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Guinea Pig 에 있어 Asorbic Acid 지속성 캅셀제제의 생체이용률에 관한 연구
안형수,박재길,한창훈 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.1
Bioavailability studies in guinea pigs and dissolution tests of sustained release capsules of ascorbic acid were investigated comparing with those of solution. The results were as follows; 1. In the dissolution test, sustained release capsules released 90% of ascorbic acid after 12 hours, and ascorbic acid in the chewable tablet was dissolved. completely within 10 minutes. 2. In the determination of total ascorbic acid concentration in serum, the area under the curve between 0 and 24 hours (AUC 0∼24h) and the maximum serum concentration (C_(max)) did not show any significant difference between solution and sustained release capsule. The time to the maximum concentration (T_(max)) and the time over 50㎍/㎖ cocentration showed significant difference. 3. The time reached to maximum excretion rate (T_(max)) in sustained release capsule was longer than that of solution.
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