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      • KCI등재

        정신분열병에 대한 리스페리돈의 효과 및 안정성

        이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

        연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

      • 鋼 熔着金屬의 熱變形脆化에 關한 硏究

        鄭世喜,金台永,林載奎,鄭熙敦,朴昌彦 全北大學校 1984 論文集 Vol.26 No.-

        The susceptibility of weld metal(AWS, F76-EH14) on hot straining embrittlement has been examined. The sharp notch was machined on the weld metal of 1st bead and on coarse-grained HAZ transformed by next pass. After machining the notch, these specimens were bended at 250℃ to receive the hot straining embrittlement and they were done COD fracture toughness test by the three point bending, and then the change of plastic zone at notch tip was evaluated by microhardness test. The obtained results are summarized as follows. 1. Fracture toughness of weld metal was greater than that of base metal. 2. Fracture toughness of the coarse-grained HAZ was similar to that of weld metal. 3. Hardness of weld metal reheated by next pass was lower than that of weld metal owing to the effect of heat treatment. 4. Plastic deformation of the coarse-grained HAZ was less than that of weld metal.

      • 신경망을 이용한 비집중 제어방법의 비교

        정희태 부산 외국어 대학교 2001 外大論叢 Vol.22 No.1

        In this paper, we analysis the control performance and structure of neural network controlled interconnected system.The comparison is accomplished by three method.One is the decentalized neural network system composed of two neural networks for modelling and control of each subsystems with local identification and control goals and an interaction neural network.Another method is the combination of linear controllers and a coordinator neural network.The other method is the gloval modelling and controlling system.We got the best result on control structure in the second method, and good performance by the first and second method.

      • 간접 인식신경회로망을 이용한 비선형 시스템의 적응제어

        정희태 정보과학연구소부산외국어대학교 1999 情報科學論集 Vol.1 No.-

        A new adaptive control structure is proposed for a nonlinear system using indirect identification neural network. A neural network is used to identify the feedforward nonlinearity of nonlinear system and construct a feedback controller for a unknown nonlinear system through indirect dynamic system identification. A reference model, which is introduced to incoporate a prior knowledge of controlled system, generates the teaching signal to indirect identification neural network and offers the dynamic linear control strategy. The tracking performance and adaptivility are demonstrated by simulation studies.

      • KCI등재

        경쟁결과와 성별이 원인지각에 미치는 영향

        정청희,권태엽 한국스포츠심리학회 1992 한국스포츠심리학회지 Vol.3 No.1

        본 연구의 목적은 경쟁결과와 성별이 원인지각에 미치는 영향을 검증하는 것이다. 연구를 위한 검사도구는 McAuley등이 1989년에 개발한 원인차원척도 질문지를 우리 설정에 맞게 번안한 후 타당성과 신뢰도를 검증하여 사용하였다. 연구 대상은 중학교 3학년에 재학중인 남자 28명과, 여자 20명으로 총 48명이다. 피험자들은 체육수업의 마지막 단계에서 체육교사에 의하여 배드민턴 기능 평가를 받았으며 성적편차 4점을 기준으로 능력별 대진표를 작성하였다. 작성된 대진표에 따라 피험자들은 서울대학교 체육관에서 배드민턴 경기를 하였고, 경기가 끝나는 즉시 승자와 패자로 분류하여 질문지에 반응하도록 하였다. 자료분석은 이원변량 분석의 통게기법으로 하였다. 연구결과는 다음과 같다. 첫째, 경쟁결과에 따라 내재성, 안정성, 외적 통제가능성, 내적 통제가능성의 원인지각 차원에 유의한 차이가 있었다. 즉, 승자는 패자에 비하여 자신의 결과를 내적이고 안정적인 것으로 원인지각 하였다. 그리고 외적 통제가능하고 내적 통제가능한 것으로 원인지각 하였다. 둘째, 성별에 따라 외적 통제가능성, 내적 통제가능성의 원인지각 차원에 유의한 차이가 있었다. 즉, 남자는 여자에 비하여 자신의 결과를 외적 통제불가능하고, 내적 통제가능한 것으로 원인지각 하였다. 셋째, 경쟁결과와 성별에 따라 외적 통제가능성의 원인지각 차원에서 상호작용 효과가 유의한 것으로 나타났다. The purpose of this study was designed to apply the causal dimension scale Ⅱ in a competitive sport setting and to examine differences competitive outcome and sex upon their causal attributions about performance. The subject of this study were 48 male and female in the middle school student. Of particular, interest are the causal attributions made by participants tested badminton in physical education class. With meet Director is permission, the investigator briefly explained the study to all the players at the beginning of the game, stating that the study concerned subject's causal perception of their competitive outcome. Upon completion of the game, subjects were asked to assess their competitive outcome in terms of the causal dimensions of internality, stability, external controllability and internal controllability using the CDS Ⅱ. Two-way analysis of variance were conducted to determine whether the differences in causal attribution existed between 1) winners and losers, 2) male and female. The results obtained from this study were as follows 1. Winners made more internal, stable, external controllable and internal controllable causal attributions than losers on their competitive outcome. 2. Male and female did not differ in the internality, stability of their causal dimensions. Male made more external uncontrollable, internal controllable causal attributions than female on their competitive outcome.

      • 킬레이트 수지에 의한 금속이온 흡착에 관한 연구

        정순량,양희태,오해범 又石大學校 1981 論文集 Vol.3 No.-

        The selective adsorption of metal ions by chelating agent-treated resin was studied in aqueous media. The resin was prepared by the treated conventional anion exchange resin, Dowex 1-X8(48 to 80 mesh) with chelating agent containing sulfonic groups such as 1, 2 -dihydroxy benzene- 3, 5 disulfonate(Tiron). The stability of the resin was markedly influenced by the pH of the media. The optimum conditions for the adsorption of metal ions were determined with respect to the pH, shaking time and mixture solution of metal ions. Under the optimum condition the other of the adsorption of metal ions is as follows: Fe(Ⅲ), Cu(Ⅱ), Ca(Ⅱ), Mg(Ⅱ), Ni(Ⅱ), and Zn(Ⅱ) are little. The total capacities of the resins in Fe(Ⅲ) were found 37. 98㎎/gr in the condition of pH 3 and in Cu 6.86㎎/gr in the condition of pH 3.5.

      • 비집중 제어신경망에 의한 보일러 터빈 시스템 제어

        정희태,문영득 釜山 外國語 大學校 1999 外大論叢 Vol.19 No.4

        This paper investigates the decentralized control of Neural Networks and application to a boiler turbine control system. Since the neural networks can learn the dynamical system, we use the neural networks for modeling and control of global system which consists of the decentralized control neural networks. The decentralized network model is composed of interaction, identification and control neural networks are employed for modeling and control of each subsystem with local identification and control goals. The interaction neural network is used for prediction of interaction between the subsystems. The learning algorithm is given in detail, and simulation results show that the proposed method is capable to control the boiler turbine system.

      • KCI등재

        태권도 지도 효능감의 개념 구조

        정청희,임태희,윤익모 한국스포츠심리학회 2003 한국스포츠심리학회지 Vol.14 No.3

        본 연구의 목적은 태권도 지도 효능감의 개념 구조를 확인하고 서구에서 개발된 스포츠 코칭 효능감(Feltz 등, 1999)과 한국형 코칭 효능감(박정근, 1996)의 차이를 규명하는데 있다. 전국 소재 태권도 도장 지도자 90명을 대상으로 한 개방형 설문지 반응을 귀납적 내용분석 하였으며, 여기에서 얻어진 130개 문항을 2차 수정과정을 거쳐, 탐색적 요인분석과 확인적 요인분석을 실시하여 구조 타당성을 검증하였다. 요인탐색에서 5개 요인에 21개 문항이 탐색되었고, 최종적으로 확인적 요인분석에서 기술지도, 동기유발, 지도자 수양, 지도자 상담으로 네 개 요인에 총 19개 문항을 확정했으며, 확인적 요인분석의 적합도 지수 값들이 대체적으로 적합한 것으로 나타났다. 결과적으로, 본 연구를 통해 한국 태권도 지도 효능감의 개념은 기술지도, 동기유발, 지도자 수양, 지도자 상담 요인 등 네 개의 일반영역으로 구성되며, 스포츠 코칭 효능감의 개념구조와는 다른 것으로 나타났다. The purpose of this research was to extract dimensions of the TaeKwonDo Coaching-Efficacy and to confirm the conceptual construction, which is based on TaeKwonDo Coaching-Efficacy. An open-questionnaire made through a pilot study was administered to 90 TaeKwonDo coaches, who were distributed in the whole country, to collect sources of TaeKwonDo Coaching-Efficacy, which were conducted by inductive analysis. There were collected 1,225 cases of the foundational basic data on the efficacy. However, 125 cases were selected by excepting overlapping data and collecting similar ones among those things in specialist groups. 125 cases of the sources were categorized in 23 detail domains. In the field of the detail territories, the Questionnaire of TaeKwonDo Coaching-Efficacy(QTKDCE) was created by two adjustments. According to adjustment, there were selected 74 questions through specialists' meeting. These researches were performed by two kinds of methods. The exploratory factor analyses were done in the first research. In the second one, the confirmatory factor analyses were used. The results were produced in two researches as follows. The first, TaeKwonDo Coaching-efficacy were confirmed as teaching techniques(5 scales), arousing motivation(5 scales), master's cultivation(5 scales), master's consultation(4 scales) with four factors and nineteen scales totally. The second, the result of confirmatory factor analyses, most index values were appeared probably appropriate fit. According to this study the conception of TaeKwonDo Coaching-Efficacy was confirmed that it was different with Feltz(1999)'s and Park(1996)'s conceptual construction.

      • 세자리 Schiff base Cobalt(Ⅱ)와 Nickel(Ⅱ) 착물들의 합성과 전기화학적 성질

        정만태,이송주,채희남,정병구 광주보건대학 1994 論文集 Vol.19 No.-

        Co(Ⅱ) and Ni(Ⅱ) complexes containing tridentate Schiff base ligand SOIPH [salicylidene-o-iminopyridine] derived from salicylaldehyde with 2-aminopyridine were synthesized. These complexes were characterized 표 elemental analysis, thermogravimetric analysis(T.G.A.), solution conductivity, and IR and UV-visible spectra. It was found that Co(Ⅱ) and Ni(Ⅱ) complexes had a 2 : 1 Schiff base ligand to metal(Ⅱ) ratio and were octahedral configuration. The redox processes of these complexes in DMF and DMSO containing 0.1M TEAP as supporting electrolyte were investigated at glassy carbon electrode by cyclic voltammetry (CV) and at HMDE(hanging mercury drop electrode) by differential pulse polarographic (DPP) technique. Reduction of Co(Ⅱ) complex was two steps, whereas Ni(Ⅱ) complex was one step. Reduction of these complexes observed as one electron process irreversibly and diffusion- controlly. Reduction of the Co(Ⅱ) complex was observed positive potential than Ni(Ⅱ) complex.

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