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      • KCI등재
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        Rare Mechanism of Acquired Resistance to Osimertinib in Korean Patients with EGFR-Mutated Non-small Cell Lung Cancer

        이지윤,심준호,박웅양,김희경,선종무,이세훈,안진석,박근칠,안명주 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

        Epidermal growth factor receptor (EGFR)tyrosine kinase inhibitors (TKIs) are effective clinical therapeutics for EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib, a thirdgeneration EGFR TKI, has proven effective against T790M mutations. However, the vast majority of patients acquire resistance following successful treatment. A 59-year-old female patient with metastatic NSCLC developed resistance after 43 weeks of osimertinib. CancerSCAN of the metastatic liver lesion revealed a EGFR C797G mutation at an allele frequency of 72%, a preexisting T790M mutation (73%) in cis and an exon 19 deletion (87%). Another 53-year-old female patient developed systemic progression after 10 months of osimertinib. CancerSCAN of the lung biopsy identified an EGFR L718Q mutation at an allele frequency of 7%, concomitant PIK3CA E545K (12.90%) and preexisting EGFR L858R (38%), but loss of the T790M mutation. The heterogeneity of osimertinib resistance mechanisms warrants further investigation into novel or combination agents to overcome the rare acquired resistances.

      • KCI등재

        The Mediating E ect of Anxiety in the Relationship between Nightmares and Night Eating Syndrome in Female Undergraduate Students

        이지윤,서수연 대한수면학회 2018 sleep medicine research Vol.9 No.2

        Background and ObjectiveaaA nightmare is an unpleasant dream that awakes individuals and causes anxiety, fear and despair which lead to impulsive behaviors such as night eating. e purpose of this study is to investigate the mediating e ects of depression and anxiety on the relationship be- tween nightmare and night eating syndrome (NES). Both depression and anxiety are strongly rele- vant to a nightmare, which could increase night eating behaviors. MethodsaaParticipants of the study were 171 female undergraduate students (mean age 21.70 ± 1.76 years). All completed the following questionnaires: Disturbing Dream and Nightmare Severity Index, Night Eating Questionnaire, Hospital Anxiety and Depression Scale, and the Insomnia Se- verity Index. resultsaaResults showed there was a signi cant correlation among nightmare severity and night eating, depression, anxiety and insomnia (p < 0.05). A er controlling for insomnia, anxiety contin- ued to partially mediate the relationship between nightmare severity and NES (n = 171, B = 0.033, 95% CI = 0.001, 0.107). However, depression was not signi cant. ConclusionsaaIn conclusion, anxiety but not depression may be an important treatment target in treating females who have both nightmares and night eating.

      • KCI등재

        패션제품 대여 서비스 이용자의 구매의사결정과정과의복 쇼핑성향에 관한 탐색적 연구

        이지윤,신은정,고애란 대한가정학회 2018 Family and Environment Research Vol.56 No.6

        This study identified the characteristics of fashion rental service users as well as analyzed their purchase decision-making processes. A qualitative investigation was conducted through in-depth interviews with 13 women in their 20s–30s who have experienced renting fashion items due to a high interest in fashion. The results of the study are summarized as follows. The need recognition stage analyzed ventilation by mass media, SNS impact, curiosity, saving shopping time and money, awareness of situational necessity, and creation of various styles. The information search stage analyzed how users obtained information from 2 different sources of nonmarketer-dominated sources and marketer-dominated sources. The pre-purchase stage analyzed the evaluation of alternatives in which study participants used 2 evaluation criteria for fashion rental services and fashion rental items. The purchase stage analyzed how participants wait and select desired items (when receiving the notification of rentable items) or select alternative products. The consumption stage examined the usage frequency and usage method. The study divided the post-consumption evaluation stage into 2 categories for evaluation: personal feelings and service. The post-consumption behavior stage analyzed how participants displayed WOM, eWOM and purchase rental product behavior. Clothing shopping orientation of study participants is displayed in 5 dimensions of brand-seeking propensity, individuality-seeking propensity, economic efficiency-seeking propensity, rationality-seeking propensity, and pleasure-seeking propensity. This study identified three main characteristics in the study participants: interest in the fashion, favorable attitude toward used fashion items, consciousness of others.

      • KCI등재

        통일형 벼에서 메소트리온계 제초제 저항성 연관 DNA marker 탐색

        이지윤,조준현,이종희,조수민,권영호,박동수,송유천,고종민 한국육종학회 2018 한국육종학회지 Vol.50 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        This study was conducted to identify DNA markers related to resistance to herbicide containing mesotrione in Tongil type rice. Two Tongil type elite lines; Milyang154 and Suweon382, showed resistance to mesotrione, whereas the others were susceptible at 20 days after mesotrione application, and severe growth inhibition was observed in the remaining 13 lines. As a result of analysis of mesotrione resistance using 190 F2 populations derived from a cross of Hanareum2 (susceptible) and Milyang154 (resistant), the mesotrione resistance locus was shown to be a single dominant gene with a 3:1 segregation ratio (X2=1.19, P=0.31). To identify a DNA marker closely linked to the mesotrione resistance gene, bulked segregant analysis (BSA) was adopted. The DNA marker RM3501 was identified on chromosome 2 with a recombinant value of 0.53 to the mesotrione resistance gene. Mst1(t) was located between SSR (simple sequence repeat) markers RM3501 and RM324 with a physical map distance of 10.2 Mb–11.4 Mb on chromosome 2. The band pattern of agarose gel electrophoresis of the SSR marker RM3501 showed the same segregation pattern with respect to mesotrione treatment in 20 Tongil type varieties and a BC2F2 segregation population derived from a cross between Unkwang (resistant) and Hanareum2 (susceptible). Thus, the RM3501 DNA marker could be used in breeding programs for Marker Assisted Selection in mesotrione resistant rice breeding.

      • KCI등재

        배 ‘원황’(Pyrus pyrifolia) 유전체 해독에 기반한 SSR 마커 개발 및 유전자 지도 작성

        이지윤,서미숙,원소윤,임경아,신일섭,최동수,김정선 한국육종학회 2018 한국육종학회지 Vol.50 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        High-density genetic linkage mapping is critical for undertaking marker-assisted selection and confirming quantitative trait loci, as well as helping to build pseudomolecules of genomes. We constructed a genetic map using 94 F1 populations generated from the interspecific cross between Korean cultivar “Wonwhang” (Pyrus pyrifolia, NCBI BioSample SAMN05196235) and European cultivar “Bartlett” (Pyrus communis). We designed a total of 24,267 SSR markers based on the genome sequences of “Wonwhang” for this. To select the markers that are linked to the traits important in pear breeding programs, SSR-containing genomic sequences were subjected to nucleotide sequence homology searches, which resulted in 510 SSR markers with high similarity to genes encoding proteins with putative functions such as transcription factors, resistance proteins, flowering time, and regulatory genes. Of these, 70 markers showed polymorphisms in parents and segregating populations and were used to construct a genetic linkage map, together with the unpublished 579 SNPs obtained from genotyping by sequencing analysis. The genetic linkage map covered 3,784.2 cM and the average distance between adjacent markers was 5.8 cM. Seventy SSR markers were distributed across 17 chromosomes with more than one locus.

      • KCI등재

        블록체인을 활용한 IoT 기기인증 방안에 관한 연구

        이지윤,홍승필 보안공학연구지원센터 2018 보안공학연구논문지 Vol.15 No.5

        IoT is utilized in various fields due to the expansion of the market size and device distribution and it is receiving the attention as a core added value industry-leading new industries in ICT market. However, because the Internet of Things is a system that is based on data exchange, it is critical to security threats such as the insertion of malicious codes, modulation of data due to hacking and botnet. Since most of the devices in the market are the low specification, there are limitations in applying device authentication technologies that require high throughput. In this paper, we are going to contribute to the establishment of a stable IoT environment by proposing a secure device authentication methods based on Blockchain to complement the device authentication issues that occur within the IoT environment. IoT는 시장 규모의 확대 및 기기의 보급화로 다양한 분야에 활용되고 있으며, ICT 시장의 신산업을 이끄는 핵심 부가가치 산업으로 주목받고 있다. 하지만 사물인터넷은 데이터 교환이 근간인 시스템으로 해킹, 봇넷으로 인한 데이터의 위·변조 및 악성코드 삽입과 같은 보안 위협에 치명적이다. 보급된 기기의 대다수가 저 사양 디바이스이므로 높은 연산량을 요구하는 기존 기기 인증 기술을 적용하기에는 한계가 있다. 본 논문에서는 사물인터넷 환경 내에서 발생하는 기기 인증 이슈를 보완하기 위해 블록체인 기반의 안전한 기기인증 방안을 제안하여 안정적인 IoT 환경 조성에 기여하고자 한다.

      • KCI등재

        인공신경망을 이용한 조산 단태아의 분만 임신주수 예측

        이지윤,조수정,정은진,이광식,김승우,김호연,조금준,홍순철,오민정,김해중,안기훈 한국모자보건학회 2018 한국모자보건학회지 Vol.22 No.3

        Purpose: The objective of the present study was to predict the gestational age at preterm birth using artificial neural networks for singleton pregnancy. Methods: Artificial neural networks (ANNs) were used as a tool for the prediction of gestational age at birth. ANNs trained using obstetrical data of 125 cases, including 56 preterm and 69 non-preterm deliveries. Using a 36-variable obstetrical input set, gestational weeks at delivery were predicted by 89 cases of training sets, 18 cases of validating sets, and 18 cases of testing sets (total: 125 cases). After training, we validated the model by another 12 cases containing data of preterm deliveries. Results: To define the accuracy of the developed model, we confirmed the correlation coefficient (R) and mean square error of the model. For validating sets, the correlation coefficient was 0.839, but R of testing sets was 0.892, and R of total 125 cases was 0.959. The neural networks were well trained, and the model predictions were relatively good. Furthermore, the model was validated with another dataset of 12 cases, and the correlation coefficient was 0.709. The error days were 11.58±13.73. Conclusion: In the present study, we trained the ANNs and developed the predictive model for gestational age at delivery. Although the prediction for gestational age at birth in singleton preterm birth was feasible, further studies with larger data, including detailed risk variables of preterm birth and other obstetrical outcomes, are needed.

      • KCI등재

        Mild Water Deficit Increases the Contents of Bioactive Compounds in Dropwort

        이지윤,오명민 한국원예학회 2017 Horticulture, Environment, and Biotechnology Vol.58 No.5

        The objective of this study was to determine the effects of mild water deficit on the contents of bioactivecompounds in dropwort (Oenanthe stolonifera). Dropwort plantlets with 2-3 offshoots were transplanted into plastic potscontaining horticultural growing medium. The plantlets were grown at 22°C under a relative humidity of 60%, photosyntheticphoton flux density (PPFD) of 285 μmol·m-2·s-1, 12-hour light period, and CO2 concentration of 600 μmol·mol-1andsubirrigated with nutrient solution for 3 weeks after transplanting. To induce mild water deficit, we placed wick culturesystems (4- and 6-cm long wicks) between the bottom of each pot and the water surface at 3 or 4 weeks after transplanting. The control plants were subirrigated at the pot bottom without wick treatment. The soil water content of plants underwater-deficit averaged 45% lower than that of the control at 5 weeks after transplanting. Moreover, mild water-deficittreatment reduced the leaf water potential by 7-25% compared to the control. However, mild water-deficit treatmentdid not significantly affect the fresh or dry weights of dropwort shoots at 6 weeks after transplanting. All treatmentssignificantly inhibited the photosynthetic rate at 5 weeks after transplanting. In particular, water-deficit treatment usinga 6-cm long wick for 2 weeks resulted in a 16% lower photosynthetic rate than that of the control. The totalphenolic content and antioxidant capacity of dropwort stems did not significantly differ between treatments. However,in the leaves, total phenolic content and antioxidant capacity of all plants subjected to water-deficit treatments averaged43 and 64% higher, respectively, than those of the control. The total anthocyanin content in all treatment groups,except for treatment with a 4-cm wick at 4 weeks, was significantly higher than that of the control. These resultssuggest that dropwort plants subjected to mild water deficit effectively accumulate antioxidant phenolic compounds,including anthocyanins, which is more reminiscent of reddish, small dropwort plants that grow under limited waterconditions than of water dropwort.

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