정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정구선수의 자기관리가 경쟁불안에 미치는 영향

장봉우, 김병두 忠北大學校 平生體育硏究所 2014 平生體育硏究所 論文集 Vol.26 No.-

The purpose of this study was to examine the self-management behavior of secondary school male tennis players and the influence of their self-management on competition anxiety in an effort to provide some information on the pre-match self-management and competition anxiety of players and instructors and the improvement of the athletic performance of players. The subjects in this study were 170 male players who participated in the tennis competitions of the national secondary school autumn league in August, 2014. After the importance of this study and the items of the questionnaire to be used were explained to the players, a survey was conducted, and the answer sheets from 158 respondents were analyzed except for 12 ones that were incomplete. The collected data were analyzed by a statistical package SPSS 22.0. A frequency analysis was made to find out the general characteristics of the secondary school male tennis players, and an exploratory factor analysis was made to verify the validity of the variables. Cronbach‘s alpha coefficients were calculated to test reliability, and t-test and one-way ANOVA were utilized to see if there would be any differences in self-management and competition anxiety according to their career and prize-winning experience. Besides, a correlation analysis and multiple regression analysis were made to determine the correlation and influential relationship of self-management and competition anxiety. The findings of the study were as follows: First, there were differences among the secondary school male tennis players in self-management according to their player career, class and prize-winning experience among general characteristics. Second, there were no differences among the secondary school male tennis players in competition anxiety according to their player career, class and prize-winning experience among general characteristics. Third, the self-management of the secondary school male tennis players exercised an influence on their competition anxiety. The above-mentioned findings illustrated that there were differences among the secondary school male tennis players in self-management according to their player career, class and prize-winning experience, and that self-management had an impact on competition anxiety and its sub factors. Therefore it will produce better results and serve to maximize the athletic performance of secondary school male tennis players if their instructors guide them by map out teaching plans and strategies in consideration of the findings of the study.

원형 탈모증 환자에서의 감정표현불능증

박두병,전창무,손인기,민경준,김영돈,노병인 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 감정표현불능증이 정신신체질환의 특징적인 성격 경향 인지에 대해 논란이 많이 있어 왔다. 이에 정신신체질환이면서 피부과 외래 환자의 다수를 차지하는 원형탈모증 환자에 있어서의 감정표현불능증에 대해 알아보았다. 방 법 : 원형탈모증 환자군(31명)과 연령, 성별을 대비시킨 정상대조군(31명)에서 MMPI, SCL-90-R, TAS-20K를 시행하였다. 정신신체질환 이외의 질환에 의한 영향을 배제하기 위해 다른 정신과 질환이 있다고 판단되는 경우는 제외시켰다. 집단간의 비교를 위해 paired t-검증을 실시하였다. 결 과 : 원형탈모증 환자군에서 MMPI 결과는 F 척도, K 척도, Hs 척도, D 척도, Hy 척도, Pd 척도, Pa 척도, Pt 척도, Sc 척도의 점수가 정상대조군에 비해 의미있는 차이를 보였고(p<0.05), SCL-90-R 점수에서는 SOM 척도, O-C 척도, I-S 척도, DEP 척도, ANX 척도, HOS 척도, PHOB 척도, PAR 척도, PSY 척도, GSI, PSDI, PST 점수가 정상대조군보다 유의하게 높은 점수를 보였다(p<0.05). 또한 TAS-20K 점수에서는 환자군이 정상대조군에 비해 Factor 1과 총점에서 유의하게 높은 점수를 보였다(p<0.05). 결 론 : 결론적으로, 원형 탈모증 환자군에서 정상 대조군에 비해 감정표현불능증이 더 심하고 특히 자신의 느낌을 잘 알지 못하는 것으로 나타났다 이는 원형탈모증 환자의 심리적인 대처기전을 세워 나가는데 좀더 주의를 기울이고, 더 많은 관심을 가져야 한다는 것을 의미한다. Objectives : Alexithymia has been regarded as the general personality of psychosomatic disease, but it's controversial. The object of the study is to find out the relationship between alexithymia and alopecia areata. Methods : Thirty one alopecia areata patients were compared to 31 normal healthy persons in alexithymic tendency using TAS-20K Also MMPI and SCL-90-R were checked in both groups. Psychiatric diseases were ruled out. Results : The scores of F, K, Hs, D, Hy, Pd, Pa, Pt and Sc of MMPI in alopecia areata patients were different from those in normal healthy persons. The scores of SOM, O-C, I-S, DEP, ANX, HOT, PHOB, PAR, PSY,GSI, PSDI, and PST of SCL-90-R in alopecia areata patients were significantly higher than those in normal healthy persons. In TAS-20K, the scores of Factor I and Total in alopecia areata patients were higher than those in normal healthy persons. Conclusion : Our results suggest that alopecia areata patients are more alexithymic than normal healthy persons.

소아 함치성 낭종의 치험례

이두형,안병준,장충현 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

Dentigerous cyst originates from the crown of the tooth has been completely formed by accumulation of fluid between the reduced enamel epithelium and the tooth crown. In the incidence age, dentigerous cyst occur with a more even distribution among the age groups but there is noticeable drop in the patients younger than ten. There is greater incidence of cysts in the maxilla than in the mandible, but dentigerous cysts differ in the respect ; there are found more often in the lower jaw. We experienced 4 cases of dentigerous cysts which is rare in first decade and acquired satisfying result by surgical excision.

계면활성제의 체인길이에 따른 구형 MCM-41의 합성

이두형,최병열,장원철,서길수,이태진 영남대학교 공업기술연구소 1999 工業技術硏究所論文集 Vol.27 No.1

Mesoporous MCM-41 exibits a hexagonal arrangement of uniform mesopores whose dimensions may be engineered in the range of ∼20Å to greater than 100Å. The MCM-41 typically have high surface areas above 1000m2/g, and then capacities of MCM-41 to accommodate the larger hydrocarbon is still higher than the general molecular sieve. At the present, many surfactants as organic templates have been proposed for various formations of these MCM-41. In this study, we synthesized mesoporous MCM-41 which has a spherically hexagonal structure. Also, the pore size of MCM-41 could be changed by the control of alkyl chain length of surfactants.

가토 뇌 Protein Methylase Ⅱ에 관한 연구

이창래,권기량,임규,황병두 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Protein methylase II has been purified from rabbit brain approximately 1,600 folds with a 6% yield by the methods of homogenation, (NH_4)_2SO_4 saturation, S-adenosyl-L-homocysteine sepharose 4B column chromatography and hydroxyapatite column chromatography. The enzyme shows a pH optimun around 6. The enzyme is easily inactivated by heat treatment for 5 minutes at 60℃, and when stored at -20℃ in the presence of 10% glycerol, 40% of activity has been lost in a week. Fe^2+ and Se activate this enzyme upto 16% and 22% at 2mM concentration and Ni, Zn^2+ and Cu^2+ inhibit upto 17%, 32%, 100% at 2mM respectively. The inhibition by 250μM Cu^2+ is completely recovered by 2.5mM DTT and 40% recovered by 300μM DEDTC. The apparent Km value for S-adenosyl-L-methionine was 2.2 x 10 exp (-6)M and kinetic analysis of this enzyme in the presence of 30μM cupper ion shows that the nature of the inhibition to the enzyme is noncompetitive.

Polydimethylsiloxane-Polyurethane Zwitterionomer의 합성과 그 특성에 관한 연구

姜斗煥,吳炳昌 단국대학교 1995 論文集 Vol.29 No.-

Polydimethylsiloxane-polyurethane zwitterionomer was prepared by ionizing polyester type polydimethylsiloxane-polyurethane copolymer containing tertiary amine with 1, 3-propane sultone. Unsaturated polyester type polydimethylsiloxane-polyurethane copolymer containing tertiary amine was prepared by reacting unsaturated polyester type polydimethylsiloxane polyol with MDI, and then chain extended with N-methyldiethanol amine. Mechanical properties of polydimethylsiloxane-polyurethane copolymer and polydimethylsiloxane-polyurethane zwitterionomer were measured. The mechanical properties of Polydimethylsiloxane-polyurethane zwitterionomer, Young's modulus increased from 5MPa to 14MPa, tensile strength increased from 3.4MPa to 7.1MPa, while elongation decreased from 115% to 97% because of the increase of bond energy in the hard domains and crystallinity by ionization.

胎盤組織의 Nucleases에 關한 硏究(Ⅱ) : 사람 胎盤組織의 Alkaline Deoxyribonucleases의 性狀 Properties of Alkaline Deoxyribonucleases from the Early Human Placenta

白汶基,黃炳斗,李正馥,琴基昌 충남대학교 의과대학 지역사회의학연구소 1978 충남의대잡지 Vol.5 No.1

Properties of alkaline deoxyribonucleases from cytosol and membane fractions of the early human placenta have been investigated. Evidence is indicating that the cytosol deoxyribonuclease (DNase) having an optimal pH around 9 and the plasma membrane bound DNases having an optimal pH around 8 (pH- 8-PM-DNase) and 9. 5 (pH-9.5-PM-DNase), respectively, are distinct enzyme entities. The cytosol DNase, partially purified, is activated by 1mM CO^2+ and the pH-8-PMDNase and the pH-9. 5-PM-DNase are required Mg^2+ and Co2^2+, respectively, for its maximal activity. The cytosol DNase is relatively heat-labile, whereas the plasma membrane bound DNases are heat-labile with some differnce. The above DNases act both on the native DNA and the heat-denatured DNA with preference for the latter. Kinetic analysis shows that the maximal velocity is independent of Co^2+, while Km decreases from 4. 16 × 10 exp(-4) M DNA-p in the absence of Cot^2+ to 9. 4×10 exp(-5) M DNA-p in the presence of Co^2+. From the above result and the fact that the DNA is not only associated with membrane structure, but also membrane-DNA interaction may be relevant to several pathologic process, including aging and carcinogenesis, we discussed that the PH-9-PM-DNase is related to the differenciation of the early placenta.

내분비기관으로서의 심방의 형태학적 특징에 관한 연구 - Ⅱ. 흰쥐의 심방 내강 및 내표면 구조

이무삼,두홍서,고병문,강경진,정우송,박병건,이창현 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.2

人蔘이 닭의 血中葡萄糖 및 遊離脂肪酸濃度에 미치는 影響

李神雄,李載欣,黃炳斗,琴基昌 충남대학교 의과대학 지역사회의학연구소 1974 충남의대잡지 Vol.1 No.1

Effect of Panax Ginseng on the plasma glucose and free fatty acid levels of the normal chicken and experimentally induced-hyperglycemic chicken, and on the release of glucose and glycogen contents in the chicken liver slices was investigated. 1) Plasma glucose levels was not influenced, but plasma FFA level decreased significantly by intravenous administration of Panax Ginseng in the normal chicken. 2) Epinephrine-induced hyperglycemic and hyperlipemic response and hyperglycemia induced by pancreatic ligation were inhibited by Panax Ginseng, and in the glucose tolerance test, Ginseng shortened the recovery time to normal glucose level. 3) In the chicken liver slices, Panax Ginseng inhibited the release of glucose from the specimen, but did not affect glycogen contents of the tissue.