Surgical technique for single-port laparoscopy in huge ovarian tumors: SW Kim`s technique and comparison to laparotomy

( Jeong Sook Kim ),( In Ok Lee ),( Kyung Jin Eoh ),( Young Shin Chung ),( Inha Lee ),( Jung-yun Lee ),( Eun Ji Nam ),( Sunghoon Kim ),( Young Tae Kim ),( Sang Wun Kim ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.2

Objective This study aimed to introduce a method to remove huge ovarian tumors (≥15 cm) intact with single-port laparoscopic surgery (SPLS) using SW Kim`s technique and to compare the surgical outcomes with those of laparotomy. Methods Medical records were retrospectively reviewed for patients who underwent either SPLS (n=21) with SW Kim`s technique using a specially designed 30×30-cm2-sized 3XL LapBag or laparotomy (n=22) for a huge ovarian tumor from December 2008 to May 2016. Perioperative surgical outcomes were compared. Results In 19/21 (90.5%) patients, SPLS was successfully performed without any tumor spillage or conversion to multi-port laparoscopy or laparotomy. There was no significant difference in patient characteristics, including tumor diameter and total operation time, between both groups. The postoperative hospital stay was significantly shorter for the SPLS group than for the laparotomy group (median, 2 [1 to 5] vs. 4 [3 to 17] days; P<0.001). The number of postoperative general diet build-up days was also significantly shorter for the SPLS group (median, 1 [1 to 4] vs. 3 [2 to 16] days; P<0.001). Immediate post-operative pain score was lower in the SPLS group (median, 2.0 [0 to 8] vs. 4.0 [0 to 8]; P=0.045). Patient-controlled anesthesia was used less in the SPLS group (61.9% vs. 100%). Conclusion SPLS was successful in removing most large ovarian tumors without rupture and showed quicker recovery and less immediate post-operative pain in comparison to laparotomy. SPLS using SW Kim`s technique could be a feasible solution to removing huge ovarian tumors.

지역사회 거주 노인의 영적안녕, 사회적 지지, 생활만족도 및 우울의 관계

김소남 ( So Nam Kim ),이상복 ( Sang Bok Lee ) 경희대학교 동서의학연구소 2013 동서간호학연구지 Vol.19 No.2

노화가 진행됨에 따라 노인들은 역할상실, 신체 및 건강의 퇴화 등으로 인해 신체적, 정신적, 사회적, 영적 문제가 심각하게 대두되고 있다. 노인의 스트레스나 위기 상황에서 완충역할을 할 수 있는 영성(Reed, 1991)과 사회적 지지는 노인들의 건강한 삶을 유지, 증진시켜 안녕감을 높여 줄 수 있는 중요한 요소(Nam, 2004)이다.본 연구결과에 의하면, 영적 안녕은 득점범위 20-80점 중에서 평균 55.90점으로 중상정도의 영적수준으로 나타났다. 이는 지역사회 노인을 대상으로 한 Lee (2002)의 연구결과(53.50)를 지지하는 결과이다. 일반적 특성에서 신체적 건강 상태, 종교, 종교에 대한 만족도, 경제상태에서 영적 안녕정도에 차이가 있는 것으로 나타났다. 일상생활수행능력이 좋을수록 영적 안녕이 높게 나타난 Lee와 Lee (2011)의 연구결과와 같이 본 연구에서도 신체적 건강이 좋은 대상자가 영적 안녕점수가 높게 나타나 신체적 건강과 영성이 관계가 있음을 나타냈다. 그러나 입원노인환자를 대상으로 한 Choi (2002)의 연구결과보다 영적 안녕점수가 낮았다. 이는 본 연구 대상자의 60%는 신체적 건강상태가 보통이상이라고 지각하고 있는 일상생활 수행이 가능한 지역사회 노인인 반면 Choi (2002)의 연구 대상자는 입원 및 질병으로 인한 고통과 삶의 위기에 직면한 환자로서 위기를 통해 자신의 의지가 아닌 신과의 관계를 통한 영적 소망으로 영적 안녕 점수가 높게 나타났다고 사료되므로 일상생활 수행능력과 현재 질병 중증정도에 따른 영성과의 관계에 대한 추후연구가 필요할 것으로 생각된다. 종교가 있는 경우가 종교가 없는 경우에 비해 영적 안녕 점수가 높았다. 종교와 영적 안녕과의 관련성에 있어서 입원노인환자를 대상으로 한 Choi (2002)와 Kim, Kwon, Sung과 Kwak (2007)의 연구에서 종교가 있는 노인이 종교가 없는 노인보다 영적 안녕정도가 높은 것으로 나타나 본 연구결과를 지지 하였다. 재가 노인의 영적 안녕 영향요인을 평가한 Jang과 Kim (2003)의 연구에서 종교가 삶에 미치는 중요성 인식정도가 33.1%의 설명력을 보였고, 취약계층 독거 여성노인을 대상으로 한 Lee와 Lee (2011)의 연구에서도 종교가 영적 안녕에 관해 14.9%의 설명력을 나타내 개인의 영적 안녕에 종교가 큰 영향을 미치고 있음을 알 수 있다. 그러나 영적 안녕의 하위 영역별로는 실존적 안녕이 28.85점으로 종적 안녕 27.05점보다 더 높은 점수를 나타냈다. 특히 일반적 특성에서 경제상태, 신체적 건강상태, 삶에 대한 만족도, 사회적 모임의 유무에서 실존적 안녕 점수에 차이가 있었는데, Song과 Kim (2011)의 연구에서는 성별과 만성질환의 개수에서 실존적 안녕점수에 차이가 있는 것으로 나타나 본 연구와는 다른 특성들에서 유의한 결과를 보였다. Sung (1999)은 노인의 영적 안녕, 희망, 지각된 건강실태에 대한 연구에서 실존적 안녕 점수가 높았고, 영적 안녕은 지각된 건강상태와 관계가 있다고 했으며, 암환자를 대상으로 한 Lim (1998)의 연구에서도 실존적 안녕에 더 의미를 두었으며, 종교와 믿음 정도에서 영적 안녕에 대해 유의한 차이가 있다고 보고하였다. 이는 노인들에서 실존적 안녕감이 높을수록 스스로 대응하고 조절하며, 삶의 어려운 문제들을 극복하고 수용할 수 있다는 Song과 Kim (2011)의 연구결과를 뒷받침하며, 이러한 선행연구를 통해 볼 때 노인은 자신과 신의 관계에서 느끼는 종교적 안녕감은 물론 종교와 무관하게 자기 삶의 의미와 목적, 만족감을 나타내는 실존적 안녕감을 통한 영적 안녕을 추구함을 알 수 있다.또한 대상자의 사회적 지지는 경제수준, 신체적 건강상태, 삶에 대한 만족도에서 유의한 차이가 있었다. 경제 수준이 보통 수준 이상의 노인과 삶에 매우 만족 하는 노인이 사회적 지지의 하위 영역인 가족, 친구, 특별 지지 각 영역에 있어서 통계적으로 높은 사회적 지지를 지각하는 것으로 나타났는데 이는 Lee 등(2004)의 연구와 일치하였으며, 중간 수준 이상의 생활수준과 아울러 월 지출액 만족을 지각하는 노인이 사회적 지지망 형성에 있어서 관계맺기의 어려움이 적을 것이라는 Joo와 Kim (2011)의 연구결과를 뒷받침 한다. 신체적 건강상태가 매우 좋은 노인이 통계적으로 높은 사회적 지지를 지각했는데, 건강이 좋을수록 신체적, 심리적으로 여러 가지 활동에 대한 어려움이 감소하여, 사회적 모임과 같은 상호작용적 관계를 형성하고 지속시킬 수 있는 것으로 생각된다. 또한 사회적 지지가 높을수록 영적 안녕이 높은 것으로 나타났고, 영적 안녕에 대해 30%의 설명력을 나타내어 영적 안녕에 영향을 미치는 변수로 나타났다. 노인들은 실질적으로 도움을 주거나 받는 관계에 있는 주위 사람들의 수를 나타내는 사회적 지지망의 구조적 크기가 클수록 노인들의 영적 안녕이 통계적으로 유의하게 높게 나타난 Jang과 Kim (2003)의 연구결과를 뒷받침한다.대상자의 일반적 특성에 따른 생활만족도와 우울은 신체적 건강상태가 좋을수록, 경제적 상태가 좋을수록, 삶에 대한 만족도가 높을수록 우울점수가 유의하게 낮았으며, 생활만족도가 유의하게 높았다. 신체적 건강상태가 노인의 우울에 중요한 영향을 미치며 신체적 건강상태와 생활에 대한 만족 정도가 삶의 질을 결정하는 중요한 인자(Youm et al., 2005)가 된다는 연구결과와 일치한다. 우리나라는 산업화로 인한 가족환경의 변화로 노인 단독가구의 비율 증가에 따른 독거노인의 증가로 고독과 소외감 등의 문제가 심화되고 있는있는데(Joo & Kim, 2011) 신체적으로 건강하고 삶의 만족도가 높은 노인이 지역사회의 다양한 사회적 활동에 적극적으로 참여하여 다른 노인들과의 상호작용을 통해 친밀한 사회적 지지망을 구축함으로써 우울이 감소하고 생활만족도가 높은 것으로 생각된다. 생활만족도가 높을수록 영적 안녕이 높은 것으로 나타났고 영적 안녕에 대해 35.2%의 설명력을 나타내어 노인의 생활만족도를 증진시키기 위해서 영적 안녕감을 향상시킬 수 있는 심리적 간호중재가 필요하다고 생각된다. 그러나 영적 안녕과 우울에서 유의한 상관관계가 없는 것으로 나타나 영적 안녕이 증가할수록 우울이 감소한다는 Youm 등 (2005)의 연구결과와 상반되지만 신체적으로 매우 건강한 노인이 우울정도가 유의미하게 낮게 나타나 우울이 노인의 건강증진행위에 대한 설명력이 큰 요인이라는 Seo와 Ryu (2010)의 연구결과를 뒷받침한다.따라서 노인의 생활만족도를 높이고 우울을 감소시켜 안녕을 증진시키기 위해서는 노인들이 문화생활, 여가활동, 종교활동과 같은 개방적인 사회적 지지망을 이용하여 사회적 지지의 양을 늘리고 불안과 우울을 감소시켜 주는 영적 안녕을 증진시켜 대상자의 심리적인 측면의 간호지지를 제공하여야 할 것이다.결론적으로 본 연구에서는 영적 안녕과 사회적 지지, 생활만족도 및 우울이 노인의 일반적 특성과 관련이 있으며, 특히 실존적인 안녕이 생활만족도에 더 유의한 영향을 미쳐 노인의 안녕과도 긍정적인 상관이 있는 것으로 나타났다. 따라서 노년기의 영적 안녕과 사회적 지지 및 생활만족도는 삶의 의미를 부여하고 삶의 위기를 대처할 수 있는 중요한 요소이며, 신체적, 정신적, 정서적, 사회적 영역을 강화하여 총체적으로 건강한 상태를 유지하는데 필요한 자원이 될 수 있다. 본 연구의 결과는 노인의 안녕을 평가할 때 영적 안녕을 고려하고 다양한 사회적 지지체계를 형성 할 수 있도록 돕는 간호중재 개발의 기초자료의 확장에 기여하였다는데 의의가 있다. 그러나 본 연구결과는 일부 도시 지역에 거주하는 노인들을 대상으로 편의 표집 하여 조사하였으며, 시설입소노인, 입원노인, 치매노인과의 비교평가를 하지 못했다는 제한점이 있다. 향후 본 연구결과를 토대로 이를 확인하기 위한 추후연구가 필요하다. The purposes of this study were to identify correlation of spiritual well-being, social support, life satisfaction and depression in the community dwelling elderly, and to explore a possibility to apply the spiritual well-being, and social support as resources to promote welfareof the elderly. Methods: A structured questionnaire was used to obtain data from a convenience sample of 222 senior citizens, who visited social welfare centers in Gangwon-do from September to October, 2010. Data were analyzed using t-test, ANOVA, and multiple regression.Results: There were significant differences in spiritual well-being based on religion, satisfaction to religion, economic status, physical health, and life satisfaction. Social support was significantly different according to economic status, physical health, life satisfaction, and social gathering.The existential well-being, family support, and special support had a significant effect on life satisfaction, and demonstrated positive correlations with the well-being of the elderly. Conclusion: Spiritual well-being and social support have significant effects on depression and life satisfaction of senior citizens. Thus spiritual well-being and social support can be considered as important factors that improve the elderly`squality of life.

산후에 발병한 특발성 부갑상선 기능저하증 I 예

김정인,김상용,신병철,김경남,서영욱,이범주,김진화,배학연 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Hypoparathyroidism is usually the result of an inadvertent surgical removal of all the parathyroid glands, In some instances, not all the tissues are removed, but the remainder undergoes vascular supply compromise secondary to the fibrotic changes in the neck after surgery, Previously, the surgery for hyperthyroidism was the most frequent cause of acquired hypoparathyroidism. Idiopathic hypoparathyroidism is a relatively rare disease that is characterized by hypocalcemia and hyperphosphatemia due to a parathyroid hormone deficiency of an unknown cause, It usually develops at a young age, and shows various clinical symptoms and signs accompanied with hypocalcemia. In addition, it is rarely associated with polyglandular autoimmune syndrome during the follow-up. Hypocalcemia and idiopathic hypoparathyroidism associated with labor and lactation are rarely reported condition previously. We here describe a case of a woman in whom the symptomatic severe hypocalcemia appeared after her delivery. We reviewed all the previously reported cases and suggest a possible physiological explanation for the association between pregnancy, lactation, and the appearance of symptomatic hypocalcemia.

남성 성기자해

김상훈,문남식,황걸,박상학,김학렬,김경환 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: Intentional self-mutilation of the genitals in male is exceedingly rare. As the authors experienced 3 cases of male genital self-mutilation while psychotic, we investigated with psychiatric points of view including general and psychiatric characteristics of genital self-mutilation in Korea. Materials and Methods: Total 21 cases of the genital injury were obtained from the index book of Journal of Korean Neuropsychiatric Association and the Electronic Library Search Engine. From these, excluding the 4 accident-caused cases of penile amputation, the authors investigated 17 cases in terms of general epidemiological characteristics, the type of mutilation, diagnostic classification, psychodynamics of their behavior. Results: Epidemiological data showed that the most of the genital self-mutilation cases are twenties (52.9%); most are single (64.7%). In terms of the mutilation types, complete transection of penis type were committed most frequently (72.1%). The formal diagnoses were mainly schizophrenia (82.3%) and schizoid personality disorder(11.8%). Psychodynamically, lots of cases could be explained as to punish failures in the male role (20.6%), related to religiosity (14.7%), and related to physical pain or somatic illness (14.7%). Conclusion: We are unable to say exactly what prompts a man to divest himself of his genitals. On the basis of 17 cases, we are willing to hazard several risk factors. For individuals psychotic at the time of act there seem to be at least three paradigmatic at-risk groups: (1) younger acutely psychotic men with related to cure or punish failures in the male role, (2) the men with personality disorders who act rageful feelings against themselves and/or close objects, and (3) sociocultural factors known to contribute to such an act include some complex religious belief regarding purification or resisting temptation. Psychological factors yet undetermined may be' equally important.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

2형 당뇨 환자에 있어서 C형 간염의 유병률에 관한 연구

김구영,서광섭,유광렬,임병욱,채선애,강남훈,김창훈,권영우,김희수,류성태,이정환,박성우,오웅식,김정한 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1

Background: We have doubt about the truth that Type 2 DM is associated with chronic hepatitis C infection. The aim of our study was to prove a close relationship between chronic HCV infection and type 2 DM in korean patients. Methods: We reviewed the out-patient's medical records of 466 patients with type 2 DM who visit the Sung-ae hospital from March 2000 to August 2001. Diabetic patients were analyzed for the following variables: age, sex, waist circumference, weight, waist/hip ratio, using of self monitoring of blood glucose, method of therapy, duration of disease, experience of previous transfusion, major surgical procedure, accompanied disease, liver function tests (LFT), HbA1 c. We ruled out patients with liver cirrhosis. Results: Hepatitis C virus infection was observed more frequently in patient with Type 2 DM. Of 466 Type 2 DM patients, 13 patients were infected with Hepatitis C virus (2.79%). Compared with mean prevalence of Korean population (1.3~1.6%), it's value is very high. the other hand, 21 patients were infected with Hepatitis B virus (4.5%). Such results are similar to mean prevalence of the general public (4~5%). Conclusions: Prevalence of hepatitis C was closely associated in korean patients with type 2 DM. And an increased prevalence is independent of cirrhosis.

중추신경계 합병증을 동반한 삼일열 말라리아 1례

김문석,김가연,강유민,김낙현,전재현,박완범,김홍빈,김남중,박상원,홍윤호,오명돈 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

Plasmodium vivax malaria is an endemic disease in Korea, which rarely causes severe complications including those occurring in the cerebrum. There are limited numbers of complicated cases that have been reported around the world. We experienced a case of vivax malaria with cerebral complication: cognitive impairment and ataxia. A 55-year-old female with diabetes mellitus presented to the emergency department with acute fever of two days’ duration. She did not have any history of travelling abroad or receiving blood transfusions. Peripheral blood smear revealed vivax malaria with parasitemia density of 0.53 percent. She demonstrated loss of orientation, especially regarding time and place, and ataxia. Although the initial hydroxychloroquine treatment for malaria was successful, cognitive impairment and ataxia persisted and were not recovered. Brain MRI showed no structural abnormality. Brain PET showed diffuse hypometabolism in right parieto-temporal lobe of the brain.

Promotional Strategies of Local Drugstores

Kim,Seung-Mi,Lee,Sang-Yoon,Kim,Pan-Jin,Kim,Nam-Myun,Youn,Myoung-Kil 한국유통과학회 1999 유통과학연구 Vol.1 No.1

The retail business of drugstore was introduced to Korea for the first time 10 years ago. Since Olive Young introduced a retail store in the name of drugstore in 1999 for the first time in Korea, new distribution channel combining drugstore, cosmetic products and dairy products, etc has been made. At initial stage, the new distribution channel grew up slowly because of low specialty and economic stagnation. However, the three big distribution channels, that is to say, Olive Young (CJ), Watsons (GS) and W Store (Kolon Well Care), etc, were established to produce new distribution system following large-scaled discount stores as well as convenience stores. The purpose of the study is to investigate ways making Korean style drugstore be new retail business in addition to traditional markets, department stores, E-Mart and other general super markets and to examine problems preventing the drugstore from being promoted and to find out solutions. The speciality retailers that is called a category killer attacking department stores as well as marts is expanding market quickly. New consumption trend that gives priority to wellbeing is being expanded in accordance with high level of standards of living life: The drugstore is thought to be new alternative of distribution because it keeps special products. Young ladies who are main customers of drugstores respond to the trend sensitively to have more buying power that is thought to be promising. And, consumers' desire has become concrete and special. This is because consumers want not only convenient shopping but also special shopping system that is current trend. These days, so called Multi-shop and Total shop and other special shops have been recently opened. Special multi-shop has been concentrated on fashion product and miscellaneous goods so far: Health total wellbeing shop shall be popular in accordance with wellbeing trends. Drugstores can play an important role. Drugstores were opened for the first time ten years ago. In

소에서 盲腸擴張을 동반한 第4胃食滯 手術 1例

김명철,김덕환,신상태,임준호,김남중,김종만 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

Abomasal impaction with cecal dilatation was diagnosed in a 3 years old holstein cow. The clinical signs were loss of appetite, scant feces and moderate distension of the abdomen. Ping sound was revealed in the right 11th intercostal space by auscultation. Cecal dilatation and abomasal impaction were ascertained by right flank laparotomy and abdominal exploration, and intestinal content and gas were removed from the cecal apex incised. One day later, 2.5㎏ of sand was removed by ventral paramedian abomasotomy.

Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.