신증후군 환자의 고지혈증에 있어서 procerofen ( Lipanthy1 ) 의 치료효과

문희식,양승호,강영준 대한신장학회 1986 학술대회및초록집 Vol.5 No.1

저나트륨 혈증의 급속교정후 일시적인 회복뒤에 발생한 삼투성 탈수초 증후군

문희식,박동욱,이영주,김호중 대한신장학회 1997 춘계학술대회 초록집 Vol.1997 No.-

〈 감정교육 〉에 있어서의 물의 이미지와 언어에 대한 고찰

문희식 한국불어불문학회 1987 불어불문학연구 Vol.22 No.1

慢性 腎不全症 患者에서 血液透析前後의 血淸 인슐린 및 C-peptide의 變動에 관한 硏究

文熙植,金衡準,朴勇宣,姜英俊 全南大醫大 1987 전남의대학술지 Vol.24 No.1

B형 간염백신의 면역성 및 안전성에 관한 연구(抄)

김세종,문희식,남광우,홍경표,이상혁,유주용 임상약학사 1992 臨床藥學 Vol.12 No.10

응급환자의 저칼륨혈증의 분석

김호중,조균석,문희식,노유균 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.3

Objectives: Hypokalemia is one of the most common electrolyte disorders encountered in clinical medicine. It is important electrolyte disorder because it is account for neuromuscular, cardiovascular and renal disturbance. But there are few studies to evaluate the incidence and cause of hypokalemia in emergency patients. Present study was performed to evaluate the incidence and cause of hypokalemia and coincidental changes of other electrolyte and chemi- cal parameters of blood and urine. Methods: Hypokalemia was defined as a serum potassiurn concentration less than 3.5mEq/L. A total 80 medical patient without renal failure were prospectively studied for 62 days. Electrolytes and chemical parameters of the blood and urine were determined at emergency room. Results: 1) Of medical inpatients through emergency room, hypokalemia was detected in high frequency(32%) and mild degree(mean,' 3.1+O.lmEq/L). 2) The most common cause of hypokalemia was diuretics(23%), other causes were vomiting, SIADH, diarrhea, alkalemia, and unidentified cause(each; 15.4%). 3) Compared to the normokalemic group, the hypokalemic group showed significant decrease in urinary anion gap(P=0.003). 4) There was no significant difference of spot urine potassium concentrations between renal and extrarenal origin of hypokalemia. Conclusion: The hypokalemia in emergency patients was detected in high frequency and mild degree. Urine anion gap was significantly decreased in hypokalemic group than normokalemic group. Spot urine potassium concentration was less effective in differentiation of renal and extrarenal origin of hypokalemia.

만성 신부전증 환자에서 혈청 Prolactin 치의 변동에 관한 연구

양승호,김형준,강영준,문희식 대한내과학회 1986 대한내과학회지 Vol.30 No.6

In order to clarify the influence of chronic renal failure and hemodialysis on plasma prolactin concentration, plasma prolactin concentration was measured in 7 patients with chronic renal failure receiving conservative treatment, 12 uremic patients on intermittent hemodialysis and 10 subjects with normal renal function. The results were as follows: 1) There was marked elevation of plasma prolactin concentration in the patients with chronic renal failure as compared to the patients with normal renal function. 2) There was a positive correlation between plasma prolactin concentration and plasma creatinine, but there was no significant correlation between plasma prolactin concentration and BUN. 3) In 12 subjects undergoing hemodialysis, there was no significant change of plasma prolactin concentration between before and after hemodialysis.

신증후군 환자의 고지혈증에 있어서 Procetofen(Lipanthyl) 의 치료 효과

김형준,박용선,강영준,문희식 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.1

It is well documented that hyperlipidemia was com- mon feature of the nephrotic syndrome. There has been considerable debate about whether the hyperlipidemia in such patients leads to an increased risk of atheros- clerotic coronary heart disease and whether these patients require treatment to lower the level of plasma lipids. We studied the plasma lipids level including total cholesterol, triglyceride and HDL cholesterol as well as relation among total cholesterol, triglyceride, total protein and plasma albumin concentration in 15 adult patients with uncomplicated nephrotic syndrome before and after treatment of Procetofen. The following results were obtained: 1) The total cholesterol and triglyceride concentrations were significantly decreased after treatment as compared with the concentrations before treatement (P$lt;0.01, P$lt;0.05), while the HDL cholesterol was significantly increased after treatment (P$lt;0.05). 2) Total plasma protein and albumin concentrations were significantly increased after treatment (P$lt;0.05). 3) A significant inverse relation was found between the total plasma cholesterol concentration and both total plasma protein and albumin concentration (before; r= - 0.69 vs - 0,75, after; r= - 0.71 vs- 0.78), but not significant relation among triglyceride and both total plasma protein and albumin concentrations (before; r= - 0.30 vs - 0.35, after; r= 0.45 vs- 0.45).

신경증상을 동반한 심한 저나투륨혈증의 임상분석

김호중,박근태,조균석,문희식 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.2

Objective: Severe hyponatremia is rare but constitute a true medical emergency since it has deleterious effects on the central nervous system. The etiology and clinical presentation of severe hyponatremia are diverse and nonspecific, furthermore, the opt.imal therapeutic approach is debatable at the present time. Therefore, the purpose of this study is to analyze the clinical manifestations of severe hyponatremic patients and to assess the outcomes with special reference to the rate of its correction. Methods: This retrospective study analyzed the clinical course of 27 consecutive patients(pts) at a single medical center who presented with neurologic hyponatremic symptoms as well as a serum sodium (Na) concentration less than 125mEq/L. Results: Of 27 hyponatremic patients, male to female ratio was almost equal, 13 to 14, and mean age was 67.1 years. The most common cause of hyponatremia was SIADH(11 pts, 40.7%), followed by hypovolemia(11 pts, 37.1%), and edema(4 pts, 14.8%), Hyponatremic neurologic symptoms included lethargy(33.3%), confusion with drowsy mentality (33.3%), dizziness(18.6%), and semicoma(7.4%), respectively. The rate of increase to a serum Na concentration to 125mEq/L during correction of hyponatremic averaged 0.56±0.49mEq/L/hr while the maximum increase in serum Na concentration during any period of the hospital course, mostly initial phase, averaged 0.69±0.63mEq/L/hr in all 27 pts, of whom 18 pts(66.7%) was less than 0.5mEq/L/hr, 3 pts from 0.5 to 1.0mEr(11.1%), and 6 pts more than 1.0mEq/L/hr(22.2%). All 27 pts but one recovered from neurologic symptoms due to hypona- tremia without neurologic sequale. Extrapontine myelinolysis with locked in condition was developed during the course of treating hyponatremia in a pts, of whom serum Na concentration before treatment was the lowest(92mEq/L) with the rate of correction to 125mEq/L by 1.26mEq/L/hr and the initial rate of correction within the first 6 hour by 3.17mEq/L/hr. No one died of hyponatremia itself during the course o its treatment but 3 deaths of 27 pts were attributed to the pts severe underlying diseases. Conclusion: Surprisingly, these data revealed the relatively benign course of severe symptomatic hyponatremia. However, in assessing the outcome of severe symptomatic hyponatrernia, the initial degree of hyponatremia as well as the rate of correction during its treatment, particularly the initial rate of co- rrection within the first 6 hour, would be considered.

B 형 간염 백신의 면역성 및 안전성에 관한 연구 - 유소아군과 청장년군의 면역성을 중심으로 -

김세종(Sei Jong Kim),문희식(Hee Sig Moon),남광우(Kwang Woo Nam),홍경표(Kyung Pyo Hong),이상혁(Sang Hyuk Lee),유주용(Joo Yong Yoo) 대한내과학회 1987 대한내과학회지 Vol.33 No.1

N/A The immunogenicity and safety of highly purified, formalin inactivated hepatitis B vaccine (Hepavax-B®), containing 20 mg HBsAg to the age over 10 and 10 mg to the age under 10, were studied in 34 subjects of healthy human volunteers, which were comprised 19 subjects of the age under 15 and 15 subjects over 16. It was given intramusculary in the deltoid muscle at 0, 1, and 6 months. Serum HBsAg, anti-HBs and anti-HBc were detected by enzyme immunoassay using Abbott kits. The aminotransferase (AST and ALT) activity were measured by automatic kinetic methods. The aminotransferase and HBV markers were checked at 0, 1, 2, 3, 6, 9 and 12 months. The results were as follows: 1) The anti-HBs response to the vaccine was seen in 11.8% at 1 month, 35.3% at 3 months, 73.5% at 6 months and 94.1% at 9 and 12 months. The anti-HBs response in group of age under 15 and over 16 were 10.5% and 13.3 % at 1 month, 36.8% and 33.8% at 3 months, 89.5% and 53.3% at 6 months, 100/o and 86.7% at 9 and 12 months respectively. Group of age under 15 showed a tendency of more higher anti-HBs response than group of age over 16, But there were no significance statistically. 2) Anti-HBs titer over 50mIU/ml were 47.1% at 6 months, 85.3% at 9 months, 91.2% at 12 months respectively. After third injection, the titers were markedly elevated than second injection (p<0.01). Anti-HBs titers over 50 mIU/ml in group of age under 15 and over 16 were 52.6% and 40.6% at 6 months, 100% and 66.9% at 9 months, 100% and 80% at 12 months respectively. Group of age under 15 showed a tendency of more higher anti-HBs titer, even though there were no significance statistically. 3) There were no abnarmal elevation of aminotransferase and no appearance of HBsAg, anti-HBc for 1 year follow-up. The main side effects after first vaccination were pain (8.S%) and redness (5.9%) at injection site, general weakness (5.9%), myalgia (5.9%) and transient febrile sensation (2.8%). Side effects after second vaccination were pain (5.9%) and redness (2.9%). There were no side effects after third vaccination. The results suggest that safety and immunogenicity of hepatitis B vaccine (Hepavax-B®) seems to be excellent. There was a tendency of more rapid anti-HBs response and higher anti-HBs titers in group of age under 15 than over 16.