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      • 뇌졸중 환자에서 파킨슨병의 위험이 적은가?

        고성범 대한뇌졸중학회 2003 Journal of stroke Vol.5 No.1

        Department of Neurology, Korea University College of MedicineBackgroud : The data on the relationship between Parkinson‘s disease and stroke have been inconsistent; some showed a reduced risk of stroke in Parkinson’s disease patient, while others showed increased risk of stroke. Method : We measured the frequency of idopathic Parkinson’s disease(IPD) in stroke patients who admitted to Korea University hospital from January 2000 to September 2002. We compared these data to those observed in Parkinson‘s disease prevalence in Ansan-city, Korea (general population study). We investigated stroke risk factors in Parkinson‘s disease patients with stroke. Result : We screened 7 patients with Parkinson’s disease with stroke among 849 stroke patients. The relative risk for IPD in stroke patients was 0.64 compared to the Dutch population-based study & 0.55 compared to prevalence in Ansan-city. Conclusion : In our study, we found lower risk for Parkinson’s disease in stroke patients as compared to general population.

      • KCI등재
      • KCI등재

        Validation of the Korean-Version of the Nonmotor Symptoms Scale for Parkinson’s Disease

        고성범,김재우,마효일,안태범,조진환,이필휴,정선주,김중석,권도영,백종삼 대한신경과학회 2012 Journal of Clinical Neurology Vol.8 No.4

        Background and Purpose Non-motor symptoms are common in Parkinson’s disease (PD),and are the primary cause of disability in many PD patients. Our aim in this study was to translate the origin non-motor symptoms scale for PD (NMSS), which was written in English, into Korean (K-NMSS), and to evaluate its reliability and validity for use with Korean-speaking patients with PD. Methods In total, 102 patients with PD from 9 movement disorders sections of university teaching hospitals in Korea were enrolled in this study. They were assessed using the K-NMSS,the Unified Parkinson’s Disease Rating Scale (UPDRS), the Korean version of the Mini-Mental Status Examination (K-MMSE), the Korean version of the Montgomery-Asberg Depression Rating Scale (K-MADS), the Epworth Sleepiness Scale (ESS), and Parkinson’s Disease Questionnaire 39 (PDQ39). Test-retest reliability was assessed over a time interval of 10-14 days in all but one patient. Results The K-NMSS was administered to 102 patients with PD. The internal consistency and reliability of this tool was 0.742 (mean Cronbach’s α-coefficient). The test-retest correlation reliability was 0.941 (Guttman split-half coefficient). There was a moderate correlation between the total K-NMSS score and the scores for UPDRS part I [Spearman’s rank correlation coefficient,(rS)=0.521, p<0.001] and UPDRS part II (rS=0.464, p=0.001), but there was only a weak correlation between the total K-NMSS score and the UPDRS part III score (rS=0.288, p=0.003). The total K-NMSS score was significantly correlated with the K-MADS (rS=0.594, p<0.001), KMMSE (rS=-0.291, p=0.003), and ESS (rS=0.348, p<0.001). The total K-NMSS score was also significantly and positively correlated with the PDQ39 score (rS=0.814, p<0.001). Conclusions The K-NMSS exhibited good reliability and validity for the assessment of nonmotor symptoms in Korean PD patients.

      • KCI등재

        5-HT 수용체 길항제를 이용한 파킨슨 환자의 정신 증상의 치료

        고성범,박건우,이대희,Koh, Seong-Beom,Park, Kun-Woo,Lee, Dae-Hie 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

        Current treatment strategies for levodopa-induced psychosis in advanced Parkinson's disease have had limited success. Reduction or discontinuation of levodopa and coadministration with dopamine-blocking neuroleptics may attenuate the psychotic symptoms, but these strategies are associated with worsening of parkinsonian symptoms. Administration of 5-HT3 receptor antagonist ; ondansetron, a newer strategy to attenuate psychosis of Parkinson'disease without motor deterioration was introduced. A 41-year-old young-onset male, who was diagnosed as Parkinson's disease 7 years ago, was treated with levodopa therapy, and had levodopa-induced psychosis(delusion, hallucination, paranoid, insomnia). After trial of ondansetron, he showed improvement in the Brief Psychiatric Rating Scale(from 21 points to 9 points) in spite of increasing the dosage of levodopa. With ondansetron, we could increase the dosage of levodopa without psychotic complications(esp, hallucination), and he showed improvement in the motor fluctuation.

      • 악성 신경교종에 대한 ACNU-CDDP 요법

        고성범,유헌,고영초 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2

        Object: The purpose of our study was to evaluate the activity and toxicity of ACNU-CDDP chemotherapy for malignant gliomas. Materials and Methods: Six patients with malignant gliomas entered the study. Four patients had glioblastoma, ACNU (40㎎/㎡/day) and CDDP (40㎎/㎡/day) were administered concurrently for 3 days every 4-6 weeks. Results: After chemotherapy we obtained 2 CRs, 1 PR, 2SDs, and 1 PD. The over all response rate was 83%. The TTP after chemotherapy ranged from 2 to 8 months. The survival time after chemotherapy ranged from 2 to 14 months. Hematologic toxicity grade Ⅳ in two patients and grade Ⅲ in one patient, especially thrombocytopema, were the major complications due to chemotherapy. Conclusions: ACNU-CDDP chemotherapy regimen appears to have significant efficacy in malignant gliomas. However, even though the initial response was very remarkable, the duration of response was relatively short. Less toxic maintenance regimen which can be used concurrently or after radiation therapy should be investigated after induction of remission with ACNU-CDDP chemotherapy.

      • KCI등재후보
      • 복잡계 정보 처리를 위한 사람과 에이전트의 결합 모델

        고성범,김동근 한국정보과학회 2003 정보과학회논문지 : 소프트웨어 및 응용 Vol.30 No.7

        고속 전철 도입이나 대우 자동차 매각 같은 대규모의 B2B 거래에는 엄청나게 다양한 변수와 혼돈 요소가 직접 흑은 간접적으로 작용한다 소위 복잡계로 묘사되는 이런 유형의 도메인에 대하여 효율적인 정보처리가 가능하기 위해서는 인간의 묵시적 정보 처리 능력과 에이전트의 명시적 정보 처리 능력이 효율적으로 결합될 수 있어야 한다. 본 논문에서는, 이 두 가지 이질적 능력의 결합을 가능케 하는 결합 모델을 제안하였으며, 제안된 모델이 대표적 복잡계의 하나인 B2B 협상에서 어떻게 사용될 수 있는지를 보였다. In the large scale B2B transaction like buying ´Express-Train´ or selling ´Daewoo Motor`, a tremendous amount of variables and factors of chaos functionate in it directly or indirectly. To get the effective information processing on the so called complex system like this, it should be possible to unite the human´s ability on the implicit information processing and the agent´s ability on the explicit information processing. In this paper, we suggested a union model for uniting these two heterogeneous abilities and showed how the suggested model can be used for processing the information of such a complex system as B2B negotiation.

      • KCI등재

        복잡계 정보 처리를 위한 사람과 에이전트의 결합 모델

        고성범,김동근 한국정보과학회 2003 정보과학회논문지 : 소프트웨어 및 응용 Vol.30 No.8

        In the large scale B2B transaction like buying 'Express-Train' or selling 'Daewoo Motor', a tremendous amount of variables and factors of chaos functionate in it directly or indirectly. To get the effective information processing on the so called complex system like this, it should be possible to unite the human's ability on the implicit information processing and the agent's ability on the explicit information processing. In this paper, we suggested a union model for uniting these two heterogeneous abilities and showed how the suggested model can be used for processing the information of such a complex system as B2B negotiation. 고속 전철 도입이나 대우 자동차 매각 같은 대규모의 B2B 거래에는 엄청나게 다양한 변수와 혼돈 요소가 직접 혹은 간접적으로 작용한다. 소위 복잡계로 묘사되는 이런 유형의 도메인에 대하여 효율적인 정보처리가 가능하기 위해서는 인간의 묵시적 정보 처리 능력과 에이전트의 명시적 정보 처리 능력이 효율적으로 결합될 수 있어야 한다. 본 논문에서는, 이 두 가지 이질적 능력의 결합을 가능케 하는 결합 모델을 제안하였으며, 제안된 모델이 대표적 복잡계의 하나인 B2B 협상에서 어떻게 사용될 수 있는지를 보였다.

      • KCI등재

        무선 ATM에서 Crossover Switch 탐색 알고리즘의 성능 향상에 관한 연구

        고성범,정재일 한국통신학회 2001 韓國通信學會論文誌 Vol.26 No.8

        무선 ATM에서 핸드오프 시의 경로 재설정 과정에서 필요한 COS 선택 알고리즘에 관하여 기존의 알고리즘과는 다른 새로운 알고리즘을 제안한다. 제안하는 Short search COS 선택 알고리즘은 매 핸드오프 시마다 COS를 검색하지 않고 이전에 검색된 COS 노드를 최대한 활용하여 핸드오프 지연 성능을 저하시키지 않으면서 전체적인 망 이용 효율성은 향상시키는 결과를 나타낸다. 알고리즘의 개선된 성능을 시뮬레이션을 통해 검증되고 그래프 및 결과 테이블을 통해 보여진다.

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