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김한울,이소영,이지현,우소연,김경효 대한의학회 2019 Journal of Korean medical science Vol.34 No.23
Background: After the introduction of the meningococcal ACWY-CRM197 conjugate vaccine (MenACWY-CRM) in 2012 and the meningococcal ACWY-diphtheria toxoid conjugate vaccine (MenACWY-DT) in 2014, immunization was recommended for certain high-risk groups including new military recruits in Korea. However, comparative immunogenicity studies for these vaccines have not been performed in Korea. Here, we compared the immunogenicity of these two vaccines in healthy adults. Methods: A total of 64 adults, 20–49 years of age, were randomly divided into two groups (1:1) to receive either of the two vaccines. The sera were obtained before and 1 month after vaccination and tested for serogroup-specific serum bactericidal activity using baby rabbit complement. Results: There were no significant differences post-vaccination in the geometric mean indices and the seropositive rate to all serogroups between the vaccines. The proportion of seropositive subjects after vaccination ranged from 88% to 100%. Conclusion: Both meningococcal conjugate vaccines showed good immunogenicity in healthy Korean adults without statistically significant differences. Further investigations for serotype distribution of circulating meningococci and the immune interference between other diphtheria toxin-containing vaccines concomitantly used for military recruits are needed to optimize immunization policies.
Atrioventricular Flow Wave Patterns before and after Birth by Fetal Echocardiography
김한울,이효연,백수진,홍영미 한국심초음파학회 2012 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.20 No.2
Background: Doppler echocardiographic measurements of both valves during intrauterine life can be used to calculate peak early filling velocity (E)/late peak atrial filling velocity (A) ratio as a single index of diastolic performance. The purposes of this study were to estimate the changes in atrioventricular valve flow from gestational age 37-40 weeks to 1 month of postnatal life and to clarify the difference in right and left ventricular diastolic filling patterns. Methods: Atrioventricular flow waves were analyzed in 24 full-term pregnant women by fetal echocardiography. Postnatal follow-up studies were performed at 1 hour, 6 hours, 24 hours, 3 days, 1 week and 1 month. In each time point, pulsed Doppler echocardiography was used to interrogate Doppler waveform of E velocity, A velocity, total area under the curve (time velocity integral) and heart rate. Results: Mitral E/A ratio significantly increased from 0.7 ± 0.1 before birth to 1.0 ± 0.3 at postnatal 1 hour, 1.0 ± 0.2 at 1 week,and 1.5 ± 1.0 at 1 month. Tricuspid flow E/A ratio was 0.8 ± 0.3 before birth, 0.8 ± 0.1 at 1 hour, 0.8 ± 0.2 at 3 days, 0.9 ± 1.0 at 1month. Time velocity integral of tricuspid flow was significantly higher than that of mitral flow before birth, but there was no difference after birth. Conclusion: The dominance of mitral A wave before birth was changed very quickly after birth to the dominance of E wave,but the dominance of tricuspid A wave was maintained at 1 month. Diastolic function and compliance of mitral valve were better than those of the tricuspid valve after birth.
김한울,이지현,조혜경,이현주,서호성,이소영,김경효 대한의학회 2017 Journal of Korean medical science Vol.32 No.5
Group B streptococcus (GBS) infection is a leading cause of sepsis and meningitis among infants, and is associated with high rates of morbidity and mortality in many countries. Protection against GBS typically involves antibody-mediated opsonization by phagocytes and complement components. The present study evaluated serotype-specific functional antibodies to GBS among Korean infants and in intravenous immunoglobulin (IVIG) products. An opsonophagocytic killing assay (OPA) was used to calculate the opsonization indices (OIs) of functional antibodies to serotypes Ia, Ib, and III in 19 IVIG products from 5 international manufacturers and among 98 Korean infants (age: 0–11 months). The GBS Ia, Ib, and III serotypes were selected because they are included in a trivalent GBS vaccine formulation that is being developed. The OI values for the IVIG products were 635–5,706 (serotype Ia), 488–1,421 (serotype Ib), and 962–3,315 (serotype III), and none of the IVIG lots exhibited undetectable OI values (< 4). The geometric mean OI values were similar for all 3 serotypes when we compared the Korean manufacturers. The seropositive rate among infants was significantly lower for serotype Ia (18.4%), compared to serotype Ib and serotype III (both, 38.8%). Infant age of ≥ 3 months was positively correlated with the seropositive rates for each serotype. Therefore, only a limited proportion of infants exhibited protective immunity against serotype Ia, Ib, and III GBS infections. IVIG products that exhibit high antibody titers may be a useful therapeutic or preventive measure for infants. Further studies are needed to evaluate additional serotypes and age groups.
2P-549 Inhibition of methanol oxidation reaction of monocyclic cation structure based ILs
김한울,김영규,김미주,이병일,김성준,성영은 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Ionic liquids (ILs) are defined as ionic species that melt below 100°C. ILs have unique properties, for example, ionic conductivity, high thermal stability and non-volatility. They have been used in various fields such as electrolytes, green solvents. Using various ILs, we tested methanol oxidation reaction activity in direct methanol fuel cell cathode. Herein, we will present MOR activity data of ILs for structure-activity relationship(SAR) study.
김한울,이재훈 한국마린엔지니어링학회 2021 한국마린엔지니어링학회지 Vol.45 No.6
The necessity of decommissioning offshore plants is becoming increasingly important because of aging. Therefore, a proper selection of decommissioning equipment and evaluation of the structural stability is necessary for the efficiency and safety of decom-missioning work. In this research, methods for designing and evaluating the structural stability of a diamond wire cutting saw (DWS), which is one of the major equipment in decommissioning offshore plants, are introduced. Parametric analyses are performed to appro-priately design and evaluate the structural stability. Consequently, stress decreased significantly (from 195.5 MPa to 112.3 MPa in the cutter part and from 168.2 to 110.1 MPa in the arm part) and weight increased minimally (3% in the cutter part and 0.1% in the arm part) from the initial design. Notably, the DWS is considered that appropriate design was performed by selecting proper design variables, design values that satisfied the allowable stress, and minimizing the weight increase.