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Functional Connectivity of the Hippocampus in Early- and vs. Late-Onset Alzheimer’s Disease
박기형,노영,최은정,김형식,천소현,손영돈 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4
Background and Purpose Early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) have different clinical and neuroimaging characteristics, but memory decline is usually present in both types. However, there have been few functional studies focused on the hippocampus in Alzheimer’s disease. We therefore investigated the functional connectivity between the hippocampus and other brain regions using resting-state fMRI and compared the findings between EOAD and LOAD. Methods We recruited 13 patients with EOAD and 19 patients with LOAD at the early disease stage. Twenty-one young controls and ten old controls were also recruited. Each participant completed a standardized neuropsychological battery of tests and underwent T1-weighted structural MRI. fMRI data were acquired during the resting state using 3-T MRI. The functional connectivity to the hippocampus was calculated based on automated anatomical labeling templates. Results The functional connectivity from the hippocampus to other brain regions differed between patients with EOAD and LOAD. The LOAD patients showed decreased hippocampal connectivity to cortical regions, such as to the middle temporal cortex, orbitofrontal cortex, postcentral cortex, supramarginal cortex, and rolandic operculum. In contrast, EOAD patients showed smaller functional changes of the cortical regions connected to the hippocampus, such as the middle frontal cortex. Conclusions EOAD and LOAD patients exhibited different hippocampal connectivity. The memory decline in EOAD may be due to brain areas other than the hippocampus.
DC Servo Motor를 이용한 초정밀 위치결정기구의 컴퓨터 시뮬레이션 및 제어성능 평가
박기형,김재열,윤성운,이규태,곽이구,송인석,한재호 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.6
Recently, High accuracy and precision arc required in various industrial field especially, semiconductor manufacturing apparatus, Ulna precision positioning apparatus, Information field and so on. Positioning technology is a very important one among them. As such technology has been rapidly developed, this field needs the positioning accuracy as high as submicron. It is expected that the accuracy of 10nm and 1nm is required in precision work and ultra precision work field, respectively by the beginning of 2000s. High speed and low vibration arc also needed. This work deals with the design method and control system of Ultra precision positioning apparatus. Control perfor-mance and stability analysis were performed in advance by modeling and designing the controller with Simulink.
[논문]거리변환알고리즘을 이용한 이동로봇의 경로 계획 및 추적
박기형,최영규 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-
본 논문에서 자율이동로봇의 효율적이고 안전한 주행을 위해서 경로계획과 추적 및 장애물 회피의 문제들이 다루어진다. 경로계획을 위해서 기존의 거리변환알고리즘의 검색순서를 단순화하고 경로재생성부분을 추가하여 개선시키고, 개선 된 거리변환알고리즘을 이용하여 기존의 방법에 의한 것보다 짧은 거리의 경로를 얻는다. 경로추적 단계에서는 퍼지 논리 제어기를 사용하여 경로추적 행위와 장애물회피 행위를 실행한다. 컴퓨터 시율레이션을 통하여 자율이동로봇의 주행에 적용된 본 연구방법의 효율성을 입증한다.
박기형,김성완,신동진,박현미,이영배,성영희,Park, Kee Hyung,Kim, Sung-Wan,Shin, Dong-Jin,Park, Hyun-Mi,Lee, Yeong-Bae,Seung, Young-Hee 대한생물정신의학회 2008 생물정신의학 Vol.15 No.1
Posterior cortical atrophy(PCA) is a presenile dementia that presents primarily with signs and symptoms of cortical visual dysfunction, while memory is relatively preserved until the late stage of the disease. We report a patient with PCA, confirmed by brain magnetic resonance imaging (MRI) and $F^{18}$-fluorodeoxyglucose positron emission tomography(FDG PET). A 58-year-old right-handed woman presented initially with visual dimness and difficulty finding things around her. She had partial Balint's syndrome, partial Gerstmann syndrome, and idiomotor apraxia. She also had a mild memory disturbance, but preserved insight of her disease. Neuropsychological evaluation showed decreased parietal and left temporal functions bilaterally. Brain MRI and $F^{18}$-FDG PET revealed typical bilateral occipitoparietal atrophy and hypometabolism, which were slightly worse on the right side. Cholinesterase inhibitor administration for 6 months improved the memory impairment slightly, but not the cortical visual dysfunction. This is a typical case of PCA, confirmed by neurologic signs and imaging findings.
박기형,임재성,서상원,정용,노영,Koh Seong-Ho,배재성,Park Sun Ah,Yang Soh-Jeong,김희진,Chin Juhee,노지훈,안성수,Academic Committee of the Korean Dementia Association 대한치매학회 2020 Dementia and Neurocognitive Disorders Vol.19 No.2
Because of repeated failures of clinical trials, the concept of Alzheimer's disease (AD) has been changing rapidly in recent years. As suggested by the National Institute on Aging and the Alzheimer's Association Research Framework, the diagnosis and classification of AD is now based on biomarkers rather than on symptoms, allowing more accurate identification of proper candidates for clinical trials by pathogenesis and disease stage. Recent development in neuroimaging has provided a way to reveal the complex dynamics of amyloid and tau in the brain in vivo, and studies of blood biomarkers are taking another leap forward in diagnosis and treatment of AD. In the field of basic and translational research, the development of animal models and a deeper understanding of the role of neuroinflammation are taking a step closer to clarifying the pathogenesis of AD. Development of big data and the Internet of Things is also incorporating dementia care and research into other aspects. Large-scale genetic research has identified genetic abnormalities that can provide a foundation for precision medicine along with the aforementioned digital technologies. Through the first international conference of the Korean Dementia Association, experts from all over the world gathered to exchange opinions with association members on these topics. The Academic Committee of the Korean Dementia Association briefly summarizes the contents of the lectures to convey the depth of the conference and discussions. This will be an important milestone in understanding the latest trends in AD's pathogenesis, diagnostic and therapeutic research and in establishing a future direction.