정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

만성 활동성 간염에 동반된 간소엽의 변화에 대한 조직학적 연구

李重達,朴耀翰,李昌弘 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2

The study of liver biopsy specimens taen from 67 Korean adults with B-viral chronic active hepatitis (CAH) revealed lobular inflammation which was seldom seen in European-American patients. These findings suggested that the morphologic difference may be indicative of the ultimate prognosis and pathogenesis for chronic hepatitis B in Korean. The author reviewed biopsy materials form the 67 patients with CAH and found 24 cases of labourlar inflammation of varying degree (35%). Serum aminotransferases (SGOT/SGPT) and hepatitis B viral markers (HBs Ag, Ab-HBs, Ab-HBc, Hbe Ag, Ab-Hbe) were tested at the time of liver biopsy. In view of pathogenesis of the lobular changes in CAH, correlation between histologic changes, SGOT/SGPT, and hepatitis B viral markers was discussed, and the results led to following conclusions. Lobular changes associated with CAH consisted of ballooning degeneration, acidophilic bodies, and spotty necrosis which were present mainly in the centrilobular zone around the terminal venules. No correlation was noted between the degree of lobular inflammation and piecemeal necrosis. Lobular changes in the severe degree, however, correlated to the corresponding degree of piecemeal necrosis. The severe degree of lobular inflammation corresponded with the value of serum aminotransferases. No correlation was, however, found between the mild degree of lobular changes and serum aminotransferase values. Of 20 CAH cases with lobular changes tested for hepatitis B viral markers, 18 wee positive for HBs Ag and 9 Hbe Ag. These findings were indicative of the high infectivity of the CAH with lobular changes.

Projections of summertime ozone concentration over East Asia under multiple IPCC SRES emission scenarios

Lee, Jae-Bum,Cha, Jun-Seok,Hong, Sung-Chul,Choi, Jin-Young,Myoung, Ji-Su,Park, Rokjin J.,Woo, Jung-Hun,Ho, Changhoi,Han, Jin-Seok,Song, Chang-Keun Elsevier 2015 Atmospheric environment Vol.106 No.-

<P><B>Abstract</B></P> <P>We have developed the Integrated Climate and Air Quality Modeling System (ICAMS) through the one-way nesting of global–regional models to examine the changes in the surface ozone concentrations over East Asia under future climate scenarios. Model simulations have been conducted for the present period of 1996–2005 to evaluate the performance of ICAMS. The simulated surface ozone concentrations reproduced the observed monthly mean concentrations at sites in East Asia with high R<SUP>2</SUP> values (0.4–0.9), indicating a successful simulation to capture both spatial and temporal variability. We then performed several model simulations with the six IPCC SRES scenarios (A2, A1B, A1FI, A1T, B1, and B2) for the next three periods, 2016–2025 (the 2020s), 2046–2055 (the 2050s), and 2091–2100 (the 2090s). The model results show that the projected changes of the annual daily mean maximum eight-hour (DM8H) surface ozone concentrations in summertime for East Asia are in the range of 2–8 ppb, −3 to 8 ppb, and −7 to 9 ppb for the 2020s, the 2050s, and the 2090s, respectively, and are primarily determined based on the emission changes of NO<SUB>x</SUB> and NMVOC. The maximum increases in the annual DM8H surface ozone and high-ozone events occur in the 2020s for all scenarios except for A2, implying that the air quality over East Asia is likely to get worse in the near future period (the 2020s) than in the far future periods (the 2050s and the 2090s). The changes in the future environment based on IPCC SRES scenarios would also influence the change in the occurrences of high-concentrations events more greatly than that of the annual DM8H surface ozone concentrations. Sensitivity simulations show that the emissions increase is the key factor in determining future regional surface ozone concentrations in the case of a developing country, China, whereas a developed country, Japan would be influenced more greatly by effects of the regional climate change than the increase in emissions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Change in ozone level is determined by the combination of NO<SUB>x</SUB> and NMVOC emissions. </LI> <LI> Ozone level over East Asia would get worse in the near future (the 2020s) than far future. </LI> <LI> A high-concentration event generally increases and more frequently occurs in the future. </LI> <LI> Change in ozone air quality in a developing country depends more on emissions change. </LI> <LI> Change in ozone air quality in a developed country depends more on climate change. </LI> </UL> </P>

해도분석을 통한 낙동강 하구 사주 면적의 시ㆍ공간 변화

유창일(CHANG-ILL YOO),윤한삼(HAN-SAM YOON),류청로(CHEONG-RO RYU),이인철(IN-CHEOL LEE) 한국해양공학회 2006 韓國海洋工學會誌 Vol.20 No.6

This study discusses characteristic of spatiotemporal changes of the sand barrier in the Nakdong estuarine for the last century, focusing on geomorphologic evolution and mobility of sand barriers in the view of coastal engineering. The Nakdong estuarine, the research subject, has a complexly changing natural environment by interaction between ground and marine elements such as ocean wave, tidal current, sediment, etc. Moreover, recently, unnatural geomorphologic changes (e.g., seaside reclamation, new harbor construction, etc.) has been radically increased in this area with increasing desire for coastal development. Because of this, its sand barrier has developed quite unstable condition. Therefore, to identify the development process of geomorphologic changes in this area, required is a close examination on historical characteristics of spatiotemporal changes of the sand barrier in relation to surrounding seaside reclamation and physical environmental changes. This study, based on the marine charts published in between 1927 and 1995 year, analyzes the length and area of the sand barrier for the last hundred years, and investigates the cause of the changes by looking into the change of water depth for the last two years and doing ocean-physical site observations. In conclusion, the sand barrier of the Nakdong estuarine expands toward the open sea by 7.4~26 m in annual average, maintaining a fixed distance of 1,241~1.279 m, and its area is expected to increase about 2.8 k㎡ annually. This is characterized by the wocean wave from the open sea and the discharge of Nakdong River.

가강수량의 변화패턴과 기후인자와의 상관성 분석

이다래 ( Darae Lee ),한경수 ( Kyung Soo Han ),권채영 ( Chaeyoung Kwon ),이경상 ( Kyeong Sang Lee ),서민지 ( Minji Seo ),최성원 ( Sungwon Choi ),성노훈 ( Noh Hun Seong ),이창석 ( Chang Suk Lee ) 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.3

수증기는 지구 장파 복사에너지의 주요 흡수인자이다. 따라서 수증기량의 변화를 모니터링하고 변화의 원인을 세밀하게 조사하는 것은 필수적이다. 본 연구에서는 위성관측에 의해 얻어지는 Total Precipitable Water (TPW)자료를 사용하여 가강수량의 변화패턴을 모니터링 하고자 한다. 또한 기후인자들 중 수증기를 통해 생성되어 수증기의 변화패턴을 분석하는데 있어 중요한 역할을 하는 강수량과 다른 기후인 자들에 비해 비교적 주기적으로 나타나는 엘니뇨를 통해 가강수량의 변화패턴과 기후인자와의 상관성분석을 실시하고자 한다. 본 연구에서는 TERRA/AQUA 위성의 Moderate-Resolution Imaging Spectroadiometer (MODIS) 센서를 통해 관측된 TPW의 장기적인 변화와 한반도 중남부지방의 강수량변화를 정량적으로 분석 하고, 이들의 관계를 엘니뇨와 함께 비교하였다. 이를 통해 엘니뇨의 발생이 한반도 중남부지방의 강수량과 TPW의 변화에 영향을 주고 있는 지에 대해 조사하고자 한다. 먼저, 시계열 분석을 통해 TPW와 중남부지방 강수량의 변화를 정량적으로 산출하고 anomaly분석을 통해 이들의 변화를 세밀하게 분석한 결과 서로 반대 의 양상을 띠는 부분이 발견되어 엘니뇨의 anomaly분석결과와 비교하였다. 그 결과 대부분 같은 양상을 띠고 있던 TPW와 강수량이 엘니뇨가 발생한 후 서로 반대의 양상을 띠는 것을 확인하였다. Water vapor is main absorption factor of outgoing longwave radiation. So, it is essential to monitoring the changes in the amount of water vapor and to understanding the causes of such changes. In this study, we monitor temporal variability of Total Precipitable Water (TPW) which observed by satellite. Among climate variables, precipitation play an important part to analyze temporal variability of water vapor because it is produced by water vapor. And El Nino is one of climate variables which appear regularly in comparison with the others. Through them, we analyze relationship between temporal variability of TPW and climate variable. In this study, we analyzed long-term change of TPW from Moderate-Resolution Imaging Spectroadiometer (MODIS) data and change of precipitation in middle area of Korea peninsula quantitatively. After these analysis, we compared relation of TPW and precipitation with El Nino. The aim of study is to research El Nino has an impact on TPW and precipitation change in middle area of Korea peninsula. First of all, we calculated TPW and precipitation from time series analysis quantitatively, and anomaly analysis is performed to analyze their correlation. As a result, TPW and precipitation has correlation mostly but the part had inverse correlation was found. This was compared with El Nino of anomaly results. As a result, TPW and precipitation had inverse correlation after El Nino occurred. It was found that El Nino have a decisive effect on change of TPW and precipitation.

Carotenoids 식이와 알코올이 혈액학적 성분과 간조직에 미치는 영향에 관한 연구

조만희,김연선,이상한,우기민,장예진,김창세 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Alcohol is well known agent which can damage the human tissues such as liver via stimulating lipid peroxidation and storage, denaturation of macromolecules, and inhibiting protein metabolism. On the other hand, carotenoids in addition to vitamins A, C, E and lipoic acid, play important roles in protecting these oxidative damages as well as preventing the production of free radicals. This study was carried out to elucidate the precise effects of alcohol administration into rats on the antioxidative functions of dietary carotenoids and isolated β-carotene, and to find out any parameters to uncover more detailed biochemical mechanisms of these agents. For these purposes, two different approaches were performed: 1) examination of the changes in hematological parameters (e.g., total proteins, A/G ratio, ALT/AST et. al) and statistical correlations among inter- and intragroups, 2) examination of the histopathological changes by an electron microscope. The results were analyzed and summarized as following; (1) Carrot diet for one week caused a slight increase in albumin. A/G ratio and AST levels, and a slight decrease in ALT, ALP, BUN and uric acid levels. Two-week alcohol administration following carrot diet increased total proteins, albumin A/G ratio and BUN levels. However, both groups were shown to have little significant changes in cholesterol concentrations. (2) Cheese diet for one week caused a significant increase in total proteins, albumin, AST, ALP, uric acid and total cholesterol levels, and a significant decrease in A/G ratio and glucose concentrations. However, two-week β-carotene diet following cheese intake increased total proteins albumin, A/G ratio, BUN and total cholesterol levels, whereas AST, ALT, ALP and uric acid levels were decreased. (3) Alcohol administration for one week caused an increase in AST activities and a decrease in total proteins, albumin, ALT, ALP and BUN levels. A successive β-carotene diet following alcohol administration increased total proteins, albumin, ALT, ALP and BUN levels, whereas decreased AST and uric acid levels. However, there were not significant changes in A/G ratio, glucose and total cholesterol levels in both groups. (4) β-carotene diet for one week caused a slight increase in albumin, glucose, AST and uric acid levels, and a slight decrease in ALP and BUN levels. Two-weeks alcohol administration following β-carotene diet increased albumin, glucose, BUN and total cholesterol levels, whereas decreased AST, ALT, ALP and uric acid levels. (5) Although the pathological investigation on the liver did not reveal significant changes, cheese diet group (CH-BC/1-CH) was shown to have some lipid deposits. Some results were unexpected and different from typical hematological changes shown by other researchers. Nonetheless, these results strongly suggest that the liver damage or hepatism caused by alcohol intake affects many kinds of biochemical metabolisms, which results in significant changes in many hematological parameters. In addition, dietary carotenoid and isolated β-carotene were shown to have protective roles against the biochemical changes by alcohol intake.

Estimating the production and mortality of fine roots using minirhizotrons in a Pinus densiflora forest in Gwangneung, Korea

Han, S. H.,Yun, S.,Lee, J.,Kim, S.,Chang, H.,Son, Y. Springer Science + Business Media 2016 Journal of forestry research Vol.27 No.5

<P>The aim of this study was to estimate fine root production (FP) and fine root mortality (FM) at 0-10, 10-20, and 20-30 cm soil depths using minirhizotrons in a 75-year-old Pinus densiflora Sieb. et Zucc. forest located in Gwangneung, Korea. We developed the conversion factors (frame cm(-2)) of three soil depths (0.158 for 0-10 cm, 0.120 for 10-20 cm, and 0.131 for 20-30 cm) based on soil coring and minirhizotron data. FP and FM were estimated using conversion factors from March 26, 2013 to March 2, 2014. The annual FP and FM values at the 0-30 cm soil depth were 3200.2 and 2271.5 kg ha(-1) yr(-1), respectively. The FP estimate accounted for approximately 17 % of the total net primary production at the study site. FP was highest in summer (July 31-September 26), and FM was highest in autumn (September 27-November 29). FP was positively correlated with seasonal change in soil temperature, while FM was not related to that change. The seasonality of FP and FM might be linked to above-ground photosynthetic activity. Both FP and FM at the 0-10 cm depth were significantly higher than at 10-20 and 20-30 cm depths, and this resulted from the decrease in nutrient availability with increasing soil depth. The minirhizotron approach and conversion factors developed in this study will enable fast and accurate estimation of the fine root dynamics in P. densiflora forest ecosystems.</P>

안전상비의약품 판매 이후 중독환자 특성 변화

김창영,이의중,이성우,김수진,한갑수,Kim, Chang Yeong,Lee, Eui Jung,Lee, Sung Woo,Kim, Su Jin,Han, Kap Su 대한임상독성학회 2018 대한임상독성학회지 Vol.16 No.1

Purpose: On November 15, 2012, sales of OTC (Over-The-Counter) drugs began at convenience stores, which changed the accessibility of some drugs. As a result, the exposure and access patterns of these drugs could have changed. In this study, we reviewed the changes in the characteristics of drug poisoning patients because of the reposition of nonprescription drugs according to the revised Pharmaceutical Affairs Act. Methods: A retrospective study was conducted to evaluate changes in characteristics of drug poisoning patients between 2008 and 2016. A registry was developed by an emergency medical center in a local tertiary teaching hospital, and patients who visited the center were enrolled in this registry. We compared two periods, from 2008 to 2012 (Pre OTC) and from 2013 to 2016 (Post OTC), for type of intoxicant, time from poisoning to visiting the emergency center, intention, psychiatric history, previous suicidal attempt, alcohol status, and emergency room outcomes. The primary outcome was the number of patients who took acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Secondary outcomes were ICU admission rate, mortality rate, and number of patients who visited the ER when the pharmacy was closed after taking acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Results: Among 1,564 patients, 945 and 619 patients visited the emergency room during pre and post OTC periods. The number of patients with acetaminophen and NSAIDs poisoning decreased from 9.2% to 6.1% (p=0.016). The ICU admission rate and mortality rate in the emergency room did not show significant results in the relevant patient groups, and so was the number of patients visiting ER when the pharmacy was closed taking acetaminophen and NSAIDs. Conclusion: Despite the sales of nonprescription drugs at convenience stores, the number of acetaminophen and NSAIDs poisoning patients decreased.

담배 박각시나방 Manduca sexta의 계획된 세포죽음동안의 Proteasome의 변화

이구봉,우기민,조만희,이상한,장예진,김창세 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

모든 진핵세포의 주요 단백질 분해요소인 proteasome은 변성되거나 상해된 불필요한 단백질을 제거할 뿐만 아니라, 세포주기를 비롯한 다양한 대사과정들의 주요 효소들을 필요 시 적절히 분해함으로써 항상성을 유지시키는 필수적인 효소로 잘 알려져 있다. 또한 proteasome은 특정 포유동물 조직의 계획된 세포죽음(programmed cell death 또는 apoptosis)와 밀접하게 관련되어 있다고 보고된 바, 본 연구에서는 담배 박각시나방(Manduca sexta)의 변태과정에서 일어나는 마디간 근육(intersegmental muscle)의 급격한 파괴과정동안의 proteasome의 변화양상을 발현 및 단백질 분해활성을 중점으로 조사하였다. 정상근육과 파괴직전의 근육으로부터 proteasome을 분석한 결과 단백질 분해활성이 최소한 6배 이상 증가하였으며, proteasome의 주요 구성성분들의 발현 변화를 각각의 항체(antibody)를 이용하여 조사한 결과 세포죽음 직전에 급격히 증가함을 보였다. 이러한 구성성분들의 발현증가가 proteasome 복합체 형성을 통해 활성의 증가를 일으키는지 조사한 결과, 세포내에서 실질적으로 단백질 분해활성을 담당한다고 여겨지는 26S proteasome(2,000 kDa)의 위치에서 커다란 활성의 변화와 구성성분의 증가를 볼 수 있었다. 따라서, 담배 박각시나방의 계획된 세포죽음 현상은 특정 호르몬의 신호에 의해 proteasome의 발현이 급격히 증가하여 26S proteasome의 복합체 형태로 세포 내 대부분의 단백질들을 분해함으로써 30시간이내 근육조직을 완전히 소멸시키는 것을 알 수 있었다. 한편, proteasome을 구성하는 특정 구성성분의 과다 발현이 세포의 단백질 분해현상에 어떠한 영향을 미치는 지 조사하기 위하여 쥐의 fibroblast cell에 26S proteasome의 ATPase 구성성분인 m56 유전자를 삽입한 후 세포의 추출물로부터 proteasome의 양과 활성의 변화를 관찰하였다. Proteasome을 초원심분리로 추출하여 관찰한 결과, 담배 박각시나방의 경우와는 달리 유전자 삽입 세포는 모든 실험에서 정상 세포와 전혀 차이를 보이지 않았다. 이 결과로부터 세포의 생명 유지에 필수적이고 매우 다양한 기능을 가진 proteasome은 40여개의 구성성분들의 발현이 매우 정교하게 조절되고 있으며, 특정 세포죽음 자극(apoptotic signal)이 왔을 때 일련의 구성 성분들의 발현과 26S proteasome 복합체 형성이 증가함으로써 그 기능을 수행하는 것을 알 수 있으며, 보다 자세한 연구는 비정상적 단백질 분해나 세포죽음을 동반하는 여러 질환들의 원인과 현상을 규명할 수 있으며, 또한 그 활성을 조절함으로써 궁극적인 치료의 방향도 제시 가능할 것으로 기대된다.

Surface albedo from the geostationary Communication, Ocean and Meteorological Satellite (COMS)/Meteorological Imager (MI) observation system

Lee, Chang Suk,Han, Kyung-Soo,Yeom, Jong-Min,Lee, Kyeong-sang,Seo, Minji,Hong, Jinkyu,Hong, Je-Woo,Lee, Keunmin,Shin, Jinho,Shin, In-Chul,Chun, Junghwa,Roujean, Jean-Louis Informa UK (TaylorFrancis) 2018 GISCIENCE AND REMOTE SENSING Vol.55 No.1

<P>The surface albedo is an essential climate variable that is considered in many applications used for predicting climate and understanding the mechanisms of climate change. In this study, surface albedo was estimated using a bidirectional reflectance distribution function model based on Communication, Ocean and Meteorological Satellite/Meteorological Imager data. Geostationary orbiting satellite data are suitable for a level 2 product like albedo, which requires a synthetic process to estimate. The authors modified established methods to consider the geometry of the solar-surface-sensor of COMS/MI. Of note, the viewing zenith angle term was removed from the kernel integration used for estimating spectral albedo. Finally, the spectral (narrow) albedo was converted into the broadband albedo with shortwave length (approximately 0.3-2.5 m). This study determined conversion coefficients using only one spectral albedo of visible channel. The estimated albedo had a relatively high correlation with Satellite Pour l'Observation de la Terre/Vegetation and low unweighted error values specific for land types or times. The validation results show that estimated albedo has a root mean square error of 0.0134 at Jeju flux site that indicates accuracy similar to that of other satellite-based products.</P>