dyskinesia was high in chronically institutionalized schizophrenic inpatients and that age was the most significant risk factor of tardive dyskinesia. The relationship between tardive dyskinesia and both negative symptoms and cognitive impairment, however, was not revealed.

모래쥐(Gerbil)에서 지속적 및 간헐적 뇌혈류차단이 뇌부종과 허혈성 신경세포 손상에 미치는 영향

전병윤,주진양,이규창,김태승 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.7

Temporary occlusion of the cerebral blood flow is an effective maneuver to prevent and/or to control excessive bleeding during neurosurgical operations. Many studies have been reported employing single occlusion of various durations. However, there has been only a few studies examing the consequences of repeated occlusions on the development of cerebral edema and neuronal injury in the gerbil. Three separate episodes of 5-minute ischemia spaced at varied time interval was produced in Mongolian gerbils by occlusion of bilateral common carotid arteries. Quantitative estimates of cerebral edema and neuronal injury were obtained 24 hours after the third occlusion. The result was compared to that of single 15-minute occlusion. In gerbils with three 5-minute occlusions at 10-minute intervals. cerebral edema was not significant. However, the animals killed 24 hours after three 5-minute occlusions at 1-hour intervals or single 15-minute occlusion showed severe cerebral edema. Such animals showed significantly more neuronal injury than in animals with three 5-minute occlusions at 10-minute intervals. These results suggest that ischemic brain damage may be reduced with repeated vascular occlusions spaced at short intervals.

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

동시출현빈도 사용의 제한 피어슨 알고리즘

金鎭相,尹秉周 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - For offering suitable recommendations in an electronic commerce syste, recommendation algorithms that use the Collaborative Filtering scheme have been studied. The Collaborative Filtering is a way that offers recommendation to the consumers on the basis of the relationship among the consumers instead of the features of the products. Here, we suggest a new algorithm - the Constrained Pearson algorithm that uses co-occurrence. Our algorithm is expected to improve preference and the accuracy of prediction because our method takes advantage of the merits of the Constrained Pearson algorithm as well as those of the co-occurrence algorithm. In addition, we proved the superiority of the suggested algorithm as we tried it to predict the preference through experiments. Then, we used comparison-criteria such as MAE(Mean Absolute Error), the prediction time, and the extent (scope) of prediction.