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Seong Hoon Kim,Ji Hoon Kim,Jae Hoon Lee,Dong‑Woo Suh,Jae Sang Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9
Prediction of retained austenite fraction is quite important in designing advanced high strength steels since retained austeniteis the source of transformation-induced plasticity. The present study investigates the phase constitution of a medium-carbonQ&P steel by comparing various approaches to the transformation stasis of bainitic ferrite and applying them to the partitioningprocess. Among them, the modified GEB approach gave the best agreement with the experimental observation, includingthe effects of heat-treatment condition and chemical composition on phase constitution. This indicates phase transformationduring partitioning can be effectively described by the physics of Gibbs energy balance approach.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
國內飼育 犬에 있어서 心臟絲狀蟲의 感染率에 관한 調査 硏究
Ji Hee Seong(成知禧),Hwa Joong Yoon(尹和重),Won Chang Lee(李元暢),Kwang Ho Kim(金光浩),Seung Won Kang(姜承遠) 한국예방수의학회 1996 예방수의학회지 Vol.20 No.2
The purpose of this study was carried out an epidemiological survey on the prevalence rate of the canine heartworms in Seoul City and the districts of Pa-Ju, Seong-Nam and Po-Chon in Kyonggi province of Korea from September 1994 to the end of September 1995. The blood samples from 292 male and 193 female dogs (pet, 363 ; fighting dogs, 60 ; working dogs, 62) were examined for the adult heartworms cuticle antibodies using the enzyme-linked immunosorbent assay (ELSA) kits. The test was designed to detect the antibodies of the host against the specific cuticle antigens produced with the adult heartworms.
난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
김지태,한명애,곽현,배성렬 漢陽大學校 工學技術硏究所 2000 工學技術論文集 Vol.9 No.1
이취미물질중에서 페놀, Geosmin, 2-MIB를 선정하여 응집제(PACS)와 흡착제(PAC) 및 산화제(Cl2, ClO2)로 처리하였을 때 제거율을 알아보았다. 페놀의 경우 이산화염소(ClO2)와 분말활성탄(PAC)으로 처리하였을 때 제거효율이 높았고, Geosmin과 2-MIB는 분말활성탄(PAC)으로 처리하였을 때 제거효율이 높았다. 그러나 페놀, Geosmin, 2-MIB 모두 응집제(PACS), 염소(Cl2)로 처리하였을 경우에는 제거효율이 거의 없음을 알 수 있었다. The removal ratio of phenol, geosmin, and 2-MIB selected in odor and taste causing materials was investigated, when water was treated with coagulant(PACS), adsorbent(PAC), and oxidants(Cl2, ClO2). Phenol was removed at a relatively higher rate by the treatment with CIO2 and PAC(Powder Activated Carbon). The other side, geosmin and 2-MIB were removed at a higher rate by the treatment with PAC. But it was found that the treatment with coagulant(PACS) and chlorine(Cl2) for the removal of phenol, geosmin and 2-MIB was little removal efficiency.
액시드 캅셀(니자티딘 150 mg)에 대한 넥스 캅셀의 생물학적 동등성
김지만,이상봉,전성실,신영희 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
The purpose of the present study was to evaluate the bioequivalence of two nizatidine capsules, Axid (Lilly Korea Pharm. Co., Ltd.) and Nex (Bi-nex Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The nizatidine release from the two nizatidine capsules in vitro was tested using KP Apparatus method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). The dissolution profiles of two nizatidine capsules were very similar at all dissolution media. Twenty four normal male volunters were divided into two groups with a randomized 22 cross-over study. After two capsules (300 ㎎ nizatidine) were orally administrated, blood as taken and the concentrations of nizatidine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as AUC_(t), C_(max) T_(max) were determined. The result showed that the differences in AUC_(t), C_(max) and T_(max) between two nizatidine capsules absed on the Axid were-6.16%, -8.26% and -1.82%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.91) ∼log(0.97) and log(0.85)∼log(0.99) for AUC_(t) and C_(max), respectively), indicating that Nex capsule is bioequivalent to Axid capsule.
소방대원들의 실내, 실외 근무 형태에 따른 유산소 운동능력 및 등속성 근력
김남익,장지훈,성기홍,윤성 한국유산소운동과학회 2002 대한스포츠융합학회지 (jcses) Vol.6 No.1
The purpose of study was to investigate the influence of cardiopulmonary function and isokinetic knee joint muscle strength on duty form in the fm fighters. 28men who aged 30-40 years were measured by resting pulmonary function test, exercise stress test(Q4500, Quinton, Co.) and isokinetic knee joint muscle strength testing(Cybex 6000 dynamometer system). Subjects were divided into the 2 groups that were indoor duty group and outdoor duty group. Statistical analysis was performed using analysis of variance t-test. Major findings and conclusion are as follows: In body fat test, outdoor duty groups was showed lower than that of indoor duty group. For the lung function test at rest, lung volume, vital capacity, MVV, FEVO.5-1.0, expiratory and inspiratory flow rate were checked. In results, outdoor duty group was showed higher than that of indoor duty group. During exercise stress test, heart rate, ventilation, and oxygen uptake, were checked by automatic gas analyzer. In results, outdoor duty group was showed higher than that of indoor duty group. In isokmetic knee joint muscle strength, peak torque and average power of indoor duty group was showed significantly lower than that of outdoor duty group. At Comparison of right and left knee joint, isokinetic strength, isokinetic power and isokimtic endurance of right knee joint was showed significantly higher then that of left knee joint, but in 60 degree per second, left knee joint was showed higher then that of right knee joint. Result from this investigation show greater personal training and fire quell a not, emergency rescue activity was increased knee joint muscle strength. Therefore, physical fitness and health maintenance programs for fire fighters have been developed, implemented and proven to reduce morbidity and mortality and financial expenditures.
Pseudomonas putida SM 25의 Catechol 1,2-Dioxygenase의 부분정제와 이에 의한 cis,cis-Muconic Acid의 생성
김지연,김성태,강사욱,민경희 숙명여자대학교 환경과학연구소 1995 환경과학 Vol.2 No.-
Pseudomonas putida SM 25 로부터 catechol 1,2-dioxygenase를 ammonium sulfate precipitation, DEAE-sepharose A-50 CL-6B ion exchange chromatography, phenyl-sepharose CL-4B hydro-phobic chromatography 및 preparative gel permeation chromatography를 통해 정제배율 806.2배, 정제수율 10.6%로 부분정제하였다. Phenol, benzoate, catechol 및 salicylate가 효소를 유도하였으며, 그 중 5mM phenol이 가장 좋은 결과를 나타내었다. 이 효소는 catechol에 대해서는 우수한 효소 활성을 보였으나, 4-methylcatechol, pyrogallol 및 protocatechuate에 대해서는 거의 활성을 보이지 않았으며, catechol에 대한 Km 값은 7.8 M 이었다. 이 효소는 pH 7.5, 40℃에서 가장 높은 활성을 보였다. 이 효소는 pH 7.0∼11.0에서 안정하였으며, 열에 불안정하여 50℃에서 15분 내에 활성을 완전히 잃었고, thiol기 저해제에 의한 영향을 받지 않았다. 이 효소에 의한 catechol의 반응산물을 UV-visible spectroscopy, HPLC-diode array spectroscopy, GC-mass spectrometry로 분석한 결과 cis,cis-muconic acid로 확인되었다.