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소아 백일해 감염의 유행 및 임상 양상(2000. 3-2001. 3)
유신,안경옥,박은혜,조현상,박종영,이혜란,Yoo, Shin,Ahn, Kyong Ouk,Park, Eun Hye,Cho, Hyun Sang,Park, Chong Young,Lee, Hae Ran 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.5
목 적 : 최근 연간 10여건으로 감소추세로 보고되고 있는 백일해의 유행실태와 임상양상을 분석함으로써 백일해에 대한 역학적 자료와 임상적 진단의 지침 마련에 도움이 되고자 본 연구를 시행하였다. 방 법 : 2000년 3월부터 2001년 3월까지 본원에 입원한 환아 중 1주일 이상의 심한 백일해양 기침 증상을 보인 환아 49명을 대상으로 비인두 가검물을 채취하여 PCR과 배양검사를 실시하였다. 결 과 : 49명의 검사 의뢰 환아 중 10명이 PCR 양성이었고 이중 4명이 배양검사 양성이었다. 이환 환아는 모두 봄철인 3-5월과 가을철인 9-11월에 발생하였고, 나이별로는 10명 모두 6개월 미만이였고 이중 8명이 DTaP 미접종 환아이었다. 결 론 : 본 연구에서 백일해로 진단된 환아들은 대부분 지역의원에서 질병 초기에 세기관지염, 폐렴 및 기관지염으로 진단되어 치료를 받다가 전원 되었다. 그러므로 특히 DTaP 접종을 받지 않은 영아에서 특징적인 '흡' 소리가 없더라도 심한 기침이 있는 경우 관심을 가지고 백일해 진단을 위한 검사를 시행한다면 보다 많은 수의 백일해 환자가 진단될 가능성이 있다고 사료된다. Purpose : Pertussis is a highly communicable infectious disease in children with high mortality, especially in young infants. The incidence of pertussis in South Korea has decreased to about 10 cases a year in late '90s. Doubting previously reported incidences of pertussis, we designed this study to establish exact epidemiology and a diagnostic basis of pertussis. Methods : From Mar. 2000 to Mar. 2001, polymerase chain reaction(PCR) and cultures of nasopharyngeal aspirates were taken from 49 patients who were clinically suspected of pertussis in Kangdong Sacred Heart Hospital. Results : Among 49 patients suspected of pertussis, 10 cases showed positive results by PCR method. Four out of those 10 cases were positive in culture. The peak outbreak was noticed in the spring(Mar.-May) and the autumn(Sep.-Nov.). The mean age of the patients was 3.6 months. Eight of the 10 cases which were PCR positive results proved not to be immunized against pertussis. Conclusion : Most of the pertussis patients in our study were diagnosed as bronchiolitis, pneumonia or bronchitis at the beginning of the disease and only a few patients showed typical clinical manifestations of pertussis, including whooping. When the above results are taken together, we suggest the possibility that the actual prevalence of pertussis in South Korea might be higher than that of previous reports. The importance of pertussis screen tests should be emphasized in children with severe coughs.
유신,이완주,강현철,Lew, Sheen,Lee, Wan-Joo,Kang, Hyun-Chul 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.4
영상 안정화(image stabilization)는 흔들림이 있는 영상을 영상처리 기법으로 안정화 시키는 과정을 말한다. PA(projection algorithm)기법을 이용한 디지털 영상 안정화는 쉽게 글로벌 모션을 얻을 수 있어 많이 연구가 되어 왔다. PA기법은 실현이 간단하고 속도가 빠른 장점이 있지만 고정된 탐색범위를 사용함으로 탐색범위를 초과한 떨림을 안정화 시킬 수 없고 또한 큰 떨림을 안정화 하기위하여 탐색범위를 크게 하면 모션 추적에 참여하는 블록이 작아져 적확한 글로벌 모션을 얻지 못하게 된다. 본 논문에서는 기존의 PA기법의 단점을 해결하기 위하여 여러 가지 흔들림의 크기에 절용할 수 있는 IPA(Iterative Projection Algorithm)기법을 제안하여, 차량에서 찍은 연속된 영상 1000프레임에 적용하였을 때 기존의 알고리즘을 사용하고 서로 다른 탐색범위를 사용한 결과보다 PSNR이 최저 6.8%, 최고 28.9% 향상 되었다. The image stabilization is the procedure of stabilizing the blurred image with image processing method. Due to easy detection of global motion, PA(Projection algorithm) based on digital image stabilization has been studied by many researchers. PA has the advantage of easy implementation and low complexity, but in the case of serious rotational motion the accuracy of the algorithm will be cut down because of its fixed exploring range, and, on the other hand, if extending the exploring range, the block for detecting motion will become small, then we cannot detect correct global motion. In this paper, to overcome the drawback of conventional PA, an Iterative Projection Algorithm (IPA) is proposed, which improved the correctness of global motion by detecting global motion with detecting block which is appropriate to different extent of motion. With IPA, in the case of processing 1000 continual frames shot in automobile, compared with conventional algorithm and other detecting range, the results of PSNR is improved 6.8% at least, and 28.9% at the most.
동방결절에서 과분극에 의해 활성화되는 내향전류에 대한 Cyclic-GMP의 영향
유신,호원경,엄융의,Yoo, Shin,Ho, Won-Kyung,Earm, Yung-E 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.6
The aim of present study is to investigate the effects of cGMP on hyperpolarization activated inward current ($I_f$), pacemaker current of the heart, in rabbit sino-atrial node cells using the whole-cell patch clamp technique. When sodium nitroprusside (SNP, $80{\mu}M$), which is known to activate guanylyl cyclase, was added, $I_f$ amplitude was increased and its activation was accelerated. However, when $I_f$ was prestimulated by isopreterenol (ISO, $1{\mu}M$), SNP reversed the effect of ISO. In the absence of ISO, SNP shifted activation curve rightward. On the contrary in the presence of ISO, SNP shifted activation curve in opposite direction. $8Br-cGMP(100\;{\mu}M)$, more potent PKG activator and worse PDE activator than cGMP, also increased basal $I_f$ but did not reverse stimulatory effect of ISO. It was probable that PKG activation seemed to be involved in SNP-induced basal $I_f$ increase. The fact that SNP inhibited ISO-stimulated $I_f$ suggested cGMP antagonize cAMP action via the activation of PDE. This possibility was supported by experiment using 3-isobutyl-1-methylxanthine (IBMX), non-specific PDE inhibitor. SNP did not affect $I_f$ when $I_f$ was stimulated by $20{\mu}M$ IBMX. Therefore, cGMP reversed the stimulatory effect of cAMP via cAMP breakdown by activating cGMP-stimulated PDE. These results suggest that PKG and PDE are involved in the modulation of $I_f$ by cGMP: PKG may facilitate $I_f$ and cGMP-stimulated PDE can counteract the stimulatory action of cAMP.