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      • 구인 Lumbricus terestris Goto et Hatai의 藥理學的 硏究 : 구인의 Methanol 엑스가 家兎血淸中 Total Cholesterol 含量變化 및 血糖量에 미치는 影響 The Effectes of Vermis-extracts on the Serum Total Cholesterol and Blood-Sugar Levels from Rabbits

        陳惠英,李尙仁,姜孝信,鄭址昌 中央醫學社 1975 中央醫學 Vol.28 No.1

        The effects of Vermis-(Lumbricus terestris Goto et Hatai)extracts on. The serum cholesterol and blood-sugar levels from normal and alloxan-diabetic rabbits were observed. The crude drug was extracted by methanol, and extracted samples were orally administrated to the normal and alloxan-diabetic rabbits. The serum total cholesterol and blood-sugar Ievels of normal rabbits admistrated with sample, no significant variation were detected. The serum cholesterol and blood-sugar levels of alloxan-diabetic rabbits were significantly increased after 3 days. The increased serum total cholesterol levels of alloxan-diabetic rabbits were significantly decreased by administration of the Vermis-extracts, and were returned to the control levels after 11days. However, the increased blood-sugar levels of alloxan-diabetic rabbits were not significantly decreased by administration of the drug. According to the above results, it would be concluded that the Vermis-extracts influences for the recovery of the increased serum total cholesterol levels.

      • KCI등재후보

        재가장기요양기관의 운영관리에 영향을 미치는 요인에 관한 연구 - 기관장의 서번트 리더십을 중심으로 -

        진혜영,김형준 한국통합사례관리학회 2014 한국케어매니지먼트연구 Vol.11 No.-

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        본 연구는 재가 장기요양기관장들의 운영관리에 서버트 리더십이 미치는 요인을 검증하여 유효성이 있는 기관 운영관리를 위한 제언을 하고자 진행하였다. 수원, 안양, 화성지역의 재가 장기요양기관장 94명을대상으로 이루어졌다. 분석은 t-검정, 분산분석(ANOVA), 상관분석, 다중회귀분석 방법으로 실시하였다. 연구결과는 서번트 리더십을 발휘할수록, 월수입이 많을수록, 기관 소재지의 규모가 클수록, 종교가 있을수록 재가 장기요양기관장의 기관 운영관리에 영향을 준다는 결과가 나타났다. 노인의 의료복지의 측면에서재가 장기요양기관장의 서번트 리더십을 발휘할수록 기관 운영관리의 유효성을 높을 것이라는 만큼, 타인을 섬기는 리더십(서번트 리더십)을 발휘하여야 할 것이며. 월수입이 많을수록, 소재지의 규모가 클수록 기관 운영관리 측면에 유리하다는 것으로 밝혀진 만큼, 재가장기요양기관에 안정된 수입 보장을 위한 정책적인 노력과 함께, 일관성 있는 정책수립이 요구된다. 대⋅중⋅소도시, 농촌 등의 지역별 기관설치 및 기관운영의 유효성을 맞춤형으로 설계하여 효율성 있는 정책이 이루어져야 할 것이다. It has been intended to submit a proposal for the servant leadership management with theverification that the factor affects on the administrative control for the Head/Director of theDomiciliary Long-term Care Facilities. This paper/study involved 94 persons, Head of theDomiciliary Long-term Care Facilities where located at Suwon, Anyang and Hwasung areas. Analysis methods were used by T-test, Analysis of Variance, Correlation Analysis and MultipleRegression Analysis. Upon research result, the more Head who shows his/her ability, the moreHead who has a high income, the more the location where is in a sizable city and the moreHead who has religion, the more influential in operation and management for the DomiciliaryLong-term Care Center’s Head. With the practical respect, welfare for senior citizens, therewould be high availability for the Head’s management as much showing the servant leadershipas serving others. With the policy aspect, there would be to the facilities' advantage uponoperation and management in accordance with a high income and a sizable city. Therefore it isthought that the intentional efforts for a steady income and the policy making with a coherentplan are required for the Domiciliary Long-term Care Facilities. And it ought to be done thatthe facility might be established by the regional group such as major city, small-medium sizedcity and farming area, and the availability of the facilities' management should be planned intothe customized management style in order to accomplish an efficient policy in future.

      • KCI등재

        A Study on the Heritage Value and Construction Characteristics of Unregistered Garden of Cultural Heritages

        진혜영,정미애,신현실,노재현 한국전통조경학회 2019 한국전통조경학회지 Vol.17 No.-

        This study established the hypothesis that the value of private gardens not designated as state-designated cultural heritages is being inherited. In addition, the value of authenticity and integrity was derived for unregistered private gardens created during the Joseon Dynasty in the Yeongnam region. Through this, we will draw out traditional garden that need preservation today, and preserve it to provide basic data for the popularization. To this end, the final destination was extracted from unregistered private gardens located in the Yeongnam region based on the authenticity and integrity of traditional garden spaces for at least 50 years of history, and the following results were obtained by conducting a study. First, the private home garden of 20 sites has a history of at least 70 years. The Jeong, Cheon-Sang’s house had a history of 350 years, so it now secured a historical authenticity that goes beyond the standard date of national registered cultural heritages. This is because each house has been used as a living space, inherited by its descendants after the initial support. Second, the study areas were all located in traditional villages, single lineage village, and historical villages. Houses were located in accordance with the Confucian hierarchy of the Joseon Dynasty, and 15 of the old houses had the location of Baesanimsu(with back to the mountain and facing the water) according to the Feng-shui. This made it relatively easy to protect traditional spaces and allowed them to stay in shape until now. Third, most of the sites in terms of the layout of the buildings have a “ㅁ shape-type" housing, which is a characteristic of the Yeongnam region. Each of the zoned spaces had variations, with building lines expanding or depending on the changes in life, which also led to changes in the garden space. Fourth, elements of the traditional landscape existed in the study area, and among them, a large proportion of the elements, including an oddly shaped stone, standing stones, stone mortar, and earthen wall. It was planted according to the traditional method of planting according to the meaning of the trees. Fifth, there were 36 old trees in 14 of the study areas, meeting the value of traditional garden.

      • KCI등재

        한·중 면세점 사업의 비교 연구

        진혜영,장로,이상학 한국제도경제학회 2019 제도와 경제 Vol.13 No.3

        면세점 사업은 출국자에게 보세판매장, 즉 면세점에서 면세 제품을 판매하는 사업이다. 소득증가 및 항공 요금의 인하 등에 힘입어 한국과 중국을 방문하는 관광객 및 한·중 양국의 해외여행객이 증가하 면서 양국 면세점의 매출은 빠르게 증가하고 있다. 본 논문은 한·중 양국의 면세점 사업의 현황과 제 도를 비교 분석하였다. 특히 한·중 양국의 면세점 매출의 증가 요인에 대해 ‘변이-할당 분석’을 실시 하고 이로부터 시사점을 도출하였다. 분석결과, 한·중 양국의 면세점 사업이 세계 및 아시아·태평양 지역보다 빠르게 성장하여 경쟁력 있는 산업임을 확인하였다. 또한 한·중 양국의 면세점 사업과 제도 를 비교하여 유사점과 차이점을 확인하고, 동반 성장이 가능한 정책을 제안하였다. 본 논문의 연구결과 는 한·중 양국의 면세점 사업의 지속적 발전을 위한 정책 설계에 기초자료로 활용될 수 있을 것이다. The duty-free shop business is a business that sells duty-free products at duty-free shops, which are bonded shops, to domestic residents and foreigners who travel to other countries. Thanks to the increase in income and spread of low-cost airlines, the number of tourists visiting Korea and China and the number of tourists in both Korea and China have increased rapidly, resulting in a rapid increase in sales at duty-free shops in both countries. This paper compares the duty-free shops of Korea and China. In particular, we conduct a shift-share analysis on the growth factors of duty-free shops in Korea and China, respectively, and draw implications from them. It is confirmed that Korean and Chinese duty-free businesses are more competitive than those in the rest of the world and Asia-Pacific region. In addition, this paper compares the duty-free policies of Korea and China to identify similarities and differences, and suggest policies for mutual growth of duty-free businesses. The results of this study can be used as a basis for policy development for sustainable development of duty-free business in Korea and China.

      • KCI등재

        철모깍지벌레(Saissetia coffeae)에 대한 애홍점박이무당벌레(Chilocorus kuwanae)의 포식능력

        진혜영,안태현,이봉우,전혜정,이준석,박종균,함은혜 한국응용곤충학회 2015 한국응용곤충학회지 Vol.54 No.4

        This study, examined Chilocorus kuwanae for biological control of Saissetia coffeae. We measured basic developmental characteristics of C. kuwanae and its capability to prey on the second-instar larvae of S. coffeae by indoor breeding under the following conditions: 25℃± 2℃, humidity 70% ± 5%, and day length 16L : 8D. The average daily consumption of the second-instar larvae of S. coffeae by C. kuwanae adults was approximately 77.5 larvae/day, which was significantly 2.8 and 2.9 times higher than consumption by Chrysoperla carnea and Cryptolaemus montrouzieri, respectively. During the nymphal period, C. kuwanae consumed a total of 659.0 second-instar larvae of S. coffeae. The interaction between C. kuwanae and the second-instar larvae of S. coffeae varied according to their densities, with the increase in C. kuwanae consumption rate noted to decelerate and gradually level off at the maximum, rsembling Holling’s Type II functional response. Duration of egg to adult development varied from 21.1 days to nearly 27.9 days at temperatures of 25℃± 2℃. Hatchability, pupation rate, and adult emergence were greater than 72.3%, 77.8% and 83.3%, respectively. 철모깍지벌레의 생물적 방제를 위한 애홍점박이무당벌레의 포식능력과 기초 생태특성을 25℃± 2℃, 70% ± 5%, 16L : 8D로 설정된 사육실에서 검정한 결과, 애홍점박이무당벌레 성충은 하루에 77.5마리의 철모깍지벌레를 포식하여, 깍지무당벌레 포식력의 2.9배, 어리줄풀잠자리 포식력의 2.8배 이상의 뛰어난 포식능력이 관찰되었다. 1령 ~ 4령 유충 기간 동안 659.0마리의 철모깍지벌레를 포식하였고, 애홍점박이무당벌레와 철모깍지벌레의 밀도 별 상호작용을 조사한 결과 Holling (1959)의 기능반응곡선 제 II 형과 유사한 포식반응을 확인하였다. 애홍점박이무당벌레는 철모깍지벌레를 먹이로 공급했을 때 알에서 성충까지 21.1일 ~ 27.9일이 소요되었으며, 72.3%, 77.8%, 83.3%의 높은 부화율, 용화율과 우화율을 보였다.

      • KCI등재

        Hepatic glycogenosis in a patient with poorly controlled type 1 diabetes mellitus

        진혜영,강대영,최진호 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.11

        Hepatomegaly and liver dysfunction might develop in patients with diabetes mellitus due to glycogen deposition or nonalcoholic steatohepatitis. We experienced a case of hepatic glycogenosis in a patient with type 1 diabetes mellitus who presented with recurrent hypoglycemia, suggesting impairment of glycogenolysis and gluconeogenesis. A 10-year-old girl with a 4-year history of type 1 diabetes mellitus was admitted because of recurrent hypoglycemia and abdominal pain in the right upper quadrant. She had Cushingoid features and hepatomegaly that extended 6 cm below the right costal margin. Laboratory data and radiologic examination revealed elevated liver enzyme levels due to fatty liver. Periodic acid-Schiff (PAS) staining revealed intense glycogen deposition in the cytoplasm of the hepatocytes and PAS reactivity was lost with diastase treatment. At 2 months after administration of glucagon injection and uncooked cornstarch between meals and at bedtime, the hypoglycemic episodes and liver dysfunction improved. It is important to distinguish hepatic glycogenosis from steatohepatitis, because it is possible to prevent excessive hepatic glycogen storage in hepatic glycogenosis cases by strictly controlling blood glucose level and by glucagon administration. To prevent severe hypoglycemic symptoms accompanied by hepatic glycogenosis, we suggest that uncooked cornstarch, which is effective in maintaining blood glucose level, can also be administered.

      • KCI등재

        Transient neonatal diabetes mellitus with macroglossia diagnosed by methylation specific PCR (MS-PCR)

        진혜영,최진호,김구환,유한욱 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.3

        Transient neonatal diabetes mellitus (TNDM) has been associated with paternal uniparental isodisomy of chromosome 6, paternally inherited duplication of 6q24, or a methylation defect at a CpG island of the ZAC or HYMAI gene. We experienced a case of TNDM in which the patient presented with hyperglycemia, macroglossia, and intrauterine growth retardation, caused by a paternally derived HYMAI. An 18-day-old female infant was admitted to the hospital because of macroglossia and recurrent hyperglycemia. In addition to the macroglossia, she also presented with large fontanelles, micrognathia, and prominent eyes. Serum glucose levels were 200–300 mg/dL and they improved spontaneously 2 days after admission. To identify the presence of a maternal methylated allele, bisulfite-treated genomic DNA from peripheral blood was prepared and digested with BssHII after polymerase chain reaction (PCR) amplification with methylation-specific HYMAI primers. PCR and restriction fragment length polymorphism analysis showed that the patient had only the paternal origin of the HYMA1 gene. TNDM is associated with a methylation defect in chromosome 6, suggesting that an imprinted gene on chromosome 6 is responsible for this phenotype.

      • KCI등재

        급성림프구성백혈병에서 면역조직화학염색에 의한 p16 단백질 소실의 의의

        진혜영,강경인,김선영,윤유숙,강준원,조덕연,권계철,박경덕 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.1

        Purpose:p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance of p16 alterations is still controversial in ALL and has been reported to be either unfavorable or similar to that of other patients. We studied the correlation between loss of p16 protein confirmed by immunohistochemical staining and clinical outcomes of patients diagnosed as ALL. Methods:We performed an immunohistochemical staining for p16 protein in 74 cases of bone marrow biopsy slide initially diagnosed as ALL between January 1998 and December 2006. We reviewed the clinical manifestations, laboratory findings, treatment outcomes retrospectively. Results:Of 74 slides, 12 were negative for p16 protein. Seven were males and 5 were females with a median age at diagnosis was 5.8 (1.3-18.8) years. Initial WBC were 17,225 (500-403,300)/µL. By immunologic surface marker analysis, 7 patients were early pre-B CALLA (+) and 5 patients were T-cell ALL. Two patients of intermediate risk group had relapsed and died. Three patients had family history of breast cancer. Four patients died and overall survival rates were 53.5±18.7%. Conclusion:Loss of p16 protein is supposed to be an independent risk factor of childhood ALL associated with poor outcomes. In clinical setting, the clinician must take into account p16 status, not only at the genomic but also at the protein level. Further clinical experience on thoroughly investigated cases will help a better understanding between p16 status and clinical outcomes. (Korean J Pediatr 2008;51:73-77) Purpose:p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance of p16 alterations is still controversial in ALL and has been reported to be either unfavorable or similar to that of other patients. We studied the correlation between loss of p16 protein confirmed by immunohistochemical staining and clinical outcomes of patients diagnosed as ALL. Methods:We performed an immunohistochemical staining for p16 protein in 74 cases of bone marrow biopsy slide initially diagnosed as ALL between January 1998 and December 2006. We reviewed the clinical manifestations, laboratory findings, treatment outcomes retrospectively. Results:Of 74 slides, 12 were negative for p16 protein. Seven were males and 5 were females with a median age at diagnosis was 5.8 (1.3-18.8) years. Initial WBC were 17,225 (500-403,300)/µL. By immunologic surface marker analysis, 7 patients were early pre-B CALLA (+) and 5 patients were T-cell ALL. Two patients of intermediate risk group had relapsed and died. Three patients had family history of breast cancer. Four patients died and overall survival rates were 53.5±18.7%. Conclusion:Loss of p16 protein is supposed to be an independent risk factor of childhood ALL associated with poor outcomes. In clinical setting, the clinician must take into account p16 status, not only at the genomic but also at the protein level. Further clinical experience on thoroughly investigated cases will help a better understanding between p16 status and clinical outcomes. (Korean J Pediatr 2008;51:73-77)

      • KCI등재

        소아 및 청소년기에서 골수이식 후에 발생할 수 있는 내분비 기능 부전

        진혜영,최진호,임호준,서종진,문형남,유한욱 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.3

        Purpose:Several complications can occur in patients who received bone marrow transplantation (BMT) during childhood and adolescence. This study aims to investigate endocrine dysfunctions after BMT so that better care can be provided to care for long-term survivors of BMT. Methods:One hundred patients (61 males, 39 females) were included in this study. Clinical parameters such as initial diagnosis, age at BMT, conditioning regimen, presence of graft-versus-host disease (GVHD), growth pattern, thyroid function, and pubertal status were retrospectively reviewed to evaluate risk factors associated with endocrine dysfunction. Results:Height standard deviation score (SDS) at BMT, after 1 year of BMT, and at the last visit were 0.08±1.04, -0.09± 1.02, and -0.27±1.18, respectively (P=0.001). Height SDS significantly decreased in patients who received total body irradiation (TBI) (P=0.017). One of the patients who received TBI demonstrated growth hormone deficiency. Thirty (31.9%) of 94 patients had compensated hypothyroidism. Incidence of compensated hypothyroidism was higher among those who had GVHD (odds ratio 2.82, P=0.025). Of the 32 patients (17 males, 15 females) who were over 14 years in male and 13 years in female at the last visit, 16 (3 males, 13 females) had increased luteinizing hormone (LH) or follicle-stimulating hormone (FSH). Abnormal elevation of LH or FSH was more common in females (odds ratio 30.3, P=0.001). Conclusion:The most common endocrine dysfunction was ovarian insufficiency. Regular check-up for endocrine function needs to be required due to high incidence of endocrine dysfunction in patients with BMT. 목적:소아와 청소년기에 골수이식을 받은 환자들은 여러 가지 조기 또는 후기 합병증이 발생할 수 있다. 본 연구에서는 이식 후 발생할 수 있는 내분비 기능 부전에 대해 분석하여 이식 후 추적 관리에 도움이 되고자 하였다. 방법:골수이식을 받은 100명(남자 61명, 여자 39명)의 환자들을 대상으로 진단명, 이식 당시 연령, 전처치 방법, 만성 이식편대 숙주병 유무, 성장 패턴, 갑상샘 기능, 사춘기 발달 상태 등을 후향적으로 조사하여 내분비 기능 부전과 관련이 있는 위험 인자가 있는지 분석하였다. 결과:이식 당시, 이식 1년후, 최종 내원시의 신장 표준편차 점수는 각각 0.08±1.04, -0.09±1.02, -0.27±1.18로 의미있게 감소하였다(P=0.001). 전처치로 TBI를 받은 경우 TBI를 받지 않은 군에 비하여 이식 전보다 신장 표준편차 점수가 더 많이 감소하였다(P=0.017). TBI를 시행한 환자 중 1명에서 성장 호르몬 결핍을 보였다. 갑상샘 기능 검사를 시행한 94명 중 30명(31.9%)이 보상성 갑상샘저하증이었고 만성 이식편대 숙주병이 있었던 환자에서 보상성 갑상샘저하증의 빈도가 높았다(odds ratio=2.82, P=0.025). 최종 내원 시 만 14세 이상 남자 17명, 만 13세 이상 여자 15명 중에서 비정상적인 LH 또는 FSH의 상승을 보인 경우는 남자 3명, 여자 13명으로 여아가 의미 있게 많았다(odds ratio=30.3, P=0.001). 결론:소아나 청소년기에 골수이식을 받은 환자에서 가장 흔한 내분비 기능 이상은 난소 기능 부전이며 그 외 높은 빈도의 내분비 기능 이상을 보이므로 정기적인 내분비 기능 검사가 필요하다.

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