정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

21個 非對稱中心點群의 等價逆格子點

徐日煥,秋錦洪,李珍昊,朴晶蘭,郭相姬,金文執,李正秀,申容賢 충남대학교 자연과학연구소 1994 忠南科學硏究誌 Vol.21 No.2

32개 點群은 中心對稱(centrosymmetric)을 갖는 11가지 點群(Laue群)과 21個의 非對稱中心(noncentrosymmetric)點群으로 이루어졌다. 本 硏究에서는 21個 非對稱中心點群 各各의 等價回折面(等價逆格子點)들을 誘導하였다. The thirty two point groups consist of eleven Laue groups (centrosymmetric point groups) and twenty one noncentrosymmteric point groups. In this paper, the reciprocal lattice points equivalent under the operations of 21 noncentrosymmetric point groups are derived.

영어 등위접속 요소 간의 시간해석

서천수,김진석 釜山大學校 師範大學 1996 교사교육연구 Vol.33 No.-

The purpose of this paper is to analyse a variety of temporal interpretations amomg coordinating conjunts in terms of the event progression system. The system is composed of the event progression interpretation rule and the event progression structure. The temporal interpretation among conjuncts is determined by the rule which definite time adverbials, the orderliness principle, the event progression interpretation, and the contextual information are considered. Formal logic proposed the truth-functional method to interpret the systematic ambiguity in a co-ordinating conjunction. According to this anaysis, 'P & Q' and 'Q & P' are logically equivalent. Grice(1975) argues that the temporal, additional, purpose and causative interpretations of co-ordinate constructions in English must be analysed as implications conveyed by conformity to the maxim 'Be orderly'. Carsten(1988) claims that these pragmatic effects of coordination are the outcome of an interaction between pragmatic principles and general properties of the mind, rather than the meaning of 'and'. Blakemore(1987) argues that co-ordinate utterances are not processed in exactly the same way as independent utterances. However, the temporal order in which conjuncts are stated may have significant syntactic, semantic, and pragmatic effects. Thus, a co-ordinating conjunction needs to be interpreted as the temporal interpretation rule of coordinate constructions including liguistic knowledge and world knowledge.

Four-circle Diffractometer를 이용한 결정방위행렬과 단위포상수 결정

서일환,이진호,심해섭,이정수,성백석,이창희,김문집 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2

A theoretical process to determine the unit cell parameters a, b, c, , β, γ of single crystals and then to collect intensities of ?? using four-circle diffractometer has been shown.

초등영어에서의 문장간 시간 관련성 지도방안

서천수,김진석 釜山大學校 師範大學 1999 교사교육연구 Vol.38 No.-

The purpose of this study is to review the previous study of theoretical frames on temporal relationships among sentences, to present the ways to distinguish temporal relationships among sentences, and to apply them to classroom activities. To achieve this goal, the criterion for deciding temporal relationship among sentences is reviewed, and teaching methods appropriate to temporal relationships among sentences in classroom activities are considered in this paper. After describing the problem of deciding the temporal relationships, this study shows the theoretical necessity of 'order of mention' principle, tense, temporal adverbs, and world knowledge in deciding temporal relationships among sentences. Furthermore, it is argued that causal relations and explanation relations among sentences have important roles in deciding temporal relationships among sentences. For example, given a sequence of the first unembedded sentence(S1) and the second unembedded sentence(S2), the temporal relationship among sentences is as follows: (a) when S1 is the result of S2, S2 is posterior to S1, (b) when S2 is the explanation of S2, S2 is anterior to Sl. In addition, it is argued that the theoretical study on temporal relationship among sentences is applied to classroom activities. For example, teaching methods such as jigsaw game, team teaching, total physical response, and mind mapping need to be considered.

三斜晶系와 單斜晶系의 空間群에 對한 論解

徐日煥,李正秀,李珍昊,秋錦洪,成百石,林星秀,柳保盈 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.2

三斜晶系에는 2個의 空間群이 있고 單斜晶系에는 13個의 空間群이 있다. 本 論解에서는 이 空間群들을 誘導한후 各 空間群에 屬한 一般位置, 原點移動, 特殊座標 및 反射條件들을 說明 하였다. There are two and thirteen space groups in triclinic and monoclinic systems respectively. After derivation of the space groups, the general coordinates, the special coordinates and the reflection conditions of each space group have been discussed and change of origin of certain space groups is also shown.

Reciprocal Lattice Explorer의 原理와 使用法

徐日煥,李珍昊,秋錦洪,林星秀,柳保盈,朴晶蘭,金文執,趙素羅,金憲俊,李正秀,成百石 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.2

Reciprocal lattice explorer는 de Jong-Bouman camera와 Buerger precession camera를 合친것이다. 이 explorer를 使用하면 goniometer에 한번 固定한 試料를 使用하여 그 試料의 空間群을 決定하는데 必要한 모든 寫眞을 撮影할 수 있으며 그들은 찌그러지지 않은 逆格子面의 寫眞들이다. 本 論文에서는 de Jong-Bouman 과 Buerger precession 寫眞術의 原理와 使用法을 記述 하였고 또한 de Jong-Bouman의 振動寫眞과 zeroth layer 寫眞으로부터 11個 Laue群의 識別方法도 提示하였다. The reciprocal lattice explorer is an instrument which incorporates the principles of both the Buerger precession and the de Jong-Bouman methods. On the explorer all photographs which are necessary for a space group determination can be taken with a single setting of a crystal and the photographs show undistorted pictures of the reciprocal lattice planes. In this paper, the principles and the usages of the de Jong-Bouman and the Buerger precession photography are described, and a method of 11 Laue group identification using the de Jong-Bouman oscillation and zeroth layer photographs is shown.

고관절 전 치환 성형술 후 탈구에 관한 치험 및 연구

서유성,김동진,박종석,임수재,나수균,최창욱 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Dislocation is one of the serious complications in total hip replacement arthroplasties. The purpose of this study is to evaluate the risk factors of dislocation, including age, sex, preoperative diagnosis and bilaterality, history of previous hip surgery, positioning of component, soft tissue tension, treatment after dislocation or redislocation. Authors reviewed 190 patients of total hip replacement arthroplasty, which were performed from Jan. 1990 to Dec. 1996. 15 cases developed dislocation after surgery. Incidence of dislocation was 7.89%(15 of 190 cases). Dislocation after revision was not happened(0 of 18 cases). Inclination of acetabular cup was average 37.5° (range: 31° - 43° ). Average anteversion of the acetabular component was 18.1" by Woo and Morrey method, 11.4° by Hassan method. They were normal range except 3 cases. Dislocation was not prevented even though inclination and anteversion of acetabular cup were within normal range. Soft tissue tension is determined by change of limb and femoral neck length. Average limb length difference was -0.2mm(range; -l0mm - +10mm) and average offset difference was +1.7mm(range;-4mm - +18mm). Revision must be accomplished as soon as possible when limb shortening happen by upward migration of the acetabular component. In conclusion, anteversion of acetabular cup may be most important factor in our cases, so cup position must be fixed in proper position during operation.

ASYMUNT: 21개 Noncentric 점군이 갖는 X선 데이터의 asymmetric Units

서일환,박정란,박영수,이진호,이창희,김문집 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.2

결정학적 가설 ??은 anomalous dispersion을 나타내는 원자를 갖고있는 비대칭 결정에 대해서는 성립하지 않는다. 만약 이들의 결정구조가 Lane group 보다는 오히려 noncentric point group의 X선 강도 데이터의 asymmetric unit로부터 정해질 수 있다면, 그 구조는 강도 데이터가 2배로 증가하기 때문에 보다 신뢰성이 증가한다. 본 논문에서는, 21개 noncentric point group 각각에 들어가는 강도 데이터의 asymmetric unit 의 정확한 범위를 계산하는 프로그램을 제안하였다.

비만도에 따른 최대지방연소를 위한 운동강도 설정에 관한 연구

서상진,박수연,박철빈 경희대학교 체육과학연구소 1999 體育學論文集 Vol.27 No.-

In order to provide the basic data required for an effective physical exercise program to get rid of obesity, women in their 20s to 50s who had never participated in a regular physical exercise were classified into GroupI, GroupII, and GroupIII consisting of 10 persons each with 25 to 30%,34 to 35%, and over 36% of body fat rate respectively, and then they were checked up with their maximum physical exercise intensity by using RAMP II protocol to analyze relations of physiological causes of change at the time of the maximum fat oxidation intensity for the three groups with the result of analysis as follows, 1.Maximum fat oxidation and fat -free weight(r=.396, p〈.03), oxygen uptake(r=.569, p〈.001) and ruts piratory exchange rate(r=.673, p〈.000) have notable co-relations one another. 2.At the time of the maximum fat oxidation intensity, oxygen uptake, heart rate, respiratory exchange rate, fat oxidation, and energy consumption among the 3 group have shown no notable statistical difference one another. 3.At the time of the maximum fat oxidation intensity, percentage in the maximum oxygen uptake value(% VO2max) shows a notable difference among the three groups. A post verification shows GroupIII has a notable difference from GroupI or GroupII(p〈.05) while there is no notable difference between GroupII and GroupI. In conclusion at the time of the maximum fat oxidation intensity, GroupIII(body fat rate of over 36%) shows a notably high relative intensity. Accordingly people of high body fat rate need the tensity of 60% VO2max in aerobic exercise to reduce their fat.