단체놀이활동이 초등학생의 행동체력과 인성변화에 미치는 영향

장봉희,홍관이 강원대학교 체육과학연구소 2001 江原大學校附設體育科學硏究所論文集 Vol.- No.24

The purpose of this study was to examine in which way the active physical fitness and personality change of elementary school students were affected by programs constituted by group plays they contacted in daily living. The subjects in this study were 60 elementary school students in I-kun, K Province, who were divided into experimental and control groups. The 32-member experimental group were engaged in group play for 10 weeks, five times a week, 40 minutes each, and the 28-member control group was blocked from group play activities. The group play used in this study included snail house play, 8-shape play, the 38th-parallel play, turning round in triangular form, peanut play and squid play. To measure active physical fitness, speed, explosive muscular strength, muscular endurance, cardiorespiratory endurance, agility, balance and flexibility were tested. And the personality was tested by the Korea Psychological Advisory Research Institute's special personality inventory A. The pretest and posttest results were analyzed with SAS program, and t-test was conducted to test the research questions. The findings of this study were as below: 1.The group play activities served to develop the speed, explosive muscular strength, cardiorespiratory endurance, agility and balance of the boy students. 2.For the girl students, speed, muscular endurance, agility, balance and flexibility got better after engaged in group play activities. 3.The group play activities brought a positive change to the self- esteem and stress of the boy students. 4.The group play activities resulted in lowering the sex role security of the girl students, but their stress and deviant behavior control showed a positive change.

Real-Time External Compensation of Threshold Voltage Shift Using Double-Gate Oxide TFTs in a Gate Driving System

You, Bong-Hyun,Lee, Soo-Yeon,Hong, Seok-Ha,Lee, Jae-Hoon,Kim, Hyun-Chang,Ju, Ha-Ram,Choi, Moon-Chul,Jeong, Deog-Kyoon IEEE 2016 Journal of display technology Vol.12 No.9

<P>In order to suppress the malfunction caused by the shift of the threshold voltage (V-TH) of oxide thin film transistors (TFTs) to a negative value, double-gate TFTs are used in the shift register of the gate driving system to control V-TH by adjusting the top gate bias. The proposed circuit detects the current consumption of the shift register and adjusts V-TH so that the current consumption of the shift register is regulated within the desired value. The system includes a compensation algorithm, which can search for an optimized top gate bias in various circumstances such as process fluctuations and ambient temperature change. The proposed system provides a stable operation compared with a conventional structure especially at high temperature. Experimental results show that, in the conventional system without compensation, the output voltage of the shift register deteriorates at 80 degrees C and above, and the power consumption increases from 1.15 to 2.14 mW after 21600 s of continuous operation at 60 degrees C. On the other hand, the proposed system provides a stable gate output up to 100 degrees C and keeps the power consumption below 1.10 mW by adjusting the top gate bias responding to environment changes.</P>

Genome-Wide Analysis of DNA Methylation before- and after Exercise in the Thoroughbred Horse with MeDIP-Seq

Gim, Jeong-An,Hong, Chang Pyo,Kim, Dae-Soo,Moon, Jae-Woo,Choi, Yuri,Eo, Jungwoo,Kwon, Yun-Jeong,Lee, Ja-Rang,Jung, Yi-Deun,Bae, Jin-Han,Choi, Bong-Hwan,Ko, Junsu,Song, Sanghoon,Ahn, Kung,Ha, Hong-Seok Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.3

Athletic performance is an important criteria used for the selection of superior horses. However, little is known about exercise-related epigenetic processes in the horse. DNA methylation is a key mechanism for regulating gene expression in response to environmental changes. We carried out comparative genomic analysis of genome-wide DNA methylation profiles in the blood samples of two different thoroughbred horses before and after exercise by methylated-DNA immunoprecipitation sequencing (MeDIP-Seq). Differentially methylated regions (DMRs) in the pre-and post-exercise blood samples of superior and inferior horses were identified. Exercise altered the methylation patterns. After 30 min of exercise, 596 genes were hypomethy-lated and 715 genes were hypermethylated in the superior horse, whereas in the inferior horse, 868 genes were hypomethylated and 794 genes were hypermethylated. These genes were analyzed based on gene ontology (GO) annotations and the exercise-related pathway patterns in the two horses were compared. After exercise, gene regions related to cell division and adhesion were hypermethylated in the superior horse, whereas regions related to cell signaling and transport were hypermethylated in the inferior horse. Analysis of the distribution of methylated CpG islands confirmed the hypomethylation in the gene-body methylation regions after exercise. The methylation patterns of transposable elements also changed after exercise. Long interspersed nuclear elements (LINEs) showed abundance of DMRs. Collectively, our results serve as a basis to study exercise-based reprogramming of epigenetic traits.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국인의 우울증 진단기준의 특성

장성만,손지훈,이준영,최지환,조성진,전홍진,함봉진,이동현,조맹제 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

목적 국내의 여러 역학 조사에 따르면 한국인은 서구에 비하여 우울증의 유병률이 낮은 것으로 보고되고 있다. 낮은 유병률에 대하여 서구에서 정의하는 우울증의 진단 기준이 한국인의 문화에 맞지 않다는 진단 기준의 오류를 제시하거나, 실제로 유병률이 낮다는 설명을 시도하기도 하였다. 본 연구는 DSM-IV에서 제시하는 우울증의 진단 기준에 대하여 한국인의 반응 특성을 알아보고자 한다. 방법 2001년 KECA 연구에 응답한 만 18세 이상 65세 미만의 6,275명을 대상으로 하였다. 한국어판 CIDI (K-CIDI)를 통해 정신장애의 이환을 진단하였으며, K-CIDI 내의 우울장애 진단 기준만을 추출하여 분석하였다. 분석은 문항반응이론(Item Response Theory)을 적용하였다. 결과 한국인에서 DSM-IV의 주요우울장애 진단 기준의 오류는 없었으나, 진단 기준의 역치는 높았다. 한국인이 호소하는 우울증상으로서 "피로감"과 "집중력 저하", "수면 변화"는 진단되는 우울증의 초기부터 잘 나타나는 증상 들이며, "정선운동변화", "죽음/자살사고", "무가치함/죄책감"은 보다 심한 우울증에서 잘 나타나는 증상들이었다. 결론 DSM-IV가 제시하는 주요우울장애 진단 기준은 한국인의 우울증을 평가하는 데 있어 타당하기는 하나, 진단 기준의 역치가 높다. 우울증의 중증도에 따라 호소하는 증상들이 달랐다. Baekgrounds : Many Korean epidemiologic studies reported lower prevalence rates of depression than those of Western countries. For the low prevalence, it is explained that there's something wrong in the direct application of diagnostic criteria of depression to Korean culture, i.e. categorical fallacy, or it may be truly low-prevalent. We will analyze diagnostic criteria for depression detined by Western. Methods : Six thousand and two hundred seventy-five cummunity dwelling subjects, aged 18-64 years were interviewed by using Korean version of Composite International Diagnostic Interview (K-CIDI). Diagnostic criteria for depression defined by DSM-IV were analyzed using the item response theory. Rcsults : We could not find any fallacies of diagnostic critcria tbr depression defined by DSM-IV when assessing depre-ssion among Koreans. Fatigue, concentration difficultics, and sleep disturbance appeared more fequently in mild depression, while psychomotor change, death/suicide, and worthlessness/guilt did not appear until severe depression. Cunclusion : The diagnostic criteria for depression defined by DSM-IV arc appropriate for the Koreans. There are different responding levels, i.e. threshold, of depressive criteria according to severities of depression. Koreans with depression are more likely to complain of appetite change, but less of worthless or guilty feelings than Western people.

콘크리트가 RC 인장부재의 인장거동에 미치는 영향

홍창우,김남윤,윤경구,이봉학 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

This paper presents evaluation results of the tensile behavior of reinforced high strength concrete. The effects of different sizes of reinforcing bar, ranging from D22 to D29, on the formation of cracks was investigated. Two different strength concretes, 270kg/㎠ and 550kg/㎠, were used in the specimens to investigate the influence if concrete strength on tension stiffening. In the present investigation a method was developed to obtain reliable load-deformation behavior in tension. The experimental results show that (1) high-strength concrete members exhibited larger amounts of tension stiffening than the companion normal-strength concrete members, (2) as the bar diameter increases, the beneficial influence of high-strength concrete on tension stiffening is reduced.

직접인장 모드에 의한 신·구콘크리트의 부착강도 특성 분석

이봉학,홍창우,김동호,김성환 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

본 연구에서는 부착 특성평가를 위하여 코어깊이, 덧씌우기 두께, 기존 콘크리트와 덧씌우기 재료의 탄성계수비, Steel Disk의 두께를 변화하여 유한요소해석을 실시하였다. 이때 부착면에 발생한 응력의 특성을 비교하여 응력집중계수를 산출하여 최적의 직접인장시험 기준을 마련하고자 하였다. 제안된 실험 방법의 검증을 위하여 보통콘크리트와 초속경 라텍스 개질 콘크리트를 사용하여 실내실험을 실시하였다. 이 두 재료의 부착강도특성을 분석하기 위해서 보통콘크리트와 라텍스 개질 콘크리트로 구성된 복합콘크리트 슬래브를 제작하여 직접인발실험(Pull-out test)을 실시하였다. 주요 실험변수로써 코어직경, 코어깊이, 부착면의 수분상태에 따른 초속경 라텍스 개질 콘크리트의 부착강도 특성을 분석하였다. Significant improvements in the bond strength between new and existing concretes can be achieved through the modification of the new concrete by latex modification. But, no test method has been adopted as a standard to measure the bond strength between the concretes used to repair and the substrate being repaired. The performance of old and the new concretes construction depends upon bond strength between old and the new concretes. Current adhesive strength measurement method ignores the effect of stress concentration by shape of specimens. Therefore, this research calculated stress concentration coefficient using finite element analysis and direction tensile strength test (pull-off test). The result showed that the minimum required core depth was 2.5㎝. Elastic modulus and overlay thickness did not affect to stress concentration.

조기탈형을 위한 라텍스 개질 초속경 콘크리트의 개발 및 강도발현 특성

이봉학,홍창우,이주형,정원경 강원대학교 석재복합신소재제품연구센터 2001 석재연 논문집 Vol.6 No.-

현재 스틸렌-부타디엔 라텍스(styrene-butadiene latex)를 혼입한 콘크리트는 광범위하게 사용되고 있다. 교면포장용으로 라텍스 개질 콘크리트(LMC)의 사용은 일반 콘크리트와 다르지 않지만 라텍스에 의해 콘크리트의 특성을 향상시킨다. 그러나, 이와 같은 라텍스 개질 콘크리트와 다르지 않지만 라텍스에 의해 콘크리트의 특성을 향상시킨다. 그러나, 이와 같은 라텍스 개질 콘크리트는 장시간 양생을 요하는 문제로 인해 긴급을 요하는 곳에는 적용할 수 없다. 따라서 본 연구에서는 초속경시멘트를 사용한 라텍스 개질 콘크리트를 개발하고, 이에 따른 작업성 및 강도발현특성을 분석하는데 그 목적이 있다. 실험결과, 지연제와 소포제를 사용한 라텍스 개질 초속경 콘크리트(RSLMC)의 강도발현을 확인할 수 있었으며, 제안된 최적배합은 초속경성의 강도발현으로 인해 현장에서 긴급보수에 적용이 가능함을 알 수 있었다. 따라서 라텍스 개질 초속경 콘크리트는 교면포장, 포장체, 빌딩등의 보수에 적용이 가능할 것으로 판단된다. Concrete containing styrene-butadiene latex is widely used, nowadays, as a protective system for bridge. The usage of latex modified concrete (LMC) as an overlay system is not all that different from any quality concrete, but the improved properties impart to the concrete by the latex. However, this may not be used for repair works because the bridge lane could not be closed for several weeks for curing. Therefore, this study focused on the development of rapid-setting cement latex modified concrete (RSLMC), and on the investigation of workability and strength development. As a result, this study clearly validated the strength development of RSLMC by introducing a retarder and an antifoam agent. The proposed optimized concrete mixtures might be satisfactorily applied for the repair works in fields, because of its rapid strength development, respectively. Therefore, RSLMC could be used in many repair or overlay works such as bridge deck, pavement or building.

시멘트 종류에 따른 SB 라텍스 개질 콘크리트의 강도 및 투수특성

이봉학,홍창우,이주형,김동호 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

This study focused on the investigation of strength development and permeability of LMC(Latex Modified Concrete) and RSLM(Rapid-Setting Cement Latex Modified Concrete) as the latex content cement types and s/c ratio changed. The compressive strength of latex modified concrete decreased slightly and the flexural strength increased quitely at 15% of latex content. This may be due to the flexibility of latex filled in voids and interconnections of hydrated cement and aggregates by a film of latex particles, respectively. The permeability test results showed that the permeability of LMC was considerably lower than that of conventional concrete. Results of chloride permeability test, for RSLMC indicated very low at an early age caused by the early formation of needle-shape ettringites and latex film.

유한요소해석을 이용한 현장 덧씌우기 콘크리트의 부착강도 평가 방법 제안

이봉학,홍창우,이주형,김성환 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

Significant improvements in bond strength between new and existing concrete can be achieved through the modification of the new concrete by latex modification. But, no test method has been adopted as a standard to measure the bond strength between the concrete used to repair and the substrate being repaired. The performance of old and the new concrete construction defends upon band strength between old and the new concrete. Current adhesion strength measurement method is inaccurate method that ignore effect of stress concentration by shape of specimens. Therefore, this research calculates stress concentration coefficient using finite element analysis and direction tensile strength test (pull-off test). The result shows that the required core depth is 2.5cm. Elastic modulus and overlay thickness do not influence in stress concentration.