Risk for Parkinson’s disease in patients with Behcet’s Disease: A nationwide population-based dynamic cohort study in Korea

( Min Ji Kang ),( Ji Min Seo ),( Joo Hee Lee ),( Dong Soo Yu ),( Young Bok Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Although several studies have reported a correlation between Behcet’s disease and Parkinson’s disease, this association has not yet been clarified. Objectives: The aim of this study is to determine the risk of Parkinson’s disease in patients with Behcet’s disease. Methods: Behcet’s disease patients (n = 17,179; mean age, 51.12±8.09 years; male, 34.95%) without known previous diagnosis of Parkinson’s disease were selected from the Korean National Health Insurance Database between 2010 and 2013. An age and gender-matched control population of individuals without Behcet’s disease was randomly sampled at a ratio of 3:1 (n = 34,575). Both cohorts were followed for development of Parkinson’s disease until 2015. Results: Among a total of 11,525 Behcet’s disease patients, 50 (0.43%) developed Parkinson’s disease, whereas only 51 among the 34,575 individuals in the non- Behcet’s disease group developed Parkinson’s (0.15%, P < 0.0001). The incidence of Parkinson’s disease was significantly higher in Behcet’s disease patients than in controls. In addition, during the follow-up period, patients with Behcet’s disease were more likely to be diagnosed with Parkinson’s disease than those in the non- Behcet’s disease group. Conclusion: Behcet’s disease patients had a higher risk of Parkinson’s disease compared to non- Behcet’s disease controls. Physicians should carefully monitor patients with Behcet’s disease for potential development of Parkinson’s disease.

Surgical Outcomes of Spine Disorders in Patients with Parkinson's Disease

박상혁,오재근,김태엽,김의현,이효상,유남규,최귀현,이성,하윤,윤도흠,김긍년 대한척추신경외과학회 2011 Neurospine Vol.8 No.3

Purpose: Patients with Parkinson’s disease also commonly have movement disorders, osteoporosis, and other comorbidities. These patients are more likely to have complications after spinal surgery. The aim of the present study is to show the relation ship between complications of spinal surgery and Parkinson's disease. Methods: A computerized search using diagnostic and procedural codes identified 13 patients with Parkinson's disease who underwent spinal surgery between January 1998 and December 2010. Their medical records and imaging studies were reviewed and recent updatesfor all patients were done by telephone interview. Results: Retrospectively, 13 consecutive patients were reviewed. The mean age was 63.8 (range 44~87) years old and the mean durationof Parkinson's disease was 7.6 (range 1~22) years at the time of the index procedure. The mean T score of the lumbar spine on Dual-energy X-ray absorptiometry (DEXA) scan bone mineral density (BMD) was -2.5 (range -1.0~-5.1). These patients had nine lumbar lesions, two thoracic lesions, one cervical lesion, and one thoracolumbar lesion. Nine patients required no more surgical treatment for lesions which had been previously operated on (index level). However, four patients (30.8%) needed at least one more operation related to their index procedure; segmental degeneration on the adjacent levels in two, retropulsion of an intervertebral cage with screw loosening in one, and pedicle fracture in one. Conclusion: It has been reported that patients with Parkinson's disease have high complication rates in spinal surgery. Spine surgeons should be aware of the risk of complications and need to conduct careful follow-up after the surgery. Purpose: Patients with Parkinson’s disease also commonly have movement disorders, osteoporosis, and other comorbidities. These patients are more likely to have complications after spinal surgery. The aim of the present study is to show the relation ship between complications of spinal surgery and Parkinson's disease. Methods: A computerized search using diagnostic and procedural codes identified 13 patients with Parkinson's disease who underwent spinal surgery between January 1998 and December 2010. Their medical records and imaging studies were reviewed and recent updatesfor all patients were done by telephone interview. Results: Retrospectively, 13 consecutive patients were reviewed. The mean age was 63.8 (range 44~87) years old and the mean durationof Parkinson's disease was 7.6 (range 1~22) years at the time of the index procedure. The mean T score of the lumbar spine on Dual-energy X-ray absorptiometry (DEXA) scan bone mineral density (BMD) was -2.5 (range -1.0~-5.1). These patients had nine lumbar lesions, two thoracic lesions, one cervical lesion, and one thoracolumbar lesion. Nine patients required no more surgical treatment for lesions which had been previously operated on (index level). However, four patients (30.8%) needed at least one more operation related to their index procedure; segmental degeneration on the adjacent levels in two, retropulsion of an intervertebral cage with screw loosening in one, and pedicle fracture in one. Conclusion: It has been reported that patients with Parkinson's disease have high complication rates in spinal surgery. Spine surgeons should be aware of the risk of complications and need to conduct careful follow-up after the surgery.

포스트 코로나 시대, 파킨슨 환자를 위한 미디어 무용교육의 방안

이은형 ( Eun-hyoung Lee ),이선경 ( Sun-kyoung Lee ) 기독교학문연구회 2021 신앙과 학문 Vol.26 No.1

본 연구는 포스트 코로나 시대의 파킨슨 환자를 위한 미디어 무용교육의 방안을 모색하고자 연구되었다. 고령화 사회로 접어들면서 노인인구는 더욱 증가하게 되었고 그로 인하여 노인성 질환자도 함께 증가 하였다. 3대 노인성 뇌 신경계 질환 중 하나인 파킨슨병 역시 매년 노인인구가 증가함에 따라 그 발병률이 증가하고 있다. 파킨슨병은 발병원인이 뚜렷하게 밝혀지지 않아 질병의 진행 억제와 증상완화를 위한 약물치료와 수술치료, 그리고 운동치료를 통하여 치료를 하고 있다. 그러므로 파킨슨 환자들에게 꾸준한 약물치료와 운동치료는 매우 중요하다.무용은 파킨슨 환자의 신체 기능을 향상시키고 우울감과 스트레스 해소 등의 긍정적인 효과를 주는 것으로 연구되고 있으며 파킨슨 환자들 역시 무용프로그램에 적극적으로 참여하고 있다.코로나19 바이러스의 발생은 인간 생활의 많은 부분을 변화시켰다. 재택근무, 원격수업, 온라인수업 등 비대면 방식이 활성화 되었고 앞으로 코로나19 바이러스 이후의 시대인 포스트 코로나 시대에는 온라인을 통한 미디어 활용 방식이 더욱 활성화 될 것으로 기대한다. 이에 따라 파킨슨 환자를 위한 무용교육 또한 미디어를 활용한 방안으로 연구되어야 할 것으로 사료된다.따라서 본 연구는 파킨슨 환자를 위한 무용교육의 방안 모색을 위해 세 가지의 방안과 그로 인한 긍정적인 기대효과를 제시하였다. This study was conducted t o s eek measures for media dance education for patients with Parkinson's disease in the Post-COVID-19 Age. Entering an aging society, in South Korea, the population of the aged has further increased, and accordingly, patients with senile diseases have increased, too. The prevalence of Parkinson’s disease, one of the big three senile diseases in the cerebral nervous system, increases as the population of the aged increases each year. Since the cause of the occurrence of Parkinson’s disease has not yet been revealed, it is treated through medication, operative treatment, and exercise therapy for the suppression of its progress and the alleviation of its symptoms. Thus, for patients with Parkinson's disease, continuous medication and exercise therapy are very important.As it has been reported that dance enhances the physical functions of patients with Parkinson's disease and has positive effects on the alleviation of depression and stress, patients with Parkinson's disease also actively participate in dance programs.The occurrence o f C OVID-19 h as c hanged m any p arts of human life. Untact methods such a s telecommuting, remote learning, and online classes, etc. have been revitalized, and it is expected that in the Post-COVID-19 Age after the end of COVID-19 in the future, the online methods utilizing media will further be revitalized. Thus, it is judged that it is necessary to investigate measures utilizing media also in dance education for patients with Parkinson's disease.Therefore, this study presented three methods and the positive expected effects of this to explore ways of dance education for Parkinson's patients.

파킨슨병 환자의 정량적 뇌파분석 -비선형분석을 이용한 정상인 및 본태성 진전 환자와의 비교

조은경,최병옥,김용재,박기덕,김응수,최경규,Cho, Eun-Kyoung,Choi, Byung-Ok,Kim, Yong-Jae,Park, Ki-Duck,Kim, Eung-Su,Choi, Kyoung-Gyu 대한임상신경생리학회 2006 Annals of Clinical Neurophysiology Vol.8 No.2

Background: Parkinson's disease is movement disorder due to dopaminergic deficiency. It has been noted that cognitive dysfunction also presented on Parkinson's disease patients. But, it is not clear whether such a cognitive dysfunction was a dopaminergic dysfunction or cholinergic dysfunction. Using linear and non-linear analyses, we analysed the effect of cognitive and motor symptom on EEG change. Methods: EEGs were recorded from patients with Parkinson's disease and essential tremor, and normal controls during rest. We calculated the power spectrum, correlation dimension and Lyapunov exponent by using 'Complexity'program. The power spectrum, correlation dimension, and Lyapunov exponent were compared between Parkinson's disease patients and essential tremor patients. Results: Theta power was increased in Parkinson's disease patient group. Correlation dimension was increased in Parkinson's disease patients. Positive correlation was noted between MMSE and correlation dimension, and negative correlation was noted between MMSE and Lyapunov exponent. Lyapunov exponent was decreased in Parkinson's disease patient. Conclusions: We conclude that the state of Parkinson's disease patient is characterized by increased correlation dimension and decreased Lyapunov exponent.

파킨슨 환자의 사상체질 및 UPDRS 분포 연구

정지철,김건형,박상민,이상훈,장대일,이윤호 대한침구의학회 2005 대한침구의학회지 Vol.22 No.4

Objective: In order to find Sasang constitutional therapies on Parkinson's disease and to make a fundamental basis for clinical application, this study was performed . Method : We recruit thirty five person as the disease group and we test them by QSCCII. also, We estimate them by UPDRS scale. Results : In the distribution of sasang constitution among parkinson's disease patients and controls, we can know that in the distribution of sasang constitution among parkinson's disease patients, Taeumin has a large division. but we don't find out significantly difference statistically. In the distribution of UPDRS Std. score of sasang constitution, we find out significantly difference statistically. Conclusions : Unfortunately, we fail to lead significantly difference statistically in the sasang constitution among parkinson's disease patients and controls. But, in the distribution of UPDRS Std. score of sasang constitution, we find out significantly difference statistically. Consequencely, it is necessary that further study on the theme in the more sample

파킨슨병을 앓고 있는 노인의 질병경험에 관한 현상학적 연구

김수영,한진태,최말옥 한국노인복지학회 2015 노인복지연구 Vol.0 No.68

Concerns on chronic degenerative diseases and caring for the long-term care elderly are increasing as progresses in a highly compressive aging society. Parkinson's disease brings difficulties in daily living activities, accompanying muscle stiffening, hand trembling, while the disease brings less impairment in cognitive functions, which on the other hand increases mental stress for patients and family burden as well. The purpose of this study is to investigate essential meaning of the experience going through the Parkinson's disease by discovering the feelings of the elderly with Parkinson's disease. By drawing 6 patients with Parkinson's disease, we conducted 2~3 sessions of interview from April to September in 2012. The study is conducted by analyzing interview recordings and observation note of their exercise program with phenomenological methodology. The results indicate the central phenomenon of elderly with Parkinson's disease as a process of 'Searching for attitude to the life by looking back upon one's life'. 26 subcategories and 7 topics are deducted throughout the process. Topics are classified as the time sequence, and each topic is correlated. Experience of disease according to the time sequence were classified as follows; ‘Discovering oneself different from the past.', ‘fatal diagnosis', ‘Trying to make efforts on putting back myself as in the past’, ‘Ashamed of own incompetence’, ‘Finding coping method of own’, ‘Finding hope out of dispair’, ‘Still remaining task’. Based on the fact, the study suggests practical and political alternatives on self management of elderly with Parkinson's disease and increasing quality of life. Through suggested measures, elderly with Parkinson's disease are expected to live within the community as a whole member of society. 우리나라는 압축적인 고령화가 진행되면서 만성 퇴행성질병과 장기요양보호 대상자들의 돌봄에 대한 관심이 증가하고 있다. 그 중 하나인 파킨슨병은 질병이 진행되면서 근육경직, 손떨림 등 여러 증상으로 인해 일상생활 수행이 어려워지지만, 인지기능의 손상은 없는 편이어서 환자들의 정신적인 스트레스와 가족부담이 다른 만성질환보다 많은 편이다. 현재 발병율은 높지 않지만, 발병율 증가속도가 치매 등에 비해 더 빠르다는 것을 감안한다면 사회적 지원 대상으로 관심을 높일 필요가 충분하다. 그러한 필요성을 토대로 본 연구에서는 파킨슨병을 앓고 있는 노인의 질병체험을 통한 본질의 의미를 탐구하고자 하였다. 2012년 4월~9월까지 약 5개월간 6명의 파킨슨병 환자를 대상으로 2~3회에 걸쳐 면접한 녹취록과, 그들의 운동프로그램 참여정도를 관찰한 관찰노트 등으로 현상학적 연구방법에 의해 연구하였다. 그 결과 파킨슨병을 앓고 있는 노인의 질병체험의 중심현상은 ‘되돌려 보는 여정을 통한 남은여생의 삶의 좌표 찾기’과정이었다. 그 과정에서 26개의 하위범주와 7개의 주제가 도출되었다. 파킨슨병을 앓고 있는 노인의 질병경험의 본질을 찾기 위하여 시간차원의 순서로 주제를 분류하였으며, 각각의 주제는 서로 연관되어있다. 시간차원에 의한 질병경험의 주제는‘이전과 다른 나의 발견’,‘하늘이 무너지는 진단명’,‘이상한 나를 이전의 나로 만들려는 노력’,‘아무 것도 할 수 없는 부끄러운 나’,‘나만의 대처방법 찾아가기’,‘절망속의 희망찾기’, ‘아직도 남아있는 숙제’로 분류되었다. 분석결과를 바탕으로 파킨슨병 환자인 노인들의 내면을 이해하고, 질병관리 및 삶의 질 향상을 위한 실천적, 정책적 과제를 제시하였다. 여러 대안들은 파킨슨병을 가진 노인들이 질병이 진행되어도 지역 공동체 속에서 사회구성원으로 함께 살 수 있는 방안을 모색하는 데 도움이 될 것이다.

Parkinson’s Disease in Sub-Saharan Africa- A Review of Epidemiology, Genetics and Access to Care.

Uduak Williams,Olivier Bandmann,Richard Walker 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2

A low prevalence of Parkinson’s disease has been reported in the Sub-Saharan Africa region. Genetic causes and indeed the clinical features of Parkinson’s disease are poorly described. Very few reports have examined the availability and access to evidence-based quality care for people living with Parkinson’s disease in the region. We reviewed all publications focusing on idiopathic Parkinson’s disease from Sub-Saharan Africa published up to May 2016 and observed a prevalence of Parkinson’s disease ranging between 7/100,000 in Ethiopia to 67/100,000 in Nigeria. The most recent community based study reported a mean age at onset of 69.4 years. Infrequent occurrence of mutations in established Parkinson’s disease genes was also observed in the region. Treatments were non-existent or at best irregular. There is also a lack of well trained medical personnel and multidisciplinary teams in most countries in the region. Drugs for treating Parkinson’s disease are either not available or unaffordable. Large-scale genetic and epidemiological studies are therefore needed in Sub-Saharan Africa to provide further insight into the role of genetics and other aetiological factors in the pathogenesis Parkinson’s disease. The quality of care currently available also needs urgent improvement to meet the basis level of care required by Parkinson’s disease patients.

Validation of the Korean Version of the Scales for Outcomes in Parkinson's Disease-Sleep

성영희,김희진,고성범,김중석,김상진,천상명,조진환,김윤중,마효일,박미영,백종삼,이필휴,정선주,김종민,송인욱,김한준,김지영,권도영,이재혁,이지영,김지선,윤지영,홍진용,김미정,윤진영,김지선,오응석,양희준,윤원태,유수연,권겸일,박형은,이수윤,김연수,김희태,안태범 대한의학회 2018 Journal of Korean medical science Vol.33 No.2

Background: Sleep problems commonly occur in patients with Parkinson's disease (PD), and are associated with a lower quality of life. The aim of the current study was to translate the English version of the Scales for Outcomes in Parkinson's Disease-Sleep (SCOPA-S) into the Korean version of SCOPA-S (K-SCOPA-S), and to evaluate its reliability and validity for use by Korean-speaking patients with PD. Methods: In total, 136 patients with PD from 27 movement disorder centres of university-affiliated hospitals in Korea were enrolled in this study. They were assessed using SCOPA, Hoehn and Yahr Scale (HYS), Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Sleep Scale 2nd version (PDSS-2), Non-motor Symptoms Scale (NMSS), Montgomery Asberg Depression Scale (MADS), 39-item Parkinson's Disease Questionnaire (PDQ39), Neurogenic Orthostatic Hypotension Questionnaire (NOHQ), and Rapid Eye Movement Sleep Behaviour Disorder Questionnaire (RBDQ). The test-retest reliability was assessed over a time interval of 10–14 days. Results: The internal consistency (Cronbach's α-coefficients) of K-SCOPA-S was 0.88 for nighttime sleep (NS) and 0.75 for daytime sleepiness (DS). Test-retest reliability was 0.88 and 0.85 for the NS and DS, respectively. There was a moderate correlation between the NS sub-score and PDSS-2 total score. The NS and DS sub-scores of K-SCOPA-S were correlated with motor scale such as HYS, and non-motor scales such as UPDRS I, UPDRS II, MADS, NMSS, PDQ39, and NOHQ while the DS sub-score was with RBDQ. Conclusion: The K-SCOPA-S exhibited good reliability and validity for the assessment of sleep problems in the Korean patients with PD.

Network pharmacology of Withania somnifera against stress associated neurodegenerative diseases

Duyu Taaza,Khanal Pukar,Dey Yadu Nandan,Jha Sajal Kumar 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.3

Withania somnifera is a Rasayana of the Ayurvedic system of medicine that is widely used to treat stress-related neurological disorders. Although its anti-stress activity is reported in experimentally-induced stress models, the probable mechanism for neuroprotection has not been elucidated yet. Hence, the present study aimed to evaluate the effect of Withania somnifera against two neurodegenerative diseases (Parkinson’s and Alzheimer’s diseases) using a network pharmacology followed by molecular docking. The bioactives were retrieved from ChEBI and PCIDB databases; targets were predicted using BindingDB and were enriched via STRING. The combination synergy analysis of the constructed network was performed using Cytoscape. Similarly, molecular docking was performed using autodock4.0. Out of 45 phytoconstituents, 23 were predicted to modulate the proteins involved in the pathogenesis of Parkinson’s disease and Alzheimer’s disease. The combination synergy identified 10 and 6 targets interacting with 22 and 18 compounds in Parkinson’s disease and Alzheimer’s disease respectively. Pathways involved in Parkinson’s disease was cholinergic synapse; further cholinergic synapse and neuroactive ligand-receptor interaction were primarily involved in Alzheimer’s disease. Further, phytoconstituents-target-pathway interaction revealed that the highly modulated protein(s) involved in Parkinson’s disease was PRKCD whereas COX-1 and 2 in Alzheimer’s disease along with some common proteins in both. Network pharmacology analysis elucidated the probable molecular mechanisms of Withania somnifera in the management of stress-associated neurodegenerative diseases, identified the lead molecules, their targets, and possible pathways. However, the current findings are based on processor simulations and further experimental validation of the constructed network is still required to confirm the present findings.

침 및 운동 치료로 호전된 파킨슨병 환자 1례에 대한 증례보고

박미소,박상수,이승현,허왕정,유호룡 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.5

Objectives: Parkinson’s disease is characterized by progressive, irreversible damage to dopamine neurons in the substantia nigra pars compacta, as well as motor and non-motor symptoms. This disease currently has no dependable disease-modifying treatment. In this paper, we describe the treatment of a 67-year-old female with Parkinson’s disease using acupuncture and exercise therapy. Case Presentation: Clinical symptoms and the United Kingdom Parkinson’s Disease Society Brain Bank Diagnostic Criteria were used to diagnose the patient with Parkinson’s disease. Over a 12-week period, the patient visited a Korean medicine hospital 18 times and was treated with acupuncture and exercise therapy in addition to anti-Parkinson’s drugs. Before and after treatment, clinical examinations were performed using tools such as the Unified Parkinson’s Disease Rating Scale, Fall Efficacy Scale, Parkinson’s Disease Questionnaire, Berg Balance Scale, and Non-Motor Symptoms Scale. Furthermore, functional near-infrared spectroscopy was used to assess cortical hemodynamics. All clinical examination results improved after 12 weeks of intervention. In particular, improvements on the Total Unified Parkinson’s Disease Rating Scale and Part III of this scale demonstrated large, clinically important differences. Conclusion: This case suggests that combining acupuncture and exercise therapy could produce an effective treatment for Parkinson’s disease patients.