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      • SCOPUS

        일부 중학생의 빈혈과 식이요소와의 연관성에 관한 환자-대조군 연구

        이숙영,김정순 한국역학회 1985 Epidemiology and Health Vol.7 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

      • 기관지천식에서 기도재구성 정도에 따른 임상적 특징

        이숙영,김영균,박성학,문화식,송정섭,장재순,권순석,김관형 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.3

        Background:We observed airway remodeling, which is the thickness of the susepithelial layer, in asthmatic patients and inhealthy subjects in order to determine its relationship with severity of disease, such as symptom, bronchial hyperresponsiveness, and degree of acute exacerbation. Moreover, for evaluation of factors contributing to airway remodeling, we analyzed the age, sex, presence of atopy, length of asthmatic history and degree of airway inflammation. Methods: Thirty-six patients with asthma and ten healthy controls were recruited for the study. The degree of asthma symptom severity was assessed using NIH criteria. Bronchial responsiveness to methacholine was expressed as provocative concentration of methacholine causing a 20% fall in FEV1. The degree of acute exacerbation was assessed by PaCO2 during acute exacerbation. Bronchoscopy, bronchoalveolar lavage(BAL), and bronchial biopsy were performed for all subjects; the total cell counts, differential cell counts and levels of ECP were measured inBAL fluid, and the basement membrane thickness and degree of epithelial shedding were measured in biopsy samples under light microscopy. Results: The mean values of basement membrane thickness were 7.8±0.6 ㎛ in asthmatics, and 4.1±0.5 ㎛ in healthy subjects (p$lt;0.05). Basement membrane thickness in patients with severe persistent asthma differed significantly from that of patients with mild intermittent asthma (11.8±1.0 ㎛ vs 6.5±0.7 ㎛ p$lt;0.05). A lower level of PC20 for methacholine was observed in asthma with thick basement membrane(±7.5 ㎛) compared to those with basement membrane less than 7.5㎛ (0.26±0.13 mg/ml vs. 0.74±0.16 mg/ml, p$lt;0.05). No difference was found between the degree of thickening in patients with different degree of acute exacerbation with age, sex, atopy and lengths of asthmatic history. The degree of thickening was positively correlated to degree of epithelial shedding (r=0.393, p$lt;0.05), but not to the degree of total cell counts, differential cell percentage nor ECP in BAL fluid. Conclusion: We confirmed that thickening of the basement membrane is a characteristic finding of asthma. We also demonstrated that it affects symptom severity and bronchial hyperresponsiveness, and is related to degree of epithelial damage rather than duration of asthma history.

      • 기관지 천식 환자의 기관지폐포세척액내 T 세포 아형과 임상양상간의 관계

        이숙영,박성학,이상학,문화식,김석찬,송정섭,윤형규,김관형,신윤 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.6

        Background and Objective : T cells play a pivotal role in initiating and orchestrating bronchial inflammation in asthma. However, little is known about changes in T cell subset in the airways. Our objective was to study whether the proportion of CD4+ or CD8+ T cells in the bronchoa1veolar lavage fluid (BALF) of bronchial asthma is different from normal subjects, and whether it is associated with clinical characteristics. Methods : We examined the percentage of CD4+ and CD8+ cells in the BALF of 37 patients with bronchial asthma and 14 normal controls by flow cytometry. Bronchial asthma was classified as mild, moderate and severe according to bronchial hyperresponsiveness. Skin prick test and pulmonary function tests were performed. Results : The percentage of CD4+ cells in BALF did not differ between asthmatics and controls, however, the percentage of CD8+ cells was significantly higher in asthmatics than contro1s, In asthmatics, the percentage of CD4+ cells and CD8+ cells did not differ between atopic and nonatopic asthmatics. The percentage of CD8+ cells in addition to CD4+ cells was correlated with the percentage of eosinophils in BALF, and the percentage of CD8+ cells also showed negative correlation with FEV₁and FEF_(25-75%) Conclusion : These results suggest that CD8+ cells as well as CD4+ cells are associated with airway inflammation in bronchial asthma.

      • 급성 호산구성 폐렴 1례

        이숙영,김형진,배용목,서길동,황영훈,여동승,임성엽 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.3

        Acute eosinophilic pneumonia(AEP) was first described in 1989 and represents a clinical entity distinct from chronic eosinophilic pneumonia. AEP is characterized by acute respiratory insufficiency, hypoxemia, fever, diffuse radiographic infiltrates, and eosinophilia in bronchoalveolar lavage fluid or lung biopsies in the absence of infection, atopy, or asthma. Rapid response to corticosteroids is characteristic. We experienced a 47-year-old metal driller presenting typical clinical and radiological characteristics of AEP. We confirmed eosinophilic pneumonia with brochoalveolar lavage analysis and transbronchial lung biopsy. We report a case of AEP diagnosed by clinical, radiographic, and histologic findings with a brief review of the literature.

      • 기관지천식 생쥐 모형에서 interleukin - 12가 기도염증에 미치는 영향

        이숙영,송정섭 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.1

        Background: Th2-like cells are thought to play a crucial role in the recruitment and activation of eosinophil in bronchial asthma. In contrast to Th2 cytokine, Thl cytokine IFN-γdecreases eosinophil recruitment. Previous studies have shown that IL-12 promotes differentiation of Th0 into Thl and enhances production of Thl cytokine. IL-12 also prevents differentiation of Th0 into Th2 during primary immune response. Its effect on established Th2 cell, however, is well known. Objective: The objective of aur study was focused on whether IL-12 prevents recruitment of eosinophil and expression of Th2 cytokine in murine model for bronchial asthma, and whether its effect differs according to timing of dosage. Methods: Administration of IL-12 was tested in the 3 different time-frames; 1) allergic sensitization (early dosage) 2) allergic challenge (late doaage) or 3) both. The number of eosinophil in the bronchoalveolar lavage(BAL) fluid and tissue was examined for change of airway inflammation. The effect on cytokine expression was assessed by measuring cytokine in bronchoalveolar lavage fluid (ELISA) and mRNA in peribronchial lymph node (RT-PCR) Results: Early dosage of IL-12, and the combination of early and late dosages, strikingly decreased the numbers of eosinophil in both BAL fluid and tissue(p$lt;0.05). Late dosage of IL-12 decreased tissue eosinophilia, while the number of eosinophil in BAL fluid remained unchanged. IL-12 increased IL-4 and IL-5 levels, and decreased IL-2 and I~FN-γlevels. There were no dif- ferences in Thl/Th2 cytokine regulation among the three dosage times. Early dosage of IL-12, and the combination of early and late dosages, increased IL-10 level, but late dosage had no effect on IL-10. Conclusion: These results demonstrate that depending upon whether IL-12 is administered during sensitization or during subsequent allergen exposure, Thl/Th2 cytokine regulation by IL -12 shows no difference because it seems that difference of inhibition of eosinophil recruitment by IL-12 might be related with the other factors, such as IL-10.

      • KCI등재

        Effects of alpha-Chymotrypsin Modification on the FunctionalProperties of Soy Protein Isolates

        이숙영,Taehyun Ahn 한국작물학회 2006 Korean journal of crop science Vol.51 No.3

        Efects of α-chymotrypsin modification ondegre of hydrolysis (DH), solubility, emulsifying capacitytein isolate (SPI) using a lipoxygenase-defected soybean(Jinpum-kong) and commercial soy protein isolate (Supro500E) were compared. SPIs were hydrolyzed by α-chy-motrypsin at pH 7.8 and 37oC for 30 min. DHs of Supro50E and Jinpum-kong SPI were increased by α-chymot-rypsin modification, and DH of Supro 500E was higherthan that of Jinpum-kong SPI. DH of α-chymotrypsintreated Jinpum-kong SPI was similar with untreatedest. Solubility, emulsifying capacity and thermal aggrega-tion of SPIs were increased by α-chymotrypsin modification,and these changes were highly related to changes in DH.Functional properties of Supro 500E were higher thanJinpum-kong SPI in both of untreated and α-chymot-rypsin treated SPIs.

      • KCI등재


        이숙영 중국어문논역학회 2013 中國語文論譯叢刊 Vol.0 No.33

        《識英雄紅拂莽擇配》是凌濛初把唐傳奇小說《虬髯客傳》改写成戏曲作品。 《紅拂三傳》是有意分别以红拂、 虬髯翁、 李靖为主人公的。 (即是《識英雄紅拂莽擇配》(又名《北紅拂》)、 《虬髯翁》、 所佚的一传写李靖)。 与当时流行的以南曲改作的其他作品相比, 凌濛初用雜劇‘一人主唱’和‘北曲’的形式来更突出原小说的‘傳奇’色彩。 于是直接影响馮夢龍改作的《女丈夫》里红拂变成‘巾幗英雄’的模样。

      • 기관지천식 환자에서 소변내 Ieukotriene E4 측정의 의의

        이숙영,박성학,이상학,문화식,김석찬,송정섭,윤형규,김관형,신윤 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.4

        Background:Cysteinyl leukotrienes are important inflammatory mediators in bronchial asthma because they enhance microvascular permeability, increase nonspecific bronchial hyperresponsiveness, and are potent bronchoconstrictor agents. Leukotriene E₄ is a major metabolite of cysteinyl leukotriene excreted in urine and its concentration of urine can be a reliable marker of the overall leukotriene production in the body. Objective : To determine whether clinical parameters of bronchial asthma are associated with production of cysteinyl leukotrienes, expressed by urinary leukotriene E₄. Method: We measured the urinary concentration of leukotriene E₄ in bronchial asthma(127 patients) and normal control(15 persons) group by ELISA method. Pulmonary function test, allergic skin test, measurement of peripheral eosinophil count and eosinophil cationic protein were undertaken in bronchial asthma patients. Results: The concentrations of urinary leukotriene E₄ were significantly higher in bronchial asthma patients than ormal controls (p$lt;0.05). The increased concentrations of leukotriene E4 had a significant correlation with FEV1/FVC or methacholine PC20(p$lt;0.05). However, the concentration of leukotriene E4 did not have any correlation with the presence of atopy, peripheral blood eosinophil count, and eosinophil cationic protein level. Conclusion : The concentration of urinary leukotriene E₄ that represents the overall leukotriene production in the body is correlated with the degree of airway obstruction and airway hyperres- ponsiveness. So, the concentration of urinary leukotriene E₄ may be used as an adjunctive parameter of airway obstruction and hyperresponsiveness in bronchial asthma.

      • 기관지천식 환자에서 메타콜린 기도 감수성 및 반응성과 기도 병리소견의 관계

        이숙영,김영균,박성학,문화식,김석찬,송정섭,김관형,김승준 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.4

        Background:Airway hyperresponsiveness is expressed as the provocative dose or concentration of the stimulus required to achieve bronchoconstriction, a 20% fall in FEV1 (PD20 and PC20, respectively). A decrease in PC_(20) may be due to a steeper dose-response curve (hyperreactivity) or to a shift in the curve to the left (hypersensitivity), or both. It has been suggested that many factors, such as genetic factor, airway inflammation, epithelial damage or airway remodeling, are involved in the airway hyperresponsiveness in asthma. Objective: In this study, we analyzed the relationship of airway sensitivity and reactivity with bronchial inflammation and structural change in asthmatics. Method: The PC_(20) for methacholine, as the airway sensitivity parameter, and the slope between PC_(20) and PC_(40), as the airway reactivity parameter, were measured. Total cell counts and differential cell counts in BAL fluid, percentage of epithelial shedding (ES), basement membrane thickness (BMT) and depth of submucosal collagen depoition (SMC) on bronchial tissue were measured. The patients (n=27) were divided into two groups by median values of ES, BMT, or SMC (32%, 7.3㎛, 68㎛, respectively). Results: The PC_(20) showed a significant correlation with baseline FEV1% (r=0.498, p$lt;0.05), and was significantly lower in patients with over 32% of ES than in those with under 32% of ES (2.89±1.05 ㎎/㎖ vs 5.70±3.70 ㎎/㎖, p$lt;0.05). The slope was significantly steeper in patients with thicker BMT or SMC. Conclusion: These results suggest that airway hypersensitivity is affected by airway caliber, and airway hyperreactivity is affected by bronchial remodeling in asthma.

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