착화제와 유기산이 Wistar rat체내의 Sr 분포에 미치는 영향

이기호,이제호,박상윤,이승훈,유용운,윤택구 대한방사선 방어학회 1990 방사선방어학회지 Vol.15 No.2

Wistar rat에 85SrCl2를 꼬리 정맥에 주사하여 체내 기관과 혈액 내 분포, 잔존율을 조사하였고 착화제와 유기산을 투여하여 혈장 단백질에 결합하는 Sr양의 변화를 측정하였다. 혈액내에서 Sr은 혈장에 60%, 세포에 40%부착되어 이동하였다. 혈장에 존재하는 Sr중 약 50%정도는 혈장 단백질과 결합한 상태였고, 세표에는 세포 표면에 가볍게 부착되어 있었다. Erythrocyte나 granulocyte보다 lymphocyte에 많은 양의 Sr이 부착되어 있었다. 투여후 초기 1시간 이내에 혈액 내에서 급격히 감소하여 뼈에 침착되었다. 이때 각 기관에서도 Sr의 잔존율은 24시간 이내에 크게 감소하였고, 뼈로 침착된 Sr은 24시간 이후에 서서히 감소하였다. 착화제 EDTA, EGTA 및 DTPA를 투여한 경우, 혈장 단백질에 결합하는 Sr의 양은 대조군의 57%에서 27-33%로 감소하였으며 citrate 및 oxalate의 투여시는 이값이 19%와 40%로 각각 감소하였다. 85SrCl2 was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents. EDTA. EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.

복어중독에 의한 가사 상태에서 소생한 1예

송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.

HIV 감염 환자에서 발생한 편평 콘딜롬 1예

이해웅,오상현,장성은,최지호,문기찬,고재경 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

프랙탈 분석을 이용한 치근단병소 치유과정의 골 변화

이지민,박혁,정호걸,김기덕,박창서 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

Purpose : To investigate the change of bone healing process after endodontic treatment of the tooth with an apical lesion by fractal analysis. Materials and Methods : Radiographic images of 35 teeth from 33 patients taken on first diagnosis, 6 months, and 1 year after endodontic treatment were selected. Radiographic images were taken by JUPITER Computerized Dental X-ray System. Fractal dimensions were calculated three times at each area by Scion Image PC program. Rectangular region of interest (30×30) were selected at apical lesion and normal apex of each image. Results : The fractal dimension at apical lesion of first diagnosis (L_(0)) is 0.940±0.361 and that of normal area (N_(0)) is 1.186±0.727 (p<0.05). Fractal dimension at apical lesion of 6 months after endodontic treatment (L₂) is 1.076± 0.069 and that of normal area (N₁) is 1.192±0.055 (p<0.05). Fractal dimension at apical lesion of 1 year after endodontic treatment (L₂) is 1.163±0.074 and that of normal area (N₂) is 1.225 0.079 (p<0.05). After endodontic treatment, the fractal dimensions at each apical lesions depending on time showed statistically significant difference. And there are statistically significant different between normal area and apical lesion on first diagnosis, 6 months after, 1 year after. But the differences were grow smaller as time flows. Conclusion : The evaluation of the prognosis after the endodontic treatment of the apical lesion was estimated by bone regeneration in apical region. Fractal analysis was attempted to overcome the limit of subjective reading, and as a result the change of the bone during the healing process was able to be detected objectively and quantitatively.

Prospidin이 Mouse의 간장에 미치는 영향

이규식,정호삼,이민형,백두진,기춘석 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Prospidin, a new alkylating agent, has antimitotic and anticancer effect. Incubation with prospidin increases the stability of DNA and suppresses the incorporation of uridine into RNA by 15-20 percent. Prospidin is cytostatic for suspension culture and cells are blocked in G₂ phase of the cell cycle. The authors have demonstrated the effect of prospidin on the liver of mice histologically and histochemically and observed the cellular changes, loss of pyroninophilic granules and accumulation of fat in the hepatic parenchymal cells. Sixty-five healthy mice of ICR strain, average weight being 20g, were divided into two groups; control and prospidin-treated groups. All experimental animals were administered foo and water ad libitum. Animals of the prospidin-treated groups were administered prospidine 500mg per kg of body weight intraperitoneally fter dilution in the water for injection. Animals of the control group were administered only water for injection. Prospidin treated animals were sacrificed at intervals of 6, 12, 24, 36 and 48 hours after administration of prospidin. Histological preparations were made by way of hematoxylin and eosin stain for the cellular changes, methyl green-pyronin stain for pyroninophilic granules and oil red O stain for fat accumulation in the mouse liver. The results obtained are as follows. 1. Cellular swelling associated with vesicular formation were observed in the hepatic parenchymal cells of entire hepatic lobule at 24 and 36 hours after administration of prospidin. 2. A marked reduction of the pyroninophilic granules were observed in the hepatocyte of he whole hepatic lobule at 24, 36 and 48 hours following drug administration. 3. Fat deposits in the hepatic lobule were seen at 36 hours after administration of prospidin. It is suggested that prospidin acts as a cytotoxic agent and causes cellular swelling with vesicular formation, loss of pyroninophilic granules, and fat accumulation in the parenchymal cells of the liver.

L_iF 紛末의 Exo-emission Parameter

李春鎬,李起芳 全北大學校 基礎科學硏究所 1978 基礎科學 Vol.1 No.1

We make use of a method for calculating the thermoluminescence(or T.L) parameters to deduce the activation energy and the frequency factor of Lif crystal powder from TSEE glow curve on the assumption that the second-order kinetics of TL is closely related to the exoemision of trapped electron. The activation energy, also, has been calculated by the method of Kelly and Laubitz for the calculation of the activation energy from two points of the glow peaks. The deduced values of the activation evergy and the frequency factor of LiF pawder at peak temperatures 120℃ and 225℃ are 1.34±0.12ev, 1.65±0.01ev, and 4.2×10 exp (-18) sec and 6.3×10 exp (-16). According to the result of the study, we may conclude that the exo-emission of LiF powder follows the second-order kinetics of thermoluminescence.

퍼지집합 理論을 利用한 構造物의 最適設計에 관한 硏究

이종호,홍영기,우호길 충남대학교 공업교육연구소 1999 論文集 Vol.22 No.1

There exists a vast amount of fuzzy information in both objective and constraint functions of the optimization problem. Also most engineering design problems require the consideration of multiple and conflicting objectives. To handle these problems, the approach based on both fuzzy set theory and Dempster-Shafer theory is presented in this paper. In other words, original partly fuzzy multi-objective optimization problem is defuzzified into a crisp generalized multi-objective optimization problem using fuzzy set theory. The crisp generalized multi-objective problem is then transformed into an equivalent single objective optimization problem using a Dempster-shafer theory. The resulting problem can be solved to seek the best compromise solution by a common optimization technique.

HPV에 감염된 자궁경부 상피세포의 Keratin 아형 변화에 관한 연구

기근홍,이영미,장원재,임용,임성철,김창원,전호종 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The human papillomavirus (HPV) are wide spread in the world, causing proliferation of epidermal and mucosal surface. Certain papillomaviral types are oncogenic in vivo and in vitro. HPV DNA has been detected in most of cervical lesions such as condyloma acuminata, dysplasias, and invasive carcinomas. The materials for this study consisted of 5 dysplasias. 5 squamous cell carcinomas, and 5 exocervix for control, that resected for definite treatment of uterine disease at Chosen University Hospital from January, 1991 to December, 1993. All cases were performed of in situ hybridization for HPV DNA type 6/11, 16, and 18. And also immununohistochemical stain for panel of monoclonal cytokeratin (CK) antibodies were done. The result obtained is as fallows : 1. HPV DNA type 6/11 are detected in all dysplasias. HPV DNA type 16 and 18 are detected in squamous cell carcinomas. 2. Stratifed squamous epithelium of exocervix are positive staining for CK 1, CK 5/6, CK 8, CK 13, CK 14, and CK 19. HPV DNA type 6/11 infected cells are positive for CK 1, CK 13, CK 14, CK 17, CK 18, and CK 19. HPV DNA type 16/18 infected cells are positive for CK 1, CK 5/6, CK 10, CK 13, CK 14, CK 17, CK 18, and CK 19. In conclusion, HPV infection of uterine cervix is associated with change of normal cytokeratin expression pattern. Dysplastic cells are changed of CK 5/6, CK 8, CK 17 and CK18. Squamous cell carcinoma cells are changed of CK 8, CK 17, and CK 18.

구-막대 시스템에서 CDM을 사용한 강인한 제어기 설계

이호기,박용식,정찬수 崇實大學校 1999 論文集 Vol.29 No.1

All the controller design problem for linear time invariant dynamic system boils down to proper selecting the characteristic polynomials and numerator polynomials for concerned input-output relations. The propel selection of the characteristic polynomial is not so difficult, if only stability and response are to be satisfied, but it becomes complicated when robustness issue is added. The CDM could be a solution to this problem. CDM which is developed by Lipatov's conditions for stability and Kessler's standard form is easy to process of the controller design, especially it is more useful when the specifications are the settling time, rising time and overshoot. In this paper was used CDM design a simple but robust controller of the ball and beamsystem. The ball and beam system is highly nonlinear system. And it's linear transfer function used to design the controller. But CDM proved to be a solution to design even if there are some uncertainties like this linearized ball and beam system by simulations.

사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4