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이문성 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.3
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The author investigated family backgrounds, attitudes to the treatment and associated illness of alcoholic disorders, including alcohol abuse and alcohol dependence with or without alcohol induced mental disorder, among 41 alcoholic patients who were admitted to dept. of neuropsychiatry, Soon Chun Hang Univ. Hosp. for last five years. The results were summarized as follows ; 1. The ratio of alcoholic disorders among neuropsychiatric inpatients has been increased yearly, from 1.74% during 1979 to 6.62% during 1983. Average ratio of alcoholic disorders for 5 years was 3.35%. 2. The male patients were 20 times more in number than female patients. 3. Mean age was 28.0 years on alcohol abuse, 44.12 years on alcohol dependence. 4. 58.3% of alcohol abuse showed the impairment of occupational function and 72.4% of alcohol dependence had the impairment. 5. Three were no significant differences between patient's marital status and educational background. 6. Parent loss before the age of 15 due to death among the patients were 22.0%. 7. The numbers of siblings were 4.57 in average and male siblings are twice more than female siblings. 8. The patients who were in the last half of siblings are twice more than being in the first half of siblings. 9. The incidence of persistent, excessive drinking among the first relatives of alcohol dependence was significantly higher than that of alcohol abuse. 10. Affective disorders were the most frequently associated mental disorders. And schizophrenia, personality, disorders, borderline or antisocial, substance use disorder other than alcohol, paranoid disorder are also associated with alcoholic disorders in order. 11. Liver disorders such as hepatitis and liver cirrhosis were the most frequently associated physical disorder with alcoholic disorders. And hypertension, diabetes mellitus, duodenal with alcoholic disorders in order. The incidence of physical disorders associated with alcohol dependence was significantly higher than that of alcohol abuse. 12. About half of alcoholic disorders admitted via E.R. Persistent, excessive drinking as a motive for seeking treatment is only in 29.3% of alcoholics. Other motives for seeking treatment are associated mental or physical illness, alcohol withdrawal symptoms and aggressive actingout. 13. Many alcoholics admitted one time (65.9%) and for brief duration no more than 10 days (55.1%) to our dept. of neuropsychiatry. And many alcoholics (51.2%) discharged against doctor's advice. According to the aforementioned results, we could estimate that the prevalence of alcoholic disorders seem to be increasing on recent years, though these results are not enough to apply directly to general population. Eventhough this disorders cause many problems on occupation, mental or physical condition the patients himself or family member were not cooperative to treatment. And they did not consider the alcoholic disorders as a disease until physical symptoms were developed.
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간내담석증 환자에서 담도암 동반 여부의 예측인자로서 혈청 및 담즙 내 Interleukin-6의 유용성
이문성,김연수,심찬섭,조영덕,문종호,정인섭,이유경 대한소화기학회 2001 대한소화기학회지 Vol.37 No.1
Background/Aims: Interleukin-6 (IL-6) is one of growth factors of the bile duct epithelium and may be elevated in patients with cholangiocarcinoma. We performed this study to evaluate the value of IL-6 as a tumor marker for preoperative detection of cholangiocarcinoma in patients with hepatolithiasis. Methods: Sixty patients were divided into 4 groups: cholangiocarcinoma (CC) group (n=21), cholangiocarcinoma with hepatolithiasis (CC+HL) group (n=8), hepatolithiasis (HL) group (n=20) and hepatocellular carcinoma (HCC) group (n=11). Serum level of IL-6 was measured in 20 healthy adults (control) and in the 60 patients using bioactive and enzyme-linked immunosorbent assays. IL-6 of bile was measured in 35 patients of CC group (n=14), CC+HL group (n=5) and HL group (n=16). Results: An elevated serum level of IL-6 was detected in 90.5% of patients with CC, 87.5% of patients with CC+HL, 40% of patients with HL, all HCC patients and 20% of controls also showed an elevated serum level of IL-6. An elevated bile level of IL-6 was detected in all patients with CC, all patients with CC+HL and 75% of patients with HL. Median serum levels of IL-6 were significantly higher in patients with CC and CC+HL than in patient with HL and control (p$lt;0.05). Median bile levels of IL-6 were significantly higher in CC group and CC+HL group than in HL group (p$lt;0.05). Conclusions:The serum and bile IL-6 may be considered as a marker for detection of cholangiocarcinoma in patients with hepatolithiasis.
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이문성 고려대학교 한국학연구소 2001 한국학연구 Vol.14 No.-
The purpose of this article is, fist with actively studyin the former research about him and his paintings to read the situation of late of Chosun dynasty society from alte of 18th to 19th century, to know his life more through his paintings and study his life again. We do not have to hesitate to specify 〈Sang Chun Ya Hung〉·〈Ssang Gum Dae Mu〉·〈Chung Kum Sang Ryun〉·〈Jue Yu Chung Gang〉as showing situation of the pleasure place among his paintings. These paintings attract attention because the paints are showing the moment of pleasure and connection of each paint are found. Above paintings show very clearly the situation of highest status people and the top grade kisaeng at the pleasure place. Also we can find the low wtatus people and the low grade kisaeng on 〈Ju Sa Ku Bae〉and〈Hong Ru Dae Ju〉. We can visualize the phase of the pleasue place of normal people through these paintings. In other way some paintings show the normal living space about every day life and the common customs. Among these paintings, 〈Mu Nye Sin Mu〉·〈Mun Jong Sim Sa〉·〈Kae Byun Ka Hoa〉and〈Dan O Pung Jung〉attract attention. Also these paintings are important for woman life history study. Yun Bok Shin's paintings are showing the situation of late Chosun ynasty society normal life place very delicately and accurately. After studyin his paintings very carefully, his paintings are all about his life and love, and his sprite of art is found. His paintings are very important as a reference describing accurately the normal customs of late Chosun dynasty the period of his life and also give the clue to research again his vague life. His paintings are worth to be studied very carefully and throughly.
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