Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예

김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.

금궤요략 증상에 근거한 진료기록부 작성에 대한 제언

김상운 ( Sang-un Kim ),정현종 ( Hyun-jong Jung ) 대한한의진단학회 2015 大韓韓醫診斷學會誌 Vol.19 No.1

Objectives This study intends to present the writing of standardized medical records based on Korean medicine on the basis of Geum-gwe-yo-ryak symptoms. Methods 1. Excluding the sentences unrelated to the Geum-gwe-yo-ryak symptoms, the symptoms in the rest of sentences were extracted. 2. Classifying the extracted symptoms as per the review of system, the similar symptoms were integrated. 3. Calculating the frequencies of each symptom, each strain rate was calculated. 4. The above results were compared with the results of existing similar study on Sang-han-ron(『傷寒論』) symptoms Results Conclusion 1. Resulting from the analysis on all sentences in Geum-gwe-yo-ryak, a total of 1486 different symptoms were extracted. 2. As results out of total, the symptom related to the temperature sensation accounted for 12.4%, that related to sweat did 3.8%, that related to thirst did 3.8%, that related to edema did 3.4%, that related to musculoskeletal system did 6.9%, that related to breathing did 8.6%, that related to chest and hypochondrium did 6.2%, that related to abdomen did 9.5%, that related to digestive system did 9.6%, that related to stool did 6.4%, that related to urination and urinary system did 5.7%, that related to mouth, eye, ear, nose, throat did 5.3%, that related to skin did 4.5%, that related to language, mind, sleep and emotion did 6.7%. 3. Compared with Sang-han-ron, Edema appear only in Geum-gwe-yo-ryak. Therefore, edema may be a characteristic symptoms of miscellaneous disease.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성

송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.

영지버섯 리큐르주의 침출시간에 따른 성분변화

金紅出,李相元,金哲鎬,趙鏞雲 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

The physicochemical factors such as organic acid composition, pH, sugar content, acidity and color according to extraction time of Ganodema licidum liquor changed as followings; 1. The major general components of Ganodema licidum were analyzed to be crude fiber(47.5%), carbohydrate (29,4%), crude protein (14.8%), crude fat (6.5%) and crude ash (1.8%) in dry basis. 2. pH and sugar content in Ganodema licidum liquor slightly decreased, whereas acidity increased with extraction time. 3. The luminosity of color (L) showed no remarkable change. 4. The tone of color (a) decreased, whereas the chroma (b) increased as time goes by. 5. The concentration of total organic acid in Ganodema licidum liquor was 2.453%, and nine kinds of organic acids such as oxalic, citric, tartaric, succinic, lactic, formic, acetic, propionic and isobutyric acid were detected. Among them, the concentration of lactic acid was highest acetic and isobutyric acid were medium level, and that of citric, formic, succinc and tartaric acid was very low.

공역 리놀레산 유도체의 세균생장 억제효과

金紅出,趙鏞雲,李相元,金哲鎬 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

Antibacterial activity of CLA-K salt was surveyed in this paper. CLA-K(10%) exhibited antibacerial activity at the concentration more than 60 ㎕. The antibacterial activity of CLA-K in liquid culture was relatively proportional to its concentration. The resistance of bacteria against CLA-K increased as time goes by. Streptococcus mutans, Bacillus cereus KCCM-l1204, Lactobacillus plantalium and Escherichia coli ATCC-11835 were relatively sensitive to CLA-K. Staphylococcus aureus KCTC-l927 and Klebsiella pneumoniae KCTC-2208 sensitively reacted to the concentration of CLA-K.

급성 조증에서 기분안정제와 리스페리돈의 병합 투여 효과 : 다기관 개방연구

김광수,배치운,윤진상,김영훈,이양현,지익성,이철,송혜경,최성구,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Ohjective : The primary purpose of this study was a replication of the effectiveness and tolerability of rispehdone in the treatment of patients with acute mania in very larger cohon in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods : A total of 909 patients with DSM-TV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson-Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extra-pyramidal symptom (EPS). Results : This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change=-23.5±11.8, p<0.0001 ; mean change=-2.7±1.5, p<0.0001, respectively) from the baseline to the endpoint (week 6). Number of patients with 50% reduction or more in the YMRS and CGI-s scores was 693 (77.8%) and 630 (70.7%) at endpoint, respec-tively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. Conclusion : The present larger open study demonstrates that hsperidone add-on therapy is effective and tolerable in treat-ment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.

동기유발을 위한 ARCS이론을 적용한 수업이 수학과 문제해결력 신장에 미치는 영향

성열욱,김상운 한국학교수학회 2001 韓國學校數學會論文集 Vol.4 No.2

All men's achievement and behavior is always based on motivation. It has been reported that learning motivation plays an important role to get achievement of study to approximately 16∼38%. Therefore, a lot of researchers agree that learning motivation must be required for learning achievement. This study focuses on "How behavior induces learning motivation from learners?" I adapted "the Attention, Relevance, Confidence, Satisfaction" which is supported by John. M. Keller in the model of ARCS to the course of teaching-learning in order to improve them systematically. The effectiveness and results of adaptation must be considered to solve the math problems.

적외선 열화상 카메라를 이용한 머시닝 센터 주축 열변위에 관한 열해석

김재열,윤성운,임노빈,유신,마상동,양동조,송인석 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

Diagnosis or measurements using Infrared thermo-image hasn't been available. A quick diagnosis and thermal analysis can be possible when that kind of system is introduced to the investigation of each part. In this study, Infrared Camera, Thermo-vision 900 was used in order to investigate. Infrared Camera usually detects only Infrared wave from the light in order to illustrate the temperature distribution. Infrared diagnosis system can be applied to various field. Also, it is more effective to analyze temperature distribution on the machining center main-axis process.

비양론성 TiO₂-x에서 전기전도도와 결함 형태

김명호,강상수,백운규 國立 昌原大學校 産業技術硏究所 1996 産技硏論文集 Vol.10 No.-

The defect model of nonstoichiometric rutile ( TiO₂-x ) has been studied by means of the electrical conductivity measurement as function of temperature and oxygen partial pressure(Po₂). The Po₂dependence of σindicates that the major defects in rutile are doubly charged oxygen vacancies and tetravalent charged interstitial titanium ions. The interstitial titanium Ti ??'''' prevails at temperatures above 1170˚C. But the doubly charged oxygen vacancy Vo " predominates at low Po₂and temperature under 1170˚C. The proposed defect model in rutile is consistent with our previous result which was investigated by the O?? tracer diffusion.