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      • <i>Helicobacter pylori</i> infection and histological changes in siblings of young gastric cancer patients

        Nam,,Ji,Hyung,Choi,,Il,Ju,Cho,,Soo‐,Jeong,Kim,,Chan,Gyoo,Lee,,Jong,Yeul,Nam,,Su,Youn,Park,,Sook,Ryun,Kook,,Myeong‐,Cherl,Nam,,Byung‐,Ho,Kim,,Young‐,Woo Blackwell Publishing Asia 2011 Journal of gastroenterology and hepatology Vol.26 No.7

        <P><B>Abstract</B></P><P><B>Background and Aim: </B> <I>Helicobacter pylori</I> infection is a risk factor for gastric cancer. We evaluated whether <I>H. pylori</I> infection and premalignant histological changes are more prevalent in siblings of young gastric cancer patients.</P><P><B>Methods: </B> Young (age ≤ 40) gastric cancer patients (<I>n</I> = 185), their young siblings (<I>n</I> = 130), and young control participants (<I>n</I> = 287) were recruited. <I>H. pylori</I> infection and histological changes were assessed using the updated Sydney system in biopsy specimens from three regions. We analyzed the association of <I>H. pylori</I> infection and histological changes with gastric cancer using logistic regression analysis.</P><P><B>Results: </B> The <I>H. pylori</I> infection rate was significantly higher in young cancer patients than their siblings (odds ratio [OR] = 2.42, <I>P</I> = 0.001) or control participants (OR = 3.60, <I>P</I> < 0.001). In <I>H. pylori</I>‐infected subjects, corpus gastritis and premalignant changes of the corpus lesser curvature (LCv) were also more prevalent in patients than in siblings or controls. In terms of the antrum, intestinal metaplasia was more prevalent in <I>H. pylori</I>‐infected patients than in siblings or controls, while atrophy was not affected. Siblings also had a higher <I>H. pylori</I> infection rate (OR = 1.60, <I>P</I> = 0.046) and higher prevalence of intestinal metaplasia at the corpus LCv (OR = 2.88, <I>P</I> = 0.027) than control participants.</P><P><B>Conclusions: </B> Even in young adults, <I>H. pylori</I> infection is a risk factor for gastric cancer. Young adults with histological findings including corpus predominant gastritis, corpus atrophy, or intestinal metaplasia are at increased risk. Since young siblings share risk factors, screening and treatment should be considered for these family members.</P>

      • KCI등재

        The Prevalence and Characterization of Cerebral Microbleeds in Young People Having Intracerebral Hemorrhage

        Young-Min,Lee,Hae-Won,Koo,Hyung,Koo,Kang,,M.D.,Jin,Woo,Kim,Seong,Rok,Han,윤상원,Chan,Young,Choi,손문준,Chae,Heuck,Lee 대한뇌혈관외과학회 2018 Journal of Cerebrovascular and Endovascular Neuros Vol.20 No.2

        Objective : Cerebral microbleeds (CMBs) are known as the neuroimaging markers of risk in stroke and dementia. Many studies on CMBs in elderly patients with hemorrhagic or ischemic stroke have been reported; however, reports on CMBs in young populations with intracerebral hemorrhage (ICH) are lacking. Materials and Methods : A total of 272 patients aged 18-54 years presented to our hospital with ICH between December 2009 and August 2017. Among these, CMB presence, count, and topography with respect to ICH were evaluated on magnetic resonance imaging (MRI) gradient echo images (GREs). We also evaluated the prevalence and risk factors of CMBs. Results : Among 272 patients, only 66 underwent GRE T2-weighted MRI. CMBs were detected in 40 patients (61%), with 29 (73%) being of the multifocal type. Among the 219 CMBs, 150 (68.5%) were of the deep type and 69 (31.5%) of the lobar type. CMB prevalence was higher in men. In multivariate logistic regression analysis, history of hypertension (adjusted odds ratio [aOR], 4.048; 95% confidence interval [CI], 1.14-14.32; p = 0.030), and male sex (aOR, 4.233; 95% CI, 1.09-16.48; p = 0.037) were independently associated with CMBs. Conclusion : In young patients who presented with spontaneous ICH, CMBs were highly prevalent in 61% of patients and strongly associated with history of hypertension and male sex.

      • KCI등재SCOPUS

        Case Report : A Case of Fibroelastolytic Papulosis on the Neck of a Young Man

        ( Young Chan Song ), ( Byung Ho Oh ), ( Jong Hyun Ko ), ( Ji Young Kim ), ( Young Ji Hwang ), ( Yang Won Lee ), ( Yong Beom Choe ), ( Kyu Joong Ahn ), ( Kyae Yong Song ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2

        Fibroelastolytic papulosis of the neck (FEPN) encompasses a spectrum of two disorders that were previously reported as pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) and white fibrous papulosis of the neck (WFPN). The clinical presentation of FEPN is asymptomatic to mildly pruritic whitish-yellow papules that may coalesce into cobblestone patterned plaques that resemble pseudoxanthoma elasticum (PXE). The histology is characterized by a decrease or loss of elastic fibers in the papillary dermis and this is sometimes accompanied by a minimal or nodular increase of dermal collagen fibers. We report here on a 28-year-old Korean man with asymptomatic, multiple, skin-colored to slightly yellowish, match-head sized, cobblestone-patterned papules on the neck, and these were histologically consistent with FEPN and the papules showed slightly increased dermal collagen associated with decreased and fragmented elastic fibers, elastin and tropoelastin. The pathogenesis of FEPN in this case might have been related with mild dermal inflammation, followed by fragmentation, elastolysis and increased dermal collagen. (Ann Dermatol 23(2) 193∼197, 2011)

      • KCI등재

        청소년 인터넷 중독 검사 방법의 통계적 고찰 및 개선 -Young의 척도를 중심으로

        박찬정 ( Chan Jung Park ), 김형철 ( Hyung Chul Kim ), 고영민 ( Young Min Ko ), 현정석 ( Jung Suk Hyun ), 김철민 ( Cheol Min Kim ) 한국컴퓨터교육학회 2010 컴퓨터교육학회 논문지 Vol.13 No.4

        국내외에서 이루어진 기존의 인터넷 중독 검사에 대한 연구는 다양하며 방대하지만, 대부분의 연구가 중독도 검사를 위한 항목추출이거나 항목들을 이용한 중독도 분석이었지 항목간의 분석을 통한 차별화는 이루어지지 않았다. 본 논문에서는 리즈렐과 데이터마이닝 기법을 이용하여 Young의 인터넷 중독 검사방법을 고찰하고 문제점을 지적한 후, 검사 방법에 대한 대안을 제안한다. 이를 위해 Young의 척도를 이용하여 청소년 440명을 대상으로 설문을 실시하고, 요인분석을 통해 Young 척도의 문제점을 분석한다. 또한, 데이터 마이닝 알고리즘인 J48 및 PART를 이용하여 설문문항들 중에서 인터넷 중독도를 구분 지을 수 있는 항목들을 선별하고 이를 기반으로 인터넷 중독 학생들을 진단하고 처방하는데 활용하는 방법을 제안한다. So far, the researches about the Internet addiction testing are diverse and enormous. However, since the testing factors have the same importance, there is no discrimination among the factors. In our paper, we analyze the problems of the existing researches by using Lisrel and data mining algorithms. Next, we propose an alternative for the Internet addiction testing. In order to accomplish these, we make an questionnaire consisted of Young`s test and then, we asked to 440 primary and secondary school students. In addition, we analyzed the problems of Young`s test with factor analysis and then, we distinguish more important items from others with J48 and PART. Finally, based on this analysis, we propose a method to diagnose addicted students and prescribe them.

      • KCI등재
      • KCI등재

        교사용 유아 용기 척도 개발 연구

        박찬옥(Park Chan-Ok), 이은영(Lee Eun-Young) 한국열린유아교육학회 2011 열린유아교육연구 Vol.16 No.3

        본 연구는 유아교육현장에서 활용 가능한 교사용 유아 용기 척도의 타당도와 신뢰도를 검증하여 척도를 개발하는데 목적이 있다. 이를 위해 서울시와 경기도에 소재한 유치원 4곳에 재원하고 있는 만 4세와 만 5세 유아 322명을 대상으로 실시하였으며, 문헌고찰 및 자료 수집, 1차 시안 구성, 2차 시안 구성, 예비 검사, 최종 시안구성의 과정을 거쳐 완성하였다. 최종 시안으로 구성된 척도의 타당도와 신뢰도를 검증하고자 SPSS 프로그램을 이용하여 문항양호도 검증, 요인분석, 상관관계, 문항간의 내적합치도를 분석하였다. 먼저, 교사용 유아 용기 척도의 타당도를 분석한 결과, 본 척도의 문항 양호도는 매우 높게 나타났다. 다음으로 구인타당도 검증을 위한 요인분석을 실시한 후, 전체 설명 변량의 41.12%를 차지하고, 부하량이 .50이상인 요인과 문항을 추출하였다. 이에 신체적 용기 12문항, 사회적 용기 12문항, 인지적 용기 6문항, 심리적 용기 6문항의 4개 요인의 36개 문항이 추출되었으며, 전체 용기와 하위요인의 상관관계가 통계적으로 유의미한 것으로 나타났다. 마지막으로 교사용유아 용기 척도의 신뢰도를 분석한 결과, Cronbach ?계수가 .84~.94로 매우 높게 나타났다. 즉, 본 연구에서 개발한 교사용 유아 용기 척도는 타당도와 신뢰도가 양호한 것으로 드러나, 유아교육현장에서 유아교사들이 본 척도를 활용하기에 적합한 척도라고 할 수 있다. This study was conducted to develop a measure of young children's courage on a teacher's observation scale. The subjects were 322 young children consisting of 151 four-year-old children and 171 five-year-old children in four different kindergartens located in Seoul and Gyeonggi province. The results of exploratory factor analysis show that thirty-six items from the four factor categories are related to young children's courage. The four factors are0 ‘physical courage', ‘social courage', ‘cognitive courage' and ‘psychological courage'. In addition, there are significant positive correlations between the sub-area scores and the overall in the young children's courage scale(r=.12~.83, p<.05, p<.001). The young children's courage scale has a high reliability: Cronbach α shows .93 overall and .84~.94 for the four factors individually. These results explain that this scale is an appropriate tool for measuring young children's courage.

      • SCOPUSKCI등재

        소화성궤양 환자에서 Helicobacter pylori의 DNA지문 분석

        조주영,이준성,김진오,이문성,황성규,김연수,박용순,심찬섭,조영덕,이희발,이영홍,홍수진,봉형근,황승덕 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

        DNA Fingerprinting of Helicobacter pylori Isolated from Patients with Peptic Ulcer Su Jin Hong, M.D., Yong Soon Park, M.D., Young Hong Lee, M.D., Young Deok Cho, M.D., Jin Oh Kim, M.D., Hyung Keun Bong, M.D., Joo Young Cho, M.D., Joon Seong Lee, M.D., Moon Sung Lee, M.D., Yun Soo Kim, M.D., Seong Gyu Hwang, M.D., and Chan Sup Shim, M.D., Seung Duk Hwang, M.D. * and Hi Bahl Lee, M.D.* Department of Internal Medicine, Digestive Research Institute and Hyonam Kidney Laboratory* Soonchunhyang University College of Medicine, Seoul, Korea Background/Aims: The gastric pathogen Helicobacter pylori establishes long-term chronic infection that can lead to gastritis, peptic ulcers, and gastric cancer. However, little is known about the source and route of infection of this organism, and the mechanism of pathogenicity is only now beginning to be unravelled. Urease might allow the survival of the bacteria in an acidic environment, a prerequisite for colonization. H. pylori is cytotoxic to cultured human gastric epithelial cells and this toxicity is due in part to ammonia produced by hydrolysis of urea. We performed this study to evalute the usefulness of DNA fingerprinting of urease genes as a sensitive epidemiological tool for the typing of H. pylori clinical isolates. Methods: Clinical isolates of H. pylori were obtained by biopsy from 18 patients with peptic ulcer at the time of endoscopic examination. Biopsy tissues were cultured under microaerophilic conditions. DNA of H. pylori were extracted for PCR amplification. This study used the polymerase chain reaction(PCR) to amplify the urease structural subunit genes, ureA and ureB, which, when digested with restriction endonucleases, allow the differentiation of patterns on 1.5% agarose gels. Results: The 2.4 kb PCR products amplified and subjected to Hae Ⅲ restriction endonuclease digestion produced 11 distinct patterns on agarose gels, with five patterns occurring within two or three isolates. Conclusions: The urease genes of H. pylori had genetic heterogeneity, but it could be of considerable tool for epidemiological studies. Moreover the method is useful for studies of relation between H. pylori induced diseases and different strains because unique patterns were shown in two or three isolates. In conclusion, DNA fingerprinting of H. pylori could be available for epidemiological studies of H. pylori infections and for clinical applications. (Korean J Gastroenterol 1997; 29:317 - 325) Key Words : Helicobacter pylori, DNA fingerprinting , Restriction endonuclease digestion, Peptic ulcers 접수: 1996년 7월 24일, 승인: 1996년 10월 11일 연락처 : 심찬섭, 서울특별시 용산구 한남동 657-58, 순천향대학병원 소화기내과학교실

      • SCOPUSKCI등재

        병사용 진단서 발급을 위해 복강경검사에서 간조직검사를 시행한 젊은 성인 남자의 간침생검 소견 : 새로운 만성간염병리분류를 기준으로 Histologic Grading and Staging of Chronic Hepatitis

        전재윤,문영명,박영년,백용한,박찬일,한광협 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2

        Background/Aims: This study was designed to assess the etiology and characteristics of chronic liver disease among the young male adults. It was also investigated whether grades of activity and status of fibrosis defined by the new histopathologic classification system of chronic hepatitis are related with alanine aminotransferase (ALT) level and HBeAg status in HBsAg-positive case. Methods: Peritoneoscopic findings, clinical features and histopathologic features of liver were investigated for 140 young men who received liver biopsy for military medical certificate from January 1994 to December 1997. These features were evaluated according to the grade and stage of chronic hepatitis. Results: In Korea, hepatitis B virus was the main cause of chronic hepatitis (87.7%) in young male adults and the infection of hepatitis C virus was rare (1.4%). Among HBsAg-positive cases with normal ALT level, 82.2% of them revealed chronic liver disease, and 48.3% of them showed chronic active hepatitis/cirrhosis in biopsy specimens. The grade of chronic hepatitis showed weak correlation with ALT level and the stage did not. There was no significant difference in the grade and stage of chronic hepatitis according to the serum HBeAg status. Conclusions: The most common cause of chronic liver disease in Korean young male adults was hepatitis B virus, and most (92.6%) of HBsAg-positive cases were proved to have chronic liver diseases histologically, regardless of the serum ALT level. According to new histopathologic classification system of chronic hepatitis, serum ALT level correlated with necroinflammatory activity of chronic hepatitis B, but not with fibrosis in HBsAg-positive cases.

      • KCI등재

        난화기법을 활용한 집단미술활동이 유아의 사회성 발달과 정서지능에 미치는 효과

        곽미혜(Mi Hye Kwak), 김태영(Tae Young Kim), 이종찬(Jong Chan Lee), 김종운(Jong Un Kim) 학습자중심교과교육학회 2015 학습자중심교과교육연구 Vol.15 No.10

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        This study aims at looking into effects of group of art activities using the scribble technique on young children s social development and emotional intelligence. Regarding to research objects, the study selected A and B childcare centers that were located in Busan and young children s living standards were similar, and objected total 20 young children by dividing them into the experiment group and control group such like 10 children in A and B childcare centers respectively among full 3, 4 years old infants. The study carried out t-Test on the data in order to confirm homogeneity existence between the experiment group and control group according to scales before implementing the program, and executed covariance analysis(ANCOVA) after calculating average and standard deviation of pre-post tests between the experiment group and control group. Research conclusions are same as the following. First, group are activities using the scribble technique show effects on the social development of young children. Second, group are activities using the scribble techniques have positive effects on young children s emotional intelligence. This study considers that group are activities using the scribble technique give positive effects on the social development and emotional intelligence of young children. Therefore, the study expects that such method could be utilized as an are program to improve the positive emotion and social development for young children who cannot grasp own feelings and thoughts correctly or express them in the language. 본 연구의 목적은 난화기법을 활용한 집단미술활동이 유아의 사회성 발달과 정서 지능에 어떠한 효과가 있는지 검증하는 것이다. 이를 위해 부산광역시에 소재하고, 생활수준이 유사한 A, B 어린이집에 재원중인 만 3, 4세 유아 중 A 어린이집 유아 10명, B 어린이집 유아 10명을 실험집단과 통제집단으로 나누어 총 20명의 유아를 대상으로 하였다. 두 집단 중 A 어린이집의 유아들은 실험집단에 배정하고, B 어린 이집의 유아들은 통제집단으로 배정하였다. 통제집단은 모든 실험이 끝난 뒤에 똑같 은 프로그램을 실시하였다. 자료는 동질성 여부를 확인하기 위하여 t-검증을 실시하 였으며, 실험집단과 통제집단 간의 사전, 사후검사의 평균과 표준편차를 구하고 공 변량 분석(ANCOVA)을 실시한 결과, 난화기법을 활용한 집단미술활동이 유아의 사 회성 발달과 정서지능에 긍정적인 효과가 있는 것으로 나타났다. 이를 통해 난화기 법을 활용한 집단미술활동을 유치원이나 어린이집에서 자신의 느낌이나 생각을 정 확하게 파악하거나 언어로 표현하지 못하는 유아들에게 사회성 발달과 정서지능을 향상시키기 위한 집단미술활동의 한 모델로 활용할 수 있을 것으로 기대된다.

      • SCIESCOPUSKCI등재

        Original Article : Clinical Distinct Features of Noncardiac Chest Pain in Young Patients

        ( Tae Ho Seo ), ( Jeong Hwan Kim ), ( Jung Hyeon Lee ), ( Soon Young Ko ), ( Sung Noh Hong ), ( In Kyung Sung ), ( Hyung Seok Park ), ( Chan Sub Shim ) 대한소화관운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.2

        Background/Aims: Noncardiac chest pain (NCCP) is a very common disorder world-wide and gastroesophageal reflux disease (GERD) is known to be the most common cause. The prevalence of NCCP may tend to decrease with increasing age. However, there is Little report about young aged NCCP. The aim of this study was to examine the prevalence of GERD and to evaluate the efficacy of proton pump inhibitor (PPI) test in the young NCCP patients.Methods: Thirty patients with at Least weekly NCCP Less than 40 years were enrolled. The baseline symptoms were assessed using a daily symptom diary for 14 days. Esophago-gastro-duodenoscopy (EGD) and 24 hr esophageal pH monitoring were performed for the diagnosis of GERD and esophageal manometry was done. Then, patients were tried with Lansoprazole 30 mg twice daily for 14 days, considering positive if a symptom score improved ≥ 50% compared to the baseline.Results: Nine (30%) of the patients were diagnosed with GERD at EGD and/or 24 hr esophageal pH monitoring, also, 3 (10%) were diagnosed with GERD-associated esophageal motility disorder and 3 (10%) were non GERD-associated. Concerning PPI test, GERD-related NCCP had a higher positive PPI test (n = 8, 89%) than non GERD-related NCCP (n = 5, 24%) (p = 0.002). Conclusions: In young patients with NCCP, a prevalence of GERD diagnosed using EGD and/or 24 hr esophageal pH monitoring was 30%. PPI test was very predictable on diagnosis of GERD-related NCCP, thus, PPI test in young NCCP patients may assist to the physician`s clinical judgment of NCCP.(J Neurogastroenterol Motil 2010;16:166-171)

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