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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
P124 : The efficacy and safety of cryo fat reduction in the treatment of pseudogynecomastia
( Jung Tae Park ),( Bori Kim ),( Sang Young Byun ),( Soon Hyo Kwon ),( Jung Won Shin ),( Kyoung Chan Park ),( Jung Im Na ),( Chang Hun Huh ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Options for the treatment of pseudogynecomastia, a condition of enlarged male breast primarily due to the accumulation of adipose tissue, have been limited, including weight reduction and surgical liposuction. Cryo fat reduction provides noninvasive, selective, localized subcutaneous adipocyte destruction without epidermal or dermal injury by inducing adipocyte apoptosis. Objectives: This study was designed to evaluate the efficacy of cryo fat reduction in the treatment of pseudogynecomastia. Methods: In this prospective, 28-week trial, 12 male patients with psudogynecomastia were treated with cryo fat reduction twice bimonthly. Efficacy was determined by breast circumference measurement, ultrasonographic measurement of subcutaneous layer thickness, physician’s global photographic assessment, and patient’s satisfaction at baseline at week 4, week 8, week 16 and week 28. Safety was evaluated by questionnaire at each visit. Results: For the 11 subjects completing the trial, breast circumference and thickness of fat layer determined by ultasonography significantly improved at week 8, andgradually reduced until week 28. Physician’s photographic assessment and patient’s satisfaction showed significant improvement at each visit. No adverse event was observed except transient pain immediately after the treatment and bruise at the treated site. Conclusion: Cryo fat reduction is a safe and effective therapeutic option of the treatment of pseudogynecomastia.
Na Gyeong Geum(Na Gyeong Geum),Ju Hyeong Yu(Ju Hyeong Yu),So Jung Park(So Jung Park),Min Yeong Choi(Min Yeong Choi),Jae Won Lee(Jae Won Lee),Gwang Hun Park(Gwang Hun Park),Hae-Yun Kwon(Hae-Yun Kwon),J 한국자원식물학회 2022 한국자원식물학회지 Vol.35 No.6
Under the COVID-19 pandemic, interest in immune enhancement is increasing. Although the immune-enhancing activity of plants of the genus Hibiscus has been reported, there is no study on the immune-enhancing activity of H. syriacus. Thus, in this study, we investigated the immune-enhancing activity of Hibiscus syriacus leaves (HSL) in mouse macrophages, RAW264.7 cells, and immunosuppressed mice. HSL increased the production of immunostimulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) and activated the phagocytosis in RAW264.7 cells. The HSL-mediated production of immunostimulatory factors was dependent on toll-like receptor 4 (TLR4), p38, and c-Jun N-terminal kinase (JNK) in RAW264.7 cells. In the immunosuppressed mouse model, HSL increased the spleen index, the levels of the cytokines, and the numbers of lymphocytes, neutrophils, and monocytes. Taken together, HSL may be considered to have immune-enhancing activity and be expected to be used as a potential immune-enhancing agent.
춘계학술대회 : 포스터전시 ; 과호산구증후군 간 침범시 발견된 Rosette 형성에 관한 전자 현미경적 관찰: 만성 바이러스성 간염과의 비교
( Su Jung Baik ),( Yoon Joo Na ),( Hae Sun Jung ),( Chang Yoon Ha ),( Min Jung Kang ),( Ji Min Jung ),( Hyun Joo Song ),( Tae Hun Kim ),( Ki Nam Shim ),( Sung Ae Jung ),( Kwon Yoo ),( Kyu Won Chung ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)
춘계학술대회 : 포스터전시 ; 만성 C형간염환자에서 인터페론과 리바비린 치료 중 발생한 허헐성 대장염
( Su Jung Baik ),( Tae Hun Kim ),( Yoon Joo Na ),( Hae Sun Jung ),( Chang Yoon Ha ),( Min Jung Kang ),( Ji Min Jung ),( Hyun Joo Song ),( Hye Jung Yeom ),( Ki Nam Shim ),( Sung Ae Jung ),( Kwon Yoo ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)
춘계학술대회 : 포스터전시 ; 만성 간질환에서 간 신경 섬유 변성에 대한 전자 현미경적 연구
( Su Jung Baik ),( Yoon Joo Na ),( Hae Sun Jung ),( Chang Yoon Ha ),( Min Jung Kang ),( Ji Min Jung ),( Hyun Joo Song ),( Ki Nam Shim ),( Tae Hun Kim ),( Sung Ae Jung ),( Kwon Yoo ),( Kyu Won Chung ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)
나정임 ( Jung-im Na ),박정태 ( Jung Tae Park ),김보리 ( Bo Ri Kim ),김인수 ( In Su Kim ),최지웅 ( Woong Choi ),황영지 ( Young Ji Hwang ),신정원 ( Jung-won Shin ),허창훈 ( Chang Hun Huh ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.4
Carbon dioxide (CO2) laser is one of the most widely used lasers in dermatology. CO2 laser can precisely ablate the skin with good hemostasis, which makes it an ideal surgical laser. With the development of pulsed CO2 laser, which enabled cleaner ablation with less residual thermal damage, CO2 laser resurfacing became the gold standard for skin rejuvenation. The rejuvenation effect of full-face CO2 laser resurfacing is unparalleled to other methods; however, it is associated with a relative high incidence of side effects and prolonged downtime. Fractional CO2 laser was developed to overcome this problem. With a new technology of fractionating the laser beam into hundreds of microbeams, fractional CO2 laser resurfacing can improve various skin conditions including skin laxity, photodamage, and acne scars with short downtime and significantly lesser side effects. For optimal treatment results, clinicians have to decide the treatment depth and density based on proper understanding of the laser tissue interaction and underlying skin conditions. (Korean J Dermatol 2016;54(4):233~240)
춘계학술대회 : 포스터전시 ; 장기간 라미부딘 치료 만성 B형간염환자에서 YMDD 돌연변이를 동반하지 않은 라미부딘 내성 바이러스의 검출
( Su Jung Baik ),( Kwon Yoo ),( Yoon Joo Na ),( Hae Sun Jung ),( Chang Yoon Ha ),( Min Jung Kang ),( Ji Min Jung ),( Hyun Joo Song ),( Hye Jung Yeom ),( Tae Hun Kim ),( Ki Nam Shim ),( Sung Ae Jung ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)