위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

일반 모델 덧씌우기 방식을 적용한 농촌지도공무원 역량모델 개발

김진모,주대진,이진화,길대환,주현미,이정은 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.2

버섯 배지를 이용한 tyrosinase 저해제 발효

정승원,한대석,김석중,전문진 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

Tyrosinase는 식품의 효소적 갈변과 생체내에서 melanin 합성을 촉매하는 효소이다. 식용 가능한 tyrosinase 저해제의 발효생산을 통하여 melanin 합성을 저해하는 효과를 가지는 미백식품 소재를 개발하고자 현재 식품의 제조에 이용되고 있는 안전한 미생물을 대상으로 tyrosinase 저해능이 높은 균주를 선발하고 표고버섯을 주 배지원으로 발효시켜 저해제 생산의 적정조건에 대하여 연구하였다. 발효식품으로부터 분리된 NU-7을 tyrosinase 저해제 생산을 위한 발효균으로 선정하여 tyrosinase 저해제 생산 최적배지 조건을 확인한 결과 glucose가 3~20% 및 ammonium sulfate가 0~0.25%인 범위에서 균체량 증가에 따른 tyrosinase 저해제 생산능의 차이는 나타나지 않았으며, 무기질소원으로 첨가한 ammonium sulfate의 영향은 비교적 낮았다. 한편, 표고버섯(Lentinus edodes, Shiitake) 함량은 저해제 생산과 밀접한 관계를 나타내어 버섯함량(X)에 대한 저해제 생산량(Y)이 Y=-0.96X^2+13.07X+14.43의 상관식을 보였고, R value는 0.96으로 나타나 최적발효 조건을 위한 최소한의 배지는 표고버섯과 glucose 만으로도 가능한 것으로 판단되었다. 표고버섯을 이용한 발효액에서 곰팡이 독소로 알려진 아플라톡신은 검출되지 않았으며 따라서 이를 식용할 수 있는 가능성이 높은 것으로 판단되었다. Tyrosinase is an enzyme which catalyzes an enzymatic browning of some foods and in vivo synthesis of melanin. In order to produce natural and edible inhibitor of the enzyme which is expected to have whitening effect on melanogenesis, a microorganism was selected from fermented foods. It was named as NU-7, and cultured in mushroom (Lentinus edodes, Shiitake) media. Optimal media to produce tyrosinase inhibitor was formulated by varing nitrogen or carbon content. If glucose content was in a range of 3~20% and ammonium sulfate was in a range of 0~0.25%, production of inhibitor was independent of cell mass. Addition of ammonium sulfate as a nitrogen source had little effect on inhibitor production. Production of inhibitor (Y) was proportionally related to shiitake content (X) with a regression equation of Y=-0.96X^2+13.07X+14.43 (R=0.96). These results indicate that shiitake and glucose are necessary for the production of tyrosinase inhibitor. In the analysis of mycotoxin in culture broth, aflatoxin was not detected, suggesting that it would be probably edible.

고사리잎 추출액을 이용한 견직물 염색성

정진순,설정화,장정대 한국의류학회 2003 한국의류학회지 Vol.27 No.3,4

In this study, the characteristics of catechol tannin and pyrogallol tannin contained in Pteridium aquilinum were analysed by IR spectrum. Silk fabrics were dyed with Pteridium aquilinum extracts using various mordants, and their dyeing properties were discussed. Additionally the fastness to the water digestion, perspiration liquid digestion and light irradiation were investigated. IR spectrum of catechol tannin showed bands of O-H at 2417㎝^(-1), C-H at 2930㎝^(-1), C-O at 1722^(-1), C=C at 1644㎝^(-1), CH₂ at 1402㎝^(-1). And IR spectrum of pyrogallol tannin showed bands of O-H at 3409㎝^(-1), C-H at 3003㎝^(-1) and 2933㎝^(-1), C=O at 1701㎝^(-1), C=C at 1582㎝^(-1), CH₂ at 1401㎝^(-1), CO at carboxylic acid and carboxylic acid ester at 1287㎝^(-1) and 1135㎝^(-1). The maximum absorption wavelength of the extracts appeared at 270.0nm and 311.5nm. The optimum conditions for dyeing silk fabric with Pteridium aquilinum extracts were 80℃, 60min. Surface color of the silk fabric dyed with Pteridium aquilinum extracts was 2.7Y. Surface color of the pre-mordanted fabrics with Al, Cu and Fe were 4.3Y, 2.5Y and 4.7Y, respectively. And Surface color of the post-mordanted fabrics with Al, Cu and Fe were 3.7Y, 2.8Y and 0.2GY. The water fastness and the alkaline perspiration fastness were improved in the Al-mordanted silk fabrics. By acidic and alkaline perspiration treatment, △E of the unmordanted fabrics was lower than that of pre-and post-mordanted fabrics. Also after 40hour irradiation, △E of the unmordanted fabrics was lower than that of pre-and post-mordanted fabrics.

해외직접투자 정보공시와 주가반응

정경만,문대진,차영진 釜山外國語大學校國際通商硏究所 1997 國際經營論集 Vol.12 No.-

건톳 제조에 관한 연구

정창화,오창경,송대진,김수현,오명철 濟州大學校工科大學産業技術硏究所 1999 尖端技術硏究所論文集 Vol.10 No.1

고품질의 건톳제품을 제조할 목적으로 블랜칭 처리조건, 염도, 색도, 톳의 건조조건 등을 연구하였다. 생톳의 최적 블랜칭 조건은 열탕에서 5초간 처리하였고 이때의 염도는 1.8(NaCl%)로 68%의 염분 제거율을 보였다. 건톳 제조의 최적 건조조건은 열풍건조기로 60 에서 2시간 건조시켰을 때이다. 건톳제품의 수분함량은 10%로 조절하였고 색도는 a(-2.61), b(3.58)이었다. For process dried Hizikia fusiforme product of excellent quality, condition of blanching treatment, salinity, color, and dry condition were investigated. The optimum blanching condition of fresh Hizikia fusiforme was 5 seconds at boiling water. Salinity was 1.8(NaCl%), and effect of salinity elimination was 68%. The optimum drying condition was 2 hours at 60℃ in hot-air drying oven. Moisture content of dried Hijizia fusiforme product was control to 10%, Color was a(-2.61), b(3.58).

흉통과 생활변화, 대처행동양식 및 사회적 지지의 관계 : 관상동맥조영술을 받은 환자들을 중심으로 Focused on Patients Undergone Coronary Arteriography

정진대,국승희,이무석 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.3

본 연구는 흉통을 주소로 관상동맥조영술을 시행받은 환자 중 조영술상 양성군과 음성군, 대조군의 일반 인구학적 특성, 관상동맥질환의 관련요인, 흉통의 양상, 년간 생활변화량, 대처행동양식, 사회적 지지에 대한 지각의 차이, 기능장애정도 등을 비교하고자 하였다. 처음으로 관상동맥조영술을 시행하는 40명의 환자를 대상으로 의무기록지 검토, 반구조화된 면접, 사회재적응 평가척도, 대인관계지지 평가지, 대처행동 평가지, 기능장애 척도 등을 실시한 후 조영술 결과에 따라 양성군과 음성군으로 분류하였으며 이들과 흉통의 과거력이 없었던 정상대조군을 비교하여 살펴보았다. 요약하면 1) 음성군이 양성군에 비해 유의하게 여성이 더 많았고(p<0.05), 비전형적인 흉통을 호소하는 환자가 유의하게 많았다(p<0.01). 2) 년간생활변화량에서는 음성군, 양성군이 정상대조군에 비해 통계적으로 유의하지는 않지만 생활변화가 많았음을 알 수 있었고, 특히 건강과 관련한 생활변화량에서는 유의하게 높은 점수를 보였다(p<0.05). 3) 대처양식에 있어서는 음성군, 양성군이 소극적인 대처양식(정서완화적 대처)을 유의하게 많이 사용하였다(p<0.01). 4) 사회적 지지도는 음성군이 가장 부정적으로 지각하는 경향이었으나 유의한 차이는 없었다. 5) 기능장애에 있어서는 음성군과 양성군이 현저한 기능장애를 보였으나 두 군간에 유의한 차이는 없었다. 본 연구에서는 흉통환자에서 심리, 사회적인 면이 관여하는 것으로 나타났다. 그러나 다른 많은 연구결과에서 지적하듯 흉통을 호소하는 환자의 많은 수에서 이러한 심리적인 어려움이 있음에도 불구하고 지금까지 정신과적 진단과 치료가 제한되어 있었다. 본 연구는 흉통을 가진 환자들 특히, 관상동맥에 유의한 협착이 없으면서도 지속적인 흉통과 기능장애를 갖는 환자들에게 잘못된 대처양식의 수정과 같은 행동치료, 부정적 지각과 같은 왜곡된 인지에 대한 치료와 같은 정신과적 치료적 중재를 통해 증상의 재발방지와 재활에 도움을 줄 수 있을 것으로 기대된다. 향후 좀더 구체적인 심리적 프로그램에 대한 연구가 계속되어야 할 것으로 생각된다. The purpose of this study was to compare the life change unit, coping behaviors, percived social support, functional disability in patients who had a negative coronary arteriogram and those who had arteriographic evidence of coronary artery stenosis with the matched controls. Patients admitted for coronary arteriography to the cardiovascular department of the Chonnam University Hospital were assessed, on the day before coronary arteriography, on the psychological characteristics using self-rating scales such as Social Readjustment Rating Scale, Interpersonal Support Evaluation List, The Ways of Coping Checklist, and Functional Disability Scale. The results of comparing the psychological characteristics of groups with and without significant coronary artery stenosis and normal controls are as follows : In life change unit, patients with chest pain had significantly elevated health-related life events but no statistically significant differences in total life change. In coping behaviros, patients with chest pain were showed to have more passive coping(especially, tension-reduction coping) than normal controls. In social support, patients with chest pain and negative coronary arteriogram were the most negative cognition but there no statistically significant differences. In functional disability, patients with chest pain showed much higher functional disability score than normal controls. We recognized the relationship of psychological factors to the chest pain patients, psychological terapeutic intervention may provide prevention of symptom relapse and rehabilitation for the negative coronary arteriogram patients with persistent chest pain, and functional disability.

백서 중대뇌 동맥의 폐쇄에 따른 경색의 시간적 변화

정진명,정영섭,박인성,이상형,김현집,최길수,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3

For the assessment of clinical management, for the confirmation of clinical findings, and also for the evaluation of new diagnostic techniques to determine the location as well as the extent of area of infarction on evolution in cerebral tissue is essential. Sequential evolution of infarction in 2% 2, 3, 5-triphenyltetrazolium hydrochloride(TTC) staining and its concomitant neurological changes were investigated in the rat following left middle cerebral artery occlusion(MCAO). In addition, the pathological evaluation was performed in the same coronal cut slice of each TTC staining. The results were : 1) In the TTC staining method, the cerebral infarction was not found in the 2 hour group rats, and appeared as white or pink color after 4 hours. 2) The size of infarction was significantly correlated with time of occlusion before sacrifice(p<0.05). The size increment was most obvious between 8 hour and 24 hour groups. 3) The time evolution of cerebral infarction was most prominent in the cerebral cortex, and was minimal in the basal ganglia which are supplied by the 'end artery'. 4) The cerebral infarction appeared first in the coronal cuts at the 4, 6, and 8㎜ from the frontal pole, which is the main territory of MCA. 5) The cerebral infarction, mainly presented in the 4, 6, and 8㎜ coronal cuts from the frontal pole, extended from the pyriform cortex to the fronto-parietal cortex. It also appeared at 2, 10㎜ coronal cuts from the frontal pole in 24 hour group. 6) The neurologic sign was not correlated to the time of MCAO and the size of infarction on evolution. Therefore, the prediction of location and size of area of infarction on evolution was impossible by the neurological status. 7) The histopathological change was detected as early as in 2 hours. However, hematoxylin and eosin(H & E) stained sections showed only subtle changes, such as small irregular areas of cortical spongiosis and neuronal shrinkage up to 8 hours. There was no significant difference between lesion areas of 2 hour and 8 hour groups. The pathological findings of 24 hour group rats was definite and appeared as a central area of coagulation necrosis and rare faction surrounded by a zone of peripheral spongiosis.

태권도 수련생 학부모들의 도장 선택 시 고려하는 요인에 관한 분석

진중의,김종길,김원대 龍仁大學校 武道硏究所 2011 武道硏究所誌 Vol.22 No.1

이 연구의 목적은 태권도수련생 학부모들이 자녀들의 태권도장 입관을 위해 고려하는 요인들을 규명하기 위하여 관련 선행 연구들을 중심으로 가설을 설정하여 이를 규명하는데 주된 목적이 있다. 이 연구에 사용한 자료분석 기법은 기술분석(descriptive analysis), t-test, 일원변량분석(one-way ANOVA), 상관분석이었으며 이 연구에서 얻어진 결론은 다음과 같다. 첫째, 학부모들이 태권도장 선택 시 가장 많이 고려하는 요인으로는 지도자 요인은 상담 시 지도자의 친절도, 시설 요인은 태권도 수련장의 청결상태, 위치 요인은 집에서 도보이동이 가까운 위치, 프로그램 요인은 태권도장의 인성교육 프로그램 등을 태권도장 선택 시 많이 고려하고 있는 것으로 나타났다. 둘째, 학부모들의 인구통계학적 특성에 따른 도장선택 시 고려하는 요인으로 성별은 지도자요인, 위치요인에서, 연령은 지도자요인에서, 학력은 위치요인에서, 주거환경은 위치요인, 프로그램요인에서 통계적으로 유의한 차이가 있는 것으로 나타났으며, 수입에서는 모든 변인에서 집단간 통계적으로 유의한 차이가 없는 것으로 나타났다. 셋째, 학부모들의 인구통계학적 특성과 도장 선택 시 고려한 요인과의 관계를 살펴본 결과 성별은 지도자요인, 위치요인에서 월소득은 시설요인에서 주거환경은 위치요인에서 통계적으로 유의한 상관관계가 있는 것으로 나타났다.

조대술을 이용한 비교적 큰 함치성 낭종내 전위된 치아의 맹출유도에 관한 치료증례

구대학,김영진,김현정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

The dentigerous cyst originates through alteration of the reduced enamel epithelium after amelogenesis is completed, with accumulation of fluid between the layers of the enamel epithelium or between this epithelium and the tooth crown. It is always associated with unerupted teeth. there are two methods of treatment which are generally accepted. One is the enucleation of the cystic sac in its entirety, the other is the Partch operation, or the marsupialization, by which the cyst is uncovered or 『deroofed』 and the cystic lining made continuous with the oral cavity or surrounding structures. We have 3 cases involving management of impacted & displaced teeth after marsupialization of a dentigerous cyst. We would like to summarize the results of the report as follows: The teeth which had been displaced near the bottom of mandible and dislocated distally or mesially by the pressure of the cyst on which had been displaced and inclined abnormally by the pressure of the cyst, have a tendency to erupt rapidly into their normal position soon after marsupialization, even without the application of orthodontic measures.