Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

GIS를 활용한 주거용 적지분석에서의 절차적,방법론적 합리성 2: 용인시를 사례로

조규영 ( Kyu Young Cho ),옥진아 ( Jin A Ok ),서주환 ( Joo Hwan Suh ) 한국도시지리학회 2002 한국도시지리학회지 Vol.5 No.2

This study applies the proposed conceptual model for the land use suitability analysis. The study area is Young-In city which is one of the new housing development concentrated regions in the Seoul Metropolitan area. The purpose of this study is to compare the residential planning of the Yong-In City Master Plan (2001) with the proposed conceptual model application. The comparison is based on as follows: 3 methods (simple overlay method; linear standardization and AHP; Fuzzy and AHP) with 4 alternatives (city structural efficiency; environmentally sound development; and equal growth) and their conflict resolutions. The results are slightly different from each other; and very hard to conclude which method is superior. Rather, we may insist on that land use suitability analysis in Yong-In City Master Plan needs to be based on a well guided procedural model. The analysis of the plan is too naive to draw a future plan of the citizens. This may be the same in many other plans, but we need to scrutinize this subject and develop very practical and procedural analysis guidelines and manuals in order to have more rational plans.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Hepatocellular Carcinoma in the Elderly: Clinical Characteristics, Outcomes and Treatment Efficacy, Safety in Older than 75 Years

( Ji Ho Seo ),( Sunmin Kim ),( Eunae Cho ),( Chung Hwan Jun ),( Sun Young Park ),( Sung Bum Cho ),( Chang Hwan Park ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Rew ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) has been increasing because the increase in the longevity of the general population. But there is no proper management based on age stratification in elderly patients. We compared clinical characteristics, outcomes and treatment efficacy, safety between oldest-old (aged more than 85 years), middle-old (aged between 80 and 85 years) and young-old (aged between 75 and 80 years) patients with HCC. Methods: We conducted a retrospective cohort study, from January 2010 to December 2016, at Chonnam National University Hospital. A total of 550 elderly patients whose data included demographics, co-morbidity, etiology of liver disease, presence of cirrhosis, staging of HCC, treatment modality and treatment related adverse event were evaluated retrospectively. Also overall survival was assessed in enrolled patient. Results: Fifty one patients (oldest-old; median 87 years old), 153 patients (middle-old; median 82 years old) and 346 patients (young-old; median 77 years old) were diagnosed with HCC. Both oldest- and middle-old patients, compared to young-old patients had significantly lower rate of alcohol-related disease (13.7% vs 20.9% vs 34.1%, P = 0.001). There were no significant difference in underlying sex, body mass index, presence of co-morbidity, hepatitis C-related disease and stage of HCC. The Child-Pugh class (CPT class A 88.9% vs 84.1% vs 83.6%, CPT class B 11.1% vs 15.9% vs 15.0% and CPT class C 0.0% vs 0.0% vs 1.3%, respectively, P = 0.912) and Model for End Stage Liver Disease score (mean MELD score 7.22±3.34 vs 5.88±3.01 vs 5.77±3.14, P = 0.166) were no significant difference between the patients with active treatment. The modified UICC staging (stage I 5.6% vs 17.1% vs 18.6%, stage II 55.6% vs 46.3% vs 47.3%, Stage III 22.2% vs 24.4% vs 24.8%, Stage IV-A 11.1% vs 6.1% vs 4.9% and Stage IV-B 5.6% vs 6.1% vs 4.4%, respectively, P = 0.826) and Barcelona Clinic Liver Cancer staging (stage 0 5.6% vs 9.8% vs 9.3%, stage A 16.7% vs 17.1% vs 22.1%, stage B 27.8% vs 29.3% vs 24.8%, stage C 50.0% vs 43.9% vs 41.2% and stage D 0.0% vs 0.0% vs 2.7%, respectively, P = 0.878) were no significant difference between the patients with active treatment. Furthermore, there were no difference between the age groups in treatment modality (Surgical resection 0.0% vs 3.3% vs 5.2%, P = 0.166; Radiofrequency ablation 2.0% vs 8.5% vs 11.0%, P=0.113; Transcatheter arterial chemoembolization 21.6% vs 34.6% vs 41.6%, P=0.014; Best supportive care 62.7% vs 40.5% vs 29.2%, P < 0.001), adverse event related treatment (P = 0.731) and disease-free survival days (329 .3±309.1 days vs 271.7 ± 414.2 days vs 357.2 ± 511.6 days, P = 0.336). Multivariate analysis showed that age, performance status, CTP class, MELD score, modified UICC staging, presence of portal vein thrombosis and ruptured HCC are risk factors for mortality. Conclusions: Clinician should make an active treatment in elderly patients with HCC not a age but performance status, liver function and disease status of cancer.

Computer를 활용한 조경수목관리 Program개발의 기초적 연구

조영환,장영환,곽행구 木浦大學校 沿岸環境硏究所 1999 沿岸環境硏究 Vol.16 No.1

The main purpose of this study is to develop a computer-based management program of landscape woody plants, which make critical role in the outdoor environment. The program structure is composed of two functions ; Data input and Verification. The user interfaces employ pull-down menu so that the user can easily understand. The system components are as follows ; -Hardware : Pentium Processor 133MHz based system, 16MB RAM, 1.2GB Hard disk driver, SVGA Graphic Card -Software : Turbo C++ V3.0, TB(TaeBeck) V2.0 A case study is carried to verify the quality of the developed program, that is applied to the planted trees in Dorim Campus, Mokpo National University at Chungkae, Muan. The developed program as a result of this study has several merits. First, this program can operate under the environment of DOS and Windows. Second, it is possible to type and display Korea letters. Third, it is possible to verify multiply. But, the developed program should be integrated to overcome several difficulties such as Graphic Data and Data quality, etc.

GIS를 활용한 조경수목의 관리방안에 관한 연구

조영환,곽행구,송현 木浦大學校 沿岸環境硏究所 1999 沿岸環境硏究 Vol.16 No.1

This study was focused on the efficient management of landscape woody plants. The purpose of this study was to develop an inventory system and its proper application to a site for establishing a management plan. Two different approaches were used; The first was to make a newly structured inventory system through collecting, analyzing, and evaluating various types of inventories. The second approach was to apply a newly designed inventory system to the case study area, using GIS as a tool of spacial analysis, and statistics for making decisions. The results could be summarized as follows; 1.In Korea, most of the Landscape Woody Plants Inventories had datas which represented possession of trees, and only the work which they had done according to their traditional ways. There was no data related to the conditions, management needs, and site conditions of individual trees, this is essential information for organizing an inventory system. 2.There needs to be data which is balanced, containing tree characteristics and site characteristics. Through such information the management needs could be adjusted properly. The inventory list described in this paper was determined by botanical identity, placement condition, condition of tree, and types of work for maintaining as well as improving the condition of each tree. One of the most important things was to determine the location data of each tree so as to compare data with other trees. The data gained from the field survey still had some problems because of lack of scientific method for supporting objective views, and because of actual situations, especially in the field of evaluating site conditions and management needs. All data should be revised to fit a computer data management system, if possible. 3.The GIS(Geographic Information System) application showed good performance in handling inventory data for decision making. All the data used for the GIS application was divided into location and non-spatial data. Using the location data, it was easy to find the exact location of each tree on the monitor and on the maps generated by the computer, even in the actual managed site, along with various attribute data. Therefore it could be said that the entire management plan should start from data of individual trees with their exact locations, for making concrete management goals through actual budget planning.

중소기업조세지원 제도의 개선에 관한연구

曺廷煥,權英愛 경북대학교 1992 논문집 Vol.24 No.-

There are several assistance policies for the small and medium industries like financial, monetary and tax system. This study is limited tax assistance among them. And this study aims at showing the better measures by understanding the problems of the present tax assistance policies concerned to the small and medium industries. The documentary investigation was carried on to achieve the aim of this study. Business expansion orienting policy will drive the small and medium industries's tax revenues in long term point of view and this policy will be succeded by accepting complementary system for investment deficit. Tax system should be modified to improve their financial structure and also to increase deduction ratio to capital increase. Technical development is very important for the Korean economic growth. So the tax assistance policies would be necessary for improving the technical development.

都市自然公園 利用者 行態分析에 관한 硏究 : 木浦市 유달산 都市自然公園을 對象으로

趙榮煥,郭幸求 木浦大學校 沿岸環境硏究所 1995 沿岸環境硏究 Vol.12 No.1

It was the purpose of this study that offer the basic data concerning management of use and preservation in urban natural park by the analysis of user pattern of behavior. The site of case study was Yudal Urban Natural Park, which plays an important role for the environment and outdoor recreation. The analysis of user behavior and factors of determination of user satisfaction were investigated by questionnaires. The major findings were as follows; 1. Males were represented about 60%. The age group which was frequently represented in these questionaries were in the age of 20s(44.6%), 30s(20.5%), 50s(19.3%) and so on. Goverment officials were the largest one(37.8%) and the second one was the student group(26.2%) in their occupation. 2. The largest group of users was to visit this park every month(24.8%) and the time of stay was 2 hours per visit(44.9%). Many users visited the park with their lovers or friend(45.5%) Spring was the best season to their visit(44.4%) and they usualy came the park during weekend(48.2%). 3. Among the park area, Sculpture Park was the most popular place to visitors. Users were satisfy with roads for mountain climbing, but the other facilities were pointed out problems because of their bad appearence. 4.More users wanted to develop the area for the place of abundant natural charateristics for improving visitability than those who insisit on the conservation of present condition.

변단면 고층건물의 변동풍압특성

조지은,김동환,김종수,김영문 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

Nowadays the assessment of structural safety and serviceability of a tall building during strong wind is one of the important design criteria. The purpose of this study is to predict the pressure fluctuation of the tall building have different taper ratio of 5%, 10%, 15%. According to taper ratio, to know that the effect of vibration control on a tapered tall building attacked across wind. And also to give basic concepts of the tapered building on unpredictable wind directions. Acquired pressure data allowed analysis of the mean and r.m.s pressure coefficient, power spectral density function in measured taps at different levels and columns with considering the effects of wind directions and boundary layer conditions.

立地分析을 위한 GIS의 應用에 關한 硏究

趙榮煥 木浦大學校 沿岸環境硏究所 1993 沿岸環境硏究 Vol.10 No.1