Relationship between Meteorological Elements and Yield of Hot Pepper in Yeosu Area of Korea

Kwon,Byung-Sun,Choi,Seong-Kyu,Shin,Jeong-Sik,Shin,Jong-Sup,Shin,Dong-Young,Hwan,Kyu-Hyun,Kim,Hak-Jin,Kuk,Yong-In,Choi,Kyong-Ju 한국자원식물학회 2003 Plant Resources Vol.6 No.1

This study was conducted to investigate the relationships between yearly variations of meteorological elements and yearly variations of productivity in hot pepper. In addition, correlation coefficients among the yields and yield components were used to find out the relationships between meteorological elements and productivity. Yearly variation of the mean air temperature in May and July showed large with coefficients of variation(C.V.) of 25.0,8.9%, respectively, but the variation of the duration of sunshine in May were relative small. Yield and plant height was greatly with C.V. of 7.14,11.6%, respectively, diameter of fruit showed more or less C.V. of 2.28% and length of fruit showed less variation. Correlation coefficients between maximum temperature in period of cultivation from May and yield are positively significant at the level of 1 %. Correlation Coefficients between precipitation in period of cultivation from May to August and yield are negative significant at the level of 5 and 1 %, respectively. Correlation coefficients amount the plant height, length of fruit, diameter of fruit per plant, and seed yield were positively significant at the level of 1 %, respectively.

만성 견비통에 대한 동씨침 치료의 무작위 대조군의 임상 연구

김찬영,권나현,신예지,남동우,김건형,김종인,최도영,이윤호,이재동 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : To observe the effect of acupuncture treatment in chronic shoulder pain patients. Methods : 36 voluntary patients were randomly assigned to an acupuncture treatment group(E GrouP, n=18) and a control group(C GrouP, n=18). The E Group patients received acupuncture treatment on LI_(15), TE_(14), GB_(21) and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for four weeks. The C Group patients received no treatment. All patients in both groups were instructed to practise self exercise in their daily lives. Evaluations were made at baseline and after four weeks of study. The Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's subjective pain was measured by Visual Analogue Scale(VAS). The obtained data was analyzed. Results '. The E Group showed significant(p<0.05) improvement in CSA, SPADI and VAS after four weeks of treatment. The C Group showed significant(p<0.05) improvement in CSA, but the change of SPADI and VAS was insignificant(P>0.05). CSA and SPADI of E Group significantly(p<0.05) improved compared to the C GrouP, but the difference of VAS change in the two groups was insignificant(p>0.05). Conclusions : Four weeks of acupuncture treatment significantly improved CSA, SPADI and VAS. The improvement of CSA and SPADI was significant(p<0.05) compared to untreated patients.

기존의 치료에 반응하지 않는 다발성 간전이 대장암 환자에서 방사선조사와 병합한 수지상세포 면역치료의 1, 2상 임상시험

최영민(Youngmin Choi),이형식(Hyung-Sik Lee),권혁찬(Hyuk-Chan Kwon),한상영(Sang-Young Han),최종철(Jong-Cheol Choi),정주섭(Ju-Seop Chung),김창원(Chang-Won Kim),김동원(Dong-Won Kim),강치덕(Chi-Duk Kang) 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.2

목 적: 기존치료에 반응하지 않는 다발성 간전이를 동반한 대장암 환자에서 방사선치료와 병합한 수지상세포 면역 치료의 독성과 반응도를 조사하였다. 대상 및 방법: 2004년 5월부터 2006년 11월까지 다발성 간전이가 동반된 대장암 환자들 중에서 항암화학 요법에 반응하지 않은 환자 중 지원자를 대상으로 연구를 시행하였다. 본 임상 시험에 대하여 동아대학교병원과 부산대학교병원의 임상윤리심의위원회의 허가를 획득하였고, 동의서에 서명한 환자들을 임상 시험의 대상으로 등록하였다. 환자의 말초 혈액으로부터 수지상세포를 추출하여 배양하였다. 임상시험 일자에 맞추어서 6×106개의 수지상세포를 바이알(0.5 ml)에 넣어서 디씨백/아이알 주사를 만들었다. 수지상세포 면역치료는 2주 간격으로 간전이암조직에 3회 주사하고, 5주에 내약성 평가를 하였다. 내약성 평가를 통과한 환자에게는 8주에 4번째 수지상세포 면 역치료를 하였다. 병의 악화가 없거나 임상시험에 대한 환자의 동의 철회가 없는 경우에는 5, 6번째 수지상세포면역치료를 각각 12, 16주에 시행하였다. 방사선치료는 수지상세포 면역치료를 주사할 간전이암 부위에 주사하기 전일 및 당일에 4 Gy씩을 조사하였다. 내약성 평가는 3×106개의 수지상세포로부터 시작하여, 12×106개의 수지상세포까지 시행하였다. 내약성 평가의 최대 내성 용량으로 추가 임상시험을 하였다. 수지상세포 면역치료 주사를 맞은 모든 환자들에서 안전성 평가를 하였다. 4회 이상 주사를 맞은 환자들을 대상으로 10주에 치료 반응을 평가하여 유효성을 조사하였다. 결 과: 임상시험에 등록한 24명 중 22명에서 수지상세포 면역치료를 시행하였다. 내성약 평가에는 14명이 등록하여 11명에서 평가를 완료하였다. 시험약과의 관련성이 있을 것으로 생각되는 grade 3 이상의 약물반응으로 인한 이상반응은 없었다. 12×106개의 수지상세포를 내성용량으로 확인하였고, 내성용량인 12×106개 수지상세포 면역치료를 이용하여 8명에서 추가로 시험을 하였다. 치료에 대한 환자들의 내성은 양호하였고, grade 3을 초과하는 치명적인 부작용은 발생되지 않았다. 4회 이상의 수지상세포 면역치료 주사를 받은 환자가 17명이었고, 이 중의15명에서는 종양의 반응도 평가가 이루어졌다. 본 연구의 목적은 안전성 평가이지만, 면역치료의 유효성 평가를 위해, 방사선치료와 수지상세포 면역치료 주사가 시행된 부위 외의 간전이암에서 반응도를 조사 하였다. 면역치료의 반응은 평가가 이루어진 환자들에서 정지성 병변이 4명, 진행성 병변이 11명 이었다. 결 론: 수지상세포 면역치료와 병행한 방사선치료는 이론적으로 국소 및 전신 제어에 상승효과가 있을 것으로 기대할 수 있다. 하지만 기존 치료에 반응하지 않는 매우 진행된 직장암 환자들을 대상으로 한 본 연구에서는 방사선 치료와 병합한 수지상세포 면역치료로 인한 심각한 부작용의 발생은 없었다는 결과와 4예에서의 정지성 병변의 관찰을 보고한다. 수지상세포의 최대 투여 용량, 적절한 투여 방법, 적절한 방사선의 양, 방사선과 수지상 세포의적절한 투여 간격 등에 관한 추가 연구를 통하여, 향후 제 2상, 3상 시험으로서의 진행 여부에 긍정적인 결과를얻을 수 있다고 판단한다. Purpose: To assess the toxicity and tumor response induced by DCVac/IRⓇ dendritic cell (DC) immunotherapy combined with irradiation for refractory colorectal cancer patients with multiple liver metastases. Materials and Methods: Between May 2004 and November 2006, applicants from a pool of refractory colorectal cancer patients with multiple liver metastases were enrolled. The patients were registered after having signed the informed consent form, which had been approved by the Institutional Review Board from the Dong-A University and Busan National University Hospital. DCs were obtained from peripheral blood of each patient, and then cultured in vitro. A total of 6×106 DCs were packed into a vial (DCVac/IRⓇ, 0.5 ml) at the convenience of each patient’s schedule. On the day before and on the day of each vaccination, each patient received a 4 Gy radiation dose to the target tumor. On the day of vaccination, the indicated dose of autologous DCs was injected into the irradiated tumor using ultrasound-guided needle injection procedures. A total of four vaccinations were scheduled at three 2-week intervals and one 4 week interval at the Dong-A University and Busan National University Hospital. If the tumor status was deemed to be stable or responding to therapy, an additional vaccination dose or two was approved at 4 week intervals beyond the fourth immunization. A tolerance test for DCs was conducted by injecting a range of doses (3×106 to 12×106 DCs) after the 3rd injection. Moreover, the maximal tolerable dose was applied to additional patients. Treatment safety was evaluated in all patients who had at least one injection. Treatment feasibility was evaluated by the 10th week by assessing the response of patients having at least 4 injections. For systemic toxicities, the evaluation was performed using the National Cancer Institute Common Toxicity Criteria, whereas adverse effects were recorded using common WHO toxicity criteria. Results: Of the 24 registered patients, 22 received the DCs injections. Moreover, of the 14 patients that applied for the tolerance test, only 11 patients completed it because 3 patients withdrew their testing agreement. A grade 3 or more side effect, which was possibly related to the DC injection, did not occur in additional patients. The 12×106 DC injection was identified as the maximum tolerable dose, and was then injected in an additional 8 patients. Patients tolerated the injection fairly well, with no fatal side effects. In order to assess the feasibility of DC immunotherapy, the response was evaluated in other hepatic lesions outside of the targeted hepatic lesion. The response evaluation was performed in 15 of the 17 patients who received at least 4 injections. Stable and progressive disease was found in 4 and 11 patients, respectively. Conclusion: The DC-based immunotherapy and radiotherapy is theoretically synergistic for the local control and systemic control. The DCVac/IRⓇ immunotherapy combined with irradiation was tolerable and safe in the evaluated cases of refractory colorectal cancer with multiple liver metastases. Future work should include well designed a phase II clinical trials

영아에서 발생한 골수섬유증 1례

최성민,이동석,권경배,김두권,김나연,원유흥,이준희,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

특발성 골수섬유증은 만성 골수증식성 질환의 하나로 말초혈액도말에서 백적아구증, 부동변형적혈구 눈물방울세포 소견을 보이며, 골수 생검상 망상 섬유와 교원섬유로 구성된 섬유조직이 증가하는 골수의 섬유화 소견을 보이며, 골수외 조혈작용으로 인한 대상적 비장·간장 종대를 특징으로 하는 소아에서는 극히 드문 질환이다. 저자들은 본원에 복부종괴와 안면창백으로 입원하였던 8개월된 남아에서 임상증상, 말초혈액검사, 골수생검에서 특발성 골수섬유증으로 진단되어 Methylprednisolone 대량 정주 요법으로 치료하였으나 진단7개월만에 패혈증과 심부전으로 사망했던 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by anemia, leukoerythroblastosis, anisopoikilocytosis, tear-drop cell, extramedullary hematopoiesis with hepatosplenomegaly and varying degrees of myelofibrosis of bone marrow. The mean age is about 60 years, and pediatric cases are rare. We experienced a case of idiopathic myelofibrosis in a 8 months old male who was presented with pallor, huge splenomegaly, leukoerythroblastosis in peripheral blood, myelofibrosis in bone marrow biopsy. We presented a case of idiopathic myelofibrosis with brief review of the literatures.

양극산화와 절연파괴로 형성한 인산칼슘 함유 티타늄 산화피막의 특성

최원호,이용승,김동환,권용훈,배태성 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.1

This study was performed to investigate the surface properties of electrochemically oxidized pure titanium by anodic spark deposition technique. Titanium plates of 10×10×1 ㎜ were polished sequentially from # 300 to # 1,000 emery paper. They were ultrasonically washed in ethyl alcohol and acetone for 5 min and dried in a desiccator. Titanium plates and titanium screw implants were anodized in an electrolytic solution that was dissolved calcium and phosphate in water. The electrolytic voltage was set in the range of 190-340 V and the current density was 30 ㎃/㎠. The surface oxide film was characterized by X-ray deffractometer(XRD), scanning electron microscope(SEM) and X-ray photoemission spectroscopy(XPS). The main crystal structure of the titanium oxide was anatase type as analyzed with thin-film X-ray diffractometery. The diameter of micropores increased with increasing the spark forming voltage. The porous coatings showed the growth of cell structure and more compact texture with increasing the spark forming voltage. Microcracks were examined in the coating formed at voltage of 340 V. Ca/P ratio in coatings was increased with increasing the voltage.

[18F]FDG PET을 이용한 강박증 환자에서 뇌 포도당 대사의 이상에 관한 연구

권준수,이동우,이재성,최정임,이동수,정준기,조맹제,이명철,류인균 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 강박증에 대한 기능적 뇌영상 연구들에서 강박증 환자들의 안와전두엽과 미상핵의 대사율 증가 소견이 비교적 일과되게 발표되어 왔으며, 전두-피질하 회로의 이상이라는 이론이 수립되기도 하였다. 그러나 기존의 연구들은 강박증의 유병기간에 따른 구분없이 시행된 연구였고, 영상분석 방법에 있어서도 관심영역 방법을 이용했다는 한계를 지니고 있다. 본 연구의 목적은 첫째, 강박증의 유병기간에 따라 환자군을 구분하여 PET 영상소견을 분석함으로써 유병 기간에 따른 차이가 있는지를 조사하였으며, 둘째, 강바증 환자의 포도당 양전자방출 단층촬영(18-Fluor-deoxyglucose Positron Emission Tomography : FDG-PET) 영상분석에 통계적 매개변수 지도법(Statistical Parametric Mapping : SPM)을 이용함으로써 강박증의 병인기전 및 강박증상과 뇌기능 간의 관계를 명확히 규명하고자 하였다. 방법: 구조적 면담도구(Structured clinical interview for DSM-IV : SCID-IV)를 적용하여 진단된 12명의 강박증 환자들과 10명의 정상 대조군에 대해 FDG-PET을 촬영하여 SPM으로 분석하였다. PET 촬영 전 적어도 4주 동안에는 약물복용을 하지 않은 상태였다. 결과: 1) 환자군과 대조군의 비교 : 강박증 환자군은 대조군에 비해 양측 두정 영역의 대사율이 유의하게 감소되어 있었으며(P<0.01). 대사증가를 보인 영역은 없었다. 강박증의 유병기간이 10년 이상인 만성강박증 환자 4명은 양측 안와전두엽에서 유의한 대사증가 소견을 보였으며(P<0.01), 양측 두정영역에서 유의한 대사감소 소견을 보였다 (P<0.01), 유병기간이 10년 이하인 환자에서는 전체 환자군의 분석에서와 마찬가지로 대조군에 비해 유의한 대사증가 소견을 보인 영역은 없었으며, 양측 두정엽 부위에서 유 의한 대사 감소 소견을 보였다.(P<0.01). 2) 강박증상의 심각도와의 상관관계 분석 : 우측 두정엽의 대사율은 강박장애 척도 점수와 유의한 음의 상관관계를 보였으며(p<0.01), 양측 시상 영역의 대사율은 예일-브라운 강박장애 척도의 강박장애척도 점수와 유의한 양의 상관관계(p<0.01)를 보였다. 결론: 본 연구는 결과는 기존의 연구들에서 보고된 안와전두엽의 대사 증가 소견이 강박증의 만성화로 인해 나타나는 2차적 장애이며, 두정엽의 대사 저하가 보다 1차적인 장애일 가능성을 시사한다. Baxter가 수립한 전두-피질하 회로 이론은 두정엽의 이상을 포함하는 전두-두정엽 복합체 이론으로 확장되어야 할 것이다. Objectives: Functional imaging studies on obsessive-compulsive disorder(OCD) subjects have repeatedly reported increased metabolism in orbitofrontal lobes and caudate nucleus, resulting in the "frontal-subcortical" circuit abnormality theory. Limitations of the previous studies to date include little consideration for the duration of illness, and the use of regions of interest methods, as an image analysis method. Our study objectives are 1) to include the duration of illness as an important study variable, and 2) to use Statistical Parametric Mapping(SPM) method in order to tap relations between the brain function and the psychopathology and symptoms of OCD. Methods: The [18] fluorodeoxyglucose positron emission tomography(FDG-PET) scans of OCD subjects and normal comparison subjects, as diagnosed by the Structured Clinical Interview for DSM-IV(SCID-IV), were analyzed using SPM. Results: 1) Comparison of OCD and control groups : OCD subjects had significantly decreased metabolism in both parietal lobes and didn't have any areas of increased metabolism in comparison to comparison subjects(p.<0.01). four OCD subjects with the illness duration of 10 years or longer, had significantly increased metabolism in both orbitofrontal lobes<p<0.01). OCD subjects whose illness duration is shorter than 10 years didn't have any areas of increased metabolism and had significantly decreased parietal lobe metabolism, as in the analyses of all subjects(p<0.01). 2) Correlation analysis between areas and symptom severity : Metabolism of both thalamic sreas showed significant positive correlation with Yale-Brown Obsessive-Compulsive Scale(Y-BOCS) scores(p<0.01). Metabolism of right parietal area showed significant negative corre lation with Y-BOCS scores(p<0.01). Conclusions: The current findings suggest that the increased metabolism in orbitofrontal lobe, previously rported, may be a secondary phenomenon due to the extended illness dur- ation and that decreased metabolism in the parietal lobes are primary abnormality in OCD subjects. Thus Baxter's fronto-subcortical circuit theory should be extended into "fronto-pari-etal" complex theory, which includes the parietal lobes.

벼 담수산파 재배시 파종량·질소분시·물관리 방법의 차이가 생육 및 수량성에 미치는 영향

권영립,권석주,조승현,최동철 원광대학교 2005 論文集 Vol.35 No.-

This study was carried out to investigate in connection with seeding rate according to the fertilizer application method and water management in direct seeding on flooded paddy surface. The total nitrogen and chlorophyll contents was decreased as increasing amount of seeding. The total nitrogen and chlorophyll contents were high in the strong drainage methods than the custom water management. LAI and dry mater recording where the seeding amount will increase to the fertilizer application method it increases consequently were low tendency from the site which omits the omitted the top dressing at tillering stage. The number of panicles per square metre was increased according to amount of seeding, but the number of spikelets per panicle was decreased. When omitted the top dressing at tillering stage and increasing the amount of seeding, the rice yield was high and amount of seeding was 89 kg per hectare. The results indicate that increasing of seeding rate and omission of fertilizer application with strong drainage at tillering stage was to reduce field lodging degree, to economy of water culture and to save labor for fertilization.

復合材料 連結 部位를 갖는 엔진 마운트 設計에 關한 硏究

최원종,김권진,오인택,임동준,홍영길,황명신 한국항공대학교 1993 論文集 Vol.31 No.-

본 논문에서는 초경량 항공기의 엔진 마운트 구조물에 대한 유한요소 해석을 수행하였으며, 구조의 안전성 확보에 중요한 영향을 주는 부분인 복합재료 동체와 엔진 마운트 간의 연결 부위에 대한 해석을 위해 유한요소 프로그램을 작성하였다. 본 연구에 의해 작성된 유한요소 프로그램의 신뢰성을 확인하기 위해 실제로 시편 제작 실험을 실시하여 실험치와 해석치를 비교 검토하였다. The finite element analysis was performed on the ULM's engine mount to verify the structural safety Result showed that proposed engine mount structure has a large margine of safety. Strains and stresses in the vicinity of the joint between a composite fuselage and a metallic engine mount were calculated by the finite element analysis program. Numerical results from the model were compared with the test results. Good agreement was found between experiment and model results.

3분 및 4분 상완골근위부 골절에서의 외반형 및 내반형에 따른 임상적 비교

최창혁,권굉우,김신근,이상욱,신동규,이승진 대한골절학회 2002 대한골절학회지 Vol.15 No.4

목 적 : 수술적으로 치료한 3분, 4분 상완골 근위부 골절을 외반형과 내반형으로 재분류하여 임상적 결과를 비교하고자 하였다. 대상 및 방법 : Neer 분류상 3분, 4분 상완골근위부 골절로 분류된 21례에 대해 수술적 치료를 시행하고 12개월 이상 추시된 증례를 대상으로, 골절부위의 각형성, 상완골두의 방향성, 그리고 우세 전위결절의 양상에 따라 외반형과 내반형으로 재분류하여 UCLA shoulder rating scale에 따른 기능적 평가를 시행하였다. 결 과 : 단순 방사선 소견을 기준으로 Neer의 3, 4분 상완골 근위부골절을 외반형과 내반형 및 각각의 아형(subtype)으로 분류할 수 있었다. 견관절 반치환술을 시술한 2례를 제외하고 분석한 각 그룹의 UCLA 기능적 평가는 외반형에서 양호 이상의 결과가 9례중 8례(89%), 내반형에서 10례중 4례(40%)로 외반형에서 더 우수한 임상적 경과를 보였다. 결 론 : 상완골 근위부 골절에서 골두의 방향성은 골절의 각형성 및 우세 전위결절의 양상과 높은 상관관계를 가졌으며, 내반형의 경우 혈행과 신경장애가 좀더 빈번하고 예후도 불량한 것으로 나타났고, 이러한 경우 수술시 도달 방법, 연부조직 상태에 대한 평가가 더욱 신중하게 고려되어야 할 것으로 생각되었다. Purpose : We reclassified three-and four-part proximal humerus fracture by Neer's classification into valgus & varus type, and compared the results of these groups. Materials & methods : 21 cases classified as three- and four-part fracture in Neer's classifiation were treated surgically and followed for 12 months. We reclassified the 21 cases vlagus and varus type fractures, according to angulation of fractures, facing of humeral head, and dominant displaced tuberosity. Functional evaluation was done by UCLA shoulder rating scale. Results : Neer's three- and four-part proximal humerus fractures could be reclassified based on angulation, facing of humeral head, and dominant tuberosity displacement. The functional results according to UCLA shoulder rating scale were good or excellent in 8 of 9 cases of valgus type(89%), and at 4 in cases of varus type(40%). The clinical result of the valgus type was better than that of the varus type. Conclusion : Based on reclassification system of proximal humerus fractures, clinical results and radiographic findings including angulation, facing of head and domonant tuberosity displacement showed close relationship. Neurovascular complication were more frequent in the varus type. Therefore, careful evaluation including surgical approach and soft tissue status should be considered in the varus type of complex proximal humerus fracture.

결핵균체 단백항원에 대한 항결핵균 IgG 항체에 관한 연구

최대경,백태현,권지순,심운택,이동배 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

In order to study the level of IgG antibody binding to sonicate antigen of Mycobacteriumn tuberculosis H_34Rv for ammonium sulfate 30∼40 fraction in sera isolated from 209 patients and. 135 controls were measured by plastic tube enzyme-linked immunosorbent assay (ELISA). The levels of IgG antibody binding to Mycobacterium tuberculosis H_37Rv antigen in sera from all patients and controls were measured after absorption of 1 : 400 diluted sera with ,Wycobacteriuez bovis and dMlycobacterium Kansasii for ammonium sulfate 30∼40 fraction. The authors conducted the survey from August 1984 to January 1985. The results obtained were as follows : 1. At the serum dilution of 1:400, the mean ELISA values of IgG antibody to Mycobacterium tuberculosis H_37Rv after absorption with Mycobacterium kansasii antigen from far advanced patients and control were 0.8666±0.4903 and 0.2058±0.1353, respectively. 2. The mean ELISA value of IgG antibody to Mycobacterium tuberculosis H_37Rv afer absorption with Mycobacterium kansasii antigen from moderate patients was 0.6488±0.3918, the ratio of ammonium sulfate fraction 30∼40 in sera from patients and controls was 3.153. 3. The mean ELISA value of IgG antibody to Mycobacterium tuberculosis H_37Rv after absorption with Mycobacterium kansasii antigen from minimal patients was 0.4205±0.3155, the ratio of ammonium sulfate fraction 30∼40 in sera from patients and controls was 2.043.