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Volatile Organic Compounds Contribute to Airway Hyperresponsiveness
장안수,최인선,고영일,박춘식 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.1
Background : Volatile organic compounds (VOCs) in concentrations found in both the work and home environments may influence lung function. We investigated the prevalence of airway responsiveness in workers exposed to VOCs. Methods : We used allergic skin tests, nonspecific airway hyperresponsiveness testing and questionnaires to study twenty exposed workers and twenty-seven control subjects. Atopy was defined as a reactor who showed >3+ response to one or more allergens on the skin prick tests. Airway hyperresponsiveness (BRindex) was defined as log [% fall of FEV1/ log (last concentration of methacholine) +10]. Results : The VOC exposed workers, in comparison with the control subjects, tended to have a higher BRindex (1.19±0.07 vs. 1.15±0.08, respectively). Workers exposed to VOCs with atopy or smoker, as compared with the workers exposed to VOCs with non-atopy and who were non-smokers and the control subjects with non-atopy and who were non-smokers, had a significantly higher BRindex (1.20±0.05 vs. 1.14±0.06 vs. 1.10±0.03, respectively p<0.05). The BRindex was not correlated with atopy, the smoking status or the duration of VOC exposure. Conclusions : These findings suggest that VOCs may act as a contributing factor of airway hyperresponsiveness in workers exposed to VOCs. Background : Volatile organic compounds (VOCs) in concentrations found in both the work and home environments may influence lung function. We investigated the prevalence of airway responsiveness in workers exposed to VOCs. Methods : We used allergic skin tests, nonspecific airway hyperresponsiveness testing and questionnaires to study twenty exposed workers and twenty-seven control subjects. Atopy was defined as a reactor who showed >3+ response to one or more allergens on the skin prick tests. Airway hyperresponsiveness (BRindex) was defined as log [% fall of FEV1/ log (last concentration of methacholine) +10]. Results : The VOC exposed workers, in comparison with the control subjects, tended to have a higher BRindex (1.19±0.07 vs. 1.15±0.08, respectively). Workers exposed to VOCs with atopy or smoker, as compared with the workers exposed to VOCs with non-atopy and who were non-smokers and the control subjects with non-atopy and who were non-smokers, had a significantly higher BRindex (1.20±0.05 vs. 1.14±0.06 vs. 1.10±0.03, respectively p<0.05). The BRindex was not correlated with atopy, the smoking status or the duration of VOC exposure. Conclusions : These findings suggest that VOCs may act as a contributing factor of airway hyperresponsiveness in workers exposed to VOCs.
Elevation of S100A9 Protein in Sputum of Neutrophilic Inflammation in Severe Uncontrolled Asthma
장안수,( Tae Hyeong Lee ),( Jong Sook Park ),( Tae Hoon Kim ),( Young Suk Choi ),( Sung Woo Park ),( Soo Taek Uh ),( Choon Sik Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Neutrophilic airway inflammation is frequently observed in severe uncontrolled asthma as well as in controlled asthma. However, there is no sputum biomarker to differentiate the two conditions. Objective: To identify biomarkers of severe uncontrolled asthma with neutrophilic airway inflammation. Methods: Sputum with a >70% neutrophil content was pooled from 5 severe uncontrolled asthmatics (UA) and from 10 controlled asthmatics (CA). 2-DE was adopted for differential display proteomics, and candidate proteins were identified using MALDI-TOF MS analysis. S100 calcium binding protein A9 (S100A9) was identified by western blot and its level was measured in sputum from asthmatics with varying disease severity, COPD, and normal controls, by ELISA. Results: 14 protein spots exhibited differences in intensity between severe UA and CA. MALDI-TOF/TOF of these spots revealed an increase in HNP- 2, S100A9, α-amylase, NGAL, 4-aminobutyrate transaminase, and cystatin SA in patients with UA compared to patients with CA. There was a decrease in PLUNC, C3 component, immunoglobulin heavy chain variable region, GFAP1, IgM kappa IIIb SON, MLL-AF4 der (11) fusion protein, cytokeratin 8, and recombinant IgG4 heavy chain. S100A9 was detected at a higher level in western blots of neutrophilic sputum from UA, and significantly increased as measured by ELISA, in neutrophilic UA compared to CA, and COPD. Conclusions: S100A9 in sputum may be a biomarker of neutrophilic inflammation in severe uncontrolled asthma.
장안수,김상헌,김태범,박형우,김세훈,장윤석,이재현,조유숙,박중원,남동호,조영주,조상헌,윤호주,최병휘,문희범,박춘식 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.3
Purpose: Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma inKorean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. Methods:We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort who had undergoneskin prick tests for aeroallergens. The patients’ clinical characteristics, lung function, PC20, and sputum and blood inflammatory cell countswere compared based on the presence or absence of atopy. Atopy was defined as one or more positive reactions (A/H ratio >1) on a skin prick test. Results: Among 11 aeroallergens, house dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) were the most prevalentcause of a positive skin prick test. As compared with non-atopic asthmatics, atopic asthmatics showed early onset of the disease. Atopic patientswith asthma had a higher FEV1, FVC, and FEV1/FVC as compared with non-atopic patients with asthma. In addition, asthmatics without atopy hadmore uncontrolled asthma (P=0.001) and severe rhinitis (P<0.05) as compared with atopic asthmatics. Smoking, as measured in pack years, washigher in the non-atopic asthmatics than in the atopic asthmatics. The erythrocyte sedimentation rate was higher in non-atopic asthmatics than inthe atopic asthmatics and patients with non-atopic asthma had a higher sputum neutrophil count than did those with atopic asthma. Conclusions:Our data indicate that atopic asthmatics had an early onset of disease and high IgE levels, while the non-atopic asthmatics had decreased lung functionand a high sputum neutrophil count, suggesting that a different approach is needed to treat atopic asthma.