불화석 용액내 불소농도의 장기변화와 첨가물의 영향에 관한 실험적 연구

유두선,이광희,최윤주,김대업 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

The purpose of this study were to measure the solubility of the stannous fluoride experimentally,to find a method for improving the solubility of the stannous fluoride,and to observe the effect of longterm storage of the variation of the concentration of fluoride in the stannous fluoride solutions.By adding such materials as antiseptics,dye,flavor,and tests to solution,the variation of the fluoride concentration was also observed. Ten groups of 0.4% stannous fluoride solutions to which glycerine,sodium chloride,chlorhexidine,dye,flavor,xylitol,and sorbitol were added were prepared.The measurements were carried out by direct calibration. The obtained results were as follows. 1.Effect of adding glycerine as solvent:This solubility of the stannous fluoride increased in the case of adding glycerine.By increasing the glycerin concentration,the fluoride level in stannous fluoride solution also increased. 2.Effect of adding sodium chloride and chlorhexidine.:Comparing to the case of pure water,low fluoride level was measured in case of adding sodium chlorid and high fluoride level was measured in case of adding chlorhexidine. 3.Effect of adding erythrosin as dye and banna essence as flavor.:Adding erythrosin and banna essence didn't affect fluoride level. 4.Effect of adding xylitol and sorbitol.:The effects of xylitol and sorbitol were nearly the same as the effect of adding erythrosin and banna essence.

미취학 아동의 우유병 우식증 유병률과 세균학적 우식활성도에 관한 연구

이광희,유두선 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.1

The purpose of study was to survey the prevalence of the nursing bottle caries and bacteriologic caries activity in preschool children. Dental caries experience of 690 preschool children in Iri city and Cheonju city was examined. Subjects were grouped by the pattern of their caries experience: Group 1-no caries, Group 2-no caries in the upper arch,Group 3-no caries among the upper incisors, Group 4-dmft in the lower arch ?? dmft in upper arch, Group 5-dmft among the upper posterior teeth > dmft among the upper incisor, Group 6- the rest, Groups 5 and 6 were regarded as the group which had experienced nursing bottle caries. The prevalence of the nursing bottle caries of the present study was 15.6% (4.6% for Group 5 and 11.0% for Group 6). dmft index of Group5 was 9.16 and the highest, and the next was 7.89 of Group 6. The prevalence of the individual tooth in Group 6 was in order as follows: the upper incisors, the lower posterior teeth the upper posterior teeth, the upper cuspids, the lower incisors. The prevalence of the upper central incisors was the highest (89.5-94.7%), and that of the lower central incisor was the lowest (1.3%). The composition of the bacteriological caries activity test medium was 20% sucrose, 2% tryptose, 0.5% sodium chloride, 5% bromcresol green solution, 0.213 units/ml bacitracin. The medium was incubated by the dental plaque and incubated for 72 hours and the PH was measured after 48 hours and 72 hours. Although Groups 5 and 6 showed the high caries activity tendency, there was no significant difference among the group.

신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

신우황청심원액의 심혈관계에 관한 약효연구

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

In order to investigate the pharmacological properties of New Woohwangchungsimwon Liquid (NCL), efects of Woohwangchungsimwon Liquid (CL) and NCL were compared. In isolated rat aorta, NCL and CL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^6M) without regard to intact endothelium or denuded rings of the rat aorta. Furthemore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxation of NCL and CL. NCL and CL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dosedependent manner. In conscious spontaneously hypertensive rats (SHRs), NCL and CL significantly decreased heart rate. NCL and CL, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NCL and CL had no efects on parameters of action potential at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NCL and CL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between two preparations.

염화수소(Hydrogen Chloride)와 관련성이 추정되는 직업성 천식 1례

임현술,유선희,김두희,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

염화수소(hydrogen chloride)는 분자식은 HCl이며 염산가스라고 불리기도 하며 강한 자극성 냄새가 나는 무색의 기체이다. 물에 녹아서 염산이 되며 공기 중에서 물에 녹기 쉬운 성질 때문에 연무 형태로 존재한다. 본 증례로 34세 남자로 타이어에 사용되는 철사를 제조하는 공장에 다니는 근로자로 간헐적으로 고농도의 염화수소에 폭로된 후 1년 8개월의 잠복기를 거친 후 기관지 천식이 발생한 예로 총 호산구수는 증가되어 있었으나 혈청 IgE는 정상 범위였다. 55가지 알레르기항원을 사용한 피부 단자검사에서 House dust, Hay dust, Mixed grain, Dermatophagoides farinae와 Dermatophagoides pterynyssinus에 양성 반응을 보였고, 유발검사에서는 양성 반응을 보였다. 직업성 여부를 파악하기 위해 작업장 내에서 8시간 동안 근무하면서 30분 내지 한시간 간격으로 폐기능검사를 시행한 결과 1초간 노력성 호기량(FEV1) 이 20%이상 감소하여 2시간 동안 지속되는 양성 반응을 관찰할 수 있었다. 본 증례는 외인성 천식 소질이 있으면서 작업장 내에서 고농도의 염산증기에 폭로되어 기관지 천식 발작이 되었는데, 작업장의 고농도의 염화수소가 기관지 천식의 기여요인 또는 악화요인으로 작용하였다고 생각한다. Occupational asthma is an importent occupation-related disease. We exprienced a case of asthma induced by high concentration of hydrogen chloride vapour. The prevalence rate of this asthma is unknown. The patient of the case complained of cough, sputum and dyspnea after exposure to hydrogen chloride. Serum IgE(IgE-PRIST) was normal range but total eosinophil count was elevated. FEV₁ was 73% of predicted value and expiratory wheezing sound was observed on whole lung field. FEV₂was decreased to 48.9% of baseline on 5 hours 30 minutes, respectively, after exposure of hydrogen chloride at workplace. On follow up examination, the patient complained of an intermittent dyspnea and cough.

신원방우황청심원의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

산업장 근로자를 대상으로 실시한 한방 건강검진의 만족도

한현정,정재열,권소희,손용선,장두섭,이기남 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

The examinees who received oriental and western health examination both and submitted questionnaire were 257 workers in workplace for 1 month during health examination for industrial workers. The research was to compare the satisfaction of oriental and western health examination by the questionnaire. The data that were collected by health examination were analyzed into frequencies, ANOVA, T-test with use of SPSS 10.0 program by the research purposes. The results were as follows: 1. Health examination in satisfaction comparison by the general characteristics of subject was significant in oriental health examination for the subjects who had 9-10 working hours(P〈0.05). 2. The workers who had high confidence in result of health examination, affirmative thinking for requirement of health examination, arbitrary decision for receiving the health examination, had high satisfaction in oriental and western health examination both, It was statistically significant difference. 3. For the difference in subjective health condition's recognition, the subject who answered " Healthy" had high satisfaction in western health examination, and it was statistically in western health examination, and it was statistically significant The subject who answered "Healthy" for the early detection of disease had high satisfaction in western health examination, The subject who answered skeptical for the early detection of disease had high satisfaction. in oriental health examination and it was statistically significant. 4. The respondent who said "Yes" for the question, whether you know about oriental health examination or not before receiving oriental health examinatgion had relatively high satisfaction For the question about including of oriental health examination continuously in the coming future, the subject who replied affirmative answer had high satisfaction in average, and it was significant difference(P〈0.05). 5. For the question that will be needed in the item of oriental health examination, the highest item was the requirement of specific oriental health examination for various diseases, followed by the requirement of medical specialist for individual need of medical examination by the item, and the prescription of herbal medicine, the medical examination of cancer, the interview for folk remedies, the parallel treatment for acupuncture cupping, etc, the medical examination for adult disease, the requirement of room for medical examination etc.

튀김에 의한 油脂의 化學的인 變化

徐華中,金和定,丁斗禮,金善姬 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

The changes of the acid value, saponification value, iodine value and peroxide value of fat and oil according to the preservation time and frequency of frying were determined. Soybean oil, corn oil, shortening and shrimp coated with flour batter were used in this experiment. The results were as follows ; The acid value and peroxide value were increased gradually by the preservation time and frequency of frying. The saponification value and iodine value were decreased as the preservation time and frequency of frying passed in soybean oil and corn oil, but increased in shortening. It is suggest that reasonable frying temperature of soybean oil, corn oil and shortening would be 160∼180℃ in home cooking.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.