In Vitro Fertilization and Embryo Cleavage in Canine Oocytes

Hae }ung Kim,Sang Ryeul Lee,Sin Hae Park,Sung Hyun Kim,Bong Soo Kim,Dong Hun Yoo,Sin Hae Park,Mi Jung Shin,Jae Wook Kim,Zae Young Ryoo 한국동물생명공학회(구 한국동물번식학회) 2006 Reproductive & developmental biology Vol.30 No.2

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

언어처리모형에 따른 실어증 연구

이해욱 부산 외국어 대학교 2001 外大論叢 Vol.23 No.1

Der Begriff Aphasie ist ein Sammelname fur allerlei Storungen im produktiven und perzeptiven Sprachgebrauch, die durch eine Gehirnverletzung verursacht werden (als Folge von Verletzungen, Tumoren und Schlaganfallen). Bei der Aphasie handelt es sich um Storungen in den zentralen Komponenten und Prozessen des Sprachverarbeitungssystems. In dieser Umschreibung sind zwei Aspekte von Bedeutung. An erster Stelle betreffen diese Storungen den Gebrauch von Sprache, also nicht die Wahrnehmung oder Kognition im allgemeinen. An zweiter Stelle sind diese Storungen zentraler Art, d.h. sie konnen unterschieden werden von Storungen z.B. des Gehors, des Gesichts oder der Artikulationsmuskulatur, die auch unabhangig von einer eventuellen Gehimschadigung auftreten konnen. Aphasie ist oft eine multimodale Storung: Storungen im Sprachgebrauch betreffen nicht immer nur das Sprechen, sondern gleichzeitig auch oft das Zuhoren, Schreiben und/oder Lesen. So kann Aphasie gleichzeitig mit anderen Storungen im visuellen Sprachgebrauch auftreten: Alexie (nicht immer lesen konnen) und Agraphie (nicht mehr schreiben konnen). Eine wichtige Unterteilung von Aphasie in der Literatur seit Ende des vorigen Jahrhunderts ist die in "flussige" und "nicht-flussige" Aphasie. Die nicht-flussige Aphasie wird gekennzeichnet durch eine stammelnde, artikulatorisch gestorte Sprechweise, die den Patienten viel Anstrengung kostet. Das Sprachverstandnis des Patienten ist dagegen oft weitgehend intakt. Neurologische Untersuchungen bringen in solchen Fallen Gehimschadigungen ans Licht, die relativ weit vorne in dem Gehimbereich liegen, der unsere Sprache und unser Sprechen versorgt (bei Rechtshandern in der linken Gehirnhalfte). Der bekannteste Aphasietyp in dieser Gruppe ist die Aphasie von Broca, auch "expressive" oder "motorische" Aphasie genannt. Im Jahre 1861 lokalisierte der franzosische Neurologe Paul Broca die Lasion bei diesem Aphasletyp im hintersten Teil der dritten Frontalwindung der linken Hemisphare. Die Formen der flussigen Aphasie werden gekennzeichnet durch eine fließende, ziemlich gut artikulierte Sprache. Der Satzbau ist variabel, auch wenn einige grammatikalische Konstruktionen manchmal mißlinden. Es kommen auch viele semantische Paraphasien vor, wobei Worter durch andere substituiert werden: Mein Auge ist taub anstatt Mein Auge ist blind und Er liest das Radio anstatt Er liest die Zeitung. Außerdem treten auch erhebliche Wortfindungsprobleme auf, u.a. bei Substantiven und Verben, die konkrete Dinge und Aktionen beschreiben. Das Verstehen von Sprache ist meistens ernsthaft gestort. Bei der haufigsten Form der flussigen Aphasie -der Aphasie von Wernicke-wurde die Lasion 1874 durch den deutschen Neurologen Carl Wernicke lokalisiert, und zwar im hinteren Teil der ersten Schlafenwindung. In der vorliegenden Arbeit habe ich versucht, die Außerungsdaten von Aphasiepatienten anhand des Sprachbenutzermodells zu erklaren.

게놈 유형이 다른 무릇(Scilla scilloides comlpex)에서 FISH를 이용한 인 우성 다양성 분석

이상은,최혜운,방재욱 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.2

Nucleolar dominance, an epigenetic phenomenon in which one parental set of ribosomal RNA gene is silenced in an interspecific hybrid, was investigated in different cytotype plants of Scilla scilloides complex; AA, BB, AABB, ABBB, BBBB and AABBB. To determine the loci of the nucleolar organizer regions (NORs) in metaphase chromosomes, physical mapping of 45S rRNA gene (3.8 Kb) using FISH method was applied. Two signals of the 45S rRNA gene loci were observed in both the cytotypes of AA (2n=16) and BB (2n=18). Four signals were found in tetraploid BBBB, while two and three signals were found in cytotypes of AABB and ABBB, respectively. However, AABB plants in the population of Daegukhul-do Island had four NORs in both the A and B genome. Four signals were found in pentaploid AABBB plants. The different numbers of 45S rRNA gene signals suggested the phenomenon of nucleolar dominance or amphiplasty among different cytotype plants of S. scilloides. It is speculated that inactivation of NORs on a2 chromosome in the cytotype AABB plants is the result of the amphiplastic suppression between A and B genomes.

정신분열병환자의 뇌량에 대한 신경병리적 고찰 : 확산텐서영상(Diffusion Tensor Image)기법의 적용

이경진,신용욱,하태현,이종민,김인영,김선일,문원진,정은철,박해정,오정은,박지영,강경훈,권기원,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

Objectives : Diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue. It is particularly useful for evaluating white matter abnormalities. In this paper, we investigated the neuropathology of the corpus callosum in patients with schizophrenia through the new methods, diffusion tensor imaging. Methods : Diffuse tensor imaging was performed in 19 schizophrenic patients and 26 healthy controls. One complementary measure, fractional anisotropy (FA), which is considered to be sensitive indices of axonal integrity, was obtained from regions of interest in the five areas of the corpus callosum. Neuropsychological measurement also underwent for measurement of frontal lobe function in two groups. Results : There were no significant differences of FA in the DTI measures for either the schizophrenic patients compared with controls. FA was significantly decreased in women compared with men. Neuropsychological measurements such as Wisconsin card sorting test were correlated with FA of patients with schizophrenia. Conclusion : FA measures revealed no differences between schizophrenia and controls. The findings suggest that the structural integrity of white matter in patient with schizophrenia was not disrupted. The results are discussed in relation to previous studies reporting positive and negative findings. It is concluded that further studies using DTI in larger samples, improved and standardized methods of data acquisition and analysis are needed.

접종제의 회주철 용탕 중 접종효과와 감쇄 거동 및 첨가 원소의 영향

이해성,권해욱 영남대학교 공업기술연구소 2001 工業技術硏究所論文集 Vol.29 No.1

The abilities and fading behaviors of 5 different inoculants were evaluated by the thermal analyses of melts during holding at constant temperature ranges after their having been added in induction melting furnace. The effects of S & Bi on the performance of Si-Ba inoculant were investigated. The better and more consistent results were obtained during holding after inoculation at higher temperature range of 1450∼1500℃ than 1350∼1400℃. The Ba-Si inoculant was the best of all on the bases of inoculation result and fading behavior. Meanwhile the performance of inoculant was deteriorated by the addition of excess amount of sulfur, that was slightly improved by small amount. That was slightly improved also by the addition of small amount of Bi.

현대 독일어의 상승현상에 관한 통사 의미론 연구

이해욱 釜山 外國語 大學校 1999 外大論叢 Vol.19 No.2

Syntaktische Hebungen definiert man als diejenige Spracherscheinung, daβ in die Subjektposition bzw. in die Objektposition des Matrixsatzes gehoben wird. Die erste nennt man Subjekthebung und die letzte Objekthebung. Ich nehme das Verb 'scheinen' als Beispiel und stelle die folgende Ableitung dar. (1) Peter scheint traurig zu sein. (2) ist die entsprechende Tiefenstruktur vom Satz(1). (2) S S NP VP NP VP S1 sein Peter V VP NP VP scheint Adj V Peter V Adj [+ Inf] Syntaktische traurig schein- traurig Hebung zu sein Das Kapitel 2 beinhaltet einen historischen Uberblick; namlich die Entwicklungstendenzen der Beschreibungsmethode der syntaktischen Hebung innerhalb der TG von der Anfangsphase 60er Jahre bis heute. Die syntaktische Behandlung dieses Prozesses grunde grunde ich auf die neueste Methode der Transformationsgrammatik. Ich habe zunachst die Probleme ber syntaktischen Hebungen in den Entwicklungsphasen des Standard Modells und des REST der Chomskyschen Grammatik argumentiert. In dieser Arbeit habe ich einige semantische Probleme in bezug auf die syntaktische Hebungen behandelt. Dies wird im Rahmen der Montague Grammatik beschrieben. Die Behandlungsmethode der syntaktischen Hebung soll im weiteren noch im Zusammenhang mit der LF (Logische Form) im Rahmen der "REST"-Modells untersucht werden.

합성피혁제조업체 근로자들의 요중 N-Methylformamide 농도의 계절적 변이

이광영,변주현,송혜란,김진하,고광욱,이용환 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.2

목적: 본 연구는 여름과 겨울의 계절적 차이에 따른 디메틸포름아미드의 체내 흡수의 변화를 알아보고자 시행되었다. 방법: 일개 합성피혁제조업체에서 직접적으로 디메틸포름아미드를 취급하는 22명의 근로자들을 대상으로 2001년 2월(겨울)과 7월(여름)에 작업환경측정을 통해 기중 DMF농도를 측정하였고 특수건강검진을 실시하여 요중 NMF의 배설량을 측정하고 간기능 검사를 시행하였다. 또한 검사 당일의 평균 기온과 평균 습도를 측정하고 설문지를 통해 알코올 음주 정도, 피부 질환의 유무, 보호구 착용 유무 등을 조사한 후 여름과 겨울의 자료를 비교 분석하였다. 결과: 겨울과 여름의 평균 공기 중의 디메틸포름아미드 기하 평균 농도는 각각 11.55ppm, 13.78ppm으로 통계적으로 유의한 차이는 없었으나 요중엔-메틸포름아미드 배설량의 기하 평균은 겨울이 31.23㎎/g creatinine인 것에 비해 여름이 96.09㎎/g creatinine으로 겨울에 비해 여름의 요중 엔-메틸포름아미드 배설량이 유의하게 높았다(p<0.05). 공기 중 디메틸포름아미드 농도(ppm)에 대한 요중 엔-메틸포름아미드 배설량 (㎎/g creatinine)의 비는 여름(1:6.97)이 겨울(1:2.70)에 비해 약 2.6배 정도 높았다. 결론: 여름과 겨울의 요중 NMF배설량의 차이는 아마도 연구 대상 사업장의 환기 시설이 미약하고 근로자들이 DMF에 적합한 보호구를 적절하게 사용하지도 않았기 때문이고, 무엇보다도 높은 온도와 습도에서 짧은 옷을 입고 근무함으로써 피부 노출면적이 증가되어 DMF의 피부 흡수의 양이 많아졌기 때문으로 판단된다. Objectives: This study was carried out to identify seasonal variations of urinary concentrations of N-methylformamide(NMF) among workers employed at a synthetic leather factory. Methods: Study subjects consisted of 16 male and 6 female workers who were involved in the direct treatment of dimethylformamide(DMF) in a synthetic leather factory. By using health examination data and the results of air measurements and biologic monitoring conducted in February and July, 2001, we identified seasonal variations of the DMF concentrations in the air and NMF concentrations in urine. Results: 1) In winter and summer, average temperatures at the working sites were 3.2℃ and 26.5℃, respectively and average humidities were 35.4% and 84.5%, respectively. 2)Airborne DMF concentrations were not significantly different between summer(13.78ppm) and winter(11.55ppm). 3)NMF concentrations in urine were found to be significantly higher in summer(96.09㎎/g creatinine) than in winter(31.23㎎/g creatinine) (p<0.001). Conclusions: The seasonal difference in the urinary excretion values of NMF may be due to increased dermal absorption of DMF with the higher ambient temperature and humidity in summer and the increased area of exposed skin.

活動基準原價시스템의 有用性에 관한 考察

李海信,許凍旭 全北産業大學校 産業經營硏究所 1997 産業經營硏究 Vol.5 No.-

Cephalometry에 의한 가토의 하악골 성장 측정

이해욱,김진환,권성택 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Much progress has been made on the study of the growth and development of craniofacial skeleton with the increase of craniofacial surgery, but many problems remain to be clarified about the chioce of appropriate experimental animals and accurate measurements. The pattern of craniofacial skeletal grwoth is unique and various methods have been attempted to assess it. Recently, serial cephalometric roentgenography in concert with radiopaque implants, which serve as fixed reliable markers, was introduced to be the most accurate method to determine it. On the other hand, some authors observed retardation of craniofacial skeletal growth subsequent to rigid fixation with miniplate and screws in craniomaxillofacial reconstruction of children. The aim of this study is as a basic reserarch to understand these problems better. New Zealand white rabbits 500-750gm in weights were used as experimental animals. Two chinically available titanium screws were implanted into the body of mandible and serial cephalometric roentgenographs were taken as the animals grew up. Obtained roentgenographs were analysed to assess the pattern and amount of mandibular growth and compared with that of the control animal group. Results of the experiments were as followings: 1) The growth of mandible by the implanted titanium screws revealed no statistically significant influence to that of control group. 2) Serial cephalometric analysis using two implanted titanium serews as fixed reference points revealed volumetric change and pattern of mandibular growth. Therefore it is a more accurate and a useful experimental method assessing the craniofacial skeletal growth.