Flunarizine이 腦虛血性흰쥐의 腦에너지 代謝에 미치는 영향

尹再順,徐銀珠 梨花女子大學校 韓國生活科學硏究院 1989 韓國生活科學硏究院 論叢 Vol.44 No.-

뇌허혈증은 뇌순환장해성질환이며 Ca^2+의 과량 유입으로 조직세포의 막전압이 변하여 정상적에너지산생이 어려워지며 결국 뇌세포는 괴사에 이르게 된다. 양측총경동맥을 결찰하여 뇌허혈을 일으킨후 대뇌피질내 에너지대사관련물질을 정량한 결과 ATP, Pcr, 및 glucose량이 정상뇌에 비해 감소하였고 lactate량은 증가하였다. 이러한 현상은 정상쥐에 비해 노령화쥐, 선천성고혈압쥐, DOCA-salt 고혈압쥐 순으로 뚜렷하였다. 허혈성흰쥐에 Ca^2+길항제인 flunarizine을 2배의 등비수열적용량 10, 20, 40mg/kg을 복강내에 전처치 하였을 때 뇌에너지대사장해는 용량의존적으로 회복되었다. 이때도 노령화쥐가 회복율이 가장 부진하였다. 허혈증모델에 flunarizine 전처치한 정상혈압허혈증모델이나 경동맥결찰 30분후 뇌혈류를 재순환시킨 어린쥐는 뇌에너지대사관련물질이 거의 정상뇌에 가깝게 회복되었다. 이와같은 결과로 flunarizine은 세포내 Ca^2+의 과잉유입을 방지하여 적혈구변형능저하방지, 혈관수축억제작용으로 뇌혈류를 증진시켜 뇌에너지대사를 개선하여 뇌보호작용이 나타난 것이라 생각된다. Recent hypothesis suggests that intracellular accumulation of Ca^2+ is a common denominator of ischemic cellular damage. Flunarizine, Ca^2+ entry blocker, increases cerebral blood flow in cerebral vascular diseases. The present study was designed to evaluate the effect of flunarizine on cerebral energy metabolism in the ischemic rat brain made by bilateral carotid artery ligation. The content of ATP, creatine phosphate and glucose decreased while lactate increased after thirty minutes ligation in the aging rats, the spontaneous hypertensive rats and the DOCA-salt treated hypertensive rats. Flunarizine improved changes of the cerebral energy metabolites in a dose-dependent-response pattern. Especially, resuscitation of brain ischmic damage showed a remarkable recovery of energy metabolite to the normal state of the brain. The results showed that flunarizine ameliorated the cerebral energy metabolism in the ischemic rat brain and had a brain protective effect.

식품 기준·규격의 합리적 관리 ·운영에 관한 연구(Ⅰ) : 두부,식용유지, 전분의 분말상 원료에 관하여 Powdered marerials of Tofu, Edible oil, Starch

김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.

남자 중학생의 식품 중량과 열량을 중심으로 한 영양교육 효과에 관한 연구

신혜주,김은영,배윤정,승정자 숙명여자대학교 건강·생활과학연구소 2006 生活科學硏究誌 Vol.- No.22

This study was planned to suggest countermeasure of nutrition education by investigating adolescents, dietary behavior, food weight, and acknowledgement of food calories. 210 middle school boys were selected and asked to fill out the questionnaire. The subjects were divided by nutrition education experience; 1st grade who received nutrition session and 3rd grade who divided subjects. In terms of acknowledgement of food calories subjects nutrition education experience had more recognition for calories than the other group(p<0.01). When one bowl of rice, a potato, a bowel of kimchi and a carrot were asked. However recognition for meats, fishes and eggs were not different between two groups. Among milk and dairy foods the educated group showed high recognition both calories and weight of a piece of cheese than the other(p<0.05). The educated group showed better recognition for calories and weight of tea-spoon of butter, a tea spoon of oil and a tea-spoon of mayonaise, compared to the other group(p<0.01, p<0.05, p<0.05). Also the educated group showed better recognition for calories and weight of a packet of shrimp snack than the other group. The results of this study suggest that nutrition education improved the recognition of calories and weights of foods in study subjects. Also, the number of foods recognized for their calories and weights was higher among subjects who received nutrition education. These results will influence the choice the food by adolescents. Also the nutrition education are thought to be more effective by using photographs or food models, not just by lectures on theories.

요양병원 환자분류체계 개발

이지윤,윤주영,김정회,송성희,주지수,김은경 대한간호학회 간호행정학회 2008 간호행정학회지 Vol.14 No.3

Purpose: To develop the patient classification system based on the resource utilization for reimbursement of long-term care hospitals in Korea. Method: Health Insurance Review & Assessment Service (HIRA) conducted a survey in July 2006 that included 2,899 patients from 35 long-term care hospitals. To calculate resource utilization, we measured care time of direct care staff (physicians, nursing personnel, physical and occupational therapists, social workers). The survey of patient characteristics included ADL, cognitive and behavioral status, diseases and treatments. Major category criteria was developed by modified delphi method from 9 experts. Each category was divided into 2-3 groups by ADL using tree regression. Relative resource use was expressed as a case mix index (CMI) calculated as a proportion of mean resource use. Result: This patient classification system composed of 6 major categories (ultra high medical care, high medical care, medium medical care, behavioral problem, impaired cognition and reduced physical function) and 11 subgroups by ADL score. The differences of CMI between groups were statistically significant (p<.0001). Homogeneity of groups was examined by total coefficient of variation (CV) of CMI. The range of CV was 29.68-40.77%. Conclusions: This patient classification system is feasible for reimbursement of long-term care hospitals.

중국 운남성 소수민족무용

최미연,천은혜,김주연 세계민족무용연구소 2002 민족무용 Vol.- No.2

프랭크 스텔라의 작품을 모티브로 한 레고 전시 공간 디자인 프로세스 연구

서민영,송윤영,정민주,이진민,신은별 숙명여자대학교 디자인연구소 2018 숙명디자인학 연구 Vol.25 No.-

본 연구는 숙명여자대학교 공간 디자인 스튜디오Ⅰ 수업에서 진행한 전시 공간 디자인 프로세스에 관한 연구로서, 디자인의 기본 요소에 대한 탐구를 바탕으로 평면회화를 통해 평면, 입체, 공간 조형까지 차원에 확장에 따른 형태적 발전에 따른 공간디자인 프로세스를 연구한다. 이를 위해 본 연구는 크게 두가지로 나뉜다. 첫째 점, 선, 면의 디자인 기본요소를 이용하여 디자인 원리에 입각해 평면 구성을 하고 이를 바탕으로 평면회화를 선택하여 입체 조형을 통해 공간의 형태를 발전시킨다. 둘째, 공간의 형태에 적합한 브랜드를 선정하였으며 이를 위한 전시 공간으로서의 기능이 적용된 공간 계획을 하였다. 그리고 프로그램, 조닝, 동선, 색채 및 재질을 계획하였다. 끝으로 본 연구는 조형적 공간 디자인의 프로세스와 전시 컨텐츠의 접목으로 향후 이와 같은 일련의 전시 공간 디자인 프로세스에서 기초적 자료로 사용될 것으로 기대한다.

두경부 마사지가 중환자실 환자의 수면과 불안에 미치는 효과

김미용,전선영,송윤희,최은진,김재희,김미성,주명순,김남선 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was to apply head and neck massage to patients in intensive care unit and to inventigate the effect of that massage on sleep and state anxiety. Method: The subjects in this study were 27 patients who were admitted in medical intensive care unit. The study was performed from June thru September of 2005 on the One-group pretest-posttest design and the sleep, state anxiety of the subjects were measured before and after head and neck massage. For data analysis, paired t-test and Pearson correlation coefficient were utilized. Result: The first hypothesis that the subjects might have a better sleep after being exposed to head and neck massage was accepted. The second hypothesis that the subjects might feel less state anxiety afrer being exposed to head and neck massage was accepted. The third hypothesis that the sleep of the ICU patients maight be correlated to their anxiety was accepted, as there appeared correlation between their sleep and anxiety. Conclusion: Head and neck massage is identified as one of independent nursing interwentions to improve the sleep of ICU patients and ease their anxiety, and it is necessary to apply it to clinical practices.

多樣한 黃芩藥鍼製劑의 安全性 및 效能에 關한 硏究

김호경,마진열,전원경,윤수영,강은정,주혜정,고병섭 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In order to detect the safety and effect of various aqua-acupunctures from Scutellariae Radix, the modifications of boiling, filtration and dilution were employed for the manufacture of aqua-acupunctures. We injected 0.2cc of aqua-acupunctures into Joksamri(足三里) of rat, repeatedly. we compared subacute toxicity of them with saline group, distilled water(D.W.) group, acupuncture group and control group. The results were summarized as follows: 1. The groups were all healthy and alive, and there was no special abnormality in physical condition and autopsy. And there were not any toxic symptoms in repeating application of aqua-acupunctures to the rat, including changes of body weight, organ weight, haematological examination and serum biochemical test. 2. There was slight change of body weight in acupuncture group : We could see significance after 3 days (p<0.05) and after 7 days (p<0.001) in body weight loss. After 9 days, all tested groups were suppressed in body weight increment. 3. Result of organ weight: In Palking aqua-acupuncture(D-2 group), saline group and acupuncture group there were some statistical significance. Especially, acupuncture group revealed significant result in liver and spleen than aqua-acupunctures. From this result, we could suggest that the efficacy of acupuncture was preceded herbal medicine. 4. In serum biochemical test, we examined glucose(GLU), triglyceride(TG) and cholesterol(CHOL). In comparison with control group, the diluted 10 times of hwanggum aqua-acupuncture (× 10 group) was recognized significant decrease of glucose, but the diluted 100 times of Hwanggum aqua-acupuncture (× 100 group), D-2 group, saline group were confirmed significant increment. There was not any meaningful change of CHOL in all of tested group, excepting the acupuncture group was exhibited statistically significant decrease(p<0.05). In TG level all tested group except complex injection of standard compound (CPA group) and HG, there were significant value in statistically. The diluted solution was more significant decrease than Hwanggaum aqua-acupuncture(HG). The mutual relationship of components of aqua-acupuncture tended to decrease level of TG, regardless of its concentration. In acupuncture group, we gained some interesting result in meaningful decrease in TG. 5. Haematological examination showed significant increment of gramulocytes(GR) in all tested groups except Hwanggum aqua-acupuncture. And the diluted solutions of HG expressed very high increment of them(p<0.001). The GR and Mean Corpuscular Volume(MCV) of acupuncture group showed statistical significance.

만성 신부전증 환자의 중중 고혈당에 따른 의식 변화 결정에 대한 연구

위형중,이창범,박성광,강성귀,임천규,박은주,윤경택,한상웅,안유헌,김호중· 대한신장학회 2000 대한신장학회잡지 Vol.19 No.6

Regional disparities in major cancer incidence in Korea, 1999-2018

Eun Hye Park(Eun Hye Park),Mee Joo Kang(Mee Joo Kang),Kyu-Won Jung(Kyu-Won Jung),Eun Hye Park(Eun Hye Park),E Hwa Yun(E Hwa Yun),Hye-Jin Kim(Hye-Jin Kim),Hyun-Joo Kong(Hyun-Joo Kong),Chang Kyun Choi(C 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: This study investigated regional disparities in the incidence of 8 major cancers at the municipal level in Korea during 1999-2018 and evaluated the presence or absence of hot spots of cancer clusters during 2014-2018. METHODS: The Korea National Cancer Incidence Database was used. Age-standardized incidence rates were calculated by gender and region at the municipal level for 4 periods of 5 years and 8 cancer types. Regional disparities were calculated as both absolute and relative measures. The possibility of clusters was examined using global Moran’s I with a spatial weight matrix based on adjacency or distance. RESULTS: Regional disparities varied depending on cancer type and gender during the 20-year study period. For men, the regional disparities of stomach, colon and rectum, lung, and liver cancer declined, and those of thyroid and prostate cancer recently decreased, despite an overall increasing incidence. For women, regional disparities in stomach, colon and rectum, lung, liver, and cervical cancer declined, that of thyroid cancer recently decreased, despite an overall increasing incidence, and that of breast cancer steadily increased. In 2014-2018, breast cancer (I, 0.61; 95% confidence interval [CI], 0.53 to 0.70) showed a high probability of cancer clusters in women, and liver cancer (I, 0.48; 95% CI, 0.40 to 0.56) showed a high probability of cancer clusters in men. CONCLUSIONS: Disparities in cancer incidence that were not seen at the national level were discovered at the municipal level. These results could provide important directions for planning and implementing local cancer policies.