간내 담관암의 초음파 및 전산화 단층촬영소견 : Ultrasound and CT Findings

김완진,김표년,김일영,홍현숙,이혜경,권귀향,김기정 순천향대학교 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Identification of Genes Modulated by High Extracellular Calcium in Coculture of Mouse Osteoblasts and Bone Marrow Cells by Oligo Chip Assay

Kim, Hyung-Keun,Song, Mina,Jun, ji-Hae,Woo, Kyung-Mi,Kim, Gwan-Shik,Baek, Jeong-Hwa The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Calcium concentration in the bone resorption lacunae is high and is in the mM concentration range. Both osteoblast and osteoclast have calcium sensing receptor in the cell surface, suggesting the regulatory role of high extracellular calcium in bone merabolism. In vitro, high extracellular calcium stimulated osteoclastogenesis in coculture of mouse osteoblasts and bone marrow cells. Therefore we examined the genes that were commonly regulated by both high extracellular calcium and 1,25(OH)_(2)vitaminD_(3)(VD3) by using mouse oligo 11 K gene chip. In the presence of 10 mM[Ca^(2+)]e or 10 nM VD3, mouse calvarial osteoblasts and bone marrow cells were co-cultured for 4 days when tartrate resistant acid phosphatase-positive multinucleated cells start to appear. Of 11,000 genes examined, the genes commonly regulated both by high extracellular calcium and by VD3 were as follows; 1) the expressions of genes which were osteoclast differentiation markers or were associated with osteoclastogenesis were up-regulated both by high extracellular calcium and by VD3; trap, mmp9, car2, ctsk, ckb, atp6b2, tm7sf4, rab7, 2) several chemokine and chemokine receptor genes such as sdf1, scya2, scyb5, scya6, scya8, scya9, and ccr1 were up-regulated both by high ectracellular calcium and by VD3, 3) the genes such as mmp1b, mmp3 and c3 which possibly stimulate bone resorption by osteoclast, were commonly up-regulated, 4) the gene such as c1q and msr2 which were related with macrophage function, were commonly down-regulated, 5) the genes which possibly stimulate osteoblast differentiation and/or mineralization of extracellular matrix, were commonly down-regulated;slc8a1, admr, plod2, lox, fosb, 6) the genes which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were commonly up-regulated;s100a4, npr3, mme, 7) the genes such as calponin 1 and tgfbi which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were up-regulated by high extracelluar calcium but were down-regulated by VD3. These results suggest that in coculture condition, both high extracellular calcium and VD3 commonly induce osteoclastogenesis but suppress osteoblast differentiation/mineralization by regulating the expression of related genes.

여대생의 체중조절 경험과 비만도, 신체상, 스트레스대처에 관한 연구

김경혜,김옥란,정경옥,정경순,이은주 김천과학대학 2004 김천과학대학 논문집 Vol.30 No.-

Purpose: The purpose of this study was to investigate about weight control experience and to search the relationship between body image and stress coping in college female students according to obesity. Method: The subjects of this study consisted of 187 college female students. The data was collected from November to December of 2003. A self-rating questionnaire was used to collect data. The data was analysed by the SPSS computer program and it included descriptive statistics, frequency, percentage, X² -test, t-test, ANOVA and the pearson correlation coefficient. Result: The 67.9 percent of subjects had a experience of the diet, why of the diet was because of the appearance at 94.5% and because of the health at 5.5%. The mean score on body image was 111.61(SD=13.58). There was a significant difference in body image among under weight, normal weight, and overweight groups. The mean score of body image in under weight was the highest compared to others. The mean score on stress coping was 73.61(SD=7.91). There was not a significant difference in stress coping among the three groups. There was a significant positive correlation between body image and stress coping. Conclusion: The findings of this study give useful information to construct further studies in intervention program relating overweight control for college female students.

암환자의 건강문제 분류를 위한 횡단적 조사연구 : 서울시내 일개 종합병원 중심으로

김조자,이원희,유지수,허혜경,진혜영,최혜경 연세대학교 간호학연구소 1989 간호학 논집 Vol.12 No.1

The impact of cancer on human life has been recognized and the demand for care for the patient with cancer is ever increasing. Yet very little study around these concerns has been reported. The subjects of this study were 388 patients with cancer who were receiving treatment .in the outpatient department of Yonsei University Cancer Center. The study dealt with the health problems experienced while receiving this treatment. The research method used in this study was the structured interview technique using a questionnaire. Data collection was done between Dec. 1. l986 and June 30. 1987. The questionnaire used in this study was a revision of three questionnaires, one developed by D.W. McCaffrey(coping with cancer), one developed by C.A. Morris(self concept as altered by the diagnosis) and one developed by M.J. Yasko(management of symptoms associated with chemotherapy). Content validity was treated with oncologists and oneology nurses & nursing faculty members. The results and recommendation of the study areas follows: 1. Results. 1) Characteristics of the Sample The diagnoses of the subjects were as follow: The most frequent diagnosis was cancer of the stomach(26.5%), followed by breast cancer, lymphoma, rectal / colon cancer and lung cancer. The average age was 48.6 years. There were an equal number of men and women. There were 116(30.4%) subjects who received chemotherapy and surgery for the treatment of their disease of the total number of subjects. 264(69.5%) were treated for less than 1 year, and 116(30.5%) were treated for more than 1 year. The average Length of treatment was 12.7 months. 2) In Summary Health problems were categorized under four areas: physical. emotional, social and economical. The patients with lymphoma and stomach cancer experienced more health problems than any others in this study. According to the age of the patients, those in their 20's complained of physical and emotional problems most frequently and of those in their 30's social-economical concerns were most evident. In female gender. physical and emotional problems were identified more frequently than male patients. And yet male patients indicated greater concern with economic problems than female patients. Regardless of the treatment method or length of treatment health problems in different areas were similar and statistically not significant. However, economic concern was statistically significant(F = 2.52. p< 0.5) in those with receiving a combination of chemotherapy and radiation Marital status and health problems were also statistically significant. That is patients who were divorced, separated or widowed had more physical, psychological and economical problems than those who were married. 2. Recommendations. 1) Since the physical symptoms of nausea / muscle weakness and malnutrition were major health problems, the patient's diet and activity need to be carefully detailed and included in the care plan and further research is needed in order to implement physical, psychological. economical & spiritual interventions. 2) A follow up study should be done using a larger number of subjects and indifferent settings to further validate the health problem checklist for cancer patients.

음악과 수학 통합 활동이 유아의 공간능력 및 음악적성에 미치는 영향

김미영(Kim Mi-young),성연정(Sung Youn-Jung),홍혜경(Hong Hae-kyung) 한국열린유아교육학회 2009 열린유아교육연구 Vol.14 No.4

본 연구는 음악과 수학 통합 활동이 유아의 공간능력향상과 음악적성에 미치는 영향을 밝혀보기 위한 목적으로 수행하였다. 연구대상은 만 5세 유아 42명으로 실험집단과 비교집단에 무선 배정하였으며, 실험처치는 음악과 수학의 통합 활동을 16회 실시하였다. 실험집단은 음악과 수학의 통합 활동올 적용한 반면 비교집단은 음악과 수학의 분리된 활동을 적용하였다. 본 연구에서 사용한 검사도구는 Del Grande(1990)의 공간 능력 구성 체계를 기초로 홍혜경(2001)이 개발한 유아 공간 능력 검사도구와 Gordon(1979)이 개발한 음악적성 검사를 사용하였다. 두 집단의 사전검사와 사후검사 점수의 변화를 비교하기 위하여 공변량 분석을 실시하였으며 연구결과는 음악과 수학 통합 활동을 실시한 실험집단이 유아의 공간능력 항상과 음악적성에 긍정적인 영항을 미치는 것으로 나타났다. The purpose of this study was to find out the effects of Kindergarten music and mathematics activities on preschoolers' spatial abilities and the musical aptitude. The subjects were 42 five-year-old kindergarteners. They were randomly assigned to the experimental group and the comparative group. The experimental treatments were conducted 4 times a week for 4 weeks, with 16 activities in total. The kindergarteners of experimental group did mathematical activities integrated with music activities but the kindergarteners of the comparative group did mathematical activities separated from musk activities. This study used the preschooler's spatial ability test instrument developed by Hong Hae-Kyung(2001) based on Del Grande's spatial ability composition system(1990) musical aptitude test developed by Gordon(1979). It conducted covariance analysis to compare the changes of scores in the two groups between pretest and posttest. Consequently, it was found that the experimental group having integrated activity with music and mathematics showed improvement and positive effects in their spatial abilities and musical aptitude.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

Voice Mismatch Meets Neurolinguistics

Gui-Sun Moon,Sun-Woong Kim,Jeong-Ah Shin,Hae-Kyung Wee,Jong Un Park,Myung-Kwan Park,Wonil Chung 현대문법학회 2018 현대문법연구 Vol.99 No.-

Gui-Sun Moon, Sun-Woong Kim, Jeong-Ah Shin, Hae-Kyung Wee, Jong Un Park, Myung-Kwan Park, and Wonil Chung. 2018. Voice Mismatch Meets Neurolinguistics. Studies in Modern Grammar 99, 85-115. This paper aims to investigate Korean advanced L2 English learners’ strategies for ellipsis resolution during sentence processing. Ellipsis resolution is known to involve several stages of information processing from the initial step of detecting an ellipsis-licensing element by the parser to the final stage of integrating the ellipsis site with the information retrieved from the antecedent of the ellipsis site. In examining these steps, we have manipulated three factors: (i) TP vs. VP-ellipsis; (ii) two types of discourse coherence relations (resemblance(-contrast) vs. cause-effect relations); (iii) voice match vs. mismatch. We found through the ERP recordings that voice mismatch in TP ellipsis elicited N400, followed by P600, irrespective of discourse coherence relations. In contrast, voice mismatch in VP-ellipsis registered N400 only in resemblance(-contrast) relation, but not in cause-effect relation. These findings lead us to conclude that Korean advanced L2 learners of English seem to undergo the full sequence of processing stages required for ellipsis resolution.

단일 기관에서 경험한 소아청소년기 Kikuchi-Fujimoto병의 임상적 고찰

강희원,김한울,이소영,유경하,김혜순,유은선,최희정,김경효 이화여자대학교 의과학연구소 2018 EMJ (Ewha medical journal) Vol.41 No.4

Objectives: Kikuchi-Fujimoto disease (KFD) is characterized by lymphadenopathy and fever, and is usually self-limited. This study analyzed the clinical characteristics of pediatric patients with KFD. Methods: This retrospective, observational, single-center study was conducted in South Korea from March 2008 to October 2015. KFD was diagnosed based on clinical, radiological or histological findings and excluded when there were any other causes of lymphadenopathy. Medical records were reviewed for clinical and laboratory manifestations. Results: A total of 35 cases were included. The mean patient age was 12.1±2.9 years (range, 5 to 17 years); the male-to-female ratio was 1:0.8. The main clinical manifestations were cervical lymphadenopathy and fever in 34 cases (97%). The mean duration of fever was 12.2±8.3 days (range, 2 to 37 days). We noted enlargement of lymph nodes in the cervical, mesenteric (n=5, 14%), axillary (n=2, 6%), and inguinal (n=1, 3%) regions. Hepatosplenomegaly, loss of appetite, and rash were observed. On laboratory examinations, elevation of ferritin, leukopenia, and positivity for anti-nuclear antibodies were frequently observed. Twelve patients underwent biopsy and 23 cases were diagnosed by radiological findings. The mean duration of hospitalization for all cases was 7.9±2.9 days (range, 3 to 13 days) and steroids were administered in 10 cases. KFD recurrence was observed in 2 cases (5.7%) with the time to relapse of 7 months and 4 years. There were no cases with systemic lupus erythematous or other autoimmune disease. Conclusion: KFD should be considered in pediatric patients with lymphadenopathy and prolonged fever. Patients with KFD should be monitored for recurrence and the development of autoimmune disease.

Flare Skirt 의 Drape 性과 着裝形態把握에 關한 연구 : Moire´ Photograph 법을 중심으로 by moire´ Topography method

金惠敬 한국의류학회 1991 한국의류학회지 Vol.15 No.1

The purpose of this study was to investigate the effect of physical properties and grain line of fabrics on the drape properties of the flare skirt. Horizontal section overlap map was obtained by three dimensional Moire Topography. It was concluded drapability of the skirt obtained by the map can be used to determine the ease of the skirt. Grain line such as bias and lengthwise direction showed the difference of quality of the drape at the hem line; skirt made by bias direction showed evenly distributed flare and effective for the aesthetic point view. No difference was observed between cotton and polyester fabrics probably due to the similar characteristics of the fabrics.