정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

레이저 코골이수술 후의 음성변화

손영익,정유석,윤영선,홍성화 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.3

변위 정보를 이용한 대형 우주 구조물의 강인 제어기에 관한 연구

손영익 동아대학교 정보기술연구소 2003 情報技術硏究所論文誌 Vol.10 No.2

A robust controller for large space structures(LSS) is studied from passivity point of view. We first show that the robust proportional-derivative (PD) control law for LSS has been designed under the passive property of the system. While velocity sensors are commonly used for PD control law to stabilize large space structures, if the structure can be controlled without velocity measurements, it is desirable against the failure of velocity sensors and for the cost reduction of the sensing system. In a recent result a dynamic output feedback control law has been provided using only displacement measurements. This paper provides an alternative stability analysis tool for the displacement feedback robust control law. The closed-loop system can be viewed as a feedback interconnection of a passive large space structure(LSS) and a strictly passive system. Consequently, the transfer function of the proposed control system has the form of sG(s) where the function G(s) is a transfer function of a strictly passive system.

인후두부 이물감을 호소하는 환자에서의 기질적 요인 및 심인성 요인의 중요성

손영익,권중근,이풍렬,이화영,유범희,김지혜 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.3

능력검정에 의한 우량 종봉 선발에 관한 연구

손영익,차용호,최광수 慶北大學校農業科學技術硏究所 2001 慶北大農學誌 Vol.19 No.-

The study was conducted to establish the method of performance test of honeybee queens under Korean environment. Colony performances of apis mellifera were tested based on wintering ability, colony population and honey yield in Sangju, Korea from November, 1999 ∼2000 season were averaged 22.6±2.6kg and 20.1±2.6kg, respectively, showing the decrease of 2.5 ±0.7kg. During 2000∼2001 winter season, the colony weight before wintering was 22.6±2.3kg and was decreased by 2.3± 0.6kg. The number of combs well covered with bees was 13.1± 4.6 as measured on the 22nd of May. 2000 and 16.0± 3.8 on the 21st of May. 2001, respectively. The rate of supering colonies were 50% and 98.5% in 2000 and 2001, respectively. The amount of honey production was 12.7± 8.6kg per colony in 2000, 14.2± 7.6kg per colony with unselected queens and 23.5± 4.9kg per colony with seleceted-tested queens in 2001, which were harvested two times during main nectar flow season of black locust, Robinia peseudoacasia.

예견퍼지 알고리즘을 사용한 트럭-트레일러의 자율주차 제어 시스템에 관한 연구

손준익,박희경,박재현,강신출,임영도 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1

본 논문에서는 예견퍼지 알고리즘을 사용하여 트럭-트레일러의 자율주차 제어 시스템의 시뮬레이션을 행한다. 트럭-트레일러의 전·후진 동특성 방정식을 설정하여 예견퍼지 제어기의 설계시에 사용하고, 새상 시스템으로도 사용한다. 제안한 알고리즘으로 시뮬레이션을 통해서 일정 지역내의 임의의 출발점에서 적절한 도중목표를 설정하여 전후진을 하면서 핸들조작 횟수가 적게 최종목표 위치에 잘 주차됨을 입증하였다.

자가지방을 이용한 성대주입술

손영익,박주현,이은경,신준호,추광철 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.12

토양미생물을 이용한 하수의 질소제거효율 향상

최영균,오동익,이종영,손대희 대구대학교 환경기술연구소 2005 미래환경기술 Vol.1 No.2

The effect of humus soil on biological denitrification was investigated through NUR batch tests. Specific denitrification rate of HMLE(Modified Ludzack Ettinger process combined with Humus soil contactor) and CMLE(Control Modified Ludzack Ettinger process) sludges as well as COD consumed for denitrification could be estimated from the batch tests. Two linear phases of denitrification rate could be observed when acetate was used as a carbon source. However, denitrification behavior was composed of three linear phases when a primary settled municipal wastewater(PW) was used as a carbon source. The specific denitrification rates on SBCOD(slowly biodegradable COD) fraction in raw wastewater were estimated 4.82 and 3.73 mg N/g VSS·hr when HMLE and CMLE sludge was used as a seed sludge. It means that the hydrolysis rate of HMLE sludge on SBCOD fraction was higher than that of CMLE sludge. Actinomycetes, one of the soil microorganisms, was estimated 150,000 actinomycetes/ml in the biomass of HMLE process, which was 10 times higher than that of CMLE process. Actinomycetes was well known for its distinguished hydrolyzing ability on particulate organic matter. Almost of input COD was utilized for denitrification and cell synthesis when HMLE sludge was used as a seed sludge in NUR batch test. While, about 70% of input COD was comsumed when CBNR sludge was used. It means that substrate utilization rate, especially SBCOD utilization rate, of HMLE sludge was higher than that of CMLE sludge.

미국과 일본의 생활체육에 관한 비교 연구

尹益善,金榮一 龍仁大學校 1996 용인대학교 논문집 Vol.12 No.-

1. Conclusion 1) The aspect of policy America has a policy which is being developed by its government. In fact, American government plays a leading role for stratificational development of its social physical education in cooperation with private organizations. 2) The aspect of administrative organization. The central government of America and each self-governing bodies are in full activities each other with due regard to each local trait. Especially, they make the most of natural environments, such as park, beach. There are three organizations in Japan ; national, private and company organization. They operate individually as well as together under the control of educational authorities, which belong to a department of education supports in many ways like making plans, financial aspect. 3) The aspect of facility In America, physical education facilities are concentrated in natural environments rather than school, for reference, Japanese school has less than 50% of their all facilities. Every fear, Natural Investigation committee try to improve various law and plans in such a way to meet the realistic needs of civil lives and social physical education. On the contrary, Japan has a slight tendency to depend on school facilities which is rising up to 50%∼60%. But they have lots of public and private facities as well.

두경부 악성종양 절제술 후 유리피판을 이용한 재건술 40예의 고찰

백정환,손영익,김성민,추광철,하범준,심영목 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7