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      • KCI등재

        장상피화생(腸上皮化生) 치료에 대한 최신 임상 연구 동향 - CNKI 검색을 중심으로

        이보람,김원일 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.6

        Objectives: The purpose of this research is to investigate recent clinical studies of Intestinal Metaplasia (IM) based on a search of the China National Knowledge Infrastructure (CNKI). Methods: We investigated recent clinical studies of Oriental medicine therapies in traditional Chinese medical journals for IM through a CNKI search. 20 clinical articles published from 2010 to 2016 were analyzed. This study examined the authors, publication years, types of studies, criteria for diagnosis and evaluation, periods, purposes of study and articles classified by methods of treatment. Results: Most of articles were classified as randomized controlled trial. IM was diagnosed using gastroscopy, pathological examination and clinical symptoms in a high proportion of articles. The criteria for evaluation most frequently used were the effective ratios of clinical symptoms, gastroscopy and pathological tests. The methods of treatment in all studies were Chinese herb medicine. Acupuncture, acupoint injection therapy, and embedding therapy were also used in several studies. Conclusion: In this study, the Chinese treatment for IM was markedly effective. To improve the treatment of IM in Korea, many clinical studies and case reports are required, based on Chinese medicine.

      • KCI등재

        소뇌기능이상의 임상양상을 특징으로 보인 뇌교부출혈 환자 1례

        이유경,공경환,용형순,고성규,부송아,Lee, You-Kyung,Kong, Kyung-Hwan,Yong, Hyung-Soon,Ko, Seong-Gyu,Bu, Song-Ah 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5

        I experienced a case of a patient with clinical features of cerebellar dysfunction in the intracranial hemorrhage which encroached the basis of lower pontine and all parts of pontine tegmentum. So I report this case with bibliographical inquiry. In addition, I applied the treatment of Oriental medicine to sequelae of intracranial hemorrhage like disorders of eye movement, central dizziness, cerebellar tremor and ataxias but the effect did not meet my expectation. I anticipate more clinical studies and reports on this hereafter.

      • KCI등재

        팔진탕합화적환(八珍湯合化積丸)과 Adriamycin의 병용처리시 나타나는 synergistic 항종양(抗腫瘍) 효과(效果)에 관(關)한 작용기전 연구(硏究)

        문구,문석재,원진희,조정연,박상구,송봉길,박래길,이병구,Moon, Gu,Moon, Seok-Jae,Won, Jin-Hee,Cho, Jung-Yun,Park, Sang-Gu,Song, Bong-Gil,Park, Rae-Gil,Lee, Byung-Gu 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

        Objective : This study was designed to evaluate the synergistic effect on cytotoxicity of combination with adriamycin and Palginhonhapwhajucwhan, a traditional prescription for cancer treatment in oriental medicine, in Chang, HL-60, Hep-3B and Alexander cells. Methods : We observed cell viability in Chang, HL-60, Hep-3B, and Alexander cells by crystal violet staining. Those cells were treated with various concentrations of adriamycin alone, Palginhonhapwhajucwhan alone and combination of two medications for 10 hr. On condition of $0.5{\mu}l/ml$ adriamycin alone, $15.6{\mu}l/ml$ Paljintanghapwhajucwhan alone and combination of two medications, at first, we observed colony forming of Chang and HL-60 cells. Second, we observed DNA fragmentation by agarose electrophoresis in Chang, HL-60, Hep-38 and Alexander cells. Third, we measured the catalytic activation of caspase-1, 2, 3, 6, 8, and 9 protease in Chang cells and caspase-3 protease in Chang, HL-60, Hep-3B and Alexander cells by using fluorogenic substrate. Finally, we isolated mRNA of Fas in Chang, HL-60, Hep-38 and Alexander cells and observed that Fas gene was amplified by RT-PCR Results : 1. The combination of adriamycin and Palginhonhapwhajucwhan synergistically augmented the cytotoxicity of Chang and HL-60 cells whereas did not in Hep-38 and Alexander cells. 2. Cotreatment of two drugs also markedly inhibited the colony forming ability both in Chang and HL-60 cells. 3. The cytotoxicity of these medicatons was revealed as apoptosis characterized by high molecular wight DNA fragmentaton. 4. The apoptotic cytotoxicity was mediated by activation of caspase-3 protease in Chang cells. 5. Synergistic increase in apoptotic cytotoxicity by combination of two medications was dependent on the expression of Fas in cancer cells. Conclusions : Combination of adriamycin and Palginhonhapwhajucwhan significantly augmented apoptotic cytotoxicity of Fas-positive cells such as Chang and HL-60 cells via acticaton of apoptosis signaling pathway.

      • KCI등재

        4기 위암환자의 증치에 관한 보고 1례

        하장,백태현,공경환,Ha, Jang,Baek, Tae-Hyeon,Kong, Kyung-Hwan 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5

        Objective : The study was to investigate Diagnosis and Treatment Based on an Overall Analysis of Signs and Symtoms(證治) of a patient on stomach cancer stage IV by means of the clinical symptoms. Methods : The observation of the clinical progress was carried out by conducting Diagnosis and Treatment Based on an Overall Analysis of Signs and Symtoms(證治) with the patient diagnosed stomach cancer stage IV. Results : Treatments such as the invigoration of qi(補氣), the flow of qi(行氣), and the relieving pain(止痛) was given because the patient showed the qi deficiency of the spleen and stomach(脾胃氣虛). There were moderate effects for anorexia, indigestion, nausea, and general weakness, but there was not any clear effect for alleviation of abdominal pain except the first period. Specially, compared with two hospitalization treatments in 1998, the third hospitalization treatment did not show any apparent improvement. It was believed that this caused by the patients bodily weakness because of deterioration of anemia from bleeding in the progress of cancer. Conclusion : Diagnosis and treatment based on an overall analysis of signs and symtoms(證治) of a patient on stomach cancer stage IV had moderate effects on the improvement of the patients condition, but in this case we had difficulty in long-term observation because of short hospitalizations or insufficient examination by an oriental-western combined medicine group.

      • KCI등재

        육미지황탕(六味地黃湯),택사탕(澤瀉湯), 실비음(實脾飮)이 메산지움세포 증식, Fibronectin 합성 및 MHC-class II 발현에 미치는 영향(影響)

        안세영,두호경,이진신,Ahn, Sae-Young,Doo, Ho-Kyung,Lee, Jin-Sin 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

        Objective : To analyze the effects of Yukmijihwang-tang, Taeksa-tang, Silbi-um on mesangial cell proliferation, fibronectin synthesis and MHC-class II expression. Methods : Laboratory studies were performed with the method of surface enzyme immunoassays or flow cytometry after addition of peripheral blood mononuclear cells(PBMC) supernatants treated with medications using the cultured human mesangial cells. Results : 1. Silbi-um produces more suppressive effect than control group and hydrocortisone group on the mesangial cell proliferation. In Yukmijihwang-tang, Taeksa-tang and Silbi-um, mesangial cell proliferation significantly decreased than in hydrocortisone group 2. In the 'without fetal bovine serum' study, Yukmijihwang-tang take more suppressive effect than Control group on the fibronectin synthesis. In the 'with fetal bovine serum' study, Yukmijihwang-tang, Taeksa-tang, Silbi-um all have suppressive effect, but it hasn' t any statistical significance. 3. Yukmijihwang-tang, Taeksa-tang, Silbi-um all have a suppressive effect on the MHC-class II expression. Conclusions : Herb medicine generally show a suppressive effect on the suppression of the mesangial cell proliferation, fibronectin synthesis and MHC-class II expression.

      • KCI등재

        동충하초(冬蟲夏草)가 Hydrocortisone을 투여한 흰쥐의 Nitric Oxide Synthase 활성 및 Testosterone 함량에 미치는 영향

        민건우,박종혁,윤철호,신억섭,한영환,정지천,Min, Gun-Woo,Park, Jong-Hyuck,Yoon, Cheol-Ho,Shin, Uk-Seob,Han, Yeong-Hwan,Jeong, Ji-Cheon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

        The fallowing are the results of the experimental studies of Cordyceps militaris (CM) on the penile nitric oxide synthase (NOS) activity and the level of blood testosterone in hydrocortisone acetate-treated rats. CM was tested for the effects on activity of xanthine oxidase and lipid peroxidation in penis of hydrocortisone acetate-treated rats. In vitro, CM didn't effect the levels of lipid peroxide and the activity of NOS. In the penis of hydrocortisone acetate-treated rats, lipid peroxide, the activities and ratio of type conversion of xanthine oxidase were increased but activity of NOS and content of nitrite were decreased. In vivo, after administration of CM to hydrocortisone acetate-treated rats, levels of lipid peroxide in penis was decreased. Also, the activities and ratio of type conversion of xanthine oxidase were decreased, too. The body weight and concentration of testosterone in the blood were increased. The effects of Cordyceps militalis Broth did better than the effects of Cordyceps militalls Mycelia, These results suggest that CM decrease the activities of free radical generating enzymes such as xanthine oxidase which form lipid peroxide and increase the penile NOS activity and the level of blood testosterone in hydrocortisone acetate-treated rats. Conclusively, CM is capable of improving of sexual ability in hydrocortisone acetate-treated rats.

      • KCI등재

        뇌졸중으로 중환자실에서 집중치료한 환자들의 합병증에 관한 임상적 고찰

        김동웅,한명아,Kim, Dong-Woung,Han, Myoung-Ah 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

        Purpose : Cerebrovascular disease is the most frequent cause of death in Korea and it remains severe disabilities disturbing normal life, According to the previous studies, mortality of the stroke in the first one week is up to the 20% and 95% of stroke patients in the acute stage are accompanied by more than one complications. These complications affect not only the acute stage mortality but also the late stage rehabilitations. In Korea the oriental medicine is preformed in the treatment of stroke. Therefore it is important to recognize thoroughly the complications in the acute stage of stroke and to prevent them. But studies about complications of acute stage stroke is rarely presented in the fields of oriental medicine. So this study is prepared for investigating the characteristics and frequency of complications in the acute stage of stroke. And we are to assess the importance of theses acute complications by systemic reviewing the previous studies. Methods : Fifty one patients are included who had been admitted to ICU(intensive care unit) of Chenju Hospital of Wonkwang Oriental Medicine. Twenty nine patients are diagnosed as ischemic stroke and twenty one patients are diagnosed hemorrhagic stroke. Medical and neurological complications were investigated retrospectively based on medical notes excluding primary symptoms of stroke Le. motor weakness, sensory disturbance and speech disorder. And risk factors of stroke such as D.M. or hypertension are excluded. Results : Medical complications are more frequent than neurological ones. Most frequent medical complication is dysuria(61%) and constipation(45%), fever(30%) and aspiration pneumonia(22%) are followed in order of frequency. In Neurological complication dysphagia(56%), the exacerbation of infarction due to increased intracranial pressure(24%), irritability or insomnia(21%) is most frequently complicated in order of frequency. Conclusions : These complications are mostly caused by bed rest state in acute stage stroke. It is supposed that more aggressive management can prevent theses ones. And it is possible to improve the medical and neurological conditions by sticking theses study results.

      • KCI등재

        삼봉강룡반어탕(三蓬薑龍半魚湯)과 가감소적백출산(加減消積白朮散)의 항암효과(抗癌效果)에 대(對)한 비교연구(比較硏究)

        김동우,고승희,최유경,심문기,여은경,박세기,박종형,고재철,전찬용,한양희,이청정혜,Kim, Dong-Woo,Ko, Seung-Hi,Choi, You-Kyung,Shim, Mun-Ki,Yeo, Eun-Kyung,Park, Se-Ki,Park, Chong-Hyeong,Ko, Jae-Chul,Jun, Chan-Yong,Han, Yang-Hee,Lee, Chung- 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

        Objective : It is well known that Gagamsojeokbackchool-san show antitumor effects and its activities are result from enhancement of immune function, we investigated the antitumor effects of Sambonggangyongbaneo-tang and its mechanism. Methods : We measured change of body weight, weight of immune organs (Spleen, Thymus), Liver, Kidney, tumor weight, cytotoxicity for investigation of antitumor effects of Sambonggangyongbaneo-tang. Results : 1. The body weight of mouse has no significant difference between control and sample groups. 2. The weights of immune organs (Spleen and Thymus) decreased significantly in sample groups. The weights of Liver and Kidney have no significant difference. 3. The tumor weights in mouse decreased significantly in sample groups and showed dose-dependent effect. 4. Cell viability of Sarcoma 180 has no significant difference in sample groups. 5. HeLa cell viability has no significant difference in low concentration, but it decreased significantly in high concentration. Conclusions : According to the above results, it could be suggested that Sambonggangyongbaneo-tang has prominant antitumor effects and cytotoxicity.

      • KCI등재

        인진(茵陳)분획물이 간세포활성, 세포주기 및 Fas-mediated Apoptosis에 미치는 영향

        김영철,이장훈,우홍정,이종훈,Kim, Young-Chul,Lee, Jang-Hoon,Woo, Hong-Jung,Yi, Jong-Hoon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

        Objective : This study was carried out to examine the effect of five fractions of an aqueous extract from Artemisia capillaris $T_{HUNB}$. Methods : The queous extract from Artemisia capillaris $T_{HUNB}$. was fractionized into 5 kinds of material. We observed the effect of each fractions on etoposide-induced apoptosis, cell viability, cell cycle progression and mRNA expression of apoptosis-related genes in human hepatocyte cell line HepG2. Results and Conclusions : The data shows that butanol fraction of Artemisia capillaris $T_{HUNB}$. has no relation with cell cycle, however, it inhibits apoptosis significantly and the action may be due to the suppression of Fas and Sax genes and activation of Bcl-2 gene.

      • KCI등재

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