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여러가지 immunomodulators 가 세포성 및 체액성 면역반응에 미치는 영향
강성귀 대한내과학회 1986 대한내과학회지 Vol.30 No.1
Immunological response is the end result of the equilibrium between many positive and negative regulatory factors. The clinical need for agents to modify immune responses in the treatment of disease has lead to an increased interest in cellular and biochemical mechanisms regulating immune response and to the development of a variety of biological and chemical substance with immunomodulatory activity. In this study the effects of various immunomodulators on immune responses were evaluated in mice. Immunomodulators employed in this study were indomethacin(IDM), a prostaglandin synthetase inhibitor, cimetidine(CT) and ranitidine(RTD) which are histamine type 2 receptor blockers, inosiplex(ISP), bacillus Calmette-Guerin(BCG), Corynebacterium parvum(Propionibacterium acnes), hepatitis B surface antigen(HRsAg) vaccine, and crude interferon(IFN). Immune responses were studied by evaluation of Arthus reaction, delayed-type hypersensitivity (DTH) to sheep red blood cells(SRBC), contact sensitiivity to picryl chloride(TNCB), rosctte forming cell, plaque forming cell(PFC), hemagglutinin, and recovery of Salmonella typhimurium from experimentally infected mice or expulsion of adult Trichinella spiralis. IDM enhanced DTH to SRBC, contact hypersensitivity to TNCB, and IgM and IgG PFC responses to SRBC. In addition to this, IDM increased the percentage of rosette forming cells and the resistance of mice to Salmonella typhimurium, Histamine suppressed the DTH to SRBC in the dose dependent fashion. CT and RTD enhanced DTH to SRBC and TNCB, but failed to demonstrate effect on antibody formation over various ranges of concentration. Rosette forming reaction was decreased by RTD but not by CT. Interestingly, RTD-treated mice were slower than their normal control mice to expel adult T. spiralis. ISP increased DTH to SRBC and TNCB, rosette forming cell response, PFC response to SRBC, and the resistance of mice to S, typhimurium infection. ISP also restored the depressed cellular immune response by newcastle disease virus(NDV) infection. However, ISP failed to restore antibody responses to SRBC. All of these results were observed only when ISP was given after immunization but did not when given before immunization. DTH, rosette formation and resistance to S. typhimurium infection in mice were significantly decreased by NDV infection of IFN administration. The development of DTH to SRBC was diminished in RCG-infected mice. However, serum antibody to SRBC were not significantly altered by BCG infection. This depression was transferred by spleen cells from RCG infected mice to normal recipient mice. The depressed DTH was restored only by ISP but only by IDM, CT and RTD. C. parvum could enhance or depress humoral and cellular immune responses in mice depending on the time and route of inoculation, The depressed effect of C. parvum was abolished by treatment of cyclophosphamide. C. parvum increased the resistance of mice to S. tyPhimurium infection. 13BsAg vaccine decreased DTH to SRBC and hemagglutinin titer, but did not give any effect on the resistance of mice to S. typhimurium infection.