정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

컬링 경기의 팀 수준간 작전 비교

조기정,백종철 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study set out to compare and analyze the strategy used by excellent male curling teams and non-excellent ones in an attempt to see if there were any differences between them based on the idea that strategy affect the results of games. For that purpose, total ten curling male teams that competed in the 2003 National Winter Athletic Games were chosen. Four of them were defined excellent while the rest six non-excellent. Among the total 1,385 strategy used by the 40 players of the ten teams, 1,124 that were identified as successful were selected. A 6㎜ Camcorder was used to tape the games, which were played using a VTR. The game data was put down on the recording document by the investigator in order to increase the validity. Based on the data recorded on the document, the frequencies were presented in percentage and x² tested according to the research purposes. Those research methods and processes led to the following results: First, there were significant differences between the excellent and non-excellent teams in strategy. Among the subcategories of the strategy, there were significant differences between the two groups in the draw strategy. Second, there were found significant differences in the strategy by ends during the early ends including End 1, 2, and 3 out of the ten ends between the two groups. Third, the two group of teams showed significant differences in the skip strategy among the strategy by positions.

상업스포츠 시설의 서비스 품질평가에 대한 소고

조기정,정영남 한국스포츠산업경영학회 1998 한국스포츠산업경영학회지 Vol.3 No.1

국민들의 스포츠활동의 욕구를 수용하고 있는 상업스포츠 시설은 양적인 증가를 보이고 있음에도 불구하고 이용자들의 만족도는 낮게 나타나고 있다. 상업스포츠 시설에 대한 의존도가 높아지고 있는 현시점에서 체계적이고 설득력이 높은 상업스포츠 시설의 서비스 품질 평가 모형 개발을 통하여 서비스에 대한 실증적 평가를 할 수 있는 근거를 제시해 주는 것은 매우 중요하다. 따라서 본고에서는 상업스포츠 시설의 특성을 파악해 보고 이를 토대로 하여 Parasuraman, Zelthaml, & Berry(1985)의 SERVQUAL(service quality) 모델에서 사용한 10가지 측정 항목, 즉, 신뢰성(reliability), 반응성(responsiveness), 능력(competence), 접근성(accessiveness), 예절(courtesy), 의사소통(communication), 신용성(credibility), 안정성(security), 이해성(understanding), 유형성(tanglbles)을 중심으로 상업스포츠 시설에서의 서비스 품질 평가문항을 제시하였다. 향후 상업스포츠 시설 이용 고객의 만족 방안을 모색하는데 기초 자료로 제공 되었으면 한다. This study consists of empirical investigations on the relationship of customer satisfaction & service quality in using commercial sport facilities. (1) commercial sport facilities as a service industry and customer satisfaction. (2) the relationship of customer satisfaction & service quality in using commercial sport facilities, and then browsing in the data on ten measurements used in Parasuraman, Zeithaml, & Berry's Servqual models as service marketing studies. (3) theoretical survey on service quality evaluation in using commercial sport facilities. Afterwards, this study supplies basic data for prospective researchers on service quality evaluation in using commercial sport facilities. In the end, this kind of study will improve customer satisfaction scale, and revitalize 'sport for all' movements. The main subjects in commercial sport services are customers, and then paticipation in the service field in a necessity. Customer types are individualized, and then depend on personal characteristics. Commercial sport facilities are individual on certain group's properties. Their first aim is to make money, using their properties in the name of sport facility. Their service traits are intangibility, inseparability, variability, perishability, and subjectivity in addition. Service quality evaluation, or supply of high-quality services in an affective strategy for service goods positioning on the market. Reliability, responsiveness, ability, proximity, etiquette, communication, credibility, safety, understandability, and types are ten measurements to evaluate service quality. Utilizing these elements in developing service quality evaluation item, the evaluation item model according to each dimension & definition plays a key role in evaluating commercial sport quality.

유도 허벅다리 걸기 동작시 주동근의 동원양상 분석

조기정,한동성 한국학교체육학회 2002 한국학교 체육학회지 Vol.12 No.1

The purpose of this study was to verify what major muscles are during Judo uchimata, and analyze major muscle type on recruitment during repeated uchimata. 16 university students(male) were participated in the exercise test. The subject were divided into two groups; expert(N=8) and non-expert(N=8). Electromyogram test was analyzed muscle type on recruitment during repeated uchimata by surface electrode. Major muscle was measured by Integrated EMC in pre-test while seoi-otoshi 3 times. The results of this study as follows: 1. In expert goop on Judo uchimata showed that major muscle of upper limb was measured Left Brachi oradialis, Left Trapezeius, Right Brachi oradialis, Left Deltoid, and major muscle of lower limb was Left Rectusfemoris, Left Castrocnemius. 2. Non-expert group on Judo Uchimata showed that major muscle of upper limb was measured Left Brachi oradialis, Left Trapezeius, Left Biceps brachii , Left Deltoid, and major muscle of lower limb was Left Rectusfemoris, Left Biceps femoris.

제조업 근로자의 수면실태에 관한 조사

노정균,류기하,이영수,조영채 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

산업체 근로자의 수면실태를 조사하고자 1993년 3월에 한 고무제품 제조업 근로자 479명을 대상으로 수면양상에 대한 설문조사를 실시한 결과는 다음과 같다. 1. 전체 조사대상자의 수면장애 유병율은 32.8%였으며, 수면장애의 유형별로는 취면곤란 11.9%, 수면유지곤란6.1%, 조조각성이 6.9%였다. 2. 연령군별 수면유지곤란은 20대가 가장 낮았고 30대가 가장 높았으며, 취침전 진정제 또는 알코올을 이용한 군의 수면장애가 비사용군에 비해 현저히 높게 나타났다. 3. 직업이나 가정에 대해 만족하는 군일수록 수면장애가 불만족군에 비해 낮았으며, 낮잠을 자는 군, 신체적 통증이 없는 군일수록 적게 나타났다. 4. 수면장애에 대한 회귀분석결과 통계적 유의성을 보인 변수는 낮잠여부, 신체적 통증여부 및 근무기간이었다. This study was conducted to investigate sleep qualitys of manufacturing workers. The data were collected from the 479 manufacturing factory workers who were most 3 shift workers. The results obtained were as follows. The prevalence rate of sleep disorder was 32.8%, rate of difficulty in intiating sleep was 11.9%, that of difficulty in maintaining sleep was 6.1%, and that of early morning awakening was 6.9%. Disorders of difficulty in maintaining sleep was low in the age group of twenties and high in thirties. The group of sedative or alcohol use before sleep induction showed high prevalence rate of sleep disorder. The group of satisfying for job or family had the lower rate of sleep disorder than the unsatisfying group. The rate of sleep disorder were low in the group of day sleeping, no physical pain. The variables such as day sleep, physical pain and job tenure showed statistical significance in the logistic regression of sleep disorder.

장기간 수지침 및 뜸요법 처치후 혈중 지질 농도 변화

김효재,정한영,조기정 한국학교체육학회 2001 한국학교 체육학회지 Vol.11 No.2

이 연구는 수지요법이 건강관련 요인에 미치는 영향을 구명하기 위하여 서울시에 거주하는 40세에서 45세 사이의 어떠한 질병치료도 받고 있지 않는 건강한 성인중 뜸요법집단 (N=5명), 뜸과 수지침 자극집단 (N=5명)으로 총 10명을 연구의 대상으로 선정하였다. 실험은 3개월간 걸쳐서 매주 3회씩 실시하였으며 채혈은 전완정맥에서 실시하였으며, 채혈시기는 실험전, 실험 1개월, 3개월 후에 채혈하여 분석하였다. 이 연구의 주요 결과는 뜸요법집단과 뜸, 침자극 집단간의 ALT농도는 유의한 차가 없는 것으로 나타났지만 기술통계 측면에서 살펴볼 때 두 집단간의 자극전, 후의 ALT농도는 group I은 12.08 ± 3.39U/ I에서 15.80 ± 4.92U/ I로 증가의 경향을 보인 반면, group Ⅱ는 뜸침자극 전 (24.20 ± 9.99U/ I)에 비해, 처치 후 (20.4 ± 8.91U/ I)로 감소하는 것으로 나타났다. 그리고, 3개월간의 자극처치 후 AST, HDL, LDL, TC, Total Cholesterol의 농도에서는 감소하는 경향으로 나타났다. The purpose of the present study was to investigate the realationship of palm acupuncture and heating stress on blood lipid profiles in healthy mid-aged adults. Ten subjects were participated in the study, and compared two regimens of palm heating stress group (N=5) and concurrent trial of palm acupuncture and heating stress group (N=5). The trials were lasted for three months and drown blood before and after one and three months. The majoring finding was that no difference in ALT was found between the groups, but the trendly of increased in both groups after three month application of palm acupuncture and heating stress. The trend of decrease in AST, HDL, LDL, TC, TC after three months application of palm acupuncture and heating stress.

Disciplinary Measurement & Evaluation in Physical Education : 운동기능평가에서의 축자확률비검사의 활용가능성

Ki Jeoung Cho 한국체육학회 1996 국제스포츠과학 학술대회 Vol.1996 No.2

MINDO/3 Theoretical Studies on Sigmatropic Hydrogen Rearrangements (Ⅱ): Systems with Central Nitrogen Atom$^*$

Cho, Jeoung-Ki,Lee, Ik-Choon,Oh, Hyuck-Keun,Cho, In-Ho Korean Chemical Society 1984 Bulletin of the Korean Chemical Society Vol.5 No.5

MINDO/3 theoretical studies were carried out on sigmatropic hydrogen rearrangements in systems with central nitrogen atom; three systems studied being (1) N-methylformaldimine, (2) nitrous acid, and (3) formaldoxime-nitrosomethane systems. It was found that in system (1), 1,3-H shift is preferred whereas in systems (2) and (3), 1,2-H shifts are favored. The relative order of reactivity for the three systems was found to be (2) < (3) < (1), which is exactly the opposite to that found for the corresponding systems with central carbon atom.

축차확률비검사의 신뢰도 추정에 관한 고찰

조기정(Cho Ki-Jeoung),이수영(Lee Su-Young),이용화(Lee Young-Hwa) 한국체육과학회 2000 한국체육과학회지 Vol.9 No.2

The purpose of this study is to scrutinize reliability estimation of sequential probability ratio test (SPRT) with a theoretical viewpoint. The reliability of SPRT, being a sort of criterion-referenced test (CRT), is defined as classification consistancy. Thus, the classification of the mastery & nonmastery of the first test is expected to be a similar classification in the secondary test. P, k, kq, kmax & etc. are being introduced as evaluation metheds on reliability. p is testee's ratio being classified with consistancy in the condition of coincidental factors. And k & kq, except for coincidental factors, are said to be classifition consistancy ratios in both of two tests. Each researcher has different opinion on the evaluation methods of reliability. Accordingly, it is important to suggest all of the above-mentioned evaluation methods.

운동기능평가에서 축차확률비검사의 이론적 고찰

조기정(Cho Ki Jeoung) 한국체육측정평가학회 1999 한국체육측정평가학회지 Vol.1 No.2