생균제(probiotics)의 이해와 작용기전

문경래 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

Probiotics are defined as nonpathogenic living micro-organisms, including some commensal bacterial flora, which have beneficial effects on host health and disease prevention and/or treatment. They have shown beneficial effects of probiotics on several human diseases, such as ntibiotic-associated diarrhea and acute infectious diarrhea, irritable bowel syndrome and atopic dermatitis in children. Most commonly employed probiotics were Lactobacillus GG, Bifidobacterium spp., Streptococcus spp., and the yeast Saccharomyces boulardii. Studies discussed in this review suggest 3 distinct cellular and molecular mechanisms for probiotic regulation : 1) Probiotics block pathogenic bacterial effects by producing bactericidal substances and competing with pathogens and toxins for adherence to the intestinal epithelium; 2) Probiotics regulate immune responses by enhancing the innate immunity and modulating pathogen-induced inflammation via toll-like receptor-regulated signaling pathways; and 3) Probiotics regulate intestinal epithelial homeostasis by promoting intestinal epithelial cell survival, enhancing barrier function, and stimulating protective responses. Significant adverse effects are rare, and there are no known interactions with medications.

소아청소년 비만의 포괄적인 예방 전략

문경래 대한소아소화기영양학회 2011 Pediatric gastroenterology, hepatology & nutrition Vol.14 No.4

With an uncontrollable amount of energy dense food engulfing children’s life today, no child is completely protected against being overweight or obese. An inordinate intake of energy dense food and lack of physical activity have resulted in a higher rate of obesity in children. In order to combat the seemingly intractable problem, various preventive measures against childhood obesity have been suggested and are currently in effect. It is imperative to evaluate the methodology and potential impact of published obesity-prevention programs, that focus primarily on home, school, and health care environments. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 325∼333)

소아 비만의 역학적 특징 - 원인, 분류, 유병률, 증상 -

문경래 한국모자보건학회 1998 한국모자보건학회 학술대회 연제집 Vol.1998 No.2

백서의 총담관 결찰에 의한 간 섬유화의 초미세구조적 및 면역조직화학적 연구

문경래,노영일,서우철,박영봉,김만우,서재홍,박상기,Moon, Kyung-Rye,Rho, Young-Ill,Seo, Woo-Chul,Park, Yeong-Bong,Kim, Man-Woo,Seo, Jae-Hong,Park, Sang-Kee 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2

Purpose: Proliferation of bile duct-like structures and fibrosis is a hepatic cellular reaction observed in most forms of human liver disease and in a variety of experimental conditions associated with liver injury. The aim of this study was to investigate the activation of Ito cells and bile duct proliferation in the rat after common bile duct ligation (CBDL). Methods: Hepatic morphological abnormalities were examined in rats whose bile ducts had been irreversibly ligated for 15, 21, 24 and 28 days. The liver was examined by immunohistochemical staining for ${\alpha}$-smooth muscle actin, the known marker of activated Ito cells, and light and electron microscopes. Results: After CBDL, the bile canalicular proliferation and interstitial fibrosis were gradually increased in the periportal areas extended to hepatic sinusoids. Ito cells positive for ${\alpha}$-smooth muscle actin were frequently observed in the periductular space and in perisinusoidal space of Disse. Ito cells and myofibroblasts were gradually increased in the interstitial fibrosis until the 28th day after CBDL. Ito cells and myofibroblasts had microfilaments with dense body at the periphery of the cell. Conclusions: Our results suggest that Ito cells may be fibroblastic or myogenic. It has also been postulated that during the development of hepatic fibrosis, Ito cells become myofibroblasts or fibroblast like cells.

소아 비만의 진단과 치료

문경래,Moon, Kyung-Rye 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.1

영·유아의 영양평가

문경래 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

Nutritional assessment therefore should be an integral part of the care in infant and and young child. Components of a complete nutritional assessment include a medical history, nutritional history including dietary intake, physical examination, anthropometrics (weight, length or stature, head circumference, midarm circumference, and triceps skinfold thickness), skeletal maturity staging, and biochemical tests of nutritional status. The use of age, gender, and disease-specific growth charts is essential in assessing nutritional status and monitoring nutrition interventions. The importance of accurate measurements using trained personnel and appropriate equipment cannot be overemphasized.

소루마사지요법이 중년여성의 하지통증, 피로, 우울에 미치는 영향

문경래,최보경 한국스포츠학회 2019 한국스포츠학회지 Vol.17 No.3

The purpose of this study was to investigate the effects of Soru-massage on lower extremity pain, fatigue, and depression in middle-aged women from 40 trainees who were trained at G Nursing Education in G Metropolitan City from August 18 to September 25, 2015. An experiment was conducted to see. The sample size was collected from 20 experimental groups and 20 control groups. The experimental group was subjected to twelve soru-massage treatments for a total of 6 weeks, and the control group did not undergo any experimental treatment. The blood pressure of each subject was measured before and after the massage therapy. Tests for pain, fatigue, and depression before and after the experiment were measured through a self-reported questionnaire. Finally, the control group consisted of 20 patients, and the experimental group dropped out of 2 due to personal circumstances. To evaluate the effect of lower limb fatigue and depression in middle-aged women, we applied the soru-massage therapy, one of the alternative therapies. In addition, the relationship between pain, fatigue and depression was related to their pain reduction, which lowered lower extremity pain in middle-aged women and had statistically significant results in pain-induced fatigue and depression. 본 연구는 2015년 8월 18일 ~ 9월 25일 까지 G광역시 V요양보호사 양성교육기관에서 교육중인 교육생 40명을대상으로 소루 마사지요법이 중년 여성의 하지통증, 피로, 우울에 미치는 영향을 알아보기 위해 실험을 실시하였다. 표본의 크기는 실험군 20명, 대조군 20명으로 표집 하였으며, 실험 군에는 총 6주간 12회의 소루 마사지요법을 적용하고대조군은 별다른 실험 처치를 하지 않았다. 마사지 요법 전과 후에 각 피험자의 혈압을 측정하였고, 실험 실시 전과 후에통증, 피로, 우울에 대한 검사를 자기기입식 설문지를 통하여 측정하였다. 최종적으로 대조군은 20명으로, 실험군은 개인사정으로 2명이 탈락하여 18명으로 총 38명이었다. 중년 여성의 하지 통증으로 인한 피로와 우울 감소에 영향을 미치는지를 알아보기 위해 대체요법의 하나인 소루 마사지요법을 적용하였다. 또한 통증과 피로, 우울간의 상관성을 조사하여그들의 통증 감소에 관련된 것으로 중년 여성의 하지 통증을 감소시키고, 통증으로 유발된 피로와 우울 감소에 통계학적으로 유의한 결과를 가져왔다.

유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의

문경래,김환정,이미자,기근홍,서재홍,양정원,조현진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.

정 맥 영 양

문경래,Moon, Kyung Rye 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.6

소아 백혈병의 혈청 철, 총 철결합능 Transferrin포화율 및 Ferritin치에 관한 연구

문경래,정은경,박상기 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Author reviewed the clinical symtoms, hematological findings and serum Fe, total iron binding capadty(TIBC), transferrin saturation and levels of 40 children diagnosed as leukemia at the pediatric department of Chosun University hospital during a period of 7 years from Jan. 1983 to Dec. 1989. Also, 20 normal children as control group were studied. The results were summarized as follows: 1) The Mean±S.D. levels of the serum Fe, TIBC, transferrin saturation and ferrtin of leukemia 40 cases and control group were 126.8±37.8㎍/㎗, 276.1±37.8㎍/㎗, 47.1±15.6%, 244.5±52.7ng/㎖ and 107.2±34.2㎍/㎗, 309.9±31.8㎍/㎗, 34.7±11.4%, 69.6±30.8ng/㎖, respectively. The difference of the serum Fe levels between leukemia and normal control was statistically not significant (P>0.1) but the serum Fe, TIBC, transferrrin saturation and ferritin levels were significantly different(P<0.05, P<0.01, P<0.001). 2) The differences in the mean levels of the serum Fe, TIBC, transferrin saturation and ferfitin among the types of leukemia were not significant. 3) The differences of the serum TIBC, transferrin saturation and ferritin levels between leukemia and normal control were statistically significant. From the very high serum ferritin levels, it is thought that serum ferritinemia as tumor marker may be useful in diagnosis of leukemia.