청국장의 제조방법과 이용실태에 관한 조사연구

김태영,김진숙,장창문,신선영,유선미,최정숙,박홍주 한국콩연구회 1996 韓國콩硏究會誌 Vol.13 No.2

The preparation method for traditional Chung-Kuk-Jang at home was surveyed by 241 housewives through the country using premade questionnaires. The 84.2% of total respondents prepared Chung-Kuk-Jang at home, mostly from October to December (95.5%), once or twice per year (71.9%). Soybean for Chung-Kuk-Jang had a relatively large grain size, and average soaking and boiling time were 5.8 hr and 3.6 hr, respectively. Only 31% of respondents used rice straw for Chung-Kuk-Jang fermentation and 90% of respondents fermented Chung-Kuk-Jang in the Korean under-door heating system for 3 days (53.2%) or 2 days (20.2%). Average subsidiary ingredients for Chung-Kuk-Jang making were salt (8.5%), garlic(2.2%), redpepper-powder (0.2%). After mixing all ingredients, Chuag-Kuk-Jang in clay pot was kept in a cool place (38.4%) or refrigerator (38.4%). The 58.5% of total respondents had experience of purchasing commercial Chung-Kuk-Jang, mostly is the market (51.1%) or supermarket (40.4%) and the respondents, who were low-aged or high - educational level or live in apartment purchased the commercial products more often than the others. The reasons for purchasing commercial products were convenience (40.4%), short of time(34%) and the criteria for purchasing were odor (34.8%) and taste by previous experience (28.4%). Respondents preferred vinyl packing (83.7%) and 300g pack (52.5%) for. single usage. The 45.4% of respondents were not satisfied with the commercial products and the reason for dissatisfaction was inferior taste (56.3%), especially without taste peculiar to the Chung-Kuk-Jang. The necessities for improving quality of Chung-Kuk-Jang were to mask off - flavour (52.3%) and to preserve deterioration (30.7%).

Cushing`s Syndrome 환자의 마취 1 예 보고

박영철,박경숙,문숙희,김순점,길찬일,신정순 대한마취과학회 1982 Korean Journal of Anesthesiology Vol.15 No.3

We have experienced the anesthetic management of bilateral adrenalectomu in a 17-years old male, who was diagnosed as Cushing's syndrome. Anesthetic problems in Cushing's syndrome are hypertension, tachrcardia, hyperglycemia, hypokalemia and acute adrenal insufficiency. Therefore anesthetic management of this disease should focus on the thorough understanding of pathophysiology and adequate control of preoperative condition. Careful monitoring of the patient and frequent measurement of electrolytes and acid base balance status during the operation are also needed. We report the case of anesthetic experience of Cushing's syndrome and review anesthetic choice and management for better outcome of the patient.

UO2 소결체에 고온연소반응을 이용한 SiC 코팅

김봉구,최용,김정원,이영우,손동성,김길무 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.5

Multi-layer coating of silicon carbide and graphite on UO₂ nuclear pellet was carried out with a fluidized bed type chemical vapor deposition unit to enhance the inherent safety of the nuclear pellet and to develop a renovative coating process. Silane, propane and argon gases were used as the source and carrier gases to deposit silicon and pyrolytic carbon. Combustion reaction was performed in an inert argon atmosphere, which conditions were pre-determined by numerical evaluation of the combustion reaction between silicon and carbon to synthesize silicon carbide. Microstructural observation of the combustion products by scanning electron microscopy showed that the inner and outer pyrolytic carbon layers were equiaxed structure. Chemical analysis by Auger electron spectroscopy and X-ray diffractometry revealed that the middle layer formed by a combustion reaction was fine crystalline beta-silicon carbide.

말기 신부전증을 동반한 전신성 홍반성 낭창 환자에서 동종 신장이식 증례

김호연,박준철,민병석,김진숙,방병기,이영석,고용복,이용각,김용일 대한신장학회 1983 Kidney Research and Clinical Practice Vol.2 No.2

In systemic lupus erythematosus renal involvement is very common and it accounts for the leading cause of death of the disease. Since SLE is a systemic disease involving many organs and it is caused by altered immunological background many physicians tend to hesitate in employing hemodialysis and renal transplantation. We report the first renal transplantion in Korea which was performed in a patient with end-stage renal failure due to SLE. The patient had positive LE pre- parations, low serum complement, antibody to native DNA and renal biopsy showing diffuse proliferative lupus nephritis but she manifested decreasing clinical activity during hemodialysis. The patient received kidney allograft from living related donor after unilateral nephrectomy. There was no clinical or his- tological evidence of rejection or recurrence of lupus nephritis in the grafted kidney. The patient maintains normal renal function 18 months after renal trans- plantation.

위장관 간질종양의 임상 및 병리학적 고찰

김영호,장우영,이순진,손희정,최규완,도재혁,백승운,이준행,이풍렬,이종철,박철근,임윤정,김갑철,김재준,임효근 대한소화기학회 2001 대한소화기학회지 Vol.37 No.3

Background & Aims: Gastrointestinal stromal tumor (GIST) constitutes primary nonepithelial neoplasms of the gastrointestinal tract and includes most tumors previously designated as leiomyomas/leiomyosarcomas. GIST is pathologically divided into benign, borderline and malignanct tumor. This study was carried out to delineate the clinical and pathologic features of GIST and to establish the features predicting malignancy. Methods: Clinicopathologic data of 84 patients who had GIST from 1995 to 1999 were reviewed. Results: The subjects were 42 men and 42 women, and their mean age was 59.3±13.2 years. We located fifty-two tumors in the stomach, 28 tumors in the small intestine and 4 tumors in the colorectum years. Histopathology revealed benign tumors in 23 of the 84 patients, borderline tumors in 22, malignant tumors in 39. The average size of tumors was 6.23 cm in diameter (range, 0.6-26 cm). Metastasis was noted in 15.5% of the patients at diagnosis. On endoscopy, ulceration was more common in malignancy. Endsonographic findings except size were not significant statistically. On contrast enhanced computed tomography, malignancy showed more irregular shape and variable attenuation than benign lesions, which seemed to be valuable factor. Conclusions: The variables predicting malignancy were large tumor size (≥5 cm), location of the colorectum, palpable abdominal mass, ulceration on endoscopy, and less uniformity in shape and variable attenuation on computed tomography.

유지방의 특성과 변화

여영근,최병국,임아영,김효정,김수민,김대곤 한국유가공기술과학회 1998 Journal of Dairy Science and Biotechnology (JMSB) Vol.16 No.2

The lipids of milk provide energy and many essential nutrients for the newborn animal. They also have distinctive physical properties that affect the processing of dairy products. Milk fat globules mainly consist of neutral lipids like triacylglycerols, whereas the globule membranes contain the complex lipids mostly. Phospholipids are a small but important fraction of the milk lipids and are found mainly in the milk fat globule membrane and other membranous material in the skim-milk phase. The milk fats of ruminant animals are characterized by the presence of relatively high concentrations of short-chain fatty acids, especially butyric and hexanoic acids, which are rarely found in milks of non-ruminants. The fatty acids of milk lipids arise from de novo synthesis in the mammary gland and uptake from the circulating blood. The fatty acid compositions of milks are usually complex and distinctive, depending on the nature of the fatty acids synthesized de novo in the mammary gland and those received from the diet in each species. The content and composition of milks from different species vary widely: presumably, these are evolutionary adaptations to differing environments. The actual process by which these globules are formed is unkonwn, but there are indications that triglyceride-containing vesicles which bleb from endoplasmic reticulum may serve as nucleation sites for globules. Recent studies on milk have centred on the manipulation of milk lipids to increase specific fatty acids, i.e. 20-carbon omega-3 fatty acids (eicosapentaenoic acid 20:5n3, decosahexaenoic acid 22:6n3) from marine sources because the fatty acids are closely associated with a decreased risk of coronary heart disease.

니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

경량구조용 Magnesium 합금의 정밀주조 공정 개발

김영직,김세광 한국주조공학회 2001 한국주조공학회지 Vol.21 No.5

이소성 ACTH 의 분비에 의한 ACTH 증후군을 동반한 소세포폐암 1 예

김경희,조성태,유재명,우인숙,박명재,박영이,지제근 대한내과학회 1997 대한내과학회지 Vol.53 No.5

About 5% of patients with SCLC have the ectopic production of ACTH. Ectopic ACTH production of SCLC is suspected when patients of SCLC have unexplained metabolic alkalosis and hypokalemia. Most patients lack the classic feature of Cushing's syndrome. According to the recent report, they have poor prognosis, which median survival is less than 4 months and associated with a high rate of complication during chemotherapy. Also a case of paraneoplastic CRH production with SCLC can mimic the ectopic ACTH syndrome hut it can be distinguished by immunohistochemistry or direct measurement of serum CRH level. We report here a case of small cell lung cancer associated with Cushing's syndrome of ectopic ACTH production. That is immunohistochemically provened by staining with ACTH.

성인에서 반복적인 위장관출혈로 발현한 공장 거대 중복성 낭종

김영호,이경수,이상수,문원,강태욱,최규완,박동일,도재혁,백승운,이풍렬,이종철,김재준,류민규 대한내과학회 2001 대한내과학회지 Vol.61 No.3

Duplication of the alimentary tract is an unusual congenital anomaly which may occur at any level, from the oral cavity to the rectum. Jejunal duplication cyst is quite rare and most of them are presented in infancy with the symptoms of abdominal mass, obstruction, hemorrhage and perforation. But some cases has not been diagnosed till adult if duplication cyst was too small enough to cause symptoms. We report a case of a 28-year-old woman who presented with recurrent gastrointestinal hemorrhage as a result of an ulceration without ectopic mucosa in jejunal duplication cyst and was successfully treated with surgery.(Korean J Med 61:264-269, 2001)