당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

CFRP 적층복합판의 충격 손상 예측 : PartⅡ: 실험 PartⅡ: Experiment

박승범,김문생 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.52 No.-

본 논문에서는 충격하중에 의하여 적층복합재의 내부에 발생하는 충격 손상의 발생과 진전에 대하여 연구하였다. 이를 위하여 강구에 의하여 횡방향 충격을 받는 CFRP 복합재료에 대하여 충격실험을 행하여, 초음파 탐조영상장치로 충격손상을 관찰하였다. 개발한 충격손상 유한해석에 의하여 예측된 결과와 비교 검토하였다. 충격에 의하여 발생하는 손상중 가장 큰 손상의 형태는 층간분리 손상으로서 충격이 계속 진행됨에 따라 경계면을 따라 진전되며, 길이방향은 경계면에 인접한 아래 단층의 섬유방향을 향한다. 충격을 가하는 외부 물체의 충격속도가 증가함에 따라 층간분리의 길이와 폭은 거의 선형적으로 증가하였다. 그리고 횡방향의 폭의 증가율 보다 종��향의 길이의 증가율이 더 크게 나타났으며, 층간분리의 진전은 주로 종방향인 길이방향으로 진행되었다. An investigation was performed to study the initiation and propagation of impact damages in laminated composites subjected to transversely impact of steel ball. For this purpose, transversely impact experiments for CFRP laminated composite plates were conducted, and impact damages were observed using the ultrasonic image scan system. As a results, interface delamination was a major impact damage mode and the longitudinal direction of the dilamination paralled to the fiber direction of the bottom layer below the interface. A linear relationship holds between impact velocity and the longiudinal length and transverse width of delmaination, and the ratio of growth in the longitudinal direction is high than in the transverse direction.

측두엽에 발생된 Gliosarcoma

박양화,권익승,홍승관,문명선,신미경 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.1

저자들은 근래 좌측 측두엽에 발생된 Gliosarcoma 1예를 수술적 부분적출 및 수술후 방사선 조사로 치료한 후 일시적 증상 호전을 보이다가 수개월 내에 급속한 임상적 악화 및 종양 재증식을 치험하고 희귀한 증례이기에 보고하고저 한다. Gliosarcoma는 악성 뇌교종과 섬유육종이 혼합된 뇌종양으로써, 문헌 고찰 결과 악성 뇌교종 내의 혈관내피세포 과증식이 어떠한 알려지지 않은 기전에 의하여 악성 변화를 일으켜 섬유육종이 발생되는 경우가 대부분으로 사료된다. A case of left temporal gliosarcoma is reported. The patient was a 40-year old man who had headache, behavior change, dysphasia, and mental confusion for about 2 months duration. On brain CT, a large partially cystic mass with homogeneous enhancement was located at left temporal lobe and associated with remarkable pentumoral edema and mass effect. Angiographic tumor vascularity was faintly visualized. Surgical subtotal resection of the tumor and post-operative radiotherapy offered transient symptomatic improvement, being followed within several months by clinical deterioration and regrowth of the tumor on brain CT. Light microscopic studies of the H & E and special stained specimens showed two different components within the tumor in a mixed fashion, i.e. intermingled glioblastoma multiforme and fibrosarcoma. Electron microscopic study of the sarcomatous cells disclosed intracytoplasmic Weibel-Palade-like bodies, a specific marker of endothelial cells. The fibrosarcomatous component of gliosarcoma is believed to be originated from malignant transformation of the hyperplastic endothelial cells within the anaplastic glioma. Literature concerned with gliosarcoma is reviewed.

말초성 신경아세포종 : 두개골 발생 증례 보고 Involving Skull

박양화,권익승,류연석,신미경,최문배,홍승관,문명선 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4

The peripheral neuroblastomas are malignant neoplasms that originate from the adrenal gland and sympathetic nervous tissues. They usually occur in childhood. They exhibit such malignant features that they metastasize early to lung, liver, bone, rarely skull and other structures. The patients with peripheral neuroblastoma have short duration of symptom and short survival period. They reveal the characteristic light microscopic features that resemble other small cell carcinomas. The establishment of final diagnosis of peripheral neuroblastoma needs various special stainings for small cell carcinomas, and the electron microscopic findings are the most reliable. The authers recently experienced a case of peripheral neuroblastoma in a 26-year old man which involved right frontoparietal skull vault. The only chief complaint was a local non-tender mass at right frontoparietal scalp. Neither headache nor any neurological deficits was detected. Simple skull X-ary revealed a punched out rediolucency at right frontoparietal bone and brain CT showed a superficial elliptical high density mass that enhanced strongly. The mass was totally removed by wide craniectomy. The tumor invaded and penetrated the dura but the arachnoid membrane. at the tumor bed was not invaded by the tumor. The tumor was confirmed as peripheral neuroblastoma by various special stainings for small cell carcinomas. Following surgical resection of the mass, post-operative radiotherpy was offered(4800 rads for about 5 weeks). The patient aggrevated progressively and showed numerous metastases to such bones as lumbar vertebrae, pelvis and humerus to became paraplegic. 8 months after the operation, the patient died.

W-3계 고도 불포화지방산의 혼합비율이 다른 유지가 지질대사에 미치는 영향

박필숙,김성희,정승용,김경숙,문순열 慶尙大學校 1988 論文集 Vol.27 No.1

혈청 콜레스테롤 및 중성지방의 농도와 밀접항 관계가 있으며 혈청 lipprotein의 대사에 영향을 미치는 w-3계의 지방산의 적정한 섭취 비율을 구명하기 위한 일환으로써 들깨기름과 라아드의 혼합비율을 달리하여 흰쥐에게 급이한 결과 다음과 같은 결과를 얻었다. 1. 혈청 총-콜레스테롤 농도는 들깨기름 7.5%+라아드2.5%를 급이한 2군에서 유의성있게 낮은 반면 10%라아드 급이군은 현저히 높았다. 2. 혈청 HDL-콜레스테롤은 3군과 4둔이 1군, 2군에 비해 낮았으며, 혈청 총-콜레스테롤에 대한 HDL-콜레스테롤 비율은 2,3,4군이 5군에 비해 높았다. 3. 혈청 중 인지질과 중성지방 농도는 5군에 비해 2,3군에서 현저하게 낮았다. 4. 간장 중 총-콜래스테롤 농도는 4군이 1,2,3군에 비해 비교적 낮았다. 5. 간장 중 인지질 농도는 각 군간에 유의적인 차이는 없었으나 중성지방의 농도는 5군보다 1,2군에서 유의성 있게 낮았다. 6. 시험유지의 지방산조성은 1군에서 lionenic acid가 dir 58%이었으며, 5군에서는 w-3계 PUFA가 0.1%, oleic acid가 47.5%이었다. 7. 혈청 lipoprotein pattern은 2군에서 HDL함량이 가장 많은 반면 LDL함량은 가장 적은 경향이었다. In order to investigate the suitable composition of the w-3 series polyunsaturated fatty acid on lipoprotein metabolism related with cholesterol and triglyceride concentrations in serum, it was examined the effects of w-3 PUFA contents of mixed fat on oil lipid metabolism in serum and liver of rats. The results were summerized as follow ; 1. The concentration of T-cholesterol in serum of rats was lowest in the group 2 (7.5% perilla oil + 2.5% lard). whereas it was highest in group 5 (10% lard). 2. The concentration of HDL-cholesterol in serum was lower in group 3, 4 than in group 1, 2 and the ratio of HDL-cholesterol to T-cholesterol were higher in group 2, 3, 4 than in group 5. 3. The concentrations of phospholipid and trigyceride in serum were significantly lower in group 2, 3 than in group 5. 4. The concentration of T-cholesterol in the liver was relatively lower in group 4 than in group 1, 2, 3. 5. Phospholipid values in the liver were not significantly different between groups, but the concentrations of triglyceride were remarkably lower in group 1, 2 than those of the group 5. 6. Linolenic acid in group 1 (10% perilla oil), in the fatty acid composition of test lipids used in the experiment. was as much as about 58%, but w-3 PUFA in group 5 was only 0.1% and oleic acid was as much as about 58%, but w-3 PUFA in group 5 was only 0.1% and oleic acid was as much as 47.5%. 7. HDL contents, in lipoprotein composition of serum were the most in group 2 (7.5% perilla oil+2.5% lard), while LDL contents were the least.

Lactobacillus plantarum을 接種한 옥수수와 수수 Silage 製造 試驗

文勝式,朴成振,鄭錫龍,宋瑛敏 진주산업대학교 농업기술연구소 1989 農業技術硏究所報 Vol.2 No.-

유산균 접종이 옥수수와 수수silage의 품질에 미치는 영향을 조사할 목적으로 L. plantarum을 대조구는 접종하지 않았고 처리구는 2×10 exp(8), 4×10 exp(8) 및 6×10 exp(8)cfu, kg^-1(fresh forage) 수준으로 접종하여 조제한 silage의 일반성분, pH 및 유기산 함량을 비교한 결과는 다음과 같다. 1. crude protein, crude ash, NDF, ADF 및 hemicellulose 함량은 접종수준이 증가할수록 높았고 moisture 및 NFE 함량은 낮았다. 2. 접종수준이 증가할수록 lactic acid와 total acid 함량은 증가한 반면 acetic acid함량과 pH는 낮았다. 3. 옥수수 silage에 비하여 수수silage에서 L. plantarum의 접종효과가 높았다. The objective of this thesis is to investigate the effects of lactic acid bacterium inoculation on the qualities of corn and sorghum silages. The control group was not inoculated : the treated group was inoculated with Lactobacillus plantarum of the levels of 2×10 exp (8), 4×10 exp(8) and 6×10 exp(8) cfu. Kg^-1(fresh forage). The chemical components, pH and organic acid contents of the developed silages were measured and compared. The results obtained are as follows : 1. As the level of inoculation was higher, the contents of crude protein, crude ash, NDF, ADF and hemicellulose became larger, but the contents of moisture and NFE became smaller. 2. As the level of inoculation was higher, the contents of lactic acid and total acid became larger, but the acetic acid content and the pH became smaller. 3. The inoculation effect of L. plantarum was greater in the sorghum silage than in the corn silage.

통상정보학의 실용성 제고를 위한 연구방향

박승락,박문서 한국통상정보학회 1999 통상정보연구 Vol.1 No.2

연구방법론의 관점에서 통상정보학은 매우 다양한 방법으로 접근이 가능하며, 특히 정보통신기술을 적극적으로 활용할 수 있기 때문에 항상 새로운 접근 방법이 출현할 수 있다. 또한, 정보기술의 급격한 발전으로 국제전자상거래가 급격히 확산되고 있는 현 시점에서 수출기업의 단순한 무역자동화 수준을 벗어난 국제간 B to B 전자상거래의 전략적 활용방안에 대한 연구가 필요한 때이다. 이에 본 연구에서는 통상정보학의 실용성 제고를 위한 구체적인 연구방향으로써 전략 정보시스템과 조직이론을 가미한 조직간 정보시스템 이론을 제시함으로써, 조직간의 전략적 연계를 통한 전략적 통합정보시스템 구축전략을 제시하고자 하였다. 이를 통하여 정보화의 이점을 통상학 분야에 도입하고, 전략적으로 활용 가치가 있는 정보를 생산, 저장, 유통 및 활용함으로써 학술적 비용발생을 최소화하며, 기업의 이윤발생을 촉진함으로써 국가경쟁력의 확보에 기여할 수 있도록 하는 것이 통상정보학의 궁극적인 지향 목표이다.

닭의 乾燥 筋胃粘膜 粉末 投與가 Egg Type Fowl에 미치는 效果에 對한 硏究 : 第Ⅰ報 增體 및 羽毛量에 미치는 影響에 關하여 Ⅰ. The effect of body weight gainand feather weight

文勝式,朴玉潤 진주산업대학교 1981 論文集 Vol.19 No.-

This experiment was conducted to investigate the effect of Fowl Gizzard Mucouse Membrane Power treatment on body weight gain and feather weight with the data obtained from 60 pieces egg type fowls Babcock (B 380, 24 days-age) fed and allotted 4 treatments at the rate of 0%(C), 1%(T_1), 2%(T_2) and 3%(T_3) of FGM during the experimental period of 56 days from September 17, 1981 to December 12, the same year at Department of Animal Science, Jin Ju Agricultural and Forestry Junior Technical College. The results obtained are summarized as follows: 1. Average body weight gain at each experimental plot was 847.63g(T_2), 842.07(T_1), 828.94(T_3) and 815.83(C). The effect of FGM in the cody weight gain was nonsignificant for all the experimental plots. Feed conversion at each experimental plot was 3.65(T_2), 3.67(T_1), 3.75(C) and 3.77(T_3). 2. Average feather weight at each experimental plot was 105.84±10.13g(T_3), 90.78±13.55(T_2), 89.06±4.66(T_1) and 88.06±7.55(C). The effect of FGM in the only feather weight of T_3 plot was significant(p<.0.01).