젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

청소년 도덕적 동기화 검사 도구 개정 연구(2차년도)

전종희 ( Jong Hee Jeon ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),윤영돈 ( Young Don Yoon ),류숙희 ( Sook Hee Ryue ),홍성훈 ( Seong Hoon Hong ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 J. Rest의 4구성요소 모형을 바탕으로 1차년도(2011년)에 개발된 도덕적 동기화 검사를 보다 신뢰롭고 타당한 도구로 개정하는 것이다. 따라서 선행연구를 보완하여 도덕 동기화의 구성 요소를 도덕지향성과 도덕적 정서귀인 등 두 항목으로 재설정하고, 스토리와 문항을 수정하였다. 개발된 세 개의 스토리(과제, 놀이공원, 작품) 별로 신뢰도를 분석한 결과, 전반적으로 .90 내외의 높고 수치를 보였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사를 위해서는 전국 중학교 2학년생 409명을 대상으로 했고, 본조사를 위해서는 전국 6,216명의 중학교 2학년생을 대상으로 실시하였다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 검증하기 위하여 요인분석을 실시한 결과, 과제 스토리와 놀이공원 스토리의 일부 문항이 가정한 요인으로 잘 묶이지 않았는데 이 문항들을 제거하고 요인분석을 다시 실시해본 결과 기대하는 바를 충족했다. 그리하여 2차년도 연구를 통해 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 9개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 28개 문항으로 확정되었다. 본 연구를 통해 수정 확정된 도덕적 동기화 검사도구는 상당히 안정적인 신뢰도와 타당도를 확보하였기에, 향후 우리나라 청소년의 도덕적 동기화 능력을 측정하기 위한 검사도구로 활용되기에 적절할 것으로 판단된다. The study aims to revise Moral Motivation Test I which was set for adolescents based on Rest`s four component model in 2011 and make standardized final morality test. In theory, this study is based on 4 components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The 4 components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral motivation. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral motivation, research team used moral orientation, moral emotion attributions. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral motivation, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “homework inspect”and “on going to park”, the factor analysis shows a little bit limitation result. Eliminated those questions, the result of factor analysis was more stable and reliable. Through these processes, to test moral motivation, this study shows 3 stories and 28 questions. And this recommends that just one simple story might be developed for one component(moral motivation).

청소년 도덕적 품성화 검사 도구 개정 연구(2차년도)

류숙희 ( Sook Hee Ryue ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),홍성훈 ( Seong Hoon Hong ),전종희 ( Jong Hee Jeon ),윤영돈 ( Young Don Yoon ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 한국 청소년들의 도덕적 품성화 능력을 측정하기 위한 검사 도구를 개발하기 위한 것으로 2011년도에 개발된 검사 도구를 수정 및 보완한 것이다. 즉, J. Rest가 주장한 도덕성의 제4요소인 도덕적 품성화에 관한 선행연구들을 체계적으로 분석하여 도덕적 품성화의 개념을 보다 명확히 하였고, 1차년도에 설정한 도덕적 품성화의 구성 요소를 개인품성과 관계품성의 두 항목으로 재설정하였다. 또한 검사의 신뢰도와 타당도를 높이기 위해 기존의 스토리와 문항을 수정하였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사는 전국 중학교 2학년생 409명을 대상으로 실시되었고, 본조사는 전국 6,216명의 중학교 2학년생을 대상으로 실시되었다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 확보하기 위해 요인분석을 실시했는데, 도덕적 품성화 능력 검사는 1개 문항을 제외하고 모든 문항이 예정된 요인으로 묶였다. 그리하여 2차년도 연구를 통한 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 10개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 29개 문항으로 확정되었다. 2차년도 연구결과 개정된 검사 도구는 2011년 검사 도구에 비해 더 안정된 검사도구로서 향후 청소년의 도덕적 품성화 측정을 위한 연구와 실무에 활용될 수 있을 것이다. The study aims to revise Moral Character Test I which was set for adolescents based on Rest`s four components model in 2011 and make standardized final morality test. In theory, this study is based on the four components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The four components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral character. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral character, research team used personal character and interpersonal character. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral character, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “on going to park”, the factor analysis shows a little bit limitation result. Even though, 1st and 2nd researches have common weak point which is highly dependent upon not factor but story. Through these processes, to test moral motivation, this study shows 3 stories and 29 questions. And this recommends that just one simple story might be developed for one component(moral character).

LSD 설계법을 이용한 합성보 설계의 경제성에 관한 연구

朴鍾圓,蔡淑熙 홍익대학교 산업기술연구소 2000 産業技術 Vol.10 No.-

Use of the Limit State Design may have an economy over the Allowable Stress Design especially in the design of composite beams. In this study, strength and serviceability limit states are checked using the two methods and the differences in the design methodologies are compared. The investigation shows that as spans increase, designs by the LSD method give lighter beam weights and require fewer shear connectors resulting in substantial savings in material costs.

감각통합기능장애에 대한 집중치료프로그램의 효과 : 사례보고

박지훈,노종수,이향숙,차정진 대한감각통합치료학회 2009 대한감각통합치료학회지 Vol.7 No.2

목적: 본 연구는 감각통합기능장애를 가진 아동을 대상으로 주간에 걸친 집중치료프로그램을 제공하였을 때 미치는 효과를 알아보기 위한 것이며, 사후 평가를 통하여 감각통합기능의 유지 여부를 알아보았다. 연구방법: 단일사례연구로써 2주간 9회기 1회기에 40분씩 치료접근을 실시하고, 가정에서 Sensory diet와 더불어 Wilbarger Protocol을 실시하였다. 초기평가와 1차 재평가 사이의 시간은 15일이며, 5개월 후 2차 재평가를 실시하였다. 결과: 집중치료프로그램 적용 후, 아동은 전반적인 감각영역에서 감각방어가 감소되었고 자기조절 (수면, 각성)이 향상되었다. 또한 실행과 시-지각에서도 향상을 보였으며, 정서적 안정과 일상생활에서도 향상을 보였다. 프로그램 적용 5개월 후 감각조절능력, 안정적인 수면은 유지되고 시-지각에서도 지속적인 발달을 보였지만 정서적인 안정은 지속되지 않았다. 결론: 집중치료프로그램이 긍정적인 효과가 있음을 알 수 있었고, 집중치료프로그램 적용 후 치료적 접근이 없어도 대부분의 감각영역에서 감각조절능력을 유지할 수 있음을 알 수 있었다. Objective : The purpose of this study was to identify effects of intensive sensory integration (SI) treatment and home-program for a child who has a sensory integration disorder. This study also examined wheth­er the positive effect is long-lasting by a follow-up test. Method : A boy with sensory integration dysfunction underwent an intensive SI treatment for 2 weeks. The intervention was consisted of 9 sessions and duration of the each session was 40 minutes. Sensory diet and Wilbarger protocol was provided as home program. The child's sensory function was evaluated be­fore and after the SI intervention. Five month later, re-evaluation was executed for follow-up purpose. Results : In the evaluation after the Si intervention, the child's sensory defensiveness was decreased. Praxis, visual perception, sensory regulation dysfunction (sleep function), affective stabilization and performance of activities of daily living are also improved. In the re-evaluation after the 5 month later, the self-reg­ulation ability, especially sleep function, has been maintained and the visual perception was developing continually. However, the child showed some affective regulation such as bothering his mother and los­ing his temper. Conclusions : The intensive SI intervention showed positive effects in terms of SI function improvement and the effect lasted long without any additional therapeutic intervention.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

직장 구조조정과 파업에 의한 근로자의 사회심리적 스트레스의 변화

박봉진,이종태,손혜숙,김성준 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted to evaluate the insecurity of employment and anxiety by downsizing and strikes affected job characteristics and psychosocial distress of workers. Methods and Material : This is a longitudinal study of the container terminal workers in Pusan. The company operated downsizing from October to December in 1999 by economic depression. In the result of that, the number of workers decreased into 627 from 662. During that period, a new union was built and it made conflict between employers and employees, so the conflict caused the strikes from February to April in 2000. The first cross-sectional study was performed in February, 2000 and the oneyear follow-up cross-sectional study was performed in February, 2001. Socio-demo graphic characteristics, stress-related behavior, job characteristics and psychosocial distress were assessed with job content questionnaire(JCQ) and Psychosocial well-being Index(PWI) in 200 workers(white-collar: 100 men, blue collar: 100 men) from 662 men in total. Results : In the first study, job strain was high in the whole, but there was no difference between white and blue-collar workers. The level of PWI was very high at 86.67 points and the level of blue-collar workers was higher than that of white-collar workers(p=0.013). In the results of follow-up study, the rate of drinking and smoking decreased as the change of stress-related behaviors. In the job characteristics change, decision authority and physical exertion of the white-collar workers got lower(p<0.05), but social support and job strain didn't have no difference. In the PWI level change, stress level got rather higher(p<0.01), especially, increase of the white-collar workers' stress was big difference from that of the blue-collar workers'. Conclusion : Job stress management programs should be made to reduce stress. And in approaches to management and prevention, excessive physical exertion, shift work and irregular meals and breaks should be considered. Especially, this stress control program should be begun with recognition on conflicts between employers and employees and between employees and employees by downsizing and strikes. And also efforts to reinforce social support should be needed.

THE EFFECT OF PRIMING ETCHED DENTIN WITH SOLVENT ON THE MICROTENSILE BOND STRENGTH OF HYDROPHOBIC DENTIN ADHESIVE

박은숙,배지현,김종순,김재훈,이인복,김창근,손호현,조병훈 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

장기적인 상아질 접착의 내구성 악화는 접착층과 혼성층의 친수성 부위에서의 가수분해에 의해 일어나는 것으로 보고 되고 있다. 본 연구의 가설은 콜라겐 망상체를 유기용매로 프라이밍하면 콜라겐 조직을 붕괴시키지 않고 수분을 밀어내고 소수성 단량체와 유기용매로 이루어진 접착제가 침투하여 접착강도를 얻을 수 있다는 것이다. 두 소수성 단량체인 Bisphenol-A-glycidylmethacrylate (Bis-GMA)와 triethyleneglycol dimethacrylate (TEGDMA)를 아세톤, 에탄올 또는 메탄올에 용해시켜 세 가지의 실험용 접착제를 준비하였다. 산 부식과 수세과정 후에, 접착제를 습윤 상아질 표면(습윤 접착)이나 동일한 용매로 프라이밍 된 상아질 표면(용매 프라이밍 접착)에 적용하였다. 48시간 후와 1개월 후, 및 10.000회의 열순환 후에 미세인장결합강도를 측정하였다 접착계면은 주사전자현미경을 이용하여 관찰하였다. 접착방법에 무관하게 대부분의 시편의 접착계면예서 잘 발달된 혼성층을 관찰할 수 있었고 가장 높은 평균 미세인장결합강도는 에탄올을 포함하는 접착제의 48시간 후 시편에서 관찰되었다. 용매를 이용하여 프라이밍하는 접착 방법에서는 에탄올이나 메탄올을 포함하는 접착제에서 열순환 후에 미세인장접착강도가 증가하는 경향을 보였다. 그러나 습윤 접착의 경우에는 시효처리 후 미세인장결합강도의 증가가 관찰되지 않았다. 본 연구에서 에탄올을 이용한 상아질 프라이밍으로 우수한 접착력을 얻을 수 있었고. 열순환 후 접착력이 더욱 증가하였다 Deterioration of long-term dentin adhesion durability is thought to occur by hydrolytic degradation within hydrophilic domains of the adhesive and hybrid layers. This study investigated the hypothesis that priming the collagen network with an organic solvent displacc water without collapse and thereby obtain good bond strength with an adhesive made of hydrophobic monomers and organic solvents. Three experimentaladhesives were prepared by dissolving two hydrophobic monomers bisphenol-A-glycidylmethacrylate (Bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA), into acetone, ethanol or methanol. After an entching and rinsing procedure, the adhesives were applied onto either wet dentin surfaces (wet bonding) or dentin .surfaces primed with the same solvent (solvent-primed bonding). Microtensile bond strength (MTBS) was measured at 48 hrs, 1 month and after 10,000 times of thermocycles. The bonded interfaces were evaluated using a scanning electron microscope (SEM) Regardless of bonding protocols, weIl-developed hybrid layers were observed at the bonded interface in most specimens. The highest mean MTBS was observed in the adhesive containing ethanol at 48 hrs. With solvent-primed bonding increased MTBS tendencies were seen with thermocycling in the adhesives containing ethanol or methanol. However in the case of wet bonding, no increase in MTBS was observed with aging.

탱자(Poncirus tripoliata RAF)잎으로부터 Mitochondrial DNA의 분리

박종필,전홍성,김연순,이숙영,김성준 조선대학교 부설 유전생물공학연구소 1992 유전생물공학연구지 Vol.2 No.-

Differaitial centrifugation, sucrose(30%, 60%) and percoll(13.5%, 21% and 45%) density gradient centrifugation were used to effectively isolate mitochondria and mitochondrial DNA (mt DNA) from the leaves of the genus Poncirus (Pondrus trifoliata RAF.) The results showed that percoll density gradient centrifugation provided a convinient and effective method for the preparation of clean mitochondria. The purity of prepared mt DNA was increased by the removal of the nuclear DNA by DNase treatment to the crude mitochondrial suspension mt DNA on the agarose gel was shown extra fluorescent background in case of isolation by differential centrifugation and more cleared band included slightly smeared patterns for sucrose density gradient, and highly paint band from percoll density gradient was appeared to the best results of the above three methods. In addition to chromosomal mt DNAs, two short mt plasmid-like elements were detected in the genus Poncirus. These elements consistently co-purified with the chromosomal mt DNAs and is widely distributed among natrual Poncirus trifoliata RAF. populations. But these elements required proteinase K treatment for mobility in agarose gels.