만성정신분열증 환자의 그림에 관한 현상학적 고찰 : 반복되는 주제를 중심으로

주명진 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.3

One frequently meets with the stereotypy in drawings during art therapy; the same motif is repeated several times in drawings. The author intended to reveal the characteristics of the stereotypy in this study. The subjects of the study include 12 chronic schizophrenics who revealed the stereotypy in their drawings. Control group include 20 chronic schizophrenics and non-schizophrenics who didn't show the stereotypy. The phenomenological characteristics of drawings of the study groups are as follows: 1. It showed more landscapes and still-lifes composed of plants and inanimate objects than the control groups, drawing. However, it revealed less human figures. 2. In terms of placement of the objects, it revealed more symmetricity than the control groups one. 3. It was composed of more cold colors than the contol groups' one. 4. In the structure of their drawings, it showed more baselines than the control groups' one. The characteristics of the study group compared with the control groups in views of clinical aspects are as follows: 1. Most of them were introvert in their premorbid personality. 2. Their ward activites and involvement to are therapy were passive in general.

Candesartan과 Lercanidipine의 병용투여에 의한 혈압 하강 상승효과

한주희,이정진,김요한,명창선 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

국내 의료종사자에서 HHV-8의 항체양성률에 대한 연구

주우철,최용준,박재은,이혜명,이진수,정문현,김수미,문지혜 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

HHV-8 virus is known to be associated with Kaposi's sarcoma (KS) in HIV seropositive patients and its seroprevalence has geographic difference, In South Korea, incidence of KS is low not only in general population but also in HIV patients compared to other countries, It is speculated that low seroprevalence of HHV-8 has contributed to the low incidence of KS in South Korea. We examined the seroprevalence of anti HHV-8 IgG of HIV seronegative health care workers in one University hospital. Enzyme-linked immunosorbent assay(ELISA) was used for diagnosis. One person (0.6% 1/164) was seropositive, six were equivocal (3.7%,6/164) and 157 people were seronegative (95.73%, 157/164). This study revealed that seroprevalence of HHV-8 in general population was. low in South Korea. Further studies are needed to be carried out to evaluate the low HHV-8 seroprevalence in Korea.

何首烏 및 白首烏엑스가 흰쥐의 實驗的 高脂血症에 미치는 影響

丁明鉉,文永熙,李炳柱,鄭銀津 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

This study was attempted to investigate the effect of Polygoni multiflori Radix and Cynanchi wilfordii Radix extract on the activities of S-GOT, S-GPT and level of total lipid, triglyceride. β-lipoprotein, phospholipid and total cholesterol in the serum of experimentally induced hyperlipermic rats, and on the effect of body, liver and spleen weight in rats. The results were shown as fouow; a) Polygoni multiflori Radix The activity of S-GOT was remarkably decreased, and activity of S-GPT was significantly decreased in all sample group, when compared with the control group(high lipid diet). The level of triglyceride and total cholesterol were remarkably decreased in all sample group, when compared with the control group. The level of total lipid and phospholipid were remarkably decreased on the 7 days after admistration of all sample group. The body weight of the rats decreased and the liver weight increased in control group were shown reduced as normal group on the administration of sample extract. b) Cynanchci wilfordii Radix The activities of S-GOT, S-GPT were remakably decreased in sample 100, 300㎎/㎏, when compared with the control group. The level of triglyceride and total cholesterol were remarkably decreased in sample 100, 300㎎/㎏. The level of phospholipid was significantly decreased in sample 100㎎/㎏. In sample treated group the death rate on the rats were 50 percentage in sample 500㎎/㎏. therefore in administration of sample 300, 500㎎/㎏ were very toxics. The body weight of the rats were remarkably decreased in all sample group, when compared with the normal and control group.

척추 수술시 자가혈액 수혈기를 이용한 자가수혈의 효과

김명호,유문집,유석주,박진영,정홍근,박희곤,문기혁 단국대학교 2000 論文集 Vol.35 No.-

Study Design : Spine fusion with fixation procedure is associated with substantial operative blood loss, which frequently necessitates transfusion. The authors evaluated the safety and efficacy of intraoperative autotransfusion using Cell Saver during spinal surgery. Summary of Literature Review : It has been reported that the contraindications to the use of intraoperative autologous transfusion are malignancy, infection, and gross wound contamination. Objectives : The purpose of this study was to evaluate the safety and efficacy of intraoperative autotransfusion using Cell Saver during spine surgery. Material and Methods : We retrospectively reviewed 62 patients who had operation for lumbosacral spinal stenosis and hypotensive anesthesia. Among them, Group Ⅰwhich received autotrans fusion using Cell Savers included 26 patients with fusion of 2 segments, and Group Ⅱ as control group included 13 patients. Group Ⅲ which received autotransfusion using Cell Savers included 17 patients with function of 3 segments, and Group Ⅳ as control group included 6 patients. We analyzed the amount of intraoperative blood salvage using a Cell Saver, the amount of total homologous transfusion amount, intraoperative blood loss, the amount of postoperative drainage amount and perioperative changes of hemoglobin, hematocrit and platelet count. Results : There was no statistical significance between Cell-Saver group and control group in amount of total homologous transfusion and intraoperative(except in 2 segment of fusion using cell saver: 86.5% increased) & postoperative blood loss(p>0.05). The circulatory balance(amount of intraoperative blood salvage using a Cell Saver plus amount of total homologous transfusion minus amount of total blood loss) was statistical significance between Cell-Saver group and Control group. The Cell-Saver group had positive balance and Control group had negative balance. There were no statistical differance in the evolusion of hemoglobin, hematoocrit and platelet count between Cell-Saver group and Control group(p>0.05). There was no transfusion reaction and thromboembolic disease in all group. Conclusion : In retrospective study, Cell Savers was safe and immediate availability in orthopedic surgery such as spinal surgery. It was effective methods for storing a sufficient volume of blood for spine surgery without affecting the patient's postoperative hemodynamic ststes, too. It was possible to operation without intraoperative homologous blood transfusion in 2 or 3 segment fusion. We may need further study.

精神病院 長期入院 患者의 病的反射

金柱漢,明好鎭 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.3

Ten pathologic reflexes were tested in 464 mental hospital inpatients and 200 normal subjects. The ages of the subjects ranged from 11 through 66 years old. The incidences of pathologic reflexes in the patient group were, 40% in the glabella reflex, 20 in the palmomental, eight in the Hoffmann and six in the snout. Whereas in control group, the glabella reflex was positive in only five %, the palmomental 20, the Hoffmann eight and the snout six. Incidences of the palmomental, snout, glabella, and Hoffmann reflex in control group increased with advancing age. The palmomental and snout reflexes in patients group also showed an increasing pattern with advancing age. The glabellar, palmomental and Hoffmann reflex appeared earlier in the age and more often in the patients group than control group. It appears that some primitive reflexes are normal phenomena in a significant proportion of the healthy population.

생쥐 대장 평활근 세포에서 내향 정류성 칼륨 전류의 특성 연구

이은주,김명,정명섭,조향훈,김기훈,하현철,김준수,최석,전제열 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Objectives: K^(+) channels play an important role in regulating cellular excitability. The aim of this study was to know whether or not inward rectifier K^(+) channel exists in colonic smooth muscle cells. Methods: Mouse colonic smooth muscle cells were isolated using collagenase, and then we recorded their membrane currents using a whole-cell patch clamp technique. Results: With 90 mM K^(+) in bath, hyperpolarization-induced inward currents from -120 mV to 20 mV with 400 ms duration at a holding potential of -10 mV showed rapid activation, inactivation and inward rectification. The inactivation showed single exponential time course. Reduction of external K^(+) to 60 mM decreased the amplitudes of the currents in whole test voltage range and shifted the reversal potential to more negative potential. The inactivation process and peak currents of hyperpolarization-induced inward currents were not affected by removing external Na^(+). External Ba^(+) blocked hyperpolarization-induced inward currents by dose-dependent manner and pure Ba^(+)-sensitive currents showed strong inward rectification. Cs^(+) also suppressed hyper- polarization-induced inward currents. Ba^(+) and Cs^(+)-induced inhibitiOn of hyperpolarization-induced inward currents was voltage-dependent, and the extent of inhibition increasing with membrane hyperpolarization. Conclusions: These results suggest that inward rectifier KU channels may exist in proximal colonic smooth muscle and may play an important role in regulating membrane potential.

피로와 의료이용, 업무상 사고 및 질병결근

장세진,고상백,강동묵,김성아,정진주,이철갑,강명근,현숙정,조정진,차봉석,박종구 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study examined the relationship of fatigue to medical utilization, occupational accident and sickness absence. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002~2004). A total of 30,146 employees categorized within the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were recruited. A structured-questionnaire was used to assess the participants' sociodemo-graphics, job-related factors, health-related behaviors, personality trait, self=perceived fatigue (MFS) and the frequency of medical utilization, occupational accident and sickness absence. Data on medical utilization and occupational accident were confirmed from company health records. Chi-square test and logistic regression analysis were used to elucidate the relationship of self-perceived fatigue to medical utilization, occupational accident and sickness absence. Results: In logistic regression analyses, self-perceived fatigue was associated with medical utilization (outpatient), occupational accident and sickness absence although the strength of the associations was higher in the blue collar workers except for medical utilization. For medical utilization, the white collar worker's adjusted odds ratios of outpatient utilization for workers scoring in the third quartile and the highest quartile, compared to workers scoring in the lowest quartile were 1.50 (95% CI: 1.20-1.87) and 2.16 (95% CI: 1.69-2.75), respectively. The blue collar workers' adjusted odds ratios of outpatient utilization for workers scoring in the second (OR: 1.23, 95% CI: 1.06-1.43), third (OR: 1.42, 95% CI: 1.22-1.66) and highest quartile (OR:1.83, 95% CI: 1.55-2.17), respectively, compared to workers scoring in the lowest quartile were statistically significant. However, no associations were found between fatigue and inpatient utilization for either the white or blue collar workers. The blue collar workers' adjusted odds ratios of being injured for workers scoring in the second, third and highest quartile were 1.41 (95% CI: 1.00-2.00), 1.57 (95% CI: 1.10-2.22) and 2.41 (95% CI: 1.69-3.44), respectively, compared to those scoring in the lowest quartile, but, those of the white collar workers were not significant. There was more likely to an increased risk of sickness absence in workers scoring in the second, third and highest quartile compared to those scoring in the lowest quartile in both white and blue collar workers, but the magnitudes of risk were higher in the blue collar workers than the white collars workers. Conclusion: This result suggests that fatigue is a determinant predictor of medical utilization, occupational accident and sickness absence, and that the pattern of risks for the three outcomes differs according to the occupational type. Some limitations of this study and considerations for future study were also discussed.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.