論文(론문) : 大腸正格證(대장정격증)과 장누수증후군(Leaky Gut Syndrome)과의 관계 考察(고찰)

이진철 ( Jin Cheoul Lee ),박상균 ( Sang Kyun Park ),방정균 ( Jung Kyun Bang ) 대한한의학원전학회(구 대한원전의사학회) 2013 대한한의학원전학회지 Vol.26 No.4

A Study on the Relationship between Dae-Jang-Jung-Gyeok(大腸正格) and Leaky Gut Syndrome Lee Jin-Cheoul1·Park Sang-Kyun2·Bang Jung-kyun3 *1Dept. of Medical History, College of Korean Medicine, Kyunghee University 2Dept. of Meridian, College of Korean Medicine, Sangji University 3Dept. of Korean Medical Classics and History, College of Korean Medicine, Sangji University Objective: If the penetration ratio of the intestinal mucosa is increased, the toxic or unhealthy materials - which should not be absorbed into our bodies - will be come into our bodies. They cause a sort of anti-toxic response or confusion of the immune system, and ultimately bring various types of diseases. This syndrome is related "Poison in Excrement" or "Internal Damage(內傷發□)" and Leaky Gut Syndrome, so I will study on the relationship between them. Method: Study on the relationship between Dae-Jang-Jung-gyeok and Leaky Gut Syndrome. Result: Korean doctors in ancient times called this syndrome "Poison in Excrement" or "Internal Damage(內傷發□)" and treated it with "Dae-Jang-Jung-Gyeok(大腸正格)". Leaky Gut Syndrome is a sort of clinical lesion, which allows foreign and harmful toxins in and results in a disorder of the immune system due to the leaking intestinal mucosa. Conclusion: Based upon the analyses, Dae-Jang-Jung-Gyeok and Leaky Gut Syndrome are closely related. Therefore diseases caused by the Leaky Gut Syndrome might be expected to be cured by Dae-Jang-Jung-Gyeok. Particularly the use of treatments for self-immune diseases and allergic diseases such as atopyic dermatitis and articular rheumatism should be expected to reveal a new path of treatment for other disorders such as Leaky Gut Syndrome. Key Words: Poison in Excrement, Internal Damage(內傷發□), Dae-Jang-Jung-Gyeok(大腸正格), Leaky Gut Syndrome

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

고관절 반 치환술의 대퇴 골절 예방을 위한 강선 고정의 효과

유정한 ( Jeong Han Yoo ),박용욱 ( Yong Wook Park ),박진수 ( Jin Soo Park ),노규철 ( Kyu Cheol Rowe ),정국진 ( Kuk Jin Chung ),김홍균 ( Hong Kyun Kim ),김형년 ( Hyong Nyun Kim ),임희준 ( Hee Joon Lim ),이철 ( Cheol Lee ),황지효 ( 대한고관절학회 2009 Hip and Pelvis Vol.21 No.2

목적: 무시멘트형 양극성 반 인공 관절 치환술에 있어서 수술 도중 발생하는 대퇴 골절 예방을 위한 예방적 강선 고정술의 효과를 분석하고자 한다. 대상 및 방법: 2004년 1월부터 2008년 8월까지 무시멘트형 양극 인공 관절 치환술을 받은 65세 이상의 환자 48명(1군)을 대상으로 하여 강선을 사용하지 않은 48명의 환자(2군)와 비교하였다. 평균 나이는 75.4세(1), 73.6세(2)이었고 평균 추시 기간은 19.1개월(1), 18.3개월(2)이었다. 수술 도중 골절 발생율 외에 수술 시간, 수술 도중 예상 출혈량, 입원 기간, 방사선학적 안정성을 측정하였고 임상적 평가를 위한 대퇴 통증과 Jensen의 기능 점수와 Parker와 Palmer의 활동 점수를 비교하였다. 결과: 1군에서는 수술 도중 골절이 발생하지 않았으며 2군에서 4예(8.3%)가 발생하였다(p=0.041). 수술 시간은 각각 172분(1), 162분(2) 예상 출혈량은 866 cc(1), 855 cc(2), 입원기간 36일(1), 35일(2)이었다. 방사선학적으로 침강은 1.59 mm(1), 1.67 mm(2)이었으며 임상적으로 대퇴 통증이 1예(1), 2예(2) 관찰되었다. 임상적으로 Jensen의 기능 점수는 평균 2점(1) 2.2점(2), Parke와 Palmer의 활동 점수는 평균 5.2점(1), 5.3점 (2)이었다. 결론: 무시멘트형 인공 관절 치환술에 있어서 예방적 강선 고정술은 골절률을 의의있게 감소시켰다. Purpose: The purpose of this study was to assess the effect of a prophylactic cable fixation for prevention of femoral fractures in cementless bipolar hemiarthoplasties. Materials and Methods: Forty-eight cementless bipolar hemiarthroplasties with prophylactic cable fixations on the femur were performed in patients>65 years of age between January 2004 and August 2008 (group 1). The control group which did not undergo prophylactic cable fixation included 48 cases (group 2). The mean age was 75.4 years (group 1) and 73.6 years (group 2). The patients were followed up for an average of 19.1 (group 1) and 18.3 months (group 2). The intra-operative fracture rates were compared. Additionally, operative time, estimated blood loss (EBL), and length of hospital stay were compared. Radiologic assessment for stem stability was performed. Clinical assessment was evaluated by the thigh pain and Jensen`s functional score, and Parker & Palmer`s mobility score. Results: There was no fractures in the cabled group (1), and 4 fractures (8.3%) in the control group (2; p=0.041). The mean operative time was 172 minutes (1) and 162 minutes (2), the EBL was 866 cc (1) and 855 cc (2), and the duration of admission was 36 (1) and 35 days (2), respectively. Radiologically, subsidence was 1.59 mm (1) and 1.67 mm (2). Clinically, one (1) and two (2) thigh pains were recorded and the functional score of Jensen was 2 (1) and 2.2 points (2), and the mobility score of Parker and Palmer was 5.2 (1) and 5.3 points (2), respectively. Conclusion: Prophylactic cable fixation is effective for reducing intra-operative femoral fractures.

노인의 Helicobacter pylori 재균율

박주상,홍원선,이영수,이은주,명승재,정훈용,양석균,김진호,민영일 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

G.A 기반 디지털 디자인에 관한 고찰

박정대,김진균 대한건축학회 2004 대한건축학회논문집 Vol.20 No.11

This paper investigates one of the newest digital design methods in architecture to date: Genetic Algorithm(GA)-based generative growth system as a creative surface synthesis process to explore for new architecture. The paper consider aspects of design computation and discuss the new understanding that these have been approached in order to make computation useful in creativity of design. The digital design based on the GA in architecture has typical features that new structural morphology, the operative mechanism of the inheritance and variation, the population-based adaptive process and the design process with intended productivity.

일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.

샤피충격시험기를 이용한 PVC/MBS 재료의 파괴인성치에 관한연구

박명균,양진승,최영식 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

The notched charpy and Izod impact test is the most prevalent technique used to characterize the effect of high impulse loads on ploymeric materials. A method of analysis in rubber toughened PVC is suggested to evaluate the critical strain energy release rate Gc from the Charpy and Izod impact energy measurement. Instrumented Charpy impact tester was used to extract ancilliary information concerning fracture properties in addition to total fracture properties and maximum critical load. The stress intensity factor Kd was calculated for the variation of rubber contents from the obtained maximum critical load and toughned effects were investigated.

"한국판 학령전기 기질성격검사[K-psTCI]" 의 신뢰도 및 타당도 검사

박진균,김지웅,기선완,신의진 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : The purpose of this study was to evaluate the reliability and validity of the Korean version of Preschool Temperament and Character Inventory (K-psTCI), a questionnaire based on Cloninger's seven-factor model of personality. Methods : The psTCI was translated into Korean and administered to 266 children aged 2-6 years. α test-retest study of the K-psTCI was conducted across a 4-month interval, Internal consistency was calculated by Cronbach a. Test-retest and reliability was analyzed by Pearson correlation analysis. Factor analyses for the temperament and character dimensions were performed using principal component analysis, rotating factors by varimax. The psTCI scores of Korean and United States preschoolers were compared Results : Cronbach α values for the K-psTCI scales ranged from .62 to .78 for each dimensions. Test-retest correlations (r) ranged from .50 to .77 for each dimensions. Explorative factor analysis with the condition of eigenvalue greater than 2 produced four factors for the temperament items and three factors for the character items like the US original version of psTCI. Through factor analyses, five items in the K-psTCI were categorized differently from the US version of psTCI. Korean preschoolers had higher mean scores on Cooperativeness (CO) in males as compared to a sample of US preschoolers. Conclusion : The results of this study suggests that the Korean preschool TCI is satisfactory in reliability and validity.

거울형 자계 구조를 갖는 진공 여과 아크 증착법을 이용한 증착 변수에 따른 다이아몬드상 탄소 박막의 증착 및 물성 분석

박창균,엄현석,서수형,박진석 漢陽大學校 工學技術硏究所 2000 工學技術論文集 Vol.9 No.1

본 논문에서는 거울형 자계 구조를 갖는 진공 여과 아크법을 이용하여 다이아몬드상 카본 박막을 증착하였다. 음극 근처에 영구자석과 자기요크를 사용하여 음극 표면에서의 아크 스팟의 이동도와 아크 플라즈마의 안정도를 증진시킬 수 있었다. 증착압력과 기판전압을 변화시켜 증착 하였으며 이에 따른 물성의 변화를 분석하였다. 그 결과 증착압력 3×10-4 Torr와 기판전압 -50V에서 가장 높은 sp3/sp2 분율을 얻을 수 있었다. 또한 500℃까지 열처리에 따른 박막의 열적 안정성을 평가하였다. DLC films are deposited by using an FCVA deposition system with a mirror-type magnetic field configuration. Permanent magnets and magnetic yokes around the cathode have been observed to enhance the mobility of arc spots on the cathode and the stability of arc plasma. Effects of reactor pressures and substrate biases on structural properties of DLC films deposited are investigated. The results show that the highest sp3/sp2 fraction is obtained when the films are deposited at a pressure of 3 × 10-4 Torr and a bias voltage of -50 V. The variation of the structural properties due to thermal stress up to 500 ℃ is also examined.

프랭크 게리의 디지털 디자인 프로세스에 관한 연구

박정대,김진균 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

The purpose of this paper investigates one of the digitally adapted design methodologies in architecture. Reverse Engineering(RE)-based digital design process as surface representation process to construct a complex free-from shape and explore for new architecture. The paper takes as its objective of inquiry a specific set of building intentions, and associated computational strategies, playing a fundamental role in Gerhy's projects the design, engineering and fabrication of surface forms. The digital design process in Frank O Gehry's architecture has typical features that new geometry, structural skin, not mass production but mass customization, new role-model of architect as master builder and cultural transition to collaborative partnerships.