강원지역의 자원관리를 위한 지리정보시스템 개발

서백수,임길재,정영준,송화선,류창희,민경원,서희정 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

강원도는 오랫동안 금속, 비금속, 석재 및 석탄과 같은 지하자원들을 공급하는 국내 주요생산지로 알려져 왔으나, 장기적인 채광과 비 계획적인 생산으로 인하여 매장량이 고갈되고 있으며, 대외적으로 생산 경쟁력 마저 잃어가고 있다. 이러한 문제점에 대한 해결방안의 일환으로 본 연구에서는 강원도내에 산재되어 있는 지하자원의 분포, 자원 생산시설 및 생산량, 경제성, 자원개발, 환경문제 등 자원관리에 필요한 제반사항을 수행할 수 있는 강원지역 자원 종합관리 GIS 시스템을 개발하였다. 이 시스템의 개발은 방대한 양의 정보 조사 및 저장, 오랜 개발기간, 많은 소요인력 및 개발 비용이 요구되기 때문에 본 연구에서는 조기에 자원관리 GIS 시스템을 개발하여 이와 관련된 생산 및 연구 분야에 조기에 적용할 수 있도록, 일차년도에는 현재 석재복합 신소재제품 연구센터의 집중적 연구대상 지역인 태백지역에 대한 탄광지역을 중심으로 자원 종합관리 GIS 시스템을 개발하였다. The Kangwon province has been well-known to be one of major underground resource producing districts which are mainly supplying metals, non-metals, stones, and coals. However, due to the long-term mining and unplanned production, the natural resource reserves have been rapidly drained and oversea production competition has been losing. In this study, we has developed a GIS system for regional resource management in the Kangwon province, which can operate, maintain, and manage the distribution of underground resources, resource production facilities, production and economic development, and environmental issues. The development of this system requires the collection, analysis, evaluation, and storage for a huge amount of research data, and in addition, the long period of time, the big research man power, and big development cost. Accordingly, to shorten the development period of time and to early apply itself to production, this stage of study has been intensively developed a regional resource GIS system for managing the mines scattered in the Tabak province, which is one of hottest RRC's research areas.

반코마이신 내성 장구균 감염에 대한 quinupristin-dalfopristin 치료 경험

추은주,최상호,조영환,정선미,김백남,김남중,김미나,김양수,우준희,류지소 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.1

VRE 감염이 중환자에서 급속히 증가하고 있으나 이에 대한 확실한 치료제가 없어 새로운 항생제에 대한 활발한 연구가 있는데 그 중 하나가 quinupristin/dalfopristin이고, 저자들은 중증 환자들의 VRE 감염에 대해 quinupristin/dalfopristin를 투여하여 치료한 임상적 경험을 하였기에 문헌고찰과 함께 보고하는 바이다. Vancomycin-resistant enterococci (VRE) was first recognized in 1992 in Korea. VRE infection have been increasingly reported in immunosuppressed patients over the past decade and have become one of major nosocomial pathogens. Clinicians carings for patients with VRE infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin is active in vitro againt vancomycin-resistant E. faecium (VREF), with a MIC_(90) of 1.0㎍/mL. We studied the clinical efficacy and safety of this agent in the treatment of VREF infection. Patients were included if they had signs and symptoms of active infection including bacteremia, intra-abdominal infection, and wound infection. A total of 13 patients with VREF infection were enrolled. A favorable clinical response (cure or improvement) occured in 10 of 11 evaluable patients. The only adverse events related to quinupristin/dalfopristin were arthralgia and myalgia, which occurred in 2 of 13 patients. These results suggest that quinupristin/dalfopristin is effective and safe as treatment for VREF infections in critically ill patients with serious underlying conditions.

Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched compar-ison with non-diabetic patients

( Chung Hee Baek ),( Hyosang Kim ),( Seung Don Baek ),( Mun Jang ),( Wonhak Kim ),( Won Seok Yang ),( Duck Jong Han ),( Su-kil Park ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.2

Background/Aims: Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome in diabetic patients compared with that in non-diabetic patients remains controversial. In addition, owing to recent improvements in the outcomes of KT and management of cardiovascular diseases, it is necessary to analyze outcomes of recently performed KT in diabetic patients. Methods: We reviewed all diabetic patients who received living donor KT between January 2008 and December 2011. Each patient was age- and sex-matched with two non-diabetic patients who received living donor KT during the same period. The outcomes of living donor KT were compared between diabetic and non-diabetic patients. Results: Among 887 patients, 89 diabetic patients were compared with 178 non-diabetic patients. The incidence of acute rejection was not different between the diabetic and non-diabetic patients. Urinary tract infection and other infections as well as cardiovascular events occurred more frequently in diabetic patients. However, diabetes, cardiovascular disease, and infection were not significant risk factors of graft failure. Late rejection (acute rejection after 1 year of transplantation) was the most important risk factor for graft failure after adjusting for diabetes mellitus (DM), human leukocyte antigen mismatch, rejection and infection (hazard ratio, 56.082; 95% confidence interval, 7.169 to 438.702; p < 0.001). Mortality was not significantly different between diabetic and non-diabetic patients (0 vs. 2, p = 0.344 by log-rank test). Conclusions: End-stage renal disease patients with DM had favorable outcomes with living donor kidney transplantation.

저온질소순환 건조방법에 의해 제조된 고춧가루의 품질 특성

김정희(Chung-Hee Kim),류승희(Seung-Hee Ryu),이민자(Min-Ja Lee),백종원(Jong-Won Baek),황홍철(Hong-Cheol Hwang),문갑순(Gap-Soon Moon) 한국식품과학회 2004 한국식품과학회지 Vol.36 No.1

한국에서 번식하는 오목눈이의 둥지장소 선택과 서식지 이용 특성

백충열 ( Chung-yeol Baek ),이진희 ( Jin-hee Lee ),노선호 ( Sun-ho No ),장경희 ( Kyung-hee Jang ),조삼래 ( Sam-rae Cho ) 한국환경생태학회 2016 한국환경생태학회지 Vol.30 No.5

본 연구는 2008년부터 2012년까지 오목눈이의 번식기에(2월에서 6월) 공주대학교 교내 및 인근지역과 계룡산국립공원 그리고 월악산국립공원에서 수행하였다. 총 98개의 오목눈이 둥지를 조사결과 15종의 수목에 둥지를 만들었으며, 특별히 선호하는 나무의 수종은 없는 것으로 나타났다. 그러나 나무의 수종을 생활형으로 구분하여 분석한 결과, 상록침엽교목과 낙엽활엽교목 그리고 낙엽활엽관목으로 나타났으며 그중 상록침엽교목을 선호하는 것으로 나타났다. 식생에 의해 오목눈이의 둥지가 가려진 정도인 은폐도는 공주대학교 교내 및 인근지역이 11.61±4.79%(n=29)로 나타났으며, 계룡산국립공원은 6.06±2.31%(n=43), 월악산국립공원은 4.38±2.19%(n=26)로 나타났다. 지역별로 이웃한 오목눈이둥지의 은폐도는 서로 비슷한 정도로 가려져 있었으나, 지역 간의 은폐도는 상관관계가 없는 것으로 나타났다. 또한 오목눈이 둥지의 보호색 정도를 살펴본 결과, 오목눈이 둥지주변 환경의 색 코드 값에서 오목눈이 둥지의 색 코드 값을 뺀 평균은 26.52±16.14(n=32)로 나타났으며, 오목눈이의 둥지는 주변 환경에 따라서 보호색을 띠고 있는 것으로 나타났다. 오목눈이 둥지의 영소목이 상록침엽교목이면 녹색의 이끼를 많이 물어와 둥지를 만드는 반면 관목이나 영소목이 균류 등에 의하여 노란색을 띠게 되면 마른이끼를 둥지 재료로 사용하여 전체적으로 노란색을 띠는 경향이 있었다. This study was carried out on Kongju National University and its neighboring area, Mt. Gyeryong national park and Mt. Worak national park in the breeding season of long-tailed tits Aegithalos caudaatus from 2008 to 2012. The result of the inquiry, the nests were found in 15 species of trees, and this result shows me it`s not choosy about them. But after having classified them according to the features and analyzed them, long-tailed tits preferred evergreen needleleaf tree and deciduous broad-leaf tree and deciduous bush, especially evergreen needleleaf tree. The concealment rate of long-tailed tits` nests was 11.61±4.79%4.38±2.19%(n=29) in Kongju National University and it`s neighboring area, 6.06±2.31%(n=43) in Mt. Gyeryong national park and 4.38±2.19%(n=32) in Mt. Worak national park. By regional groups, the concealment rates of neighboring nests were almost same, but there are no differences among the areas. The average of the color codes was 26.52±16.14(n=32) that those of the nest subtract from those of surroundings of the nest. The nests were procryptic according to their surroundings, and if their nest in a tree were evergreen needleleaf trees, they were made of moss. while if the trees of nest in a tree were yellow because of fungus, made of dried moss, they were yellow, too.

Current status of pediatric umbilical cord blood transplantation in Korea: A multicenter retrospective analysis of 236 cases

Yoo, Keon Hee,Lee, Soo Hyun,Sung, Ki Woong,Koo, Hong Hoe,Chung, Nak Gyun,Cho, Bin,Kim, Hack Ki,Kang, Hyoung Jin,Shin, Hee Young,Ahn, Hyo Seop,Baek, Hee Jo,Han, Dong Kyun,Kook, Hoon,Hwang, Tai Ju,Kim, Wiley Subscription Services, Inc., A Wiley Company 2011 American journal of hematology Vol.86 No.1

<P><B>Abstract</B></P><P>We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that the sources of the grafts were mostly unrelated donors (<I>n</I> = 226; 95.8%), only the results of unrelated UCBT were included for all statistics. The most frequent primary disease was acute leukemia (<I>n</I> = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 × 10<SUP>7</SUP>/kg and 2.00 × 10<SUP>5</SUP>/kg, respectively. The median times to neutrophil (>0.5 × 10<SUP>9</SUP>/L) and platelet recovery (>20 × 10<SUP>9</SUP>/L) were 18 and 45 days, respectively. Grade 2–4 acute graft‐versus‐host‐disease (GVHD) and chronic GVHD developed in 41.1 and 36.1% of cases, respectively. Forty‐five patients developed CMV disease. The 5‐year overall and event‐free survival were 47.5 and 36.9%, respectively. Multivariate analysis revealed that adverse factors for survival of the whole cohort were total body irradiation‐based conditioning (<I>P</I> = 0.007), salvage transplant (<I>P</I> = 0.001), failure to achieve early complete chimerism (<I>P</I> < 0.0005), and CMV disease (<I>P</I> = 0.001). The outcomes of the single‐ and double‐unit UCBT (<I>n</I> = 64) were similar, while double‐unit recipients were heavier (<I>P</I> < 0.0005) and older (<I>P</I> < 0.0005). We conclude that double‐unit UCBT is a reasonable option for older or heavier children and that the thorough surveillance of CMV infection and the development of an effective CMV therapeutic strategy may be especially important for Korean children, whose CMV seroprevalence exceeds 90%. Am. J. Hematol., 2011. © 2010 Wiley‐Liss, Inc.</P>

증례 : 급성 골수성 백혈병 환자에서 발생한 국소성 신장 아스페르길루스증 1예

정우백 ( Woo Baek Chung ),이동건 ( Dong Gun Lee ),최영기 ( Young Ki Choi ),박선희 ( Sun Hee Park ),최수미 ( Su Mi Choi ),김희제 ( Hee Je Kim ),신완식 ( Wan Shik Shin ) 대한내과학회 2004 대한내과학회지 Vol.67 No.-

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination

Lee, Moon Hee,Lee, Sung Won,Lee, Eun Joo,Choi, Soo Joon,Chung, Sung Soo,Lee, Jae Il,Cho, Joong Myung,Seol, Jae Hong,Baek, Sung Hee,Kim, Keun Il,Chiba, Tomoki,Tanaka, Keiji,Bang, Ok Sun,Chung, Chin Ha Nature Publishing Group 2006 Nature cell biology Vol.8 No.12

The p53 tumour suppressor has a key role in the control of cell growth and differentiation, and in the maintenance of genome integrity. p53 is kept labile under normal conditions, but in response to stresses, such as DNA damage, it accumulates in the nucleus for induction of cell-cycle arrest, DNA repair or apoptosis. Mdm2 is an ubiquitin ligase that promotes p53 ubiquitination and degradation. Mdm2 is also self-ubiquitinated and degraded. Here, we identified a novel cascade for the increase in p53 level in response to DNA damage. A new SUMO-specific protease, SUSP4, removed SUMO-1 from Mdm2 and this desumoylation led to promotion of Mdm2 self-ubiquitination, resulting in p53 stabilization. Moreover, SUSP4 competed with p53 for binding to Mdm2, also resulting in p53 stabilization. Overexpression of SUSP4 inhibited cell growth, whereas knockdown of susp4 by RNA interference (RNAi) promoted of cell growth. UV damage induced SUSP4 expression, leading to an increase in p53 levels in parallel with a decrease in Mdm2 levels. These findings establish a new mechanism for the elevation of cellular p53 levels in response to UV damage.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

A New Peanut Variety “Daan” with High Yield and Disease Resistance

Suk-Bok Pae,Myung-Hee Lee,Sung-Up Kim,Chung-Dong Hwang,Ki-Won Oh,Chan-Sik Jung,Deuk-Young Song,In-Youl Baek,Young-Hee Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Peanut is grown worldwide in the tropics and temperate zones primarily as an oilseed crop (38-54%) and protein source(25-30%). A new peanut variety “Daan”(Arachis hypogaea ssp. fastigiata L.) with the high yield potential was developed at the Department of Southern Area Crop Science, NICS, in Milyang in 2014. This was developed from the crossing line between cultivar “Sangpyeong” with short stem and high quality and “Dakwang” with large grain. “Daan” which is Shinpung plant type has 44cm of main stem length and 13 branch number per plant. Each pod has two grains with long ellipse shape of brown testa and yield components is composed of 34 mature pods of per plant, 127g of 100-seed weight, 75% of pod shelling ratio in the regional yield trials(RYT). Seed quality showed 47.8% of crude oil and 28.3% of protein content. This variety also showed more resistant to early leaf spot, late leaf spot, web blotch, stem rot and lodging compared with check variety “Daekwang”. In the regional yield trials “Daan” outyielded check variety by 16% with 5.00 MT/ha for kernel yield.